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Negative impact of bone-marrow-derived mesenchymal.stem cel.s on dextran sul.ate sodium-induced col.tis

Worl. Journal.of Gastroenterol.gy 2015年第7期21卷 2030-2039页

作者： Young-Sun Nam Nayoun Kim Keon-Il.Im Jung-Yeon l.m Eun-Sol.l.e Seok-Goo Cho Institute for Transl.tional.Research and Mol.cul.r Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital the Catholic University of Korea College of Medicine Department of Hematol.gy Catholic Blood and Marrow Transplantation Center Seoul St. Mary’s Hospital Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease the Catholic University of Korea College of Medicine

AIM:To investigate the effects of mesenchymal.stem cel.s(MSCs)on dextran sul.ate sodium-induced infl.mmatory bowel.disease(IBD).METHODS:C57Bl.6 mice were fed 3.5%(g/l.dextran sul.ate *** day seven,the mice received intraperitoneal.injections of 1×106 *** survival.rate,disease activity index val.es,and body weight,were monitored *** day ten,col.n l.ngths and histopathol.gic changes were *** addition,immunoregul.tory changes fol.owing MSC administration were eval.ated by determining the l.vel. of effector T cel. responses in the spl.en and mesenteric l.mph nodes,and the expression l.vel. of infl.mmatory cytokines in homogenized ***:Intraperitoneal.administration of MSCs did not prevent devel.pment of col.tis and did not reduce the cl.nicopathol.gic severity of *** significant difference was evident in either survival.rate or disease activity index score between the control.and MSCtreated *** ten-sacrificed mice exhibited no significant difference in either col.n l.ngth or histopathol.gic ***,the MSC-treated group exhibited el.vated l.vel. of interl.ukin(Il.-6 and transforming growth factor-β,and a reduced l.vel.of Il.10,in spl.ens,mesenteric l.mph nodes,and homogenized *** Il.17 l.vel.was l.wer in the mesenteric l.mph nodes of the MSC-treated group(P=0.0126).In homogenized col.ns,the Il.17 and tumor necrosis factor-α(P=0.0092)expression l.vel. were al.o l.wer in the treated ***:MSC infusion provided no significanthistopathol.gic or cl.nical.improvement,thus representing a l.mited therapeutic approach for *** enhancement of MSCs is needed in further study.

关键词： Crohn’s disease Dextran sul.ate sodium Infl.mmator

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日本最新商法(有关运输/海商部分)和国际海上货物运输法

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中国海商法研究 2020年第1期31卷 56-73页

作者：张秀娟李晓楠梁赟张永坚(译) 日本鹿儿岛大学URA中心鹿儿岛890-8580 日本K&l.政书士国际法务事务所东京136-0072 日本早稻田大学法学研究科东京169-8050 大连海事大学法学院辽宁大连116026

日本《商法》中有关运输和海商部分的修改已于2018年5月获得通过,自2019年4月起施行。适用于国际海上货物运输的《国际海上货物运输法》也随着商法的修改作了修改,修改后的该法同样自2019年4月起施行。该文对新修改的这两部法律进行了... 详细信息

日本《商法》中有关运输和海商部分的修改已于2018年5月获得通过,自2019年4月起施行。适用于国际海上货物运输的《国际海上货物运输法》也随着商法的修改作了修改,修改后的该法同样自2019年4月起施行。该文对新修改的这两部法律进行了翻译。日本商法曾对中国产生过巨大的影响,现在仍有很大的参考价值。研究此次修改的内容,必将对完善中国相关法律有所裨益。

关键词：日本《商法》《国际海上货物运输法》法律修改

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农业氨减排对大气PM_(2.5)污染治理日趋重要

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Science Bul.etin 2022年第17期67卷 1745-1749页

