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High-density fiber optic array technology and its applica- tions in functional genomic studies

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Chinese Science Bulletin 2003年第18期48卷 1903-1905页

作者： Jianbing Fan Diping Che Chanfeng Zhao Lixin Zhou Wenyi Feng Illumina Inc. San Diego USA

The development of DNA microarray technology[1] revolutionized our way of studying gene expression. Instead of examining gene expression by Northern blots or RT-PCR one by one, we can now routinely check the changes o... 详细信息

关键词： in on of is High-density fiber optic array technology and its applica studies tions in functional genomic

Geologic data collection and assessment techniques in coal mining for ground control

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International Journal of Mining Science and Technology 2020年第1期30卷 131-139页

作者： Mark Van Dyke Ted Klemetti Joe Wickline NIOSH Pittsburgh15236 PAUSA Coronado Global Resources inc. BeckleyWVUSA

The identification and mitigation of adverse geologic conditions are critical to the safety and productivity of underground coal mining *** anticipate and mitigate adverse geologic conditions,a formal method to evaluate geotechnical factors must be *** mine is unique and has its own separate approach for defining what an adverse geological condition consists *** collection of geologic data is a first critical step to creating a geological database to map these hazards efficiently and *** considerations must be taken into account,such as lithology of immediate roof and floor strata,seam height,gas and oil wells,faults,depressions in the mine floor(water)and inc.eases in floor elevation(gas),overburden,streams and horizontal stress directions,amongst many other *** geologic data is collected,it can be refined and integrated into a database that can be used to develop maps showing the trend,orientation,and extent of the adverse geological *** information,delivered in a timely manner,allows mining personnel to be proactive in mine planning and support implementations,ultimately reducing the impacts of these *** paper covers geologic exploratory methods,data organization,and the value of collecting and interpreting geologic information in coal mines to enhance safety and *** implementation of the methods described above has been proven effective in predicting and mitigating adverse geologic conditions in underground coal *** re-evaluation of data collection methods,geologic interpretations,mapping procedures,and communication techniques ensures continuous improvement in the accuracy of predictions and mitigation of adverse geologic *** a concise record of the work previously done to track geologic conditions at a mine will allow for the smoothest transition during employee turnover and *** refinements and standardization of data collection methods,

关键词： Roof control Database Mapping Hazards Geology

Acquiring synonymous attribute phrases for named entities via online encyclopedia

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High Technology Letters 2013年第4期19卷 398-405页

作者：伍大勇 Zhao Shiqi Liu Ting School of Computer Science and Technology Harbin Institute of Technology *** inc.

In this work,an approach is proposed to acquire synonymous attribute phrases of named entities(NEs) from an online *** attribute phrases are the phrases that express the same attribute with different surface forms for a class of ***,the proposed approach is composed of three ***,the entries related to a given NE class are automatically selected from an online ***,attribute phrases are extracted based on the statistics of phrase ***,synonymous attributes are identified in a pairwise manner through a classification framework combining multiple *** proposed approach is applied on Baidu Baike,a Chinese online encyclopedia,for four different NE *** results show that the approach obtains an average precision of 74%and an average F-value of 65%for the four NE *** particular,thousands of synonymous attribute phrase pairs are acquired for each class,which demonstrates the effectiveness of the proposed approach.

关键词： attribute phrase named entity (NE) synonymous attribute online encyclopedia

High-frequency and low-amplitude relative sea-level changes in the Turonian Ferron Notom Delta, Henry Mountains region Utah, USA: implications for sequence stratigraphy and hydrocarbon exploration

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Petroleum Science 2014年第1期11卷 14-27页

作者： Li Weiguo Zhu Yijie BP America inc. 501 Westlake Park Chevron Energy Technology Company

