检索结果-南通市图书馆

Prospects for the therapeutic development of umbilical cord bloodderived mesenchymal stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem cells 2020年第12期12卷 1511-1528页

作者： Soyoun Um Jueun Ha Soo Jin Choi Wonil Oh Hye Jin Jin Research Team for Immune cell therapy Biomedical Research InstituteMEDIPOST Co.Ltd.Seongnam 13494South Korea Research Team for Osteoarthritis Biomedical Research InstituteMEDIPOST Co.Ltd.Seongnam 13494South Korea Biomedical Research Institute MEDIPOST Co.Ltd.Seongnam 13494South Korea

Umbilical cord blood(UCB)is a primitive and abundant source of mesenchymal stem cells(MSCs).UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and *** the high latent selfrenewal and differentiation capacity of these cells,the safety,efficacy,and yield of MSCs expanded for ex vivo clinical applications remains a ***,immunomodulatory effects have emerged in various disease models,exhibiting specific mechanisms of action,such as cell migration and homing,angiogenesis,anti-apoptosis,proliferation,anti-cancer,anti-fibrosis,anti-inflammation and tissue ***,we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies,and discuss the concerns regarding the safety and mass production issues in future applications.

关键词： Umbilical cord blood Mesenchymal stem cell Stem cell therapy Immunomodulation Regenerative medicine Therapeutic cell manufacturing processing

Data-driven modeling and fault diagnosis for fuel cell vehicles using deep learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy and AI 2024年第2期16卷 111-124页

作者： Yangeng Chen Jingjing Zhang Shuang Zhai Zhe Hu College of Science University of Shanghai for Science and Technology(USST)Shanghai200093China Shanghai Refire Technology Co. Ltd.655 Jinyuanyi RoadJiadingShanghai201800China

The reliability and safety of fuel cell vehicle are crucial for the daily operation. Insulation resistance serves as a crucial index of vehicle reliability, especially when fuel cells operate at high voltages. Low insulation resistance can lead to vehicle malfunctions, exposing the operator to the risk of electric shock. In this study, long-term insulation resistance data from thirteen vehicles equipped with three different types of fuel cell systems are analyzed to diagnose possible low insulation resistance issues. For this purpose, a robust locally weighted scatterplot smoothing method is utilized to filter the original data. In this research, an insulation variation model is developed using a data-driven long short-term memory neural network to identify insulation resistance value anomalies caused by deionizer failure. The results indicate that the coefficient of determination of the failure model is 99.78 %. Moreover, current model efficiently identifies insulation faults resulting from reliability issues, such as conductivity issues of cooling pipes and erosion of vehicle wiring harnesses.

关键词： Fuel cell vehicles Insulation faults RLOWESS LSTM neural network

The Influence of Ethyl Branch on Formation of Shish-Kebab Crystals in Bimodal Polyethylene under Shear at Low Temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2021年第8期39卷 1050-1058,I0008页

作者： Zong-Bao Wang Yi-Min Mao Xu-Ke Li Yi-Guo Li Chatchai Jarumaneeroj Boonyakeat Thitisak Piyawan Tiyapiboonchaiya Wonchalerm Rungswangd Benjamin S.Hsiao Ningbo Key Laboratory of Specialty Polymers School of Materials Science and Chemical EngineeringNingbo UniversityNingbo 315211China Department of Materials Science and Engineering University of MarylandCollege ParkMaryland 20742USA NIST Center for Neutron Research National Institute of Standards and TechnologyGaithersburgMaryland 20899USA scg Chemicals Co. Ltd.Siam Cement Group(SCG).1 Siam Cement Rd.BangsueBangkok 10800Thailand USA Department of Chemistry Stony Brook UniversityStony BrookNY 11794-3400USA

Formation of shish-kebab crystals using a bimodal polyethylene system containing high molecular weight(HMW)component with different ethyl branch contents was *** situ small-angle X-ray scattering(SAXS)and wide-angle X-ray diffraction(WAXD)techniques were used to monitor the formation and evolution of shish-kebab structure sheared at low temperature in simple shear mode and low *** the bimodal PE with no branch formed shish-kebab crystals at the shear temperature of 129℃,and the shish length increased with the crystallization time,while bimodal PE with branch has no observable shish under the same *** degree of crystallization for bimodal PE with no branch increased with time up to above 7%,while those with ethyl branch increased continually up to above 23%.Furthermore,bimodal PE's Hermans orientation factor with no branch increased to 0.60,while those with ethyl branch only increased to a value below *** study indicated that the shish-kebab crystal formed at the low temperature of 129℃is due to the stretch of entangled chains under shear for the bimodal PE with no *** partly oriented lamellar crystals were formed for the bimodal PE with ethyl *** the results at the shear temperatures higher,closed to,and lower than the melting point,the modulation of shish crystals formation owing to different mechanisms of the coil-stretch transition and the stretched network by changing shear temperature was achieved in the bimodal PE samples.

