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magnetic resonance imaging combined with serum endolipin and galactagoglobin-3 to diagnose cerebral infarction in the elderly with diabetes mellitus

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World Journal of Diabetes 2024年第7期15卷 1509-1517页

作者： Yan-Hui Zhang Dong Liang magnetic resonance Imaging room Tianjin Huanhu HospitalTianjin 300350China Department of Endocrinology Tianjin First Central HospitalTianjin 300190China

BACKGROUND magnetic resonance imaging(MRI)combined with serum endothelin and galactagoglobin-3(Gal-3)can improve the clinical diagnosis of diabetes mellitus complicated with cerebral *** To analyze the clinical value of MRI combined with serum endolipin and Gal-3 for the diagnosis of cerebral infarction in the elderly with diabetes *** One hundred and fifty patients with acute cerebral infarction hospitalized between January 2021 and December 2023 were divided into two groups according to comorbid diabetes mellitus,including 62 and 88 cases in the diabetic and nondiabetic cerebral infarction *** samples were collected to detect the expression of serum endolipoxins,and Gal-3,and cranial MRI was performed at *** between the two groups were compared to analyze the diagnostic value of these *** Serum endolipin and Gal-3 expression were higher in the diabetic cerebral infarction group(P<0.05).The arterial wall area,vessel area,normalized wall index,and lumen stenosis rate were higher in the diabetic cerebral infarction group,while the rate of arterial lumen moderate and severe stenosis was 48.39% higher(36.36%,P<0.05).The percentage of large(29.03%)and multiple infarcts(33.87%)in the diabetic cerebral infarction group was higher(13.64% and 20.45%),and the incidence rate of lacunar infarcts was lower(37.10%vs 65.91%)(P<0.05).The total incidence of arterial plaque in patients in the diabetic cerebral infarction group was 96.77% higher(69.32%),while the incidence of necrotic lipid core plaque was 58.06%higher(26.14%)(P<0.05).Receiver operating characteristic curve analysis was performed to assess the diagnosis utility of these *** in combination with serum endoglin and Gal-3 had the highest area under the curve,the Yoden index,sensitivity and specificity(P<0.05).CONCLUSION The expression of serum endolipin and Gal-3 in elderly patients with diabetes mellitus with cerebral infarction showed an eleva

关键词： Endolipin Galectin-3 magnetic resonance imaging Elderly Diabetes mellitus Cerebral infarction

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Fluorinated [2]rotaxanes as sensitive ^(19)F MRI agents: Threading for higher sensitivity

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Chinese Chemical Letters 2024年第10期35卷 379-382页

作者： Lan Yang Yu Li Mou Jiang Rui Zhou Hengjiang Cong Minghui Yang Lei Zhang Shenhui Li Yunhuang Yang Maili Liu Xin Zhou Zhong-Xing Jjiang Shizhen Chen State Key Laboratory of magnetic resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory forOptoelectronicsWuhan430071China University of Chinese Academy of Sciences Beijing 100049China School of Pharmaceutical Sciences&College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430071China Optics Valley Laboratory Wuhan 430074China

As a promising imaging technology,the low sensitivity of fluorine-19 magnetic resonance imaging(^(19)F MRI)severely hinders its biomedical ***,we have developed an unprecedented rotaxanebased strategy to improve the sensitivity of^(19)F MRI *** threading the fluorinated macrocycle into2-blade pinwheel[2]rotaxanes,the^(19)F longitudinal relaxation rate R1was dramatically increased,resulting in a significant^(19)F MRI signal intensity enhancement of up to 79%.Through comparative molecular dynamics studies using a series of solution and solid-state^(1)H/^(19)F nuclear magnetic resonance(^(1)H/^(19)F NMR)and molecular dynamics simulations,it was found that the formation of mechanical bonds dramatically restricts the motion of the wheel fluorines and thus increasing the R1for higher^(19)F MRI *** a novel strategy for improving^(19)F MRI sensitivity,this study has established^(19)F NMR/MRI as a valuable technology for monitoring the molecular dynamics of rotaxanes,which may shed new light on high-performance^(19)F MRI agents and molecular devices.

