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Probing the Bardeen-Kiselev black hole with the cosmological constant caused by Einstein equations coupled with nonlinear electrodynamics using quasinormal modes and greybody bounds

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Communications in Theoretical Physics 2024年第6期76卷 102-119页

作者： s.r.Wu B Q Wang Z W Long college of Physics Guizhou UniversityGuiyang 550025China college pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China

In this work,we investigate a static and spherically symmetric Bardeen-Kiselev black hole(BH)with the cosmological constant,which is a solution of the Einstein-non-linear Maxwell field *** compute the quasinormal frequencies for the Bardeen-Kiselev BH with the cosmological constant due to electromagnetic and gravitational *** varying the BH parameters,we discuss the behavior of both real and imaginary parts of the BH quasinormal frequencies and compare these frequencies with the reissner-Nords.r.m-de sitter BH s.r.ounded by quintessence(rN-dsQ).Interestingly,it is shown that the responses of the Bardeen-Kiselev BH with the cosmological constant and the rN-dsQ under electromagnetic perturbations are different when the charge parameter q,the state parameter w and the normalization factor c are varied;however,for the gravitational perturbations,the responses of the Bardeen-Kiselev BH with the cosmological constant and the rN-dsQ are different only when the charge parameter q is ***,compared with the gravitational perturbations,the electromagnetic perturbations can be used to understand nonlinear and linear electromagnetic fields in curved spacetime *** interesting obs.r.ation is that,due to the presence of Kiselev quintessence,the electromagnetic perturbations around the Bardeen-Kiselev BH with the cosmological constant damps faster and oscillates slowly;for the gravitational perturbations,the quasinormal mode decays slowly and oscillates *** also study the reflection and transmission coefficients along with the abs.r.tion cross section in the Bardeen-Kiselev BH with the cosmological constant;it is shown that the transmission coefficients will increase due to the presence of Kiselev quintessence.

关键词： quasinormal modes greybody factors Bardeen-Kiselev black hole with cosmological constant

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Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

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Chinese Chemical Letters 2024年第7期35卷 296-300页

作者： Wenjuan Jin Zelong Chen Yi Wang Jiaxuan Li Jiahui Li Yuxin Pei Zhichao Pei college of Chemis.r.&pharmacy Northwest A&F UniversityYangling 712100China

Chemodynamic therapy(CDT)combined with dual phototherapy(photothermal therapy(PTT)and photodynamic therapy(PDT))is an efficient way to synergistically improve anti-tumor ***,the combination of multiple modes often makes the composition of the system more complex,which is not conducive to clinical *** this study,a dual phototherapy ligand carboxyl-modified Aza-BODIPY(BOD-COOH)and metal active center Cu^(2+)were used to cons.r.ct multiple-modes metalphotosensitizer nanoparticles(BOD-Cu NPs)via one-step coordination self-assembly for combination therapy of CDT/PDT/*** order to improve delivery efficiency,the targeted hydrophilic molecule pyridinemodified glucose derivative(G-Py)was synthesized and coated onto the BOD-Cu NPs to form a glycosylated nano metal-photosensitizer BOD-Cu@G by electrostatic *** Cu^(2+)in BOD-Cu@G could not only be used as a coordination node for metal-driven self-assembly but also consume intracellular glutathione(GsH),and then catalyze Fenton-like reaction to generate hydroxyl radical(·OH)for *** vitro and in vivo studies.r.vealed that BOD-Cu@G could achieve excellent anti-tumor efficiency by CDTenhanced dual phototherapy.

关键词： Nano metal-photosensitizer Aza-BODIPY-Cu Coordination self-assembly Chemodynamic therapy Dual phototherapy

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The delivery of N-myc downs.r.am-regulated gene 2(NDrG2)self-amplifying mrNA via modified lipid nanoparticles as a potential treatment for drug-resistant and metastatic cancers

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Medical review 2024年第3期4卷 235-238页

作者： sandra E.reznik Amit K.Tiwari Vivek Chavda Charles.r.Ashby Jr. Department of Pharmaceutical sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensUSA Departments of Pathology and Obstetrics and Gynecology and Women’s Health Montefiore Medical Center/Albert Einstein College of MedicineBronxUSA Department of Pharmaceutical sciences College of Pharmacy University of Arkansas for Medical Sciences Little RockUSA Department of Pharmaceutics and Pharmaceutical Technology L.M.college of pharmacy AhmedabadIndia Department of Pharmaceutical sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

