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Effect of building interface form on thermal comfort in gymnasiums in hot and humid climates

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Frontiers of Architectural Research 2019年第01期 32-43页

作者： Xiaodan Huang Xiaoli Ma qingyuan Zhang institute of Urban innovation Yokohama National University School of Engineering and computer science University of Hull

The thermal environment and thermal comfort of a building are greatly affected by the design of the building interface form. Most contemporary architectural designs consider only the relations between architectural form and architectural beauty. Few studies on the correlation of architectural form and thermal comfort address the influence of architectural form on thermal comfort and thermal environment. These studies are particularly important for gymnasium architectures located in hot and humid areas,which have high requirements for thermal comfort. This paper presents an experimental investigation and an analysis of the effect of the building interface form of gymnasiums on thermal comfort in hot and humid subtropical regions during summer. Results showed that the influence of the top interface forms on thermal comfort is mainly dominated by the mean radiant temperature, which could be controlled to improve thermal comfort. The influence of side interface forms on thermal comfort is mainly dominated by air velocity,and thermal comfort could be improved by promoting natural ventilation on the side interface form design to reduce indoor heat. This research enhanced our understanding of the relation between the interface form and the thermal comfort of gymnasiums. In addition, this paper provides a theoretical reference for the sustainable design of gymnasiums in hot and humid climates.

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controllable Morphology Tailoring with Solvothermal Method Toward LiMnPO_(4)/C Cathode Materials for Improved Performance and Favorable Thermostability

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Acta Metallurgica Sinica(English Letters) 2022年第5期35卷 790-800页

作者： Wei Yang Xiulian Qiu Chengyun Wang Jinhao Ye Jihua Zhu Hanbo Zou Shengzhou Chen School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou510006China GAC Automotive Research and Development Center Guangzhou511434China Sunwoda Electronics co. LtdShenzhen518107China

An environmentally friendly method for the synthesis of LiMnPO_(4)/C anode material for lithium-ion batteries by solvothermal method is *** modification of the morphology of this precursor is altered by changing the ratio of the conditioning solvent(water-ethylene glycol solution)and the order of material *** glycol(EG)exerts a considerable influence on synthesizing LiMnPO_(4)/C flake-like nanocrystal,which benefits the extraction/insertion reaction of lithium ions and improves the electrochemical activity and electrochemical performance of LiMnPO_(4)/C *** the solvent composition is H_(2)O:EG=1:3,exhibiting exceptional charge/discharge performance and rate capability,the specific discharge capacities are 155.8,153.7,148.8,141.4,129.5,and 112.6 mAh g^(−1) at the 0.1,0.2,0.5,1,2,and 5 C rates,*** the charge-discharge rate returns to 0.1 C,the LiMnPO_(4)/C material shows a reversible discharge specific capacity of 153.7 mAh g^(−1).Differential scanning calorimetry(DSC)tests verify that the thermodynamic stability of the prepared LiMnPO_(4)/C(LMP)and commercial LiFePO_(4)(LFP)materials is better than that of commercial nickel-cobalt-aluminum(NCA)ternary *** prepared LiMnPO_(4)/C composites have high electrochemical capacity and cycle stability.

关键词： LiMnPO_(4)/C solvothermal method Ethylene glycol Lithium-ion diffusion Thermostability

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生态环境曲面量子机器学习（英文）

science Bulletin 2022年第10期67卷 1031-1033页

作者：岳天祥刘熠杜正平 John Wilson 赵东一王宇赵娜史文娇范泽孟赵小敏张嵚黄宏胜邬清元周伟焦毅蒙徐喆李赛博杨阳傅伯杰 State Key Laboratory of Resources and Environment Information System Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences college of Resources and Environment University of Chinese Academy of Sciences college of Land Resources and Environment Jiangxi Agricultural University Jiangsu Center for collaborative innovation in Geographical Information Resource Development and Application Spatial sciences institute University of Southern California Origin Quantum computing technology company Limited Yanqi Lake Beijing institute of Mathematical sciences and Applications 8. Monitoring Station for Weather and Eco-Environment of Wu Gong Mountain School of Geographical sciences Southwest University Research Center for Eco-Environmental sciences Chinese Academy of Sciences Faculty of Geographical science Beijing Normal University

通过晶体管小型化增加芯片上的晶体管数量一直是计算进步的最基本部分.然而,晶体管小型化已达到极限水平.与此同时,现有计算机已无法满足许多实际问题对计算资源的巨大需求.幸运的是,量子计算机初见端倪.有关研究表明, 54量子比特的量...

