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日本人结肠直肠癌中新生癌的比例研究

世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 23-23页

作者： Goto H. Oda Y. Murakami Y. 刘丽娜 Hattori GI Endoscopy and Oncology clinic Kumamoto Japan

Background &Aims: Adenomatous polyps are main precursors of colorectal cancers (CRCs). In Japan, de novo cancers, which do not arise from preexisting adenomas, are considered to account for a substantial number of CRCs, but the relative importance of de novo carcinogenesis remains controversial. This study estimated the proportion of de novo cancers among CRCs in Japan. Methods: The subjects were persons 40-79 years of age who were relatively similar to those in the general population. The subjects underwent colonoscopy between 1997 and 2001. Early cancers among CRCs detected in this study were classified as de novo cancers or polyp cancers derived from adenomas. The age-specific incidence of the early CRCs was calculated, and the proportion of de novo cancers was estimated. The lifetime risk of early CRCs was estimated. Results: The study group comprised 14,817 persons. CRCs were diagnosed in 189 subjects, including 83 early cancers. There were no differences with regard to size and location between de novo cancers and polyp cancers, but morphology differed. Eighty-four percent (16/19) of de novo cancers were flat elevated or depressed. The expected lifetime risk of developing early CRCs was 5.27%for men and 3.21%for women. Among persons with early cancers, the expected probabilities of developing de novo cancer were 18.6%for men, 27.4%for women. Conclusions: De novo cancers account for a considerable proportion in Japan. This information suggests that the recommended interval for colonoscopic examination in Japan should be shorter than that in the United States.

关键词：结肠直肠癌腺瘤性息肉促癌作用年龄分组早期癌结肠镜检查癌前病变息肉样受试人群风险度

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促胰液素刺激能增加MR胆胰管成像显示胰腺囊性病变如侧支导管内乳头状黏液瘤的性能?

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国际医学放射学杂志 2015年第1期 97-97页

作者： A.S.Purysko N.S.Gandhi R.M.Walsh N.A.Obuchowski J.C.Veniero Abdominal Imaging Section Imaging InstituteCleveland Clinic

目的评价促胰液素在MR胆胰管成像(MRCP)显示囊性病变与胰管之间的关系以助于明确诊断侧支导管内乳头状黏液瘤(SB-IPMN)的价值。方法该研究经机构审查

关键词：胆胰管成像导管内乳头状黏液瘤促胰液素侧支胰腺囊性病变 MR

Association of chronic viral hepatitis B with insulin resistance

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World Journal of Gastroenterology 2012年第42期18卷 6120-6126页

作者： Jeong Gyu Lee Sangyeoup Lee Yun Jin Kim Byung Mann Cho Joo Sung Park Hyung Hoi Kim JaeHun Cheong Dong Wook Jeong Yu Hyun Lee Young Hye Cho Mi Jin Bae Eun Jung Choi Department of Family Medicine Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Family Medicine Medical Research InstitutePusan National University HospitalBusan 602-739South Korea Medical Education Unit Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Family Medicine clinic Yangsan Pusan National University HospitalBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Preventive Medicine and Occupational Medicine Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Family Medicine Dong-A University Medical CenterBusan 602-715South Korea Department of Laboratory Medicine Biomedical Informatics UnitPusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Molecular Biology College of Natural SciencesPusan National UniversityBusan 602-739South Korea

AIM:To investigate the relationship between chronic viral hepatitis B(CVHB) and insulin resistance(IR) in Korean ***:A total of 7880 adults(3851 men,4029 women) who underwent a comprehensive medical examination were enrolled in this *** diagnosed with either diabetes mellitus,or any other disorder that could influence their insulin sensitivity,were ***,metabolic risk factors,hepatitis B surface antigen,hepatitis B surface antibody,hepatitis B core antibody,fasting plasma glucose and insulin were measured for all *** model assessment(HOMA),quantitative insulin check index(QUICKI),and Mf fm index were used for determining insulin *** participant was categorized into a negative,recovery,or CVHB *** compare variables between groups,a t-test and/or one-way analysis of variance were *** correlation coefficients were computed to present the association between insulin resistance and other *** logistic regression analysis was used to assess the independent association between CVHB and ***:The mean age of men and women were 48.9 and 48.6 years,*** in the CVHB group had significantly higher waist circumference [(86.0 ± 7.7 cm vs 87.3 ± 7.8 cm,P = 0.004 in men),(78.3 ± 8.6 cm vs 80.5 ± 8.5 cm,P < 0.001 in women)],cystatin C [(0.96 ± 0.15 mg/dL vs 1.02 ± 0.22 mg/dL,P < 0.001 in men),(0.84 ± 0.15 mg/dL vs 0.90 ± 0.16 mg/dL,P < 0.001 in women)],fasting insulin [(5.47 ± 3.38 U/mL vs 6.12 ± 4.62 U/mL,P < 0.001 in men),(4.57 ± 2.82 U/mL vs 5.06 ± 3.10 U/mL,P < 0.001 in women)] and HOMA index [(1.24 ± 0.86 vs 1.43 ± 1.24,P < 0.001 in men),(1.02 ± 0.76 vs 1.13 ± 0.87,P = 0.033 in women)] compared to control *** HOMA index revealed a positive correlation with body mass index(BMI)(r = 0.378,P < 0.001),waist circumference(r =0.356,P < 0.001),percent body fat(r = 0.296,P < 0.001),systolic blood pressure(r = 0.202,P < 0.001),total cholesterol(r = 0.134,P < 0.00

