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Tracing overlapping biological signals in mid-infrared using colonic tissues as a model system

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World Journal of Gastroenterology 2017年第2期23卷 286-296页

作者： Ranjit Kumar Sahu Ahmad Salman Shaul Mordechai Department of Physics Ben Gurion University Department of Medicine University of Virginia Department of Physics SCE-Shamoon College of Engineering

AIMTo understand the interference of carbohydrates absorbance in nucleic acids signals during diagnosis of malignancy using Fourier transform infrared (FTIR) *** used formalin fixed paraffin embedded colonic tissues to obtain infrared (IR) spectra in the mid IR region using a bruker II IR microscope with a facility for varying the measurement area by varying the aperture available. Following this procedure we could measure different regions of the crypt circles containing different biochemicals. Crypts from 18 patients were measured. Circular crypts with a maximum diameter of 120 μm and a lumen of about 30 μm were selected for uniformity. The spectral data was analyzed using conventional and advanced computational *** the various components that are observed to contribute to the diagnostic capabilities of FTIR, the carbohydrates and nucleic acids are prominent. However there are intrinsic difficulties in the diagnostic capabilities due to the overlap of major absorbance bands of nucleic acids, carbohydrates and phospholipids in the mid-IR region. The result demonstrates colonic tissues as a biological system suitable for studying interference of carbohydrates and nucleic acids under ex vivo conditions. Among the diagnostic parameters that are affected by the absorbance from nucleic acids is the RNA/DNA ratio, dependent on absorbance at 1121 cm-1 and 1020 cm-1 that is used to classify the normal and cancerous tissues especially during FTIR based diagnosis of colonic malignancies. The signals of the nucleic acids and the ratio (RNA/DNA) are likely increased due to disappearance of interfering components like carbohydrates and phosphates along with an increase in amount of *** present work, proposes one mechanism for the observed changes in the nucleic acid absorbance in mid-IR during disease progression (carcinogenesis).

关键词： Spectral interference Fourier transform infrared diagnosis Nucleic acids Malignancy Colonic tissue

Cyber Security and Privacy Issues in Industrial Internet of Things

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Computer Systems Science & Engineering 2021年第6期37卷 361-380页

作者： NZ Jhanjhi Mamoona Humayun Saleh NAlmuayqil School of Computer Science and Engineering(sce) Taylor’s UniversitySelangorMalaysia Department of Information Systems College of Computer and Information SciencesJouf UniversityAl-JoufSaudi Arabia

The emergence of industry 4.0 stems from research that has received a great deal of attention in the last few ***,there has been a huge paradigm shift in the manufacturing and production ***,this poses a challenge for cybersecurity and highlights the need to address the possible threats targeting(various pillars of)industry ***,before providing a concrete solution certain aspect need to be researched,for instance,cybersecurity threats and privacy issues in the *** fill this gap,this paper discusses potential solutions to cybersecurity targeting this industry and highlights the consequences of possible attacks and countermeasures(in detail).In particular,the focus of the paper is on investigating the possible cyber-attacks targeting 4 layers of IIoT that is one of the key pillars of Industry *** on a detailed review of existing literature,in this study,we have identified possible cyber threats,their consequences,and ***,we have provided a comprehensive framework based on an analysis of cybersecurity and privacy *** suggested framework provides for a deeper understanding of the current state of cybersecurity and sets out directions for future research and applications.

