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Influenza and pneumococcal vaccination coverage and associated factors in patients hospitalized with acute exacerbations of COPD in China:Findings from real-world data

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Chinese Medical Journal 2024年第10期137卷 1179-1189页

作者： Ruoxi He Xiaoxia Ren Ke Huang Jieping Lei Hongtao Niu Wei Li Fen Dong Baicun Li Ye Wang Ting Yang Chen Wang School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of respiratory Medicine National Key Clinical SpecialtyBranch of National Clinical Research Center for Respiratory DiseaseXiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Institute of respiratory Medicine Chinese Academy of Medical SciencesBeijing 100029China National center for respiratory Medicine Beijing 100029China National Clinical Research center for respiratory diseases Beijing 100029China Department of Clinical Research and Data Management Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

Background:Influenza and pneumococcal vaccination are a priority in patients with chronic obstructive pulmonary disease(COPD).However,limited information is available on vaccination coverage among patients with acute exacerbations of COPD(AECOPD)in *** study aimed to determine the rates and associated factors of influenza and pneumococcal vaccination in patients hospitalized with ***:Baseline data from a national,multicenter,hospital-based study that included adult inpatients with AECOPD between 2017 and 2021 were *** outcomes of interest were the influenza vaccination in the past year and the pneumococcal vaccination in the past 5 *** ensure national representativeness,rates were weighted according to the distribution of hospital levels and types enrolled in this *** Poisson regression based on mixed-effects models were used to determine the associated *** independent variables included the region and hospital features where the participants were located,sociodemographic characteristics(age,sex,rural/urban residence,education,etc.),and clinical indicators(COPD disease history,lung function parameters,comorbidities,etc.).The treatment profiles of the vaccinated and unvaccinated participants were ***:Of 6949 eligible participants,the weighted rates of influenza/pneumococcal,influenza,and pneumococcal vaccination were 2.72%(95%confidence interval[CI]:2.34%-3.10%),2.09%(95%CI:1.76%-2.43%),and 1.25%(95%CI:0.99%-1.51%),*** multivariable models,age≥60 years(60-69 years,odds ratio[OR]:1.90,95%CI:1.11-3.25;≥80 years,OR:2.00,95%CI:1.06-3.78),geographical regions(northern China relative to Eastern China,OR:5.09,95%CI:1.96-13.21),urban residence(OR:1.69,95%CI:1.07-2.66),a higher education level(junior high school,OR:1.77,95%CI:1.21-2.58;senior high school or above,OR:2.61,95%CI:1.69-4.03),former smoking(OR:1.79,95%CI:1.15-2.79),and regular inhaled medication treatment(OR:3.28,95%CI:2.29-4.70)were

关键词： Chronic obstructive pulmonary disease Influenza Pneumococcal Vaccine AECOPD

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Determination of esophageal squamous cell carcinoma and gastric adenocarcinoma on raw tissue using Raman spectroscopy

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World Journal of Gastroenterology 2023年第20期29卷 3145-3156页

作者： Hiroaki Ito Naoyuki Uragami Tomokazu Miyazaki Yuto Shimamura Haruo Ikeda Yohei Nishikawa Manabu Onimaru Kai Matsuo Masayuki Isozaki William Yang Kenji Issha Satoshi Kimura Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue Digestive disease center Showa University Koto Toyosu HospitalTokyo 135-8577Japan JSR Corporation Tokyo 105-0021Japan Bay Spec Inc. San JoseCA 95131United States Fuji Technical Research Inc. Yokohama 220-6215Japan Department of Laboratory Medicine and Central Clinical Laboratory Showa University Northern Yokohama HospitalYokohama 224-8503Japan Department of Hematology Saitama Cancer CenterInamachi 362-0806Japan Department of Pathology Showa University Koto Toyosu HospitalTokyo 135-8577Japan

