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Dietary supplementation of zinc oxide modulates intestinal functionality during the post-weaning period in clinically healthy piglets

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Journal of Animal Science and Biotechnology 2024年第1期15卷 313-328页

作者： Dirkjan Schokker Soumya K.Kar Els Willems Alex Bossers Ruud A.Dekker Alfons J.M.Jansman Wageningen Bioveterinary research LelystadThe Netherlands Wageningen Livestock research Wageningen University&ResearchWageningenThe Netherlands royal Agrifirm Group ApeldoornThe Netherlands institute for Risk Assessment Sciences Utrecht UniversityUtrechtThe Netherlands

Background To improve our understanding of host and intestinal microbiome interaction,this research investigated the effects of a high-level zinc oxide in the diet as model intervention on the intestinal microbiome and small intestinal functionality in clinically healthy post-weaning *** study 1,piglets received either a high concentration of zinc(Zn)as zinc oxide(Zn O,Zn,2,690 mg/kg)or a low Zn concentration(100 mg/kg)in the diet during the post weaning period(d 14–23).The effects on the piglet's small intestinal microbiome and functionality of intestinal tissue were *** study 2,the impact of timing of the dietary zinc intervention was investigated,i.e.,between d 0–14 and/or d 14–23 post weaning,and the consecutive effects on the piglet's intestinal functionality,here referring to microbiota composition and diversity and gene expression *** Differences in the small intestinal functionality were observed during the post weaning period between piglets receiving a diet with a low or high concentration Zn O content.A shift in the microbiota composition in the small intestine was observed that could be characterized as a non-pathological change,where mainly the commensals *** the immediate post weaning period,i.e.,d 0–14,the highest number of differentially expressed genes(DEGs)in intestinal tissue were observed between animals receiving a diet with a low or high concentration Zn O content,i.e.,23 DEGs in jejunal tissue and 11 DEGs in ileal *** genes are involved in biological processes related to immunity and inflammatory *** example,genes CD59 and REG3G were downregulated in the animals receiving a diet with a high concentration Zn O content compared to low Zn O content in both jejunum and ileum *** the second study,a similar result was obtained regarding the expression of genes in intestinal tissue related to immune pathways when comparing piglets receiving a diet with a high concentration Zn O con

关键词： Immune system Intestinal functionality Microbiota Piglets Zinc oxide

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Harnessing marine microbiomes to develop a sustainable,all-Atlantic bioeconomy

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mLife 2024年第2期3卷 163-166页

作者： Cristiane Thompson Alice C.Ortmann Henk Bolhuis Thulani Makhalanyane Fabiano Thompson institute of Biology Federal University of Rio de Janeiro(UFRJ)Rio de JaneiroBrazil Fisheries and Oceans Canada Bedford Institute of OceanographyDartmouthNova ScotiaCanada Department of Marine Microbiology and Biogeochemistry Royal Netherlands Institute for Sea Research(NIOZ)The Netherlands Department of Microbiology School of Data Science and Computational ThinkingStellenbosch UniversityStellenboschSouth Africa

Marine microbiomes are integral to the functioning of a healthy ocean and have the potential to be key contributors toward an all-Atlantic sustainable blue bioeconomy(Figure 1).New compounds may be developed based on these *** Atlantic Ocean is a biodiversity *** All-Atlantic Ocean research and Innovation Alliance(AAORIA)Declaration,signed in 2022 in Washington,DC,is a promising mechanism to move forward marine microbiome science,technology,and innovation.

