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P2X receptors in maintenance and differentiation of neural progenitor cells

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Neural Regeneration Research 2014年第23期9卷 2040-2041页

作者： Henning Ulrich Peter Illes Departamento de Bioquímica Instituto de Química Universidade de Sao Paulo rudolf-boehm-institut für pharmakologie und toxikologie der Universitat Leipzig

Purinergic receptors are among the first cell surface receptors expressed during embryonic development （Burnstock and Ulrich, 2011）. These are characterized based on their pharmacological properties of being activated by adenosine or purine/pyrimidine nucleotides as P1 and P2 receptors. P2 receptors are further classified by their structure as P2Y metabotropic and P2X ionotropic receptors.

关键词： P2X receptors in maintenance and differentiation of neural progenitor cells

Purinergic Signaling in the Central Nervous System in Health and Disease

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Neuroscience Bulletin 2020年第11期36卷 1239-1241页

作者： Peter Illes Guang-Yin Xu Yong Tang International Collaborative Centre on Big Science Plan for Purine Signaling Chengdu University of Traditional Chinese MedicineChengdu 610075China rudolf-boehm-institut fur pharmakologie und toxikologie Universitaet LeipzigLeipzig 04107Germany institute of Neuroscience Soochow UniversitySuzhou 215123China Acupuncture and Chronobiology Key Laboratory of Sichuan Province Chengdu 610075China

The existence of purinergic signaling—the idea that almost all cells of the animal/human organism are able to communicate with each other via extracellular purines—was proposed by Geoffrey Burnstock(1929-2020)in 1972[1-3].The purinergic system includes the following constituents:(1)the four main purines:adenosine triphosphate(ATP)and its metabolites,adenosine diphosphate(ADP),adenosine monophosphate(AMP),and adenosine(ADO);(2)three key enzymes,the ectonucleoside triphosphate diphosphohydrolases(E-NTPDases:NTPDase1/CD39),ectonucleotide pyrophosphatase/phosphodiesterases(E-NPP),and ecto-5’-nucleotidase(E-5’-nucleotidase/CD73),which decompose ATP into ADP,AMP,and ADO.

关键词： ADO urine include

Glial-neuronal Sensory Organs:Evolutionary Journey from Caenorhabditis elegans to Mammals

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Neuroscience Bulletin 2020年第5期36卷 561-564页

作者： Yong Tang Peter Illes Alexei Verkhratsky International Collaborative Centre on Big Science Plan for Purine Signalling Chengdu University of Traditional Chinese MedicineChengdu 610075China Acupuncture and Tuina School Chengdu University of TCMChengdu 610075China Key Laboratory of Sichuan Province for Acupuncture and Chronobiology Chengdu 610075China rudolf-boehm-institut für pharmakologie und toxikologie Universitat LeipzigLeipzig 04107Germany Faculty of Biology Medicine and HealthThe University of ManchesterManchester MI39PTUK

Recently,a paper published in Science reported discovery of sensory peripheral glial cells[1].This paper demonstrated a rather unexpected property of non-myelinating Schwann cells(also known as Remak cells)dwelling in the subepidermal border of the skin[2].These glial cells and their interactions with nociceptive nerve terminals were characterized using a variety of genetic labelling tools,transmission electron microscopy,immunocytochemistry.

关键词： myelin border property

TASK-3:New Target for Pain-Relief

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Neuroscience Bulletin 2020年第8期36卷 951-954页

作者： Wen-Jing Ren Henning Ulrich Alexey Semyanov Peter Illes Yong Tang International Collaborative Centre on Big Science Plan for Purine Signaling Chengdu University of Traditional Chinese MedicineChengdu 610075China Acupuncture and Chronobiology Key Laboratory of Sichuan Province Chengdu 610075China Department of Biochemistry Institute of ChemistryUniversity of Sao PauloSao Paulo 05508Brazil Shemyakin-Ovchinnikov institute of Bioorganic Chemistry Russian Academy of SciencesMoscowRussia 117997 rudolf-boehm-institut fiir pharmakologie und toxikologie Universitaet Leipzig04109 LeipzigSachsenGermany

Morphine and other opioids are among the most effective analgesics for treating ***,drug dependence and other deleterious side effects of opioids have limited their clinical *** studies suggest that the use of opioids for pain control may even exacerbate disease outcomes in some pain-producing conditions,such as acute pancreatitis[1].

