检索结果-南通市图书馆

Remodeling Isoprene Pyrophosphate Metabolism for Promoting Terpenoids Bioproduction

Engineering 2023年第9期28卷 166-178页

作者： Xianhao Xu Xueqin Lv Shixiu Cui Yanfeng Liu Hongzhi Xia Jianghua Li Guocheng Du Zhaofeng Li Rodrigo Ledesma-Amaro Jian Chen Long Liu Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationJiangnan UniversityWuxi 214122China Science Center for Future Foods Ministry of EducationJiangnan UniversityWuxi 214122China richen bioengineering co. Ltd.Nantong 226000China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China Department of bioengineering and Centre for Synthetic Biology Imperial College LondonLondon SW72AZUK

Terpenoids are the largest family of natural *** are made from the building block isoprene pyrophosphate(IPP),and their bioproduction using engineered cell factories has received a great deal of *** date,the insufficient metabolic supply of IPP remains a great challenge for the efficient synthesis of *** this work,we disco.er that the imbalanced metabolic flux distribution between the central metabolism and the IPP supply hinders IPP accumulation in Bacillus subtilis(***).Therefore,we remodel the IPP metabolism using a series of genetically enco.ed two-input-multioutput(TIMO)circuits that are responsive to pyruvate or/and malonyl-co.,resulting in an IPP pool that is significantly increased by up to *** a proof-of-co.cept validation,we design an IPP metabolism remodeling strategy to improve the production of three valuable terpenoids,including menaquinone-7(MK-7,4.1-fold),lyco.ene(9-fold),andβ-carotene(0.9-fold).In particular,the titer of MK-7 in a 50-L bioreactor reached 1549.6 mg·L^(-1),representing the highest titer reported so ***,we propose a TIMO genetic circuits-assisted IPP metabolism remodeling framework that can be generally used for the synergistic fine-tuning of co.plicated metabolic modules to achieve the efficient bioproduction of terpenoids.

关键词： Terpenoids Genetic circuits Bacillus subtilis Isoprene pyrophosphate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improvement of Sinter Properties With Ultra Fine-Sized Iron co.centrate by HPRG

引用

Journal of Iron and Steel Research International 2013年第9期20卷 47-52页

作者： FAN Jian-jun QIU Guan-zhou JIANG Tao GUO Yu-feng MU Ke-lang School of Minerals Processing and bioengineering Central South University Taiyuan Iron and Steel(Group)co. Ltd.

The experiments were co.ducted on the changes of sintering performance of one kind of ultra fine-sized iron co.centrate with or without being processed by high pressure roll grinding （HPRG）. The experimental results indi eate that the specific surface area increases from 1723.0 to 2 201.6 cm^2/g when the iron co.centrate is processed by HPRG. The permeability of sintering mix increases and the iron co.centrate beco.es easy to react with CaO reagent at high temperature. The effect gets intensified when iron co.centrate and lime are processed together By HPRG. The further studies indicate that co.pared with the base case, the sinter quality also gets improved, in which the yield of sinter increases from 67.24% to 69.52% and further to 71.68%, the tumble index （TI） increases from 60.38% to 62.13% and further to 64.45%, and the productivity increases from 1.42 to 1.57 t/（m^2 · h） and further to 1.62 t/（m^2 · h） when the iron co.centrate is processed by HPRG or is processed with lime together. The metallurgical properties of sinter also get improved when the iron co.centrate is pretreated by high pressure roll. The results indicate that it is co.ducive to the increase of sinter quality and productivity when the iron co.centrates are processed by HPRG.

关键词： iron co.centrate lime HPRG permeability sinter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Direct reduction of carburized pre-reduced pellets by microwave heating

引用

Journal of Central South University 2014年第1期21卷 351-357页

作者：胡兵黄柱成易凌云姜涛 School of Minerals Processing and bioengineering Central South University Zhongye Changtian International Engineering co. Ltd.

A new iron-making process using carburized pre-reduced iron ore pellets and microwave heating is investigated. The pre-reduced pellets, with a porous structure, and fine particles are carburized homogeneously at 400-650 ℃ in a co.atmosphere. The carburized carbon not only acts reaction as a reduction agent, but also absorbs microwave in the reduction process. Hence, the carburized pre-reduced pellets can be rapidly reduced by microwave heating. There are three procedures involved in the process, namely, gas-based pre-reduction, low-temperatttre carburization and deep reduction by microwave heating. Carburized pre-reduced iron ore pellets show a rapid temperature rise that is twice as fast as the results for pre-reduced pellets in the laboratory. This not only improves the efficiency of the microwave heating, but also accelerates the reduction of iron oxides. The temperature of the pre-reduced pellets rises to 1050 ℃ in 45 min when the carburization rate is 2.02%, and the metallization rate and co.pressive strength reach 94.24% and 1725 N/pellet, respectively.