关键词： Atlantic marine ocean

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Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 308-325页

作者： Adilson Fonseca Teixeira Yanhong Wang Josephine Iaria Peter ten Dijke Hong-Jian Zhu Department of Surgery(The royal Melbourne Hospital) The University of MelbourneParkvilleVICAustralia Huagene institute Kecheng Science and Technology ParkPukou DistrictNanjingJiangsuChina Department of Cell and Chemical Biology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands

Metastasis is the leading cause of cancer-related *** growth factor beta(TGF-β)signaling drives metastasis and is strongly enhanced during cancer ***,the use of on-target TGF-βsignaling inhibitors in the treatment of cancer patients remains unsuccessful,highlighting a gap in the understanding of TGF-βbiology that limits the establishment of efficient anti-metastatic ***,we show that TGF-βsignaling hyperactivation in breast cancer cells is required for metastasis and relies on increased small extracellular vesicle(sEV)*** sEV’s unique role,TGF-βsignaling levels induced by sEVs exceed the activity of matching concentrations of soluble ligand TGF-β.Further,genetic disruption of sEV secretion in highlymetastatic breast cancer cells impairs cancer cell aggressiveness by reducing TGF-βsignaling to nearly-normal ***,TGF-βsignaling activity in non-invasive breast cancer cells is inherently low,but can be amplified by sEVs,enabling invasion and metastasis of poorly-metastatic breast cancer *** the translational potential of inhibiting sEV trafficking in advanced breast cancers,treatment with dimethyl amiloride(DMA)decreases sEV secretion,TGF-βsignaling activity,and breast cancer progression in *** both the sEV trafficking and TGF-βsignaling by combining DMA and SB431542 at suboptimal doses potentiated this effect,normalizing the TGF-βsignaling in primary tumors to potently reduce circulating tumor cells,metastasis,and tumor ***,this study establishes sEVs as critical elements in TGF-βbiology,demonstrating the feasibility of inhibiting sEV trafficking as a new therapeutic approach to impair metastasis by normalizing TGF-βsignaling levels in breast cancer cells.

关键词： metastasis doses invasion

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Unraveling the routes to distant metastases in colorectal cancer:Tumor deposits and lymph node metastases as the gateway

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Cancer Communications 2024年第10期44卷 1209-1213页

作者： Nelleke Pietronella Maria Brouwer Ayse Selcen Oguz Erdogan Shannon van Vliet Natasja Rutgers Nikki Knijn Gesina van Lijnschoten Jessica Juliana Tan Johannes Hendrik Willem de Wilt Niek Hugen Gina Brown Femke Simmer Iris Dionne Nagtegaal Department of Pathology Radboud University Medical CenterNijmegenGelderlandThe Netherlands Department of Pathology PathologyDNAArnhemGelderlandThe Netherlands Department of Pathology Eurofins/Laboratoria voor Pathologie en Medische Microbiologie NederlandEindhovenNoord-BrabantThe Netherlands GI Cancer Imaging research Unit The Royal Marsden HospitalSuttonLondonUnited Kingdom Department of Surgery Radboud University Medical CenterNijmegenGelderlandThe Netherlands Department of Surgery Netherlands Cancer InstituteAmsterdamNoord-HollandThe Netherlands Department of Surgery Rijnstate HospitalArnhemGelderlandThe Netherlands Imperial College London Hammersmith Campus LondonLondonUnited Kingdom

Currently,lymph node metastases(LNM)are seen as the gateway to distant metastases in CRC and play a crucial role in the Tumor Node Metastasis(TNM)staging system[1,2].Tumor deposits(TD)have been identified as another histological feature with a strong prognostic impact but are currently only deemed clinically relevant in the absence of LNM[2,3].TD are clusters of tumor cells in the fat surrounding the bowel and are often associated with nerves,vessels and lymphatic tissue,giving the cancer cells access to multiple routes of spread[4].

关键词： metastases cancer gateway

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Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.G.van Gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos Ronald Cornet Bruna dos Santos Vieira Nawel Lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart Esther van Enckevort Chris T.Evelo Alasdair J.G.Gray Marc Hanauer Kristina Hettne Joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon L.Willighagen Mascha Jansen Barend Mons Marco Roos Annika Jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The Leiden Academic Center for Drug research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

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Harmonious Development of Utilization and Protection of Tidal Flats and Wetlands-A Case Study in Shanghai Area

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China Ocean Engineering 2008年第4期22卷 649-662页

作者：陈吉余程和琴戴志军 Doeke EISMA State Key Laboratory of Estuarine and Coastal research East China Normal University royal netherlands institute for sea research