关键词： Relief delete producing

Purinergic Receptors in Basal Ganglia Diseases:Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease

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Neuroscience Bulletin 2020年第11期36卷 1299-1314页

作者： Talita Glaser Roberta Andrejew Agatha Oliveira-Giacomelli Deidiane Elisa Ribeiro Lucas Bonfim Marques Qing Ye Wen-Jing Ren Alexey Semyanov Peter Illes Yong Tang Henning Ulrich Department of Biochemistry Institute of ChemistryUniversity of Sao PauloAv.Prof.Lineu Prestes 74&Sao PauloSP 05508-000Brazil Key Laboratory of Sichuan Province for Acupuncture and Chronobiology Chengdu 610075China Shemyakin-Ovchinnikov institute of Bioorganic Chemistry Russian Academy of SciencesMoscow 117997Russia Sechenov First Moscow State Medical University Moscow 119992Russia rudolf-boehm-institut ftir pharmakologie und toxikologie Universitat LeipzigLeipzig 04107Germany International Collaborative Centre on Big Science Plan for Purine Signaling Chengdu University of Traditional Chinese MedicineChengdu 610075China

Huntington’s(HD)and Parkinson’s diseases(PD)are neurodegenerative disorders caused by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to hyperkinetic and hypokinetic symptoms,*** review here the participation of purinergic receptors through intracellular Ca^2+signaling in these neurodegenerative *** adenosine A2A receptor stimulates striatopallidal GABAergic neurons,resulting in inhibitory actions on GABAergic neurons of the globus pallidus.A2A and dopamine D2 receptors form functional heteromeric complexes inducing allosteric inhibition,and A2A receptor activation results in motor ***,the A2A receptor physically and functionally interacts with glutamate receptors,mainly with the mGlu5 receptor *** interaction facilitates glutamate release,resulting in NMDA glutamate receptor activation and an increase of Ca2+influx.P2X7 receptor activation also promotes glutamate release and neuronal ***,modulation of purinergic receptor activity,such as A2A and P2X7 receptors,and subsequent aberrant Ca^2+signaling,might present interesting therapeutic potential for HD and PD.

关键词： Purinergic receptor Central nervous system Huntington’s disease Parkinson’s disease 6-hydroxydopamine

Reduced expression of Ca^(2+)-regulating proteins in the upper gastrointestinal tract of patients with achalasia

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World Journal of Gastroenterology 2006年第37期12卷 6002-6007页

作者： Harald Fischer Judith Fischer Peter Boknik Ulrich Gergs Wilhelm Schmitz Wolfram Domschke Jan W Konturek Joachim Neumann Medizinische Klinik und Poliklinik B Universittsklinikum Mnster 48129 Mnster Germany institut fr pharmakologie und toxikologie Universittsklinikum Mnster 48149 Mnster Germany institut fr pharmakologie und toxikologie Martin-Luther-Universitt Halle-Wittenberg 06112 Halle (Saale) Germany Klinik fr Innere Medizin/Gastroenterologie Elbe Klinikum Stade 21682 Stade Germany

AIM: To compare expression of Ca2+-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS: Sarcoplasmic reticulum Ca2+ ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats, rabbits, and humans. furthermore, expression profi les of these proteins in biopsies of lower esophageal sphincter and esophagus from patients with achalasia and healthy volunteers were analyzed. RESULTS: SERCA 2a protein expression was much higher in human heart (cardiac ventricle) compared to esophagus. However, SERCA 2b was expressed predominantly in the esophagus. The highest CRT expression was noted in the human esophagus, while PLB, although highly expressed in the heart, was below our detection limit in upper GI tissue. Compared to healthy controls, CSQ and CRT expression in lower esophageal sphincter and distal esophageal body were signif icantly reduced in patients with achalasia (P < 0.05). CONCLUSION: PLB in the human esophagus mightbe of lesser importance for regulation of SERCA than in heart. Lower expression of Ca2+ storage proteins (CSQ and CRT) might contribute to increased lower esophageal sphincter pressure in achalasia, possibly by increasing free intracellular Ca2+.