关键词： Bimodal polyethylene Shish-kebab Ethyl branch Shear

Amphipathicity mediated endocytosis of mesoporous silica nanoparticles with tunable frameworks

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第9期17卷 8350-8359页

作者： Runfeng Lin Tiancong Zhao Liang Chen Minchao Liu Hongyue Yu Ruicong Wang Minjia Yuan Xiaomin Li Dongyuan Zhao Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Shanghai Qiran Biotechnology Co. Ltd.Shanghai 201702China

Due to the amphiphilic nature of phospholipids in the cell membrane,the amphipathicity of the nanomedicine plays a crucial role in the ***,limited biological characterization methods restrict the study of the state of nanoparticles with different amphiphilicities on cell *** understanding of interaction of amphiphilic particle with cell membrane is still ***,by combining the dissipative particle dynamics(DPD)with the framework construction of mesoporous silica nanoparticles(MSNs),we demonstrate the enhanced endocytosis induced by the *** results confirm that the presence of hydrophobic groups on the surface of nanoparticles can disturb the integrity of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine(POPC)membrane and induce activation of phospholipids to a higher energy level,thereby facilitating the wrapping of *** validate the simulation findings,uniform MSNs with hydrophilic pure silica framework and two types of amphiphilic MSNs with varying hydrophilic organic groups in the framework are rationally synthesized by using different silane *** obtained three kinds of MSNs show similar diameter(~100 nm)and mesopores(~2 nm),but distinct hydrophobicity/hydrophilicity *** phenyl-bridged MSN with a carbon content of 27.1%exhibits enhanced cellular uptake,consistent with the theoretical simulation *** work sheds light on how the surface amphipathicity influences endocytosis through the interaction with cell membrane.

关键词： mesoporous silica nanoparticles mesoporous organosilica endocytosis cell membrane amphipathicity

Integrating single Ni site and PtNi alloy on two-dimensional porous carbon nanosheet for efficient catalysis in fuel cell

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 6916-6921页

作者： Fangyao Zhou Yaner Ruan Feng Li Lin Tian Mengzhao Zhu Wenan Tie Xiaoyan Tian Bo Wang Peigen Liu Jie Xu Xiaoping Gao Peng Li Huang Zhou Yuen Wu Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of ChinaHefei 230026China Shanxi Yanchang Petroleum(Group)Co.ltd. Xian 710065China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China

The performance of catalyst depends on the intrinsic activity of active sites and the structural characteristics of the ***,we simultaneously integrate single nickel(Ni)sites and platinum-nickel(PtNi)alloy nanoparticles(NPs)on a two-dimensional(2D)porous carbon nanosheet,demonstrating remarkable catalytic performance in the oxygen reduction reaction(ORR).The single Ni sites can activate the oxygen molecules into key oxygen-containing intermediate that is further efficiently transferred to the adjacent PtNi alloy NPs and rapidly reduced to H_(2)O,which establishes a relay catalysis between active *** porous structure on the carbon nanosheet support promotes the transfer of active intermediates between these active sites,which assists the relay catalysis by improving mass ***,the obtained catalyst demonstrates a half-wave potential of up to 0.942 V,a high mass activity of 0.54 A·mgPt^(−1),and negligible decay of activity after 30,000 cycles,which are all superior to the commercial Pt/C catalysts with comparable loading of *** theoretical calculation results reveal that the obtained catalyst with defect structure of carbon support presents enhanced relay catalytic effect of PtNi alloy NPs and single Ni sites,ultimately realizing improved catalytic *** work provides valuable inspiration for developing low platinum loading catalyst,integrating single atoms and alloy with outstanding performance in fuel cell.

关键词： two-dimensional porous carbon nanosheet Pt-based alloy single atom catalysts relay effect proton-exchange membrane fuel cells

Hypoxic Mesenchymal Stem cells Promote Diabetic Wound Healing in Rats by Increasing VEGF Secretion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生物医学与环境科学:英文版 2023年第8期36卷 756-759页

作者： ZHUANG Su Jing SUN Xu Yan LUO Meng WANG Zhong ZHANG Xue Juan GAO Zong Sheng LIU Jian LIU Xin Ran LIU Shi Ze JIA Xiao Peng Shandong Qilu Stem cell Engineering Co.ltd Jinan 250102ShandongChina

Diabetes mellitus is a global public health concern affecting an estimated 537 million people,and patients with diabetes are more susceptible to developing chronic wounds^([1,2]).The wound healing process is often affected by various factors,including infection,tissue hypoxia,necrosis,exudates,and excessive inflammatory cytokines^([3]).Presently,there is no effective treatment for refractory wound healing,and the development of new techniques and therapeutic strategies is urgently required for patients with diabetes who have chronic wounds.