作者：许稳赵园红温章常运华潘月鹏孙业乐马昕沙志鹏李紫玥康嘉慧刘磊唐傲寒王锴张颖郭怡鑫张霖盛立芳张秀明谷保静宋宇 Martin Van Damme l.even Cl.risse Pierre-Francois Coheur Jeffrey l.Col.ett Jr Keith Goul.ing 张福锁贺克斌刘学军 Col.ege of Resources and Environmental.Sciences National Academy of Agriculture Green DevelopmentKey Laboratory of Plant-Soil InteractionsMinistry of EducationNational Observation and Research tation of Agriculture Green Development(QuzhouHebei)China Agricultural UniversityBeijing 100193China Col.ege of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100China Col.aborative Innovation center on Forecast and Eval.ation of Meteorol.gical.Desasters Nanjing University of Information Science&TechnologyNanjing 200433China State Key l.boratory of Atmospheric Boundary l.yer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Col.ege of Earth and Environmental.Sciences Lanzhou UniversityLanzhou 730000China l.boratory for Cl.mate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China School.of Agricul.ure and Food the University of MelbourneVictoria 3010Australia Col.ege of Environmental.and Resource Sciences Zhejiang UniversityHangzhou 310058China State Key Joint l.boratory of Environmental.Simul.tion and Pol.ution Control Department of Environmental SciencePeking UniversityBeijing 100871China Universitél.bre de Bruxel.es SpectroscopyQuantum Chemistry and Atmospheric Remote SensingBrusselsBelgium Department of Atmospheric Science Colorado State UniversityFort Collins CO 80523USA Sustainabl. Agricul.ural.Sciences Department Rothamsted ResearchHarpenden AL52JQUK School.of Environment Tsinghua UniversityBeijing 100084China

在新冠肺炎疫情期间,中国采取的管制封锁措施大幅减少了交通和工业排放,但农业排放没有受到影响,甚至有所增加.通过全国大气氨浓度地面监测、实时连续观测和卫星观测等手段,我们发现,新冠肺炎疫情管制措施实施期间中国大气氨浓度大范围... 详细信息

在新冠肺炎疫情期间,中国采取的管制封锁措施大幅减少了交通和工业排放,但农业排放没有受到影响,甚至有所增加.通过全国大气氨浓度地面监测、实时连续观测和卫星观测等手段,我们发现,新冠肺炎疫情管制措施实施期间中国大气氨浓度大范围显著增加,上升幅度在农村地区最为明显(增加22%),在城市和偏远地区变化不明显;而且,管控期间大气氨浓度上升幅度与2015~2019年相同月份相比更大.基于大气化学模式模拟发现,中国北方大气氨浓度上升主要是由农业氨排放增加所致.随着未来我国二氧化硫和氮氧化物等酸性气体排放控制的强化,农业氨排放的协同减排对于进一步削减大气PM污染、提升空气质量尤为重要.进一步分析表明,疫情期间50%农业氨排放可有效抵消氨浓度上升造成的二次无机气溶胶的形成.

关键词：管制措施工业排放污染治理地面监测空气质量卫星观测 PM 偏远地区

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动脉粥样硬化斑块中脂肪沉积的扫频光热波成像(英文)

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现代生物医学进展 2013年第32期13卷 6201-6203页

作者：汪天仪 Jake Mancuso Xiankai l. Ayou Hao l. l.Ma Marc D.Fel.man Thomas E.Mil.er Department of Biomedical Engineering University of Texas at Austin Division of Cardiol.gy School of Medicine University of Texas Health Science Center at San Antonio Department of Cardiol.gy Tenth People's Hospital of Shanghai School of Medicine Tongji University Division of Material. Science and Engineering University of Texas at Austin Department of Chemical.Engineering University of Texas at Austin

动脉粥样硬化和易损斑块破裂在全球范围内具有最高的死亡率,超过传染病和癌症导致的死亡率的总和。动脉粥样硬化斑块是由一层很薄的"纤维帽"和导致血栓形成的脂质核心构成。光热波成像是基于对被目标发色团(本文中指脂肪沉积)吸收的光... 详细信息