关键词：基因表达弛缓不能食管疾病肌集钙蛋白

心脏起搏离子通道的分子结构和功能特性(英文)

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中国药理学与毒理学杂志 2001年第2期15卷 81-87页

作者： Andreas LUDWIG Franz HOFMANN 宗贤刚 Martin BIEL Martin BIEL institut für pharmakologie und toxikologie der Technischen Universit*t München München Deutschland Department Pharmazie-Zentrum für Pharmaforschung Ludwig-Maximilians Universitt München München DeutschlandInstitut für Pharmakologie und Toxikologie der Technischen Universit*t München München Deutschland Department Pharmazie-Zentrum für Pharmaforschung Ludwig-Maximilians Universit*t München München Deutschland

心脏的起搏受控于一类存在于心脏窦房结被称作If 的离子通道 ,该通道是被细胞膜的超极化所激活 .新近 ,一类被命名为超极化激活及环化核苷酸调控的阳离子 (HCN)通道被克隆 .该家族至少有4个成员 ,即HCN1～HCN4 .其中 2个HCN2和HCN4在心... 详细信息

心脏的起搏受控于一类存在于心脏窦房结被称作If 的离子通道 ,该通道是被细胞膜的超极化所激活 .新近 ,一类被命名为超极化激活及环化核苷酸调控的阳离子 (HCN)通道被克隆 .该家族至少有4个成员 ,即HCN1～HCN4 .其中 2个HCN2和HCN4在心脏有丰富表达 .用异体表达系统表达克隆的HCN2和HCN4通道蛋白 ,其通道特性类似心脏的天然If 通道 .本综述讨论了HCN通道之间的分子结构差异。

关键词：心脏起搏离子通道分子结构功能特性超极化激活电流

From purines to purinergic signalling:molecular functions and human diseases

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1463-1482页

作者： Zhao Huang Na Xie Peter Illes Francesco Di Virgilio Henning Ulrich Alexey Semyanov Alexei Verkhratsky Beata Sperlagh Shu-Guang Yu Canhua Huang Yong Tang State Key Laboratory of Biotherapy and Cancer Center West China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengduChina International Collaborative Centre on Big Science Plan for Purinergic Signalling Chengdu University of Traditional Chinese MedicineChengduChina rudolf-boehm-institut für pharmakologie und toxikologie Universitaet LeipzigLeipzigGermany Department of Medical Sciences University of FerraraFerraraItaly Department of Biochemistry Institute of ChemistryUniversity of São PauloSão PauloBrazil Shemyakin-Ovchinnikov institute of Bioorganic Chemistry Russian Academy of SciencesMoscowRussia Sechenov First Moscow State Medical University MoscowRussia Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Department of Pharmacology Institute of Experimental MedicineHungarian Academy of SciencesBudapestHungary Acupuncture and Chronobiology Key Laboratory of Sichuan Province ChengduChina School of Basic Medical Sciences Chengdu University of Traditional Chinese MedicineChengduChina

Purines and their derivatives,most notably adenosine and ATP,are the key molecules controlling intracellular energy homoeostasis and nucleotide ***,these purines support,as chemical messengers,purinergic transmission throughout tissues and *** act as endogenous ligands that bind to and activate plasmalemmal purinoceptors,which mediate extracellular communication referred to as“purinergic signalling”.Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation,differentiation,migration,apoptosis and other physiological processes critical for the proper function of *** deregulation of purinergic signalling contributes to various diseases including neurodegeneration,rheumatic immune diseases,inflammation,and ***,gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent *** evidence indicates that purinoceptors are potential therapeutic targets,with specific purinergic agonists and antagonists demonstrating prominent therapeutic ***,dietary and herbal interventions help to restore and balance purine metabolism,thus addressing the importance of a healthy lifestyle in the prevention and relief of human *** understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.

关键词： metabolism diseases urine