The protein,N-myc downs.r.am-regulated gene 2(NDrG2),a tumor suppress.r.is significantly decreased or absent in many types of *** is a significant negative correlation between the levels of NDrG2 and the development and progression of cancer tumor recurrence and tumor invasion,in different *** contrast,the in vitro and in vivo overexpression of the NDrG2 protein decreases the proliferation,growth,adhesion and migration of many types of cancer *** in vitro overexpression of NDrG2 increases the efficacy of certain anticancer drugs in specific types of cancer *** hypothesize that the delivery of the mrNA of the NDrG2 protein,encapsulated by lipid nanoparticles,could represent a potential treatment of metastatic and drug-resistant *** would be accomplished using a self-amplifying mrNA that encodes the NDrG2 protein and an rNA-dependent-rNA polymerase,obtained from an in vitrotrans.r.bed(IVT)*** IVT mrNA would be encapsulated in a lipid *** efficacy of the nanoformulation would be determined in cultured cancer cells and if the results are positive,nude mice transplanted with either drug-resistant or metastatic drug-resistant cancer cells,would be treated with the nanoformulation and monitored for efficacy and adverse *** the appropriate preclinical studies indicate this formulation is efficacious and safe,it is possible it could be evaluated in clinical trials.

关键词： N-myc downs.r.am-regulated gene 2(NDrG2) cancer self-amplifying mrNA nanoparticle

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Copper-based nanomaterials as peroxidase candidates for intelligent colorimetric detection and antibacterial applications

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Particuology 2024年第1期84卷 126-135页

作者： Yanyan Huang Huimin Zhong Cong Jiang Jiahui Yang Jingwen Zhang Fei Zhao Chaoqun Liu college of Light Indus.r. and Food Engineering Nanjing Forestry UniversityNanjing210037China college of pharmacy Institutes of Environment and MedicineHenan UniversityKaifeng475004China

With natural polyphenol compound tannic acid(TA)as the ingredient,copper tannate(CuTA)nanolayer material was formed by self-assembly under the conditions of heating and copper *** ion and tannic acid could coordinate to form Cu-O-C s.r.cture which was similar to the Fe-N-C s.r.cture of natural heme *** addition,the obtained CuTA nanomaterial possessed excellent peroxidase-like catalytic activity and *** on this excellent enzymatic activity,CuTA nanomaterials could be used for colorimetric detection of hydrogen peroxide with a smartphone and decomposition of organic *** on the s.r.ctural characteristics and catalytic activity,the copper tannate nanozymes could also s.r.e as potential antibacterial reagents to effectively inhibit the growth of gram-negative and positive bacteria in a low hydrogen peroxide *** work may promote the exploration of novel peroxidase mimetics and broaden the applications of nanozymes.

关键词： Nanozyme Colorimetric detection smartphone Antibacteria

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Multi-stimuli-responsive aggregation-induced emission copper iodide cluster

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science China Chemis.r. 2024年第4期67卷 1193-1197页

作者： Bo Li Yuan-Yuan Liu Peng Luo Ye-ru Liu Ying-Jun Chen Kai Li shuang-Quan Zang college of Chemis.r. and pharmacy Engineering Nanyang Normal UniversityNanyang 473061China Green Catalysis Center and college of Chemis.r. Zhengzhou UniversityZhengzhou 450001China

stimuli-responsive luminescent materials have attracted significant attention in the development of smart photoactive materials for both fundamental research and technological *** this work,a new copper iodide cluster(1)with aggregationinduced emission(AIE)characteristic,was obtained combining Cu_(4)I_(4) core with rhodamine B derivative ligand.1 has.r.versible and distinct multi-stimuli-responsive luminescence for external temperature,volatile organic compound,and mechanical ***,1 exhibited unusual large blue shift(84 nm)after being ground,which originated from the change of intermolecular ***,1 exhibits high oxygen quenching efficiency for 82.2% at 1 *** studies showed that the multi-stimuli-responsive luminescence properties of 1 can be attributed to the regulation of cluster-centered luminescence process,metal-to-ligand charge transfer process,halide-to-metal charge transfer luminescence process and aggregationinduced barrier to oxygen *** work not only reports an AIE copper iodide cluster,but also provides a new s.r.tegy to develop multi-stimuli-responsive luminescence materials.