关键词： oxidized pellets pre-reduction carburizing microwave heating direct reduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of chloride ion on bacterial pre-oxidation of arsenic-co.taining gold co.centrate

引用

Journal of Central South University 2011年第5期18卷 1418-1424页

作者：杨玮覃文庆刘瑞强任允超 School of Resources Processing and bioengineering Central South University Refinery of Shandong Gold Mining co. Ltd. Engineering Design and Research co. Ltd.Shandong Gold Corporation

The bacterial pre-oxidation process of arsenic-co.taining gold co.centrates and the bacterial activity under different chloride ion co.centrations were studied by using a mixture of thermophilic strains TCJ domesticated in *** experimental result shows that with different samples and leaching systems,the adaptability and Cl- tolerance of bacteria are different,and that appropriate chloride ion co.centration is co.ductive to bacterial oxidation,while higher chloride ion co.centration will inhibit the bacterial activity and affect the pre-oxidation *** the present production co.ditions,TCJ can adapt to the changes of water quality in the source of water and its critical chloride ion tolerance value is 2.7 g/L.

关键词： chloride ions arsenic-co.taining gold co.centrate pre-oxidation bacterial adaptation critical co.centration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Life Cycle Assessment of Iron Ore Sintering Process

引用

Journal of Iron and Steel Research International 2015年第6期22卷 473-477页

作者： Zong-ping LI Xiao-hui FAN Gui-ming YANG Jin-chao WEI Ying SUN Min WANG School of Minerals Processing and bioengineering Central South University Zhongye Changtian International Engineering co. Ltd.

Iron ore sintering is an energy＇intensive process associated with emission of pollutants in iron and steel in- dustry. In order to co.prehensively evaluate the environmental impacts of sintering, a detailed life cycle assessment of a sintering plant was co.ducted. Life cycle inventory showed that, in the production of 1 t sinter ore, 241.53 kg co. , 22.68 kg co. 0. 294 kg SO2 , 0.63 kg NO, , 1.18 /lg dioxin and 0.48 kg dust were discharged. Global war- ming potentials, acidification potentials, photochemical ozone creation potentials and human toxicity potentials were selected as four impact categories, and the evaluation index for the sintering plant was calculated as 3.45 × 10 ^-12. Fi nally, based on the environmental impact analysis, several measures of reducing environmental [oadings of the sinte- ring plant were provided, which included the utilization of denitrification equipment, recirculation of the hot waste gas and process improvement to reduce fuel co.sumption.

关键词： iron ore sintering plant life cycle assessment pollutant emission environmental loading

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New Descriptors of Amino Acids and Its Applications to Peptide Quantitative Structure-activity Relationship

引用

Chinese Journal of Structural Chemistry 2008年第11期27卷 1375-1383页

作者：舒茂霍丹群梅虎梁桂兆张梅李志良 co.lege of bioengineering Chongqing University co.lege of Chemistry and Chemical Engineering Chongqing University Department of Quality co.trol Chongqing Daxin Pharmaceutical Co. Ltd

A new set of descriptors, HSEHPCSV （co.ponent sco.e vector of hydrophobic, steric, and electronic properties together with hydrogen bonding co.tributions）, were derived from principal co.ponent analyses of 95 physico.hemical variables of 20 natural amino acids separately acco.ding to different kinds of properties described, namely, hydrophobic, steric, and electronic properties as well as hydrogen bonding co.tributions. HSEHPCSV scales were then employed to express structures of angiotensin-co.verting enzyme inhibitors, bitter tasting thresholds and bactericidal 18 peptide, and to co.struct QSAR models based on partial least square （PLS）. The results obtained are as follows： the multiple co.relation co.fficient （R2cum） of 0.846, 0.917 and 0.993, leave-one-out cross validated Q2cm of 0.835, 0.865 and 0.899, and root-mean-square error for estimated error （RMSEE） of 0.396, 0.187and 0.22, respectively. Satisfactory results showed that, as new amino acid scales, data of HSEHPCSV may be a useful structural expression methodology＇for the studies on peptide QSAR （quantitative structure-activity relationship） due to many advantages such as plentiful structural information, definite physical and chemical meaning and easy interpretation.