BACKGROUND Cancer detection is a global research focus,and novel,rapid,and label-free techniques are being developed for routine clinical *** has led to the development of new tools and techniques from the bench side to routine clinical *** this study,we present a method that uses Raman spectroscopy(RS)to detect cancer in unstained formalin-fixed,resected specimens of the esophagus and *** method can record a clear Raman-scattered light spectrum in these specimens,confirming that the Raman-scattered light spectrum changes because of the histological differences in the mucosal *** To evaluate the use of Raman-scattered light spectrum for detecting endoscopically resected specimens of esophageal squamous cell carcinoma(SCC)and gastric adenocarcinoma(AC).METHODS We created a Raman device that is suitable for observing living tissues,and attempted to acquire Raman-scattered light spectra in endoscopically resected specimens of six esophageal tissues and 12 gastric *** evaluated formalin-fixed tissues using this technique and captured shifts at multiple locations based on feasibility,ranging from six to 19 locations 200 microns apart in the vertical and horizontal ***,a correlation between the obtained Raman scattered light spectra and histopathological diagnosis was *** We successfully obtained Raman scattered light spectra from all six esophageal and 12 gastric *** data capture,the tissue specimens were sent for histopathological analysis for further processing because RS is a label-free methodology that does not cause tissue destruction or *** on data analysis of molecular-level substrates,we established cut-off values for the diagnosis of esophageal SCC and gastric *** analyzing specific Raman shifts,we developed an algorithm to identify the range of esophageal SCC and gastric AC with an accuracy close to that of histopathological *** Our technique pr

关键词： Raman spectroscopy Squamous cell carcinoma Adenocarcinoma Esophagus Stomach Labelfree cancer detection Real-time diagnosis

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Long-term prognostic impact of circulating tumour cells in gastric cancer patients

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World Journal of Gastroenterology 2016年第46期22卷 10232-10241页

作者： Hiroaki Ito Jun Sato Yukio Tsujino Noriko Yamaguchi Satoshi Kimura Keigo Gohda Katsuhiro Murakami Manabu Onimaru Tohru Ohmori Fumihiro Ishikawa Haruhiro Inoue Department of Surgery Digestive Disease Center Showa University Koto Toyosu Hospital Central Research Laboratories Sysmex Corporation Department of Surgery Digestive Disease Center Showa University Northern Yokohama Hospital Department of Laboratory Medicine and Central Clinical Laboratory Showa University Northern Yokohama Hospital Institute of Molecular Oncology Showa University School of Medicine Department of Cancer Cell Biology Showa University School of Pharmacy

AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer.

关键词：传播的瘤房间胃的癌症外科 Telomerase 预后

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Risk Factors for Mortality in Acute Kidney Injury in Intensive Care Units in Togo

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Open Journal of Nephrology 2024年第1期14卷 37-47页

作者： Eyram Makafui Yoan Yawo Amekoudi Kossi Akomola Sabi Marcel David Keoula Badomta Dolaama Sarakawabalo Assenouwe Tabana Mouzou Department of Nephrology Kara University Hospital University of Kara Kara Togo Department of Nephrology and Haemodialysis Sylvanus Olympio University Hospital University of Lome Lomé Togo Department of Anaesthesia and Intensive Care University Hospital of Kara University of Kara Kara Togo

Context: Acute kidney injury (AKI) in intensive care unit (ICU) is common and associated with very high mortality. In Togo, a tropical country with limited resources and only one nephrology department in the north, acute kidney injury seems to be a real tragedy with high mortality. Aims: to determine risk factors for mortality in acute kidney injury in the intensive care units. Methods and Material: We made a multicentric cross sectional study during 6 months in the four referral centers in northern Togo. Univariate and multivariate logistic regression was used to identify factors associated with mortality. Data were analyzed using RStudio 2023.04.1. Results: A total of 12.6% of patients admitted to intensive care had presented with AKI. The mean age was 49.6 ± 17.9. The sex ratio (M/F) was 2.1. Community-acquired AKI was in the majority (67.7%). Oligo anuria was the most frequent functional sign (38.4%). In our series, 81.6% of patients were in KDIGO stages 2 to 3. AKI was organic in 56.2% of cases. Mortality was 44.3%. In multivariate analysis, the main factors predictive of death were: respiratory distress (OR = 2.36;p Conclusions: Acute kidney injury in intensive care is common in northern Togo, and mortality is high. Identification of associated factors should help anticipate prognosis.