关键词： Rotaxane ^(19)FMRI Imaging agent Mechanical bond Relaxation rate

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Illuminating β-arrestin conformational dynamics by fluorine NMR

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magnetic resonance Letters 2024年第2期4卷 73-74页

作者： Bin Xia Beijing nuclear magnetic resonance Center College of Chemistry and Molecular EngineeringSchool of Life SciencesPeking UniversityBeijing100871China

In a recent paper, solution-state ^(19)F NMR spectroscopy was used to probe the conformational dynamics of β-arrestin-1, an essential adaptor and signaling component of the G-protein couple receptor (GPCR) signaling pathway. This work reveals a highly complex conformational energy landscape of β-arrestin-1, and illuminates the molecular mechanism of the membrane phosphoinositide PIP2-induced β-arrestin-1 activation at residue level.(https://***/10.1038/s41467-023-43694-1).

关键词： conformational dynamics fluorine

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Modeling of ion cyclotron resonance frequency heating of proton-boron plasmas in EHL-2 spherical tokamak

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Plasma Science and Technology 2024年第10期26卷 39-48页

作者： Xianshu WU Jingchun LI Jiaqi DONG Yuejiang SHI Guoqing LIU Yong LIU Zhiqiang LONG Buqing ZHANG Baoshan YUAN Y.K.Martin PENG Minsheng LIU Shenzhen Key Laboratory of nuclear and Radiation Safety Institute for Advanced Study in Nuclear Energy&SafetyCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 510640People’s Republic of China Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen 518055People’s Republic of China ENN Science and Technology Development Co. Ltd.and Hebei Key Laboratory of Compact FusionLangfang 065001People’s Republic of China Siemens Shenzhen magnetic resonance Ltd. Shenzhen 518057People’s Republic of China

Ion cyclotron resonance heating(ICRH)stands out as a widely utilized and cost-effective auxiliary method for plasma heating,bearing significant importance in achieving high-performance discharges in p-^(11)B *** light of the specific context of p-^(11)B plasma in the EHL-2 device,we conducted a comprehensive scan of the fundamental physical parameters of the antenna using the full-wave simulation program *** preliminary result indicated that for p-^(11)B plasma,optimal ion heating parameters include a frequency of 40 MHz,with a high toroidal mode number like N_(?)=28 to heat the majority H *** addition,we discussed the impact of concentration of minority ion species on ion cyclotron resonance heating when^(11)B serves as the heavy minority *** significant difference in charge-to-mass ratio between boron and hydrogen ions results in a considerable distance between the hybrid resonance layer and the tow inverted cyclotron resonance layer,necessitating a quite low boron ion concentration to achieve effective minority *** also considered another method of direct heating of hydrogen ions in the presence of boron ion *** is found that at appropriate boron ion concentrations(X(^(11)B)~17%),the position of the hybrid resonance layer approaches that of the hydrogen ion cyclotron resonance layer,thereby altering the polarization at this position and significantly enhancing hydrogen ion fundamental absorption.

关键词： ICRF hydrogen-boron fusion mode conversion fundamental absorption

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Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury

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Zoological Research 2024年第3期45卷 648-662页

作者： Dan Yang Bin-Bin Nie Jin-Gang He Zong-Qiang Lv Feng-Feng Mo Si-Yi Ouyang Jie Wang Ju-Xiang Chen Tao Tao Department of Anesthesiology Central People’s Hospital of ZhanjiangZhanjiangGuangdong 524045China Key Laboratory of nuclear Radiation and nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of magnetic resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei 430071China Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghai 200082China Department of Nutrition and Food Hygiene Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Institute of Neuroscience and Brain Diseases/Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei 441021China Songjiang Hospital and Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghai 201600China Department of Anesthesiology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability *** PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely *** potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced *** this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term *** indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury *** kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of ***,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying ***,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for *** studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.

关键词： Post-traumatic headache(PTH) Mild traumatic brain injury(mTBI) Metabolic kinetics fMRI Cerebellum

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Ingenious liquid-observed vapor exchange (LOVE) NMR method revealing how sugars protect dry protein structure

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magnetic resonance Letters 2024年第2期4卷 75-76页

作者： Geying Ru Conggang Li Key Laboratory of magnetic resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China

Recently,Gary et *** an article elucidating how sugars contribute to the protection of dry protein *** utilized an ingenious liquid-observed vapor exchange(LOVE)nuclear magnetic resonance(NMR)method,providing valuable insights into the protection mechanism of sugars during the drying *** details of their study can be found in the article available at https://***/10.1021/***.2c00692.