通过晶体管小型化增加芯片上的晶体管数量一直是计算进步的最基本部分.然而,晶体管小型化已达到极限水平.与此同时,现有计算机已无法满足许多实际问题对计算资源的巨大需求.幸运的是,量子计算机初见端倪.有关研究表明, 54量子比特的量子计算机在数分钟内就可完成传统计算机需要用1万年才能完成的计算任务;机器学习可提高量子算法的精度.机器学习方法可区分为监督学习、非监督学习、强化学习和多法混合学习.本文引入的高精度曲面建模(HASM)方法是一种强化学习方法,它可转换为大型线性稀疏系统.这个大型线性系统可运用HHL量子算法进行求解.我们将HASM机器学习与HHL量子算法的合成称为HASM-HHL量子机器学习.训练实验表明,精度设置对HASM-HHL性能和量子电路参数有很大影响;量子计算对量子比特总数的需求依赖于计算域的栅格总数.运用HASM-HHL模拟整个地球表面时,在1 km×1 km空间分辨率,需要40量子比特;在1 m×1 m空间分辨率,需要45量子比特. HASM-HHL可实现相对传统计算机算法的指数级加速.由于HASM已成功应用于各种空间尺度的数字高程模型构建以及生态多样性变化、人口动态、土壤属性动态、食物供给动态、碳储量动态、二氧化碳浓度变化、气候变化和新冠病毒传播动态等的模拟分析, HASM-HHL有望成为模拟分析地球表层系统及其生态环境要素的通用量子机器学习平台.

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Organoids as preclinical models of human disease:progress and applications

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Medical Review 2024年第2期4卷 129-153页

作者： Baodan Chen Cijie Du Mengfei Wang Jingyi Guo Xingguo Liu CAS Key Laboratory of Regenerative Biology Joint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative MedicineChina-New Zealand Joint Laboratory on Biomedicine and HealthCUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative MedicineGIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research CentreInstitute for Stem Cell and RegenerationGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina University of Chinese Academy of sciences BeijingChina innovation Centre for Advanced Interdisciplinary Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Centre for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong SARChina

In the field of biomedical research,organoids represent a remarkable advancement that has the potential to revolutionize our approach to studying human diseases even before clinical *** are essentially miniature 3D models of specific organs or tissues,enabling scientists to investigate the causes of diseases,test new drugs,and explore personalized medicine within a controlled laboratory *** the past decade,organoid technology has made substantial progress,allowing researchers to create highly detailed environments that closely mimic the human *** organoids can be generated from various sources,including pluripotent stem cells,specialized tissue cells,and tumor tissue *** versatility enables scientists to replicate a wide range of diseases affecting different organ systems,effectively creating disease replicas in a laboratory *** exciting capability has provided us with unprecedented insights into the progression of diseases and how we can develop improved *** this paper,we will provide an overview of the progress made in utilizing organoids as preclinical models,aiding our understanding and providing a more effective approach to addressing various human diseases.

关键词： organoids human disease regenerative medicine drug screening tumor

Serial nuclear transfer improves the development of interspecies reconstructed giant panda (Aluropoda melanoleucd) embryos

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Chinese science Bulletin 2002年第6期47卷 467-469页

作者： LI Jinsong CHEN Dayuan HAN Zhiming ZHU Ziyu WEN Duancheng SUN qingyuan LIU Zhonghua WANG Minkang LIAN Li DU Jun WANG Pengyan ZHANG Hemin State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100080China college of Animal science and Veterinary Medicine Yangzhou UniversityYangzhou 225009China college of Life science Beijing Normal UniversityBeijing 100857China Suzhou University Suzhou 215151China Northeast Agriculture University Harbin 150030China Yunnan University Kunming 650223China China Research and conservation Center for Giant Panda Wolong Nature ReserveWenchuan 623006China