Spatial, environmental, and material resources are important for tidal flats and wetlands, thus, a harmonious balance between utilization and protection should be maintained. In the present study, the concept of tidal flat is defined, and its spatial limitation is also clarified. Located at the Yangtze Estuary, tidal flats in Shanghai area are selected for study. The relationship between water discharge and sediment transport of the Yangtze River, allowed exploration intensity and needs for wetland protection are discussed in the paper. The dynamic process and changing trend for different types of tidal flats are illustrated in detail. Regulations are proposed for a reasonable exploitation, dynamic protection, and ecosystem restoration of each individual tidal fiat and wetland. Some valuable suggestions are put forward for further study about the sustain＇able exploitation of offshore resources in Shanghai area.

关键词： Shanghai area harmarious development utilization protection tidal fiat wetland

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深海环境海洋生态系统监测与修复新技术

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Engineering 2024年第3期34卷 195-211页

作者： Jacopo Aguzzi Laurenz Thomsen Sascha Flögel Nathan J.Robinson Giacomo Picardi Damianos Chatzievangelou Nixon Bahamon Sergio Stefanni Jordi Grinyó Emanuela Fanelli Cinzia Corinaldesi Joaquin Del Rio Fernandez Marcello Calisti Furu Mienis Elias Chatzidouros Corrado Costa Simona Violino Michael Tangherlini Roberto Danovaro Instituto de Ciencias del Mar(ICM-CSIC) Barcelona 08003Spain Stazione Zoologica Anton Dohrn Naples 80121Italy University of Gothenburg Göteborg 40530Sweden GEOMAR Helmholtz Centre for Ocean research Kiel 24148Germany Fundación Oceanogràfic de la Comunitat Valenciana Valencia 46013Spain royal netherlands institute for sea research(NIOZ) Den Burg Texel 1790 ABNetherlands Polytechnic University of Marche(UNIVPM) Ancona 60131Italy SARTI-MAR of the Universitat Politecnica de Catalunya(UPC) Vilanova i la Geltrú08800Spain Lincoln institute for Agri-food Technology University of LincolnLincoln LN22LGUK Engitec Systems International Limited Limassol 3083Cyprus Consiglio per la Ricerca in Agricoltura e L’analisi Dell’economia Agraria(CREA) Centro di Ricerca Ingegneria e Trasformazioni AgroalimentariMonterotondo 00015Italy

The United Nations(UN)’s call for a decade of“ecosystem restoration”was prompted by the need to address the extensive impact of anthropogenic activities on natural *** ecosystem restoration is increasingly necessary due to increasing habitat degredation in deep waters(>200 m depth).At these depths,which are far beyond those accessible by divers,only established and emerging robotic platforms such as remotely operated vehicles(ROVs),autonomous underwater vehicles(AUVs),landers,and crawlers can operate through manipulators and multiparametric sensor arrays(e.g.,optoacoustic imaging,omics,and environmental probes).The use of advanced technologies for deep-sea ecosystem restoration can provide:①high-resolution three-dimensional(3D)imaging and acoustic mapping of substrates and key taxa,②physical manipulation of substrates and key taxa,③real-time supervision of remote operations and long-term ecological monitoring,and④the potential to work ***,we describe how robotic platforms with in situ manipulation capabilities and payloads of innovative sensors could autonomously conduct active restoration and monitoring across large spatial *** expect that these devices will be particularly useful in deep-sea habitats,such as①reef-building cold-water corals,②soft-bottom bamboo corals,and③soft-bottom fishery resources that have already been damaged by offshore industries(i.e.,fishing and oil/gas).