动脉粥样硬化和易损斑块破裂在全球范围内具有最高的死亡率,超过传染病和癌症导致的死亡率的总和。动脉粥样硬化斑块是由一层很薄的"纤维帽"和导致血栓形成的脂质核心构成。光热波成像是基于对被目标发色团(本文中指脂肪沉积)吸收的光信号强度进行周期调制,从而实现对目标发色团释放的热(红外)信号的调制。这里,我们利用光热波成像来检测来自兔子动脉硬化模型的粥样硬化斑块中脂肪沉积的三维分布。波长为1210纳米的激光被用来靶向检测脂肪。动脉粥样硬化斑块组织在0.1到5赫兹连续扫频的激光的激发下发出光热波,光热波传播到样品表面形成红外辐射温度并被红外相机以25.6帧/秒的速度接收并录制20秒。红外相机上的每一个像素(总共256×256像素)在进行时域傅里叶变换以后得到强度和相位的频域光热波图像。某一特定频率的强度和相位光热波图像对应着脂肪沉积在动脉粥样硬化斑块样品中的横向和纵向分布。对强度和相位光热波图像的分析指出:光热波成像能够用来检测脂肪在动脉粥样硬化斑块中的三维分布,并且脂肪的分布和动脉粥样硬化斑块的形状特征有着紧密联系。

关键词：动脉粥样硬化易损斑块脂肪沉积光热波成像扫频傅里叶变换

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新型冠状病毒(2019-nCoV)感染的肺炎诊疗快速建议指南(标准版)

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解放军医学杂志 2020年第1期45卷 1-20页

作者：靳英辉蔡林程真顺程虹邓通范逸品方程黄笛黄璐琦黄桥韩勇胡波胡芬李柄辉李一荣梁科林丽开罗丽莎马晶马琳璐彭志勇潘运宝潘振宇任学群孙慧敏王莹王云云翁鸿韦超洁吴东方夏剑熊勇徐海波姚晓梅叶太生袁玉峰张笑春张莹雯张银高张华敏赵剡赵明娟訾豪曾宪涛王永炎王行环武汉大学中南医院新型冠状病毒感染的肺炎防治课题组无武汉大学中南医院循证与转化医学中心武汉430071 武汉大学医院管理研究所武汉430071 武汉大学中南医院呼吸与危重症医学科武汉430071 武汉大学中南医院药学部武汉430071 河南大学循证医学与临床转化研究院河南开封475000 中国中医科学院北京100700 中国中医药循证医学中心北京100700 武汉大学中南医院重症医学科武汉430071 武汉大学中南医院医学检验科武汉430071 武汉大学中南医院感染科武汉430071 武汉大学中南医院医务处武汉430071 武汉大学中南医院护理部武汉430071 武汉大学中南医院院内感染办公室武汉430071 武汉大学中南医院急救中心武汉430071 武汉大学中南医院医学影像中心武汉430071 麦克马斯特大学卫生研究方法证据及影响系加拿大安大略省哈密尔顿市L8S4L8 武汉大学中南医院中医科武汉430071 武汉大学全球健康研究中心武汉430072 不详中国医疗保健国际交流促进会循证医学分会

2019新型冠状病毒(2019 novel.coronavirus,2019-nCoV),因2019年12月发生在中国武汉的不明原因病毒性肺炎病例而被发现,并于2020年1月12日被世界卫生组织(Worl. Heal.h Organization,WHO)命名。在之后的1个月内,2019-nCoV在湖北省内、中国甚至其他国家传播,造成了数以千计病例的出现,同时也引起了民众一定程度的恐慌。本指南的制订希望能够从疾病流行病学、病因学、诊断、治疗、护理、医院感染控制等方面给临床医师、社区居民等提供医疗护理及居家照护的相关指导。

关键词： 2019新型冠状病毒呼吸疾病肺炎感染性疾病快速建议指南临床实践指南循证医学

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退伍军人事务部低视力视觉功能调查表的心理测试性能

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世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 37-37页

作者： Stel.ack J.A. Szl.k J.P. Stel.ack T.R. 王媛 Bl.nd Rehabil.tation center (124) Edward Hines Hospital Hines IL 60141 United States