The Turonian Notom Delta is one of the Ferron fluvial-deltaic wedges deposited in the foreland basins of the Cretaceous Seaway of North *** wedge is exposed three dimensionally in the Henry Mountains region Utah,***-resolution sequence stratigraphic analysis along a 35 km dip-oriented outcrop belt shows that the wedge consists of six depositional *** and Inoceramid biostratigraphy and 40Ar/39Ar age dating of various bentonites show that the wedge was deposited from 91.25 Ma to 90.63 Ma,an interval of merely 0.62 *** each sequence is formed over a similar time span,each sequence,thus,represents about 105 yr,suggesting high-frequency depositional *** of relative sea-level changes,built on shoreline trajectory,is 2-61 m,with an average of only 20 *** inc.sion during high-frequency and low-amplitude relative sealevel fall is mainly around the highstand *** diminishes rapidly up dip and down dip,and the resultant inc.sed valleys are narrow and *** sea-level fluctuations also result in small,stratigraphically complex shoreline sandstones that need special attention during hydrocarbon exploration.

关键词： Ferron Notom Delta time stratigraphy shoreline trajectory age dating Cretaceous Seaway of North America

Development of a rapid GC-FID method to simultaneously determine triethylamine, diisopropylamine, and 1,1,3,3-tetramethylguanidine residues in an active pharmaceutical ingredient

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Journal of Pharmaceutical Analysis 2021年第2期11卷 251-256页

作者： Minshan Shou Haixiao Qiu Analytical Research and Development Abbvie Inc.North ChicagoIL60064USA

A rapid GC-FID method was developed to simultaneously determine residual levels of triethylamine(TEA), 1,1,3,3-tetramethylguanidine(TMG), and diisopropylamine(DIPA) in the synthetic route of an active pharmaceutical ingredient(API). Due to the severe absorption of amines on GC stationary phases,GC columns with various stationary phases were evaluated for optimal peak shape and *** final conditions used the Agilent CP-Volamine column to resolve the three amines in 12 min. Various inlet liners were also screened to further improve the sensitivity of the analysis. The Restek Siltek~? liner was selected to achieve the desired detectability for the method. The quantitation limits were 4, 3, and 4 mg/mL for TEA, DIPA, and TMG in the presence of API, respectively. All three amines showed good linearity(r > 0.999) and recoveries(> 90%) over the concentration range of 3 to 16 mg/mL. The testing of residual amines was initially performed at the penultimate stage of the synthesis. However, this work demonstrates that TMG can act as a proton sponge to react with salicylic acid, the counter ion of the penultimate, to form a volatile component that elutes at a different retention time. Consequently, in the final method, these three amines were monitored in the final API to circumvent the matrix *** parameters of the method were qualified per method validation requirements in ICH guidelines. The method was successfully applied for batch testing during development and implemented as an inprocess control procedure at manufacturing sites.

关键词： GC-FID Amines API Method development Method qualification

Gene Expression Versus Sequence for Predicting Function: Glia Maturation Factor Gamma Is Not A Glia Maturation Factor

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Genomics, Proteomics & Bioinformatics 2003年第1期1卷 52-57页

作者： Michael G.Walker inc.te Genomics Inc. CA 94087 USA

It is standard practice, whenever a researcher finds a new gene, to search databases for genes that have a similar sequence. It is not standard practice, whenever a researcher finds a new gene, to search for genes that have similar expression (co-expression). Failure to perform co-expression searches has lead to inc.rrect conclusions about the likely function of new genes, and has lead to wasted laboratory attempts to confirm functions inc.rrectly predicted. We present here the example of Glia Maturation Factor gamma (GMF-gamma). Despite its name, it has not been shown to participate in glia maturation. It is a gene of unknown function that is similar in sequence to GMF-beta. The sequence homology and chromosomal location led to an unsuccessful search for GMF-gamma mutations in glioma. We examined GMF-gamma expression in 1432 human cDNA libraries. Highest expression occurs in phagocytic, antigen-presenting and other hematopoietic cells. We found GMF-gamma mRNA in almost every tissue examined, with expression in nervous tissue no higher than in any other tissue. Our evidence indicates that GMF-gamma participates in phagocytosis in antigen presenting cells. Searches for genes with similar sequences should be supplemented with searches for genes with similar expression to avoid inc.rrect predictions.