关键词： Ecosystem restoration Robotic manipulation Acoustic tracking Fishery resources Artificial reefs

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Recent Ventures in Interdisciplinary Arctic research:The ARCPATH Project

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Advances in Atmospheric Sciences 2024年第8期41卷 1559-1568页

作者： Astrid E.J.OGILVIE Leslie A.KING Noel KEENLYSIDE François COUNILLON Brynhildur DAVIÐSDÓTTIR Níels EINARSSON Sergey GULEV Ke FAN Torben KOENIGK James R.MCGOODWIN Marianne H.RASMUSSON Shuting YANG institute of Arctic and Alpine research(INSTAAR) University of ColoradoBoulder CO 80303USA Stefansson Arctic institute AkureyriÍS-600Iceland royal Roads University BC V9B 5Y2Canada University of Bergen Bergen N-5007Norway Nansen Environmental and Remote Sensing Centre Bergen N-5007Norway University of Iceland Reykjavík 102Iceland Shirshov institute of Oceanology Moscow 117218Russia Moscow State University Moscow 11991Russia Chinese Academy of Sciences Beijing 100045China Swedish Meteorological and Hydrological institute SE-60176 NorrköpingSweden Danish Meteorological institute CopenhagenØ2100Denmark Obukhov institute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yongqi GAO's significant achievement in the field of interdisciplinary studies within the context of his final research project Arctic Climate Predictions: Pathways to Resilient Sustainable Societies-ARCPATH(https://***/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the Nordic countries, Russia, China, the United States, and Canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local knowledge holders. ARCPATH made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork was carried out for the project study areas of Iceland, Greenland, Norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ARCPATH was able to provide an improved framework for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ARCPATH served to create new and valuable knowledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： Recent Ventures in Interdisciplinary Arctic research:The ARCPATH Project

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Morphodynamic signatures derived from daily surface elevation dynamics can explain the morphodynamic development of tidal flats

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Water Science and Engineering 2023年第1期16卷 14-25页

作者： Tim J.Grandjean Jaco C.de Smit Jim van Belzen Gregory S.Fivash Jeroen van Dalen Tom Ysebaert Tjeerd J.Bouma Department of Estuarine and Delta Systems Royal Netherlands Institute for Sea Research(NIOZ)4401 NT YersekeThe Netherlands Faculty of Geosciences Department of Physical GeographyUtrecht University3508 TC UtrechtThe Netherlands

Understanding the sensitivity of tidal flats to environmental changes is ***,most studies rely on process-based models to systematically explain the morphodynamic evolution of tidal *** this study,we proposed an alternative empirical approach to explore tidal flat dynamics using statistical indices based on long-term time series of daily surface elevation *** elevation dynamic(SED)indices focus on the magnitude and period of surface elevation changes,while morphodynamic signature(MDS)indices relate sediment dynamics to environmental *** statistical analyses were applied to an intervention site in the netherlands to determine the effect of recently constructed groynes on the tidal *** these analyses,we were able to(1)detect a reduction in the daily SED and(2)determine that the changes in the daily SED were predominantly caused by the reduction in wave impact between the groynes rather than the reduction in tidal ***,the presented results showed that the combination of novel statistical indices provides new insights into the trajectories of tidal flats,ecosystem functioning,and sensitivity to physical drivers(wind and tides).Finally,we suggested how the SED and MDS indices may help to explore the future trajectories and climate resilience of intertidal habitats.

关键词： Surface elevation dynamics Tidal flat trajectories Morphodynamic development Morphodynamic signature Bed level dynamics

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Types of saltwater intrusion of the Changjiang Estuary

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Science China Chemistry 2001年第S1期44卷 150-157页

作者：茅志昌沈焕庭 JamesT.Liu D.Eisma State Key Laboratory of Estuarine and Coastal research Institute of Estuarine and Coastal Research East China Normal University Shanghai China institute of Marine Geology and Chemistry Sun Yat-sen University Kaohsiung China netherlands institute for sea research Den Burg-Texel Netherlands

The Changjiang Estuary is characterized by multi-order bifurcations, unsteady submerged sandbars, mid-channel sandbars, creeks and riffles. The following four types of saltwater intrusion are found: (1) direct intrusion from the sea; (2) intrusion during tidal flooding; (3) intrusion from tidal flats overflow; and (4) salt water coming upstream through other waterways. These result in a complicated temporal and spatial salinity distribution. A high chlorinity concentration zone exists from the Liuhekou to the Sidongkou along the South Branch. The salinity during neap tide or ordinary tide is higher than during spring tide.

关键词： Changjiang Estuary salt water intrusion salinity variations chlorinity freshwater resources.

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