Interspecies somatic nuclear transfer (NT) may provide a new approach for preservation of the endangered rare species. Previous interspecies cloning studies have shown that a nucleus from a quiescent somatic cell supports early development of reconstructed embryos in the ooplasm from another species. In this study, we transferred nonqui-escent somatic cells from a giant panda into the perivitelline space of the enucleated rabbit oocytes. After electrofusion (at the rate of 71.6%) and electrical activation, 4.2% of the panda-rabbit reconstructed embryos developed to blastocyst in vitro. For improving the development rate of reconstructed embryos, we used serial NT in this study, i.e. blas-tomeres from reconstructed morulae were transferred into the perivitelline space of the enucleated rabbit oocytes. The fusion rates in the groups of serial I, serial Ⅱ and serial Ⅲ were 79.5%, 84.1% and 78.0%, respectively, having no difference with that of somatic group. And the blastocyst rates in serial NT groups

关键词： nonquiescent cell giant panda rabbit interspecies nu-clear transfer serial nuclear transfer.

Replacement of inner cell mass in mouse

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Chinese science Bulletin 2003年第13期48卷 1347-1351页

作者： BI Chunming, WEN Duancheng, XU Ying, SUN qingyuan & CHEN Dayuan State Key Laboratory of Reproductive Biology, institute of Zoology,Chinese Academy of sciences, Beijing 100080, China correspondence should be addressed to Chen Dayuan(e-mail: chendy@ ***) State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences China

The intra- or inter-strain reconstitutedblastocysts were produced by replacing the inner cell mass of Kunming mouse blastocysts with that of Kunming orC57BL/6 mouse strain blastocysts. A total of 192 intra-strain reconstituted blastocysts were transferred into 17pseudopregnant Kunming mice, and 2 reconstituted embryos were developed into term; while 115 inter-strain reconstituted blastocysts were produced, analysis of thereconstituted blastocysts showed that the morphology andcytoskeleton srtucture of the blastocysts were not differentfrom those of normal blastocysts, however, no viableoffspring was obtained after embryo transfer for these inter-strain reconstituted blastocysts. The resultsdemonstrated that the intra-strain reconstituted blastocystscould normally develop into term, whereas the inter-strain reconstituted blastocysts possessed less developmental potential as the intra-strain reconstituted blastocysts. Thisstudy may give light to solve the problem of low implantation rate and placenta abnormality in mammal cloning.

关键词：内细胞群细胞替代老鼠再生胚泡形态学克隆技术

Lactate and protein lactylation:the ugly duckling of energy as the sculpture artist of proteins

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science Bulletin 2023年第21期68卷 2510-2514页

作者： Linpeng Li Shanhu Sun Yi Wu Jianghuan Lu Jingcai He Keshi Chen Wai-Yee Chan Xingguo Liu GMU-GIBH Joint School of Life sciences The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and DiseasesThe Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalKey Laboratory of Biological Targeting DiagnosisTherapy and Rehabilitation of Guangdong Higher Education InstitutesThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityCAS Key Laboratory of Regenerative BiologyGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510000China Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine China-New Zealand Joint Laboratory on Biomedicine and HealthCUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesGuangzhou 510000China Centre for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong KongChina CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine CUHK-Jinan University Key Laboratory for Regenerative MedicineMinistry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong KongChina

Metabolites play important roles in numerous cell biology processes,such as cell proliferation,differentiation,stress response,and cell death[1].Recently,lactate and lactate-derived lysine residue lactylation(Kla)have emerged as newly discovered epigenetic modifications that play critical roles in various physiological and pathological *** the history of lactate research,we can categorize the studies into three mile stones(Fig.S1 online).

关键词： death residue 能量代谢

Genetic dissection of and genomic selection for seed weight, pod length,and pod width in soybean

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The Crop Journal 2023年第3期11卷 832-841页

作者： Yijie Chen Yajun Xiong Huilong Hong Gang Li Jie Gao qingyuan Guo Rujian Sun Honglei Ren Fan Zhang Jun Wang Jian Song Lijuan Qiu college of Agriculture Yangtze UniversityJingzhou 434025HubeiChina college of Life sciences Yangtze UniversityJingzhou 434025HubeiChina National Key Facility for Gene Resources and Genetic Improvement/institute of Crop sciences Chinese Academy of Agricultural SciencesBeijing 100081China Soybean Research institute Heilongjiang Academy of Agricultural SciencesHarbin 150086HeilongjiangChina Engineering Research Center of Ecology and Agricultural Use of Wetland Ministry of EducationJingzhou 434025HubeiChina Hulunbuir institute of Agriculture and Animal Husbandry Hulunbuir 021000Inner MongoliaChina