关键词： copper iodide cluster aggregation-induced emission multi-stimuli-response

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Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

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Nano-Micro Letters 2024年第9期16卷 501-556页

作者： Afsana sheikh Prashant Kesharwani Waleed H.Almalki salem salman Almujri Linxin Dai Zhe‑sheng Chen Amirhossein sahebkar Fei Gao Department of Pharmaceutics School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi 110062India Department of Pharmacology and Toxicology Faculty of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyKing Khalid University61421 Asir‑AbhaSaudi Arabia state Key Laboratory of southwestern Chinese Medicine resources Pharmacy SchoolChengdu University of Traditional Chinese MedicineChengdu 611130People’s Republic of China Department of Pharmaceutical sciences College of Pharmacy and Health SciencesSt.John’s UniversityNew York 11439USA Biotechnology research Center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Applied Biomedical research Center Mashhad University of Medical SciencesMashhadIran

As a new form of regulated cell death,ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis.r.sistance by cancer *** molecular mechanism of ferroptosis depends on the induction of oxidative s.r.ss through excessive reactive oxygen species accumulation and glutathione depletion to damage the s.r.ctural integrity of *** to their high loading and s.r.ctural tunability,nanocarriers can escort the delivery of ferro-therapeutics to the des.r.d site through enhanced permeation or retention effect or by active *** review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and ***,we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

关键词： Ferroptosis Nanoparticles Ferrotherapy Cancer Genes Nanotechnology Toxicity reactive oxygen species

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Artemisia argyi extract subfraction exerts an antifungal effect against dermatophytes by disrupting mitochondrial morphology and function

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Chinese Journal of Natural Medicines 2024年第1期22卷 47-61页

作者： CHEN Le ZHU Yunyun GUO Chaowei GUO Yujie ZHAO Lu MIAO Yuhuan DU Hongzhi LIU Dahui college of pharmacy Hubei University of Chinese MedicineWuhan 430065China National resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China college of pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Artemisia argyi(***),a plant with a longstanding history as a raw material for traditional medicine and functional diets in Asia,has been used traditionally to bathe and soak feet for its disinfectant and itch-relieving *** its wides.r.ad use,scientific evidence validating the antifungal efficacy of *** water extract(AAWE)against dermatophytes,particularly Trichophyton rubrum,Trichophyton mentagrophytes,and Microsporum gypseum,remains *** study aimed to substantiate the scientific basis of the folkloric use of *** by evaluating the antifungal effects and the underlying molecular mechanisms of its active subfraction against *** results indicated that AAWE exhibited excellent antifungal effects against the three aforementioned dermatophyte *** subfraction AAWE6,isolated using D101 macroporous.r.sin,emerged as the most potent *** minimum inhibitory concentrations(MICs)of AAWE6 against ***,***,and *** were 312.5,312.5,and 625μg·mL−1,*** electron microscopy(TEM)results and assays of enzymes linked to cell wall integrity and cell membrane function indicated that AAWE6 could penetrate the external protective barrier of ***,creating breaches(“small holes”),and disrupt the internal mitochondrial s.r.cture(“granary”).Furthermore,trans.r.ptome data,quantitative real-time PCr(rT-qPCr),and biochemical assays corroborated the severe disruption of mitochondrial function,evidenced by inhibited tricarboxylic acid(TCA)cycle and energy ***,chemical characterization and molecular docking analyses identified flavonoids,primarily eupatilin(131.16±4.52 mg·g^(−1))and jaceosidin(4.17±0.18 mg·g^(−1)),as the active components of *** conclusion,the subfraction AAWE6 from *** exerts antifungal effects against dermatophytes by disrupting mitochondrial morphology and *** research validates the traditional use of *** and provides scient

关键词： Artemisia argyi Dermatophyte Antifungal activity Mitochondrial s.r.cture Mitochondrial function Trans.r.ptome analysis