关键词： structure sugar revealing

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Approximate constructions of counterdiabatic driving withNMR quantum systems

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Chinese Physics B 2024年第9期33卷 83-91页

作者： Hui Zhou Xiaoli Dai Jianpei Geng Yunlan Ji Xinhua Peng School of Physics Hefei University of TechnologyHefei 230009China Chinese Academy of Sciences Key Laboratory of Microscale magnetic resonance and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Counterdiabatic driving (CD) offers a fast and robust route to manipulate quantum systems, which has widespreadapplications in quantum technologies. However, for higher-dimensional complex systems, the exact CD term involving thespectral properties of the system is difficult to calculate and generally takes a complicated form, impeding its experimentalrealization. Recently, many approximate methods have been proposed for designing CD passages in many-body systems. Inthis topical review, we focus on the CD formalism and briefly introduce several experimental constructions and applicationsof approximate CD driving in spin-chain models with nuclear magnetic resonance (NMR) systems.

关键词： nuclear magnetic resonance quantum simulation quantum state engineering

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A polarized^(3)He system based on metastability-exchange optical pumping

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 72-81页

作者： Yuting Wang Liangyong Wu Kaiyuan Zhang Mei Peng Siyu Chen Haiyang Yan State Key Laboratory of nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Key Laboratory of Neutron Physics Institute of Nuclear Physics and ChemistryChina Academy of Engineering PhysicsMianyang 621900China

Hyperpolarized^(3)He nuclei have emerged as a significantly important approach in quantum precision measurement techniques,with extensive applications in fundamental physics,magnetometry,metrology,and *** this study,we report on the design and implementation of a^(3)He polarization system at the China Mianyang Research Reactor(CMRR),utilizing the metastabilityexchange optical pumping(MEOP)*** employed a Merritt coil system consisting of four square coils to furnish a uniform holding *** deployed a 2 W fiber laser to pump the metastable^(3)He atoms and conducted free induction decay(FID)detection of the polarized^(3)He nuclei using both pickup coil and optical *** the optical method,we used a50 m W linearly polarized distributed Bragg reflector(DBR)laser as the *** applied transverse light absorption polarimetry to measure the absolute nuclear polarization of the ground-state^(3)*** have developed cell fabrication capabilities at the CMRR,and cells at various pressures ranging from 100 to 1000 Pa have been fabricated and *** a typical borosilicate cell with 100 Pa pressure,the absolute polarization is measured as Pn≈70%,and the transverse relaxation time is estimated as T2≈0.5 ***,we constructed a few aluminosilicate cells,each carefully filled with pure^(3)He at a pressure of 100 ***,we conducted a comprehensive evaluation of their performance in the context of MEOP.

关键词： metastability exchange optical pumping polarized^(3)He magnetic resonance

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room-temperature phonon-coupled single-photon emission in hexagonal boron nitride

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 109-114页

作者： Jia-Min Lai Qing-Hai Tan Feilong Song Haonan Chang Yanpei Lv Xue-Lu Liu Jinghua Teng Weibo Gao Ping-Heng Tan Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Key Laboratory of magnetic Molecules and magnetic Information Materials of Ministry of Education&Research Institute of Materials Science Shanxi Normal UniversityTaiyuan 030000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore

Photon-lattice(phonon)coupling is fundamental to light-matter interaction,particularly when it reaches the quantum limit of the phonon-coupled single-photon emission,which holds great potential for quantum manipulation and quantum information ***,we report single defect state-phonon coupling in hexagonal boron nitride(h BN)at room *** ultrabroad spectrum of single-photon emissions can be achieved by selecting the excitation *** photoluminescence excitation spectroscopy,we observe single-phonon-assisted resonance-enhanced single-photon emission,along with multiple phonon replicas that herald the creation of phonon Fock *** also develop a transition model to gain insight into the physical process behind the single defect state-phonon *** work sets the stage for manipulating electron-phonon coupling state with single quantum-level precision at room temperature.

关键词： temperature phonon hexagonal

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Solid-state NMR reveals that oxygen tri-clusters make glass highly crackresistant

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magnetic resonance Letters 2024年第2期4卷 77-78页

作者： Zhiwu Yu High magnetic Field Laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China

In a recent paper,advanced solid-state nuclear magnetic resonance(SSNMR)technology was employed to reveal the underlying mechanism contributing to the high hardness and exceptional resistance to fragmentation observed in certain special glasses[1].This study utilized SSNMR to analyze the atomic-scale internal structure of glass,enabling the quantification of the fraction of three-coordinated oxygen([^((3))O]).The research findings demonstrate a quantitative relationship between[^((3))O]and the resistance of glass to crack initiation.

关键词： crack resistance glass

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