关键词： Industrial Internet of things(IIoT) cybersecurity industry 4.0 cyber-attacks

Cooling of Granules in Vibrating, Suspended Bed: Engineering Simulation

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Modern Mechanical Engineering 2016年第2期6卷 76-90页

作者： Valery Katz Slava Katz sce—Sami Shamoon College of Engineering Beer-Sheva Israel

Here we suggest an algorithm for calculation of the process parameters and design of a vertical cooler with inclined, gas-permeable blades and with a vibrating, suspended layer of granules on them (Vibrating Fluidized Bed—VFB). The algorithm is based on the use of the equations of heat and material balance, taking into account the influx of moisture into the layer with cold air and dust—as a carryover. Mode entrainment of dust particles and moisture from the VFB is described by using empirical formulas and Π-theorem. To calculate the cooling time of granules a model of the dynamics of a variable mass VFB was built, which linked the geometrical and physical process parameters to a single dependency. An example showed that mass flow of granules of 248 kg/h and a volume flow of air of 646 m3/h with temperature of 30℃ to cool the zeolite granules from 110℃ to 42℃ for 49 s required a vertical apparatus of rectangular shape with four chambers and with volume of 0.2 m3. A comparative analysis of technological parameters of the projected cooler with the parameters of typical industrial apparatuses showed that for all indicators: the cooling time of granules, the flow rate of gas (air) and the heat flow, a 4-chambered, vertical apparatus of rectangular shape with VFB was the most effective.

关键词： Cooling of Granules Vibrating Fluidized Bed Mathematical Model Calculation Algorithm

Mass Transfer in a Centrifugal Turbine Agitator-Pump

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Journal of Water Resource and Protection 2014年第5期6卷 463-472页

作者： Valery Katz Gedalya Mazor sce—Sami Shamoon College of Engineering Beer-Sheva Israel

This article is a continuation of the research, centering on a vacuum-filtration system, which is designed to reduce the concentration of calcium in water;a process is also known as—water softening. The problem of solving the concentration distribution of the initial (embryonic) particles of CaCO3-particles, which were introduced into the limited volume of the apparatus with a turbine agitator-pump, is addressed through the use of diffusion and deterministic-stochastic models of mass transfer. The solution of the extreme problem allows determining the most important process parameters, such as time of dispersions homogenization and the dispersion mass flow rate to the surface of a special filter. For these parameters a comparative analysis of the adequacy of the theory was found through experiments, performed in the study. We found that uniform distribution of concentrations along the height of the apparatus is achieved by the angular velocity of the rotation 400 rpm for the turbine with 6 - 7 blades at the time of homogenization 14s. In this case, the dispersion mass flow to the surface of the cylindrical filter is 3 50 mg/s at an average concentration of the introduced CaCO3 particles, which is equal to 10 g/L. We determined that the accuracy of the results depends on: the coordinates of the material input in the apparatus volume, the surface shape of the filter and the volumetric flow rate of the liquid (water), being discarded by the turbine blades in the normal direction to their surface.

关键词： Calcium Removal Dispersion Mass Transfer Modeling Adequacy

IoT Wireless Intrusion Detection and Network Traffic Analysis

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Computer Systems Science & Engineering 2022年第3期40卷 865-879页

作者： Vasaki Ponnusamy Aun Yichiet NZ Jhanjhi Mamoona humayun MaramFahhad Almufareh University Tunku Abdul Rahman Kampar31900Malaysia School of Computer Science and Engineering(sce) Taylor’s UniversitySelangorMalaysia Department of Information Systems College of Computer and Information SciencesJouf UniversityAl-JoufSaudi Arabia

Enhancement in wireless networks had given users the ability to use the Internet without a physical connection to the *** every Internet of Things(IoT)devices such as smartphones,drones,and cameras use wireless technology(Infrared,Bluetooth,IrDA,IEEE 802.11,etc.)to establish multiple interdevice connections *** the flexibility of the wireless network,one can set up numerous ad-hoc networks on-demand,connecting hundreds to thousands of users,increasing productivity and profitability ***,the number of network attacks in wireless networks that exploit such flexibilities in setting and tearing down networks has become very *** can launch attacks since there is no first line of defense in an ad hoc network setup besides the standard IEEE802.11 WPA2 *** feasible countermeasure is to deploy intrusion detection systems at the edge of these ad hoc networks(Network-based IDS)or at the node level(Host-based IDS).The challenge here is that there is no readily available benchmark data available for IoT network *** this benchmark data is very tedious as IoT can work on multiple platforms and networks,and crafting and labelling such dataset is very *** research aims to study the characteristics of existing datasets available such as KDD-Cup and NSL-KDD,and their suitability for wireless IDS *** hypothesize that network features are parametrically different depending on the types of network and assigning weight dynamically to these features can potentially improve the subsequent threat *** paper analyses packet and flow features for the data packet captured on a wireless network rather than a wired *** domain heuristcs and early classification results,the paper had identified 19 header fields exclusive to wireless network that contain high information gain to be used as ML features in Wireless IDS.