A biparental soybean population of 364 recombinant inbred lines(RILs)derived from Zhongdou 41×ZYD02.878 was used to identify quantitative trait loci(QTL)associated with hundred-seed weight(100-SW),pod length(PL),and pod width(PW).100-SW,PL,and PW showed moderate correlations among one another,and 100-SW was correlated most strongly with PW(0.64–0.74).Respectively 74,70,75 and19 QTL accounting for 38.7%–78.8%of total phenotypic variance were identified by inclusive composite interval mapping,restricted two-stage multi-locus genome-wide association analysis,3 variancecomponent multi-locus random-SNP-effect mixed linear model analysis,and conditional genome-wide association *** these QTL,189 were novel,and 24 were detected by multiple *** loci were associated with 100-SW,PL,and PW and may be pleiotropic loci.A total of 284 candidate genes were identified in colocalizing QTL regions,including the verified gene Seed thickness 1(ST1).Eleven genes with functions involved in pectin biosynthesis,phytohormone,ubiquitin-protein,and photosynthesis pathways were prioritized by examining single nucleotide polymorphism(SNP)variation,calculating genetic differentiation index,and inquiring gene *** prediction accuracies of genomic selection(GS)for 100-SW,PL,and PW based on single trait-associated markers reached 0.82,0.76,and 0.86 respectively,but selection index(SI)-assisted GS strategy did not increase GS efficiency and inclusion of trait-associated markers as fixed effects reduced prediction *** results shed light on the genetic basis of 100-SW,PL,and PW and provide GS models for these traits with potential application in breeding programs.

关键词： Soybean Seed weight Pod size Genetic analysis Genomic selection

Efficacy and safety of obinutuzumab for the first-line treatment of follicular lymphoma:a subgroup analysis of Chinese patients enrolled in the phase III GALLIUM study

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Chinese Medical Journal 2022年第4期135卷 433-440页

作者： Xiaonan Hong Yuqin Song Yuankai Shi qingyuan Zhang Wei Guo Gang Wu Junmin Li Jifeng Feng Anastasiia Kinkolykh Andrea Knapp Tongyu Lin Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Peking University Cancer Hospital and InstituteBeijing 100142China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin Medical UniversityHarbinHeilongjiang 150081China Department of Hematology The First Hospital of Jilin UniversityChangchunJilin 130015China Department of Medical Oncology Cancer CenterUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430023China Shanghai institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medical Oncology Jiangsu Cancer HospitalNanjing Medical University Affiliated Cancer HospitalNanjingJiangsu 210009China consultant to F.Hoffmann-La Roche ltd BaselSwitzerlandvia GCE Solutions-an IQVIA businessSwitzerland Product Development Oncology F.Hoffmann-La Roche LtdBaselSwitzerland Department of Medical Oncology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South Chinaand Collaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510075China

Backgrounds:GALLIUM is a global phase Ⅲ study that demonstrated significant improvements in progression-free survival(PFS)for obinutuzumab plus chemotherapy(G-chemo)*** plus chemotherapy(R-chemo)in previously untreated patients with follicular lymphoma(FL).This study aimed to report the results of a subgroup of patients in ***:Patients were randomized to G-chemo or *** received maintenance therapy for 2 years or until disease *** primary endpoint was investigator(INV)-assessed *** endpoints included the overall response rate(ORR)and complete response rate(CRR)at the end of induction chemotherapy,overall survival(OS),and ***:Overall,58 patients with FL were randomized to the G-chemo(n=25)and R-chemo arms(n=33).The INV-assessed PFS rate at 3 years was 81.8%in the G-chemo arm,vs.70.2%in the R-chemo arm(hazard ratio 0.35;95%confidence interval:0.09-1.34;P=0.1120).The INV-assessed CRRs(without positron emission tomography[PET])in these arms were 24.0%and 21.2%,respectively,whereas the ORRs were 80.0%and 90.9%,***-assessed CRR-PET was 52.6%in the G-chemo,vs.60.9%in the *** OS was not reached in either *** 3 to 5 adverse events were more frequent in the R-chemo arm(97.0%vs.88.0%).conclusions:The results of this subgroup analysis were consistent with those of the global population,and they suggest that G-chemo has a positive benefit-risk profile in patients from China with *** registration:***,***01332968.

关键词： Chinese Follicular lymphoma GALLIUM Obinutuzumab Rituximab