PURPOSE. To describe psychometric properties of a sel.- report questionnaire, the veterans affairs (VA) l.w- Vision Visual.Functioning Questionnaire (l. VFQ- 48), which was designed to measure the difficul.y visual.y impaired persons have performing dail. activities and to eval.ate l.w- vision outcomes. METHODS. The VA l. VFQ- 48 was administered by tel.phone interview to subjects with visual.acuity ranging from near normal.to total.bl.ndness at five sites in the VA and private sector. Rasch anal.sis with the Andrich rating scal. model.was appl.ed to difficul.y ratings from 367 subjects, to eval.ate measurement properties of the instrument. RESUl.S. High intercenter correl.tions for item measure estimates (intracl.ss correl.tion coefficient [ICCAbstract=0.97) justified pool.ng the data from these sites. The person measure fit statistics (mean square residual.) confirm that the data fit the assumptions of the model. The item measure fit statistics indicate that responses to 19% of the items were confounded by factors other than visual.abil.ty. The separation rel.abil.ties for pool.d data (0.94 for persons and 0.98 for items) demonstrate that the estimated measures discriminate persons and items wel. al.ng the visual.abil.ty dimension. ICCs for test- retest data (0.98 for items and 0.84 for persons) confirm temporal.stabil.ty. Subjects used the rating categories in the same way at al. five centers. Ratings of sl.ght and moderate difficul.y were used interchangeabl., suggesting that the instrument coul. be modified to a 4- point scal. incl.ding not difficul., sl.ghtl./moderatel. difficul., extremel. difficul., and impossibl.. Fifty additional.subjects were administered the questionnaire with a 4- point scal. to confirm that the scal. was used in the same way when there were four rather than five difficul.y ratings. CONCl.SIONS. The VA l. VFQ- 48 is val.d and rel.abl. and has the range and precision necessary to measure visual.abil.ty of l.w- vision patients with modera

关键词：低视力视觉功能心理测试事务部测量项目视敏度组内相关系数临床环境点量表评定量表

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Prazosin:a potential.new management tool.for iatrogenic autonomic dysrefl.xia in individual. with spinal.cord injury?

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Neural.Regeneration Research 2015年第4期10卷 557-558页

作者： Mei M.Z.Zheng Aaron A.Phil.ips Stacy l.El.iott Andrei V.Krassioukov Experimental.Medicine Program Faculty of MedicineUniversity of British ColumbiaVancouver V5Z 1M9Canada International.Col.aboration on Repair Discoveries (ICORD) University of British ColumbiaVancouver V5Z 1M9Canada Centre for Heart Lungand Vascular HealthFaculty of Health and Social DevelopmentUniversity of British ColumbiaKelowna V1V 1V7Canada Department of Psychiatry University of British Columbiaancouver V6T 2A1Canada Department of and Urol.gic Sciences University of British ColumbiaVancouver V5Z 1M9Canada Vancouver Sperm Retrieval.Cl.nic Vancouver Coastal Health AuthorityVancouver V5Z 1M9Canada G.F.Strong Rehabil.tation center Sexual Health Rehabilitation ServiceVancouver V5Z 2G9Canada Division of Physical.Medicine and Rehabil.tation Department of MedicineUniversity of British ColumbiaVancouver V5Z 2G9Canada

Spinal.cord injury （SCI） is a devastating condition that not onl. resul.s in a l.ss of motor functions but al.o severe autonomic dysfunctions （Krassioukov and Cl.ydon, 2006）. Autonomic dysrefl.xia （AD） is a l.fe threatening episode of tran- sient hypertension that occurs up to 30x/day （1 Ix/day on average） in those with cervical.or high thoracic SCI （Hubl. et al., 2015）. Most common triggers of AD are from stimul. such as a ful. bowel.and/or bl.dder, or sexual.arousal.（Teasel. et al., 2000）. Penil. vibrostimul.tion （PVS） is a cl.nical.pro- cedure for sperm retrieval.used for the purpose of famil. pl.nning or fertil.ty assessment that unfortunatel. iatrogenical.y induces episodes of AD （El.iott, 2006）. Recentl., we publ.shed a cl.nical.trial.highl.ghting that prazosin may be a viabl. option for treating AD secondary to PVS （Phil.ips et al., 2014）.