关键词：胰岛素抵抗病毒性肝炎慢性 Logistic回归分析协会胰岛素敏感性单向方差分析表面抗原

History and present status of pulmonary metastasectomy in colorectal cancer

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World Journal of Gastroenterology 2014年第40期20卷 14517-14526页

作者： Tom Treasure Miel Miloevi Francesca Fiorentino Joachim Pfannschmidt clinical Operational Research Unit University College London London WC1E 6BT United Kingdom clinic for Thoracic Surgery Institute for Pul-monary Diseases of Vojvodina University of Novi Sad Novi Sad 402920 Serbia Department of Cardiothoracic Surgery National Heart and Lung Institute Imperial College London W12 0NN United Kingdom HELIOS Klinikum Emil von Behring Lungenklinik Heckeshorn 14165 Berlin Germany

clinical practice with respect to metastatic colorectal cancer differs from the other two most common cancers,breast and lung,in that routine surveillance is recommended with the specific intent of detecting liver and lung metastases and undertaking liver and lung resections for their *** trace the history of this approach to colorectal cancer by reviewing evidence for effectiveness from the 1950s to the present *** sources included published citation network analyses,the documented proposal for randomised trials,large systematic reviews,and meta-analysis of observational *** present consensus position has been adopted on the basis of a large number of observational studies but the randomised trials proposed in the 1980s and 1990s were either not done,or having been done,were not *** opinion is the mainstay of current practice but in the absence of randomised trials there remains a possibility of selection *** controlled trials(RCTs)are now routine before adoption of a new practice but RCTs are harder to run in evaluation of already established *** such trial is recruiting and shows that controlled trial are possible.

关键词： Colorectal cancer Metastasectomy Liver resection P

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血流导向支架治疗后动脉瘤闭塞的细胞学改变

国际医学放射学杂志 2014年第2期 171-171页

作者： R.Kadirvel Y.H.Ding D.Dai I.Rezek D.A.Lewis D.F.Kallmes 林琳 Neuroradiology Research Laboratory Mayo Clinic College of Medicine

目的阐述在兔动脉瘤模型中血流导向支架治疗后动脉瘤颈部愈合的过程。材料与方法经机构动物保护和使用委员会的批准,用20只兔制作动脉瘤模型,并行血流导

关键词：支架治疗导向支架动脉瘤模型动脉瘤颈动脉瘤血流

Candidate Molecules and ki-67/MIB1 as Novel Diagnostic Biomarker for Human Uterine Mesenchymal Tumors

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International Journal of Medical Physics, clinical Engineering and Radiation Oncology 2013年第3期2卷 1-6页

作者： Takuma Hayashi Akiko Horiuchi Nobuo Yaegashi Susumu Tonegawa Ikuo Konishi Department of Immunology and Infectious Disease Shinshu University School of MedicineMatsumoto Nagano Japan Department of Obstetrics and Gynecology Kyoto University Graduate School of MedicineKyoto-city Kyoto Japan Department of Obstetrics and Gynecology Kyoto University Graduate School of Medicine Kyoto-city Kyoto Japan Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Miyagi Japan Horiuchi Ladies clinic Matsumoto Nagano 390-0821 Japan Picower Institution and Department of Biology Massachusetts Institute of TechnologyCambridge MA 02139-4307 USA

Human uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion;however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker, which distinguishes malignant uterine LMS from benign tumor leiomyoma (LMA), is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, to establish a clinical treatment method. Protea some β-ring subunit LMP2/β1i-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2/β1i expression to be absent in human uterine LMS, but present in human LMA. Therefore, defective-LMP2/β1i expression may be one of the risk factors for human uterine LMS. LMP2/β1i is a potential diagnostic-biomarker under the combination of candidate molecules, for instance cyclin B1, cyclin E and calponin h1 and ki-67/MIB1 counts for uterine mesenchymal tumors, especially human uterine LMS, and may be a targeted-molecule for a new therapeutic approach.