关键词： IoT machine learning traffic features IDS KDD-CUP NSL-KDD

Security Threat and Vulnerability Assessment and Measurement in Secure Software Development

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Computers, Materials & Continua 2022年第6期71卷 5039-5059页

作者： Mamoona Humayun NZ Jhanjhi Maram Fahhad Almufareh Muhammad Ibrahim Khalil Department of Information Systems College of Computer and Information SciencesJouf UniversityAl-JoufKSA School of Computer Science and Engineering(sce) Taylor’s UniversitySelangorMalaysia Department of Computer Science Bahria UniversityIslamabadPakistan

Security is critical to the success of software,particularly in today’s fast-paced,technology-driven *** ensures that data,code,and services maintain their CIA(Confidentiality,Integrity,and Availability).This is only possible if security is taken into account at all stages of the SDLC(Software Development Life Cycle).Various approaches to software quality have been developed,such as CMMI(Capabilitymaturitymodel integration).However,there exists no explicit solution for incorporating security into all phases of *** of the major causes of pervasive vulnerabilities is a failure to prioritize *** the most proactive companies use the“patch and penetrate”strategy,inwhich security is accessed once the job is *** cost,time overrun,not integrating testing and input in SDLC,usage of third-party tools and components,and lack of knowledge are all reasons for not paying attention to the security angle during the SDLC,despite the fact that secure software development is essential for business continuity and survival in today’s ICT *** is a need to implement best practices in SDLC to address security at all *** fill this gap,we have provided a detailed overview of secure software development practices while taking care of project costs and *** proposed a secure SDLC framework based on the identified practices,which integrates the best security practices in various SDLC phases.A mathematical model is used to validate the proposed framework.A case study and findings show that the proposed system aids in the integration of security best practices into the overall SDLC,resulting in more secure applications.

关键词： Security secure software development software development life cycle(SDLC) confidentiality integrity availability

Blood group type antigens in pancreatic intraductal papillary mucinous neoplasms

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 74-80页

作者： Adriana Handra-Luca Departments of Pathology Sydney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutions APHP Universite Paris Nord Sorbonne Cite-sce Anatomie Pathologique GHU Avicenne 125 rue Stalingrad Bobigny 93000 France

BACKGROUND: There are few data on blood group(BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms(IPMNs). METHODS: BG type and tumor BG-antigen(glycoprotein) expression(studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs. RESULTS: Non-O BG type predicted invasive carcinoma independently from high serum CA19-9 and male gender. BG type A was observed more frequently in women than in men. Chronic pancreatitis was more frequently seen in patients with BG type B or AB. Aberrant tumor expression(with regard to BG type) of loss of A antigen expression type occurred in 15.0% of IPMNs and of loss of B antigen expression type in 62.5% of IPMNs. Intraneoplasm BG-antigen expression was not related to dysplasia grade or invasion. CONCLUSION: The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion.