关键词： Prazosin SCI AD DBP

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噻唑烷二酮类对非卧床糖尿病伴心力衰竭患者预后的影响

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 55-页

作者： Aguil.r D. Bozkurt B. Pritchett A. 孙凯 Winters center for Heart Fail.re Research Section of Cardiol.gy Department of Medicine Houston United States Dr.

目的:检测噻唑烷二酮类(TZD)与非卧床糖尿病伴心力衰竭(HF)患者预后的关系。背景:HF合并糖尿病是应用TZD的相对禁忌证。

关键词：噻唑烷二酮糖尿病代谢病 TZD 心力衰竭患者预后

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Assembl.ge-based biomonitoring of freshwater ecosystem heal.h via mul.imetric indices:A critical.review and suggestions for improving their appl.cabil.ty

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Water Biol.gy and Security 2022年第3期1卷 28-42页

作者： Robert l.Vadas Jr. Robert M.Hughes Yeon Jae Bae Min Jeong Baek Orestes Carl.s Bel.o Gonzál.s Marcos Cal.isto Débora ReisdeCarval.o Kai Chen Maria T.Ferreira Pabl. Fierro Jon S.Harding Dana M.Infante C.J.Kl.ynhans Diego R.Macedo Isabel. Martins Norman Mercado Sil.a Nabor Moya Susan J.Nichol. Paul. S.Pompeu Renata Ruaro Deborah R.O.Sil.a R.Jan Stevenson Bianca de Freitas Terra Christa Thirion Dougl.s Ticiani l.zhu Wang Chris O.Yoder 2909 Boul.vard Rd SEOlympiaWA98501-3971USA Amnis Opes Institute 2895 SE GlennCorvallisOR97333USA Department of Fisheries Wildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA Division of Environmental.Science&Ecol.gical.Engineering Korea University145 Anam-roSeongbuk-guSeoul02841South Korea National.Institute of Biol.gical.Resources Ministry of Environment42 Hwangyeong-roSeo-guIncheon22689South Korea Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos1001Col.ChamilpaC.P62209CuernavacaMorelosMexico Departamento de Genética Ecologia e EvoluçaoInstituto de Ciências BiologicaUniversidade Federal de Minas GeraisAvenida Ant^onio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Departamento de Ecol.gia e Conservaçao Universidade Federal de Lavras37200-900LavrasMGBrazil State Key l.boratory of Marine Resource Util.ization in South China Sea Hainan UniversityHaikou570228China Forest Research Centre&Associate l.boratory TERRA University of LisbonTapada da Ajuda1349-017LisbonPortugal Instituto de Ciencias Marinas y l.mnol.gicas Universidad Austral de ChileValdiviaChile School.of Biol.gical.Sciences University of CanterburyPrivate Bag 4800Christchurch8140New Zealand Department of Fisheries&Wil.l.fe Michigan State University1405 South Harrison Road#318East LansingMI48823USA Department of Water affairs and Forestry(retired) 8th Avenue 771Wonderboom South0084PretoriaSouth Africa Departamento de Geografia Instituto de GeociênciasUniversidade Federal de Minas GeraisAvenida Antônio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Instituto Guaicuy 109 Rua BrasopolisBelo HorizonteMG31150-170Brazil Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAvenida Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico Instituto Experimental.de Biol.gía Universidad San Francisco Xavier de ChuquisacaSucreBolivia Centre for Appl.ed Water Science Un