关键词： gene function prediction expression analysis sequence analysis GMF-gamma

An evaluation of the role played by remote sensing technology following the World Trade Center attack

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Earthquake Engineering and Engineering Vibration 2003年第1期2卷 159-168页

作者： Charles K.Huyck Beverley J.Adams David I.Kehrlein ImageCat Inc.400 OceangateSuite 1050Long BeachCA90802USA Senior Vice President ImageCat Inc.400 OceangateSuite 1050Long BeachCA90802USA Project Scientist ImageCat Inc.6047 Woodhaven AvenueCarmichaelCA95608USA Vice PresidentGIS Operations

Remote sensing technology has been widely recognized for contributing to emergency response efforts after the World Trade Center attack on September 11th, 2001. The need to coordinate activities in the midst of a dense, yet relatively small area, made the combination of imagery and mapped data strategically useful. This paper reviews the role played by aerial photography, satellite imagery, and LIDAR data at Ground Zero. It examines how emergency managers utilized these datasets, and identifies significant problems that were encountered. It goes on to explore additional ways in which imagery could have been used, while presenting recommendations for more effective use in future disasters and Homeland Security applications. To plan adequately for future events, it was important to capture knowledge from individuals who responded to the World Trade Center attack. In recognition, interviews with key emergency management and geographic information system (GIS) personnel provide the basis of this paper. Successful techniques should not be forgotten, or serious problems dismissed. Although widely used after September 11th, it is important to recognize that with better planning, remote sensing and GIS could have played an even greater role. Together with a data acquisition timeline, an expanded discussion of these issues is available in the MCEER/NSF report “Emergency Response in the Wake of the World Trade Center Attack; The Remote Sensing Perspective” (Huyck and Adams, 2002) Keywords World Trade Center (WTC) - terrorism - emergency response - emergency management - ground zero - remote sensing - emergency operations - disasters - geographic information systems (GIS) - satellite imagery - synthetic aperture radar (SAR) - light detection and ranging imagery (LIDAR)

关键词： World Trade Center (WTC) terrorism emergency response emergency management ground zero remote sensing emergency operations disasters geographic information systems (GIS) satellite imagery synthetic aperture radar (SAR) light detection and ranging imagery (LIDAR)

A New Method to Calculate Water Film Stiffness and Damping for Water Lubricated Bearing with Multiple Axial Grooves

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Chinese Journal of Mechanical Engineering 2020年第5期33卷 167-184页

作者： Guojun Ren Thordon Bearings inc. 3225BurlingtonON L7M 1A6Canada

Water lubricated guide bearings for hydro turbines and pumps are conventionally designed with multiple axial grooves to provide effectively cooling and flushing away *** to the variety of groove configuration in terms of number and size,a predication of their performance is *** paper deals with an analytical procedure to investigate groove effect on load capacity,stiffness and damping for this type of bearing where it is considered as an assembly of many inc.ined slide *** result can be applied to bearings made of hard materials combined with low bearing pressure.

关键词： Water lubricated bearing Groove effect Stiffness and damping inc.ined slide bearing

Fusion Reaction Rate Coefficient for Different Beam and Target Scenarios

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Chinese Physics Letters 2015年第2期32卷 43-47页

作者：欧巍曾宪俊邓柏权苟富均 Institute of Nuclear Science and Technology Sichuan University HOPE Innovations inc. Southwestern Institute of Physics

Fusion power output is proportional not only to the fuel particle number densities participating in reaction but also to the fusion reaction rate coefficient （or reactivity）, which is dependent on reactant velocity distribution functions. They are usuMly assumed to be dual Maxwellian distribution functions with the same temperature for thermal nuclear fusion circumstances. However, if high power neutral beam injection and minority ion species ICRF plasma heating, or multi-pinc.ed plasma beam head-on collision, in a converging region are required and investigated in future large scale fusion reactors, then the fractions of the injected energetic fast ion tail resulting from ionization or charge exchange will be large enough and their contribution to the non-Maxwellian distribution functions is not negligible, hence to the fusion reaction rate coefficient or calculation of fusion power. In such cases, beam-target, and beam-beam reaction enhancement effect contributions should play very important roles. In this paper, several useful formulae to calculate the fusion reaction rate coefticient for different beam and target combination scenarios are derived in detail

关键词： Fusion Reaction Rate Coefficient for Different Beam and Target Scenarios exp