关键词： LMP2/β1i Uterine Leiomyosarcoma Uterine Leiomyoma Biomarker

PKR and PP1C Polymorphisms in Alzheimer’s Disease Risk

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Neuroscience & Medicine 2011年第3期2卷 226-231页

作者： Ernest Palomer Gerard ILL-Raga Marta Tajes Eva Ramos-Fernández Mònica Bosch-Morató Biuse Guivernau Jose J.Galan Jordi Clarimon Carmen Antunez Merce Boada Luis M.Real César Fandos Francisco J.Munoz Laboratory of Molecular Physiology and Channelopathies Department of Experimental and Health SciencesPompeu Fabra University(UPF)BarcelonaSpain NeoCodex SevillaSpain Alzheimer Laboratory Neurology DepartmentSanta Creu and Sant Pau HospitalBiomedical Research Center on Neurodegenerative Diseases(CIBERNED)BarcelonaSpain Fundacion Alzheimur Dementia UnitVirgen de la Arrixaca HospitalMurciaSpain Memory clinic of ACE Foundation Catalan Institute of Applied NeurosciencesBarcelonaSpain Neurology Department Vall d’Hebron Universitary HospitalBarcelonaSpain

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of amyloid ?-peptide (A?) produced by the cleavage of a transmembrane protein termed Amyloid Precursor Protein (APP). The amyloidogenic cleavage of APP is performed by γ-secretase complex and ?-site APP cleaving enzyme 1 (BACE1), a key enzyme in AD that can be activated by different noxious stimuli. Interestingly, some viruses could activate double-stranded RNA-activated protein kinase (PKR), which phosphorylates Eukaryotic Initiation Factor 2 alpha (eIF2α). This phosphorylation stops global translation to avoid any synthesis of viral infective proteins, but paradoxically up-regulates BACE1 translation. One of the viral mechanisms to circumvent eIF2α phosphorylation is the recruitment of protein phosphatase 1 (PP1), to fully dephosphorylate eIF2α and allow viral protein synthesis. Due to the functional relationship between BACE1, PKR, PP1 and AD we have performed a large (1122 cases and 1191 control individuals) case-control genetic analysis using two biallelic polymorphisms rs2254958 and rs7480390, located within the genes coding for PKR and the catalytic unit A of PP1, respectively. Although a trend to association of the rs2254958 TT genotype with AD risk was found, our results show that neither rs7480390 nor rs2254958 are associated with AD susceptibility.

关键词： Alzheimer’s Disease BACE1 PKR PP1 eIF2α

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第七届肝脏MRI国际论坛共识报告

国际医学放射学杂志 2016年第3期 322-322页

作者： E.Merkle C.Zech C.Bartolozzi M.Bashir A.Ba-Ssalamah A.Huppertz 王奕 clinic of Radiology and Nuclear Medicine University Hospital Basel

摘要目的肝脏特异性MRI是一个快速增长的领域,随着技术的提高和方案的完善提供了更可靠的成像,并给予了每个检查更深层次的信息。通过报道2013年10月在中国上海举办的第七届肝脏MRI国际论坛上讨论的肝脏特异性MRI目前面临的挑战以及相... 详细信息

摘要目的肝脏特异性MRI是一个快速增长的领域,随着技术的提高和方案的完善提供了更可靠的成像,并给予了每个检查更深层次的信息。通过报道2013年10月在中国上海举办的第七届肝脏MRI国际论坛上讨论的肝脏特异性MRI目前面临的挑战以及相关证据和专家意见。方法讨论的话题包括钆塞酸增强MRI在鉴别局灶性结节性增生与肝

关键词： MRI 特异性肝脏发育不良国际论坛

Non-Linear EEG Measures in Meditation

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Journal of Biomedical Science and Engineering 2014年第9期7卷 731-738页

作者： Oldrich Vysata Martin Schatz Jakub Kopal Jan Burian Ales Procházka Kuchynka Jiri Jakub Hort Martin Valis Department of Computing and Control Engineering Institute of Chemical TechnologyPragueCzech Republic Department of Neurology Faculty of Medicine in Hradec KraloveCharles UniversityHradec KraloveCzech Republic Faculty of Informatics and Statistics University of Economics PraguePragueCzech Republic Memory Disorders clinic Department of NeurologyCharles University in Prague2nd Faculty of Medicine and University Hospital MotolPragueCzech Republic International clinical Research Center St.Anne’s University Hospital BrnoBrnoCzech Republic

In this study, the performance of Sevcik’s algorithm that calculates the fractal dimension and permutation entropy as discriminants to detect calming and insight meditation in electroencephalo-graphic (EEG) signals was assessed. The proposed methods were applied to EEG recordings from meditators practicing insight meditation and calming meditation before as well as during both types of meditation. Analysis was conducted using statistical hypothesis testing to determine the validity of the proposed meditation-identifying techniques. For both types of meditation, there was a statistically significant reduction in the permutation entropy. This result can be explained by the increased EEG synchronization, which is repeatedly observed in the course of meditation. In contrast, the fractal dimension (FD) was significantly increased during calming meditation, but during insight meditation, no statistically significant change was detected. Increased FD during meditation can be interpreted as an increase in self-similarity of EEG signals during self-organisation of hierarchical structure oscillators in the brain. Our results indicate that fractal dimension and permutation entropy could be used as parameters to detect both types of meditation. The permutation entropy is advantageous compared with the fractal dimension because it does not require a stationary signal.

关键词： Permutation Entropy Fractal Dimension EEG Calming Meditation Insight Meditation