关键词： peptide quantitative structure-activity relationship principal co.ponent analysis genetic algorithm partial least square

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrometallurgical reco.ery of lithium carbonate and iron phosphate from blended cathode materials of spent lithium-ion battery

引用

Rare Metals 2024年第3期43卷 1275-1287页

作者： Shao-Le Song Run-Qing Liu Miao-Miao Sun Ai-Gang Zhen Fan-Zhen Kong Yue Yang School of Minerals Processing and bioengineering Central South UniversityChangsha410083China Zhejiang Tianneng New Materials co. Ltd.Huzhou313103China

The recycling of cathode materials from spent lithium-ion battery has attracted extensive attention,but few research have focused on spent blended cathode *** reality,the blended materials of lithium iron phosphate and ternary are widely used in electric vehicles,so it is critical to design an effective recycling *** this study,an efficient method for reco.ering Li and Fe from the blended cathode materials of spent LiFePO_(4)and LiNi_(x)co.(y)Mn_(1-x-y)O_(2)batteries is ***,87%A1 was removed by alkali ***,91.65%Li,72.08%Ni,64.6%co.and 71.66%Mn were further separated by selective leaching with H_(2)SO_(4)and H_(2)O_(2).Li,Ni,co.and Mn in solution were reco.ered in the form of Li_(2)co.(3)and hydroxide ***,98.38%Fe was leached from the residue by two stage process,and it is reco.ered as FePO_(4)·2H_(2)O with a purity of 99.5%by *** and P were present in FePO_(4)·2H_(2)O in amounts of 28.34%and 15.98%,***,the drift and co.trol of various co.ponents were discussed,and co.t-benefit analysis was used to assess the feasibility of potential application.

关键词： Spent lithium-ion battery Blended cathode materials Reco.ery Lithium carbonate Iron phosphate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents

引用

Chinese Chemical Letters 2014年第4期25卷 589-592页

作者： Xiu-Jun Wang Ming-Li Yang Lan-Ping Zhang Tong Yao Cheng Chen Lian-Gang Mao Yin Wang Jie Wu The 716th Institute of CSIC JARI Pharmaceutical co. Ltd. Department of Pharmaceutical Engineering Wuhan Bioengineering Institute

A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these co.pounds exhibited high activity against the selected tumor cells. Among them, co.pound 9 owned the best potential, its IC50 values being 5.95μmol/L （mononuclear tumor cell line （U937）） and 5.58 μmol/L （cervical cancer cell （HeLa））. Fluorescence and UV-vis studies showed that co.pound 9 co.ld bind into the minor groove of DNA.

关键词： Bis-benzimidazole Anti-tumor DNA minor groove

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Technology for recycling and regenerating graphite from spent lithium-ion batteries

引用

Chinese Journal of Chemical Engineering 2021年第11期34卷 37-50页

作者： Chenxing Yi Lijie Zhou Xiqing Wu Wei Sun Longsheng Yi Yue Yang School of Minerals Processing and bioengineering Central South UniversityChangsha 410083China Beijing Battery Green Resources Technology co. LtdBeijing 100081China

With the annual increase in the amount of lithium-ion batteries(LIBs),the development of spent LIBs recycling technology has gradually attracted *** is one of the most critical materials for LIBs,which is listed as a key energy source by many developed ***,it was neglected in spent LIBs recycling,leading to pollution of the environment and waste of *** this paper,the latest research progress for recycling of graphite from spent LIBs was ***,the processes of pretreatment,graphite enrichment and purification,and materials regeneration for graphite reco.ery are introduced in ***,the problems and opportunities of graphite recycling are raised.

关键词： Spent lithium-ion batteries Graphite Anode materials Recycle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and Characterization of Three Pentacene Derivatives

引用

Transactions of Tianjin University 2018年第5期24卷 453-460页

作者： Hongmei Qu Haijiao Shen Junqiu Li Yican Men Xu Chen Zepeng Chong Key Laboratory of Systems bioengineering (Ministry of Education) Tianjin University Tianjin Kingsrial S&T co. Ltd

The addition of substituents at the 6,13-position improved the solubility and stability of pentacene, making it possible to use the derivatives in spin co.ting of organic field-effect transistors(OFETs). Three pentacene derivatives, 6,13-bis(m-tolyl)pentacene(MP), 6,13-bis(4-butylphenyl)pentacene(BP), and 6,13-bis((4-butylphenyl)ethynyl)pentacene(BPEP) were synthesized, and their properties were investigated. 6,13-Pentacenequinone and organolithium were used in the preparation of 6,13-dihydropentacene at 0 ℃, and pentacene derivatives were synthesized with SnCl_2/HCl as reducing agent, to reduce 6,13-dihydropentacene at room temperature. The structure of the derivatives was characterized using NMR. The thermal stability, photochemical properties, and electronic structure of the three co.pounds were investigated using TGA, cyclic voltammetry, and UV–Vis. BPEP was also characterized using X-ray diffraction and atom force microsco.y. BPEP was used to fabricate an OFET device using spin co.ting. The device showed a mobility of 0.07 cm^2 V s^(-1) at V_(th) =-10 V and I_(ON)/I _(OFF) = 10~2.

关键词： Organolithium Reduction reaction Mobility OFET Spin co.ting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：