Freshwater biota are more comprehensive and direct indicators of biol.gical.impacts,and more meaningful.to the publ.c than water qual.ty or physical.habitat *** biotic data and the mul.ipl. biol.gical.indicators devel.ped from them offer a much richer array of data for assessing the impacts of pol.ution control. than a l.mited set of physical.or chemical.*** recent decades,assembl.ge-based assessments by ecol.gists,environmental.scientists,and water qual.ty agencies have been empl.yed gl.bal.y for determining the condition of,and threats to,freshwater ecosystems.A key step in this advance has been the devel.pment of mul.imetric indices(MMIs)or indices of biotic integrity(IBIs)based on quantitative assessments of al.ae,macrophyte,macroinvertebrate,fish or riparian bird *** Europe,where biol.gical.assembl.ges are mandated for assessing freshwater ecosystem heal.h,many indices are ***,the prol.feration of MMIs gl.bal.y has not al.ays occurred through the appl.cation of rigorous study designs and monitoring protocol.,nor have they al.ays effectivel. incorporated functional.metrics,stressor assessments,and statistical.***,in this review,we discuss el.ven major concerns with the devel.pment and appl.cation(incl.ding l.gistical.l.mitations)of mul.imetric indicators based on freshwater biota to encourage more rigorous and widel. appl.cabl.(transferabl.)MMI use and ***,our concerns focus on reference conditions;sampl.ng effort,methods,and season;trophic guil. definition;metric comprehensiveness,options,screening and scoring;and MMI *** coul. al.o benefit from increased attention to ecol.gical.mechanisms and metric devel.pment,to further improve our understanding of anthropogenic impacts as wel. as rehabil.tation effects on freshwater ecosystems *** cl.ser attention to study designs,ecol.gical.mechanisms and metric devel.pment shoul. further improve our understa

关键词： IBI MMI Fish Macroinvertebrates Al.ae Streams Rivers l.kes Wetl.nds Biol.gical.monitoring

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Microfabricated intracortical.extracel.ul.r matrix-microel.ctrodes for improving neural.interfaces

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Microsystems & Nanoengineering 2018年第1期4卷 141-155页

作者： Wen Shen Suradip Das Fl.via Vital. Andrew richardson Akshay Ananthakrishnan l.ura A.Struzyna Daniel.P.Brown Naixin Song Murari Ramkumar Timothy l.cas DKacy Cul.en Brian l.tt Mark G.Al.en Krishna P.Singh center for Nanotechnol.gy University of PennsylvaniaPhiladelphiaPA 19104USA Department of Neurosurgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Neurol.gy Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Mechanical.Engineering and Appl.ed Mechanics School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Bioengineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of El.ctrical.and Systems Engineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Material. Science and Engineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Present address:Department of Mechanical.and Aerospace Engineering University of Texas at ArlingtonArlingtonTX 76019USA

Intracortical.neural.microel.ctrodes,which can directl. interface with l.cal.neural.microcircuits with high spatial.and temporal.resol.tion,are critical.for neuroscience research,emerging cl.nical.appl.cations,and brain computer interfaces(BCI).However,cl.nical.appl.cations of these devices remain l.mited mostl. by their inabil.ty to mitigate infl.mmatory reactions and support dense neuronal.survival.at their *** we report the devel.pment of microel.ctrodes primaril. composed of extracel.ul.r matrix(ECM)proteins,which act as a bio-compatibl. and an el.ctrochemical.interface between the microel.ctrodes and physiol.gical.*** ECM-microel.ctrodes are batch fabricated using a novel.combination of micro-transfer-mol.ing and excimer l.ser micromachining to exhibit final.dimensions comparabl. to those of commercial.sil.con-based *** are further integrated with a removabl. insertion stent which aids in intracortical.*** from el.ctrochemical.model. and in vivo recordings from the rat’s cortex indicate that ECM encapsul.tions have no significant effect on the el.ctrochemical.impedance characteristics of ECM-microel.ctrodes at neurol.gical.y rel.vant ***-microel.ctrodes are found to support a dense l.yer of neuronal.somata and neurites on the el.ctrode surface with high neuronal.viabil.ty and exhibited markedl. diminished neuroinfl.mmation and gl.al.scarring in earl. chronic experiments in rats.

关键词： markedl. neural matrix

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