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Current and future treatments for hepatocellular carcinoma

World Journal of Gastroenterology 2015年第28期21卷 8478-8491页

作者： Alexander Schlachterman Willie W Craft Jr Eric Hilgenfeldt Avir Mitra roniel cabrera Department of Gastroenterology Hepatology and Nutrition University of Florida College of Medicine Department of Hospital Medicine Upper Valley Medical Center Department of Internal Medicine University of Florida College of Medicine Department of Internal Medicine Drexel University College of Medicine roniel cabrera Department of Gastroenterology Hepatology and Nutrition University of Florida College of Medicine

Hepatocellular carcinoma(HCC) represents a unique challenge for physicians and *** is no definitively curative ***,many treatment and management modalities exist with differing advantages and *** current guidelines and individual patient concerns must be taken into account in order to properly manage *** addition,quality of life issues are particularly complex in patients with HCC and these concerns must also be factored into treatment ***,considering all the options and their various pros and cons can quickly become complex for both clinicians and *** this review,we systematically discuss the current treatment modalities available for HCC,detailing relevant clinical data,risks and rewards and overall outcomes for each *** options discussed include resection,transplantation and *** also discuss the radiation modalities:conformal radiotherapy,yttrium 90 microspheres and proton and heavy ion *** biologic agent Sorafenib is discussed as a promising new approach,and recent clinical trials are *** then detail currently described molecular pathways implicated in the initiation and progression of HCC,and we explore the potential of each pathway as an avenue for drug *** hope this comprehensive and forward-looking review enables both clinicians and patients to understand various options and thereby make more informed decisions regarding this disease.

关键词： Hepatocellular carcinoma Hepatoma Hepatocellular cancer Liver cancer Adult Liver cell carcinoma Liver neoplasm Hepatic neoplasm

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