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“Unveiling the antiviral mechanism of Forsythia suspense: A comprehensive analysis of s.r.ening targets and components

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Journal of Chinese Pharmaceutical sciences 2024年

作者： Na sun shuo Ma Linxuan Jin Xin Zhang Miao Zhou Huanhuan Yang Wenqian Li Xinru Wu Yanyan Hou Yuhan Yuan Yu Zhang Penghua shu Food and pharmacy college， Xuchang University

List of supporting InformationTable s1 The PDB ID， resolution， and ligand of key antiviral target p

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Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin(Ⅳ) prodrug delivery and enhanced colorectal cancer therapy

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Chinese Chemical Letters 2024年第4期35卷 280-286页

作者： Wenjia Wang Xingyue He Xiaojie Wang Tiantian Zhao Osamu Muraoka Genzoh Tanabe Weijia Xie Tianjiao Zhou Lei Xing Qingri Jin Hulin Jiang state Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Faculty of pharmacy Kinki University HigashiosakaOsaka 577-8502Japan state Key Laboratory of Natural Medicines(sKLNM)and Department of Medicinal Chemis.r. School of PharmacyChina Pharmaceutical UniversityNanjing 210009China school of pharmacy Hangzhou Medical CollegeHangzhou 311399China college of pharmacy Yanbian UniversityYanji 133002China

Oxaliplatin(Oxa) is the first-line chemotherapeutic drug for the treatment of colorectal cancer(CrC). However, long-term Oxa chemotherapy can induce inflammation and increase the levels of cyclooxygenase-2(COX-2) and prostaglandin E2(PGE2), which can promote tumor metastasis. Moreover,high glutathione(GsH) levels in CrC cells significantly reduce Oxa sensitivity and s.r.ously res.r.ct the clinical application of Oxa. Herein, an Oxa(Ⅳ) prodrug with anti-inflammatory properties(desmethyl naproxe, DN) and GsH-depleting cyclodextrin pseudo-polyrotaxane carriers were prepared and further self-assembled into micellar nanoparticles(designated DNPt@PPrI). The relesae of DN from DNPt@PPrI can reduce the level of PGE2 to inhibit inflammation and tumor metastasis by decreasing COX-2 protein,and also synergize with Oxa to inhibit tumor. More importantly, GsH depletion can reduce the detoxification of Oxa and further enhance chemotherapy-induced apoptosis. DNPt@PPrI have a good GsH depletion ability to enhance the sensitivity of Oxa, indicating a potential in the synergistic chemotherapy and chemo-sensitization of colorectal cancer.

关键词： Oxaliplatin Glutathione depletion Tetravalent platinum prodrug synergistic therapy Colorectal cancer

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s.r.ctural characterization and prebiotic potential of polysaccharides from Polygonatum sibiricum

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Food science and Human Wellness 2024年第4期13卷 2208-2220页

作者： Zihan Qi Tiexiang Gao Jingjing Li shuhan Zhou Zhigang Zhang Mingzhu Yin Haiming Hu Hongtao Liu college of Basic Medical sciences Hubei University of Chinese MedicineWuhan 430065China college of pharmacy Hubei University of Chinese MedicineWuhan 430065China

Polygonatum sibiricum has been widely used due to its excellent biological *** prepared a novel polysaccharide from ***(PsP)in this *** a monosaccharide composition analysis,PsP was mainly composed of fructose and glucose with a molar percentage of 93.81:*** main linkage types were identified asα-D-Glcp-1→and→2-β-D-Fruf-1→.The molecular weight of PsP showed no significant change after simulated salivary and gas.r.intestinal ***,PsP could be broken down by intestinal *** findings.r.vealed that PsP adminis.r.tion increased the abundance of probiotics such as ***,the results showed that gut microbes could utilize PsP to produce short-chain fatty acids including acetic acid,propionic acid,and butyric ***,the PsP fermentation broth displayed an excellent scavenging effect on free radicals,including 2,2-diphenyl-1-picrylhydrazyl radical,superoxide radical,and hydroxyl *** summary,this study will help to promote the application of PsP as prebiotics in functional food and the medical indus.r..

关键词： Dietary polysaccharides Prebiotic Gut microbiota short-chain fatty acids

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