关键词： healing wound patients

Research on ECMS Based on Segmented Path Braking Energy Recovery in a Fuel cell Vehicle

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Energy Engineering 2024年第1期121卷 95-110页

作者： Wen Sun Meijing Li Guoxiang Li Ke Sun Shuzhan Bai School of Energy and Power Engineering Shandong UniversityJinan250061China Automotive Research Institute China National Heavy Duty Truck Group Co.Ltd.Jinan250061China

Proton exchange membrane fuel cells are widely regarded as having the potential to replace internal combustion engines in *** fuel cells cannot recover energy and have a slow dynamic response,they need to be used with different power *** efficient energy management strategies to achieve excellent fuel economy is the goal of *** paper proposes an adaptive equivalent fuel minimum consumption strategy(AECMS)to solve the problem of the poor economy of the whole vehicle caused by the wrong selection of equivalent factors(EF)in traditional *** this method,the kinematics interval is used to update the equivalent factor by considering the penalty term of energy recovery on SOC ***,the optimized equivalent factor is substituted into the optimization objective function to achieve efficient energy *** results under the New European Driving Cycle show that compared with the traditional ECMS based on fixed SOC benchmarks,the proposed method improves fuel economy by 1.7%while ensuring vehicle power and increases SOC by 30%.

关键词： Fuel cell PEMFC electric vehicle equivalent consumption minimization strategy

In situ anchoring in carbon matrix of Bi_(2)O_(2)CO_(3) as a high-performance anode material for Li-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第8期43卷 3634-3646页

作者： Pu-Qiang He Jun Guo Hui Huang Zhong-Cheng Guo Faculty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Research Center of Metallurgical Electrode Materials Engineering Technology Kunming 650106China Kunming Hendera Science and Technology Co. Ltd.Kunming 650106China

Bismuth-based anode materials have been regarded as promising Li-ion batteries due to their high theoretical ***,their low conductivity and associated volume expansion inhabited their *** this work,Bi_(2)O_(2)CO_(3)@C composites were successfully synthesized by in situ anchoring of flower-like Bi_(2)O_(2)CO_(3) nanosheets on a carbon-based substrate via *** unique composited structure of Bi_2O_(2)-CO_(3)@C leads to a stable specific capacity of 547 mAh·g^(-1)after 100 cycles at a current density of 0.1 A·g^(-1).Notably,it demonstrates excellent rate capability with a specific capacity of 210 mAh·g^(-1)at 5 A·g^(-1).After 550 cycles at a current density of 0.5 A·g^(-1),a high reversible capacity of nearly 400 mAh·g^(-1)was ***,in situ X-ray diffraction measurements clearly demonstrate the conversion between Bi and Li_(3)Bi during alloying/dealloying,confirming the good electrochemical reversibility of the materials for Li *** reaction kinetics of Bi_(2)O_(2)CO_(3)@C were further investigated using galvanostatic intermittent titration ***,Bi_2O_(2)-CO_(3)@C exhibited excellent long-term stability,maintaining its high reversible capacity for over 200 cycles at a current density of 0.5 A·g^(-1)in a full cell configuration using Li_(1.20)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2) as the cathode *** result further underscores its promising potential for lithium-ion *** work may provide inspiration for the design of alloy-type negative electrode materials for high-performance rechargeable batteries.

关键词： Bi_(2)O_(2)CO_(3) Composite materials Anode materials Full batteries

Directly targeting BAX for drug discovery:Therapeutic opportunities and challenges

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第6期14卷 2378-2401页

作者： Zhenwei Zhang Linghui Hou Dan Liu Shenglin Luan Min Huang Linxiang Zhao Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518000China

For over two decades,the development of B-cell lymphoma-2(Bcl-2)family therapeutics has primarily focused on anti-apoptotic proteins,resulting in the first-in-class drugs called BH3 mimetics,especially for Bcl-2 inhibitor *** pro-apoptotic protein Bcl-2-associated X protein(BAX)plays a crucial role as the executioner protein of the mitochondrial regulated cell death,contributing to organismal development,tissue homeostasis,and *** dysregulation of BAX is closely associated with the onset and progression of diseases characterized by pathologic cell survival or death,such as cancer,neurodegeneration,and heart *** addition to conducting thorough investigations into the physiological modulation of BAX,research on the regulatory mechanisms of small molecules identified through biochemical screening approaches has prompted the identification of functional and potentially druggable binding sites on BAX,as well as diverse all-molecule BAX *** review presents recent advancements in elucidating the physiological and pharmacological modulation of BAX and in identifying potentially druggable binding sites on ***,it highlights the structural and mechanistic insights into small-molecule modulators targeting diverse binding surfaces or conformations of BAX,offering a promising avenue for developing next-generation apoptosis modulators to treat a wide range of diseases associated with dysregulated cell death by directly targeting BAX.

关键词： Apoptosis Pro-apoptotic protein BAX Dynamic conformational activation Small-molecule apoptosis modulators