关键词： blood group type blood group antigen immunohistochemistry CA19-9 prognosis invasive carcinoma pancreas intraductal papillary mucinous neoplasm

Intrusion Detection Systems in Internet of Things and Mobile Ad-Hoc Networks

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Computer Systems Science & Engineering 2022年第3期40卷 1199-1215页

作者： Vasaki Ponnusamy Mamoona Humayun NZJhanjhi Aun Yichiet Maram Fahhad Almufareh Faculty of Information and Communication Technology Universiti Tunku Abdul RahmanKamparMalaysia Department of Information Systems College of Computer and Information SciencesJouf UniversityAl-JoufSaudi Arabia School of Computer Science and Engineering(sce) Taylor’s UniversitySelangorMalaysia

Internet of Things(IoT)devices work mainly in wireless mediums;requiring different Intrusion Detection System(IDS)kind of solutions to leverage 802.11 header information for intrusion ***-specific traffic features with high information gain are primarily found in data link layers rather than application layers in wired *** survey investigates some of the complexities and challenges in deploying wireless IDS in terms of data collection methods,IDS techniques,IDS placement strategies,and traffic data analysis *** paper’s main finding highlights the lack of available network traces for training modern machine-learning models against IoT specific ***,the Knowledge Discovery in Databases(KDD)Cup dataset is reviewed to highlight the design challenges of wireless intrusion detection based on current data attributes and proposed several guidelines to future-proof following traffic capture methods in the wireless network(WN).The paper starts with a review of various intrusion detection techniques,data collection methods and placement *** main goal of this paper is to study the design challenges of deploying intrusion detection system in a wireless *** detection system deployment in a wireless environment is not as straightforward as in the wired network environment due to the architectural *** this paper reviews the traditional wired intrusion detection deployment methods and discusses how these techniques could be adopted into the wireless environment and also highlights the design challenges in the wireless *** main wireless environments to look into would be Wireless Sensor Networks(WSN),Mobile Ad Hoc Networks(MANET)and IoT as this are the future trends and a lot of attacks have been targeted into these *** it is very crucial to design an IDS specifically to target on the wireless networks.

关键词： Internet of Things MANET intrusion detection systems wireless networks

Remote Health Monitoring Using IoT-Based Smart Wireless Body Area Network

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Computers, Materials & Continua 2021年第8期68卷 2499-2513页

作者： Farhan Aadil Bilal Mehmood Najam Ul Hasan Sangsoon Lim Sadia Ejaz Noor Zaman Computer Science Department COMSATS University IslamabadAttock Campus43600Pakistan Department of Electrical and Computer Engineering Dhofar UniversitySalalahOman Department of Computer Engineering Sungkyul UniversityAnyang430010Korea School of Computer Science and Engineering(sce) Taylor’s UniversityMalaysia

A wireless body area network(WBAN)consists of tiny healthmonitoring sensors implanted in or placed on the human *** sensors are used to collect and communicate human medical and physiological data and represent a subset of the Internet of Things(IoT)*** are connected to medical servers that monitor patients’*** type of network can protect critical patients’lives due to the ability to monitor patients’health continuously and *** inter-WBAN communication provides a dynamic environment for patients allowing them to move ***,during patient movement,the WBAN patient nodes may become out of range of a remote base ***,to handle this problem,an efficient method for inter-WBAN communication is *** this study,a method using a cluster-based routing technique is *** the proposed method,a cluster head(CH)acts as a gateway between the cluster members and the external network,which helps to reduce the network’s *** clustering,the cluster’s lifetime is a vital parameter for network ***,to optimize the CH’s selection process,three evolutionary algorithms are employed,namely,the ant colony optimization(ACO),multi-objective particle swarm optimization(MOPSO),and the comprehensive learning particle swarm optimization(CLPSO).The performance of the proposed method is verified by extensive experiments by varying values of different parameters,including the transmission range,node number,node mobility,and grid size.A comprehensive comparative analysis of the three algorithms is conducted by extensive *** results show that,compared with the other methods,the proposed ACO-based method can form clusters more efficiently and increase network lifetime,thus achieving remarkable network and energy *** proposed ACO-based technique can also be used in other types of ad-hoc networks as well.

关键词： Wireless body area network clustering internet of things evolutionary algorithm ant colony optimization