关键词： AKI Intensive Care Unit Dialysis Epidemiology Togo

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A Radiographic Evaluation of Short Monolithic Femoral Hip Stem (SMF) for Dysplastic Osteoarthritis: Does Stem Alignment Influence on the Stability?

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Open Journal of Orthopedics 2023年第4期13卷 182-193页

作者： Kentaro Kaneko Hiroshi Sunami Atsushi Oka Koji Kanzaki Akihiko Maeda Mariko Asahi Atsushi Kusaba Saiji Kondo Department of Orthopaedic Surgery Showa University Fujigaoka Hospital Yokohama Japan Institute of Joint Replacement Zama General Hospital Zama Japan Department of Orthopaedic Surgery Showa University Yokohama Northern Hospital Yokohama Japan

Background: There have been a few reports of SMFTM stem for dysplastic hips. The aim of this study is to evaluate the influence of stem alignment in dysplastic femurs on the stability of the implants and on the bone reaction by means of consecutive radiographical analysis. Methods: The preoperative diagnosis is dysplastic osteoarthritis in all patients. Twenty-nine hips in 28 patients after MIS-THA were followed up for two or more years (3.5 years in average). The average age at the surgery was 60. Those who belonged to Crowe’s classification I were 19 and those of II were 10 hips. The shape of the femur was classified as Dorr’s Type A in 5, B in 21, and C in 3 hips. Results: The varus alignment of the stem was 21 hips and non-varus was 8 hips. Crowe’s Grade did not have influence on the stem alignment. The ratio of non-varus alignment was more with Dorr’s Type C than with others. Achieving rate of mediolateral fixation was significantly higher in the varus alignment than in non-varus. The significant subsidence occurred in 3 hips (10.3%) although all stems became stable within 6 months. No revision was necessary. Conclusion: The varus insertion of the stem seemed more secure also in dysplastic femurs, but even non-varus ones seemed acceptable as they brought about no severe problem. Comprehensively evaluating the result, careful selection of the patient is essential to take the advantage of and to overcome the disadvantage of this short stem for dysplastic hips.

关键词： Total Hip Arthroplasty Short Stem MIS Hip Dysplasia

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Clinicopathological features of small T1 colorectal cancers

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World Journal of Clinical Cases 2021年第33期9卷 10088-10097页

作者： Yuki Takashina Shin-Ei Kudo Katsuro Ichimasa Yuta Kouyama Kenichi Mochizuki Yoshika Akimoto Yasuharu Maeda Yuichi Mori Masashi Misawa Noriyuki Ogata Toyoki Kudo Tomokazu Hisayuki Takemasa Hayashi Kunihiko Wakamura Naruhiko Sawada Toshiyuki Baba Fumio Ishida Kazunori Yokoyama Mitsuru Daita Tetsuo Nemoto Hideyuki Miyachi Digestive disease center Showa University Northern Yokohama HospitalYokohama 224-8503Japan Department of Gastroenterology Nikko Kinen HospitalMuroran 051-8501Japan Clinical Effectiveness Research Group Institute of Health and SocietyUniversity of OsloOslo 0001Norway Department of Pathology Showa University Nothern Yokohama HospitalYokohama 224-8503Japan

BACKGROUND Although small colorectal neoplasms(<10 mm)are often easily resected endoscopically and are considered to have less malignant potential compared with large neoplasms(≥10 mm),some are invasive to the *** To clarify the clinicopathological features of small T1 colorectal *** Of 32025 colorectal lesions between April 2001 and March 2018,a total of 1152 T1 colorectal cancers resected endoscopically or surgically were included in this study and were divided into two groups by tumor size:a small group(<10 mm)and a large group(≥10 mm).We compared clinicopathological factors including lymph node metastasis(LNM)between the two *** The incidence of small T1 cancers was 10.1%(116/1152).The percentage of initial endoscopic treatment in small group was significantly higher than in large group(<10 mm 74.1%vs≥10 mm 60.2%,P<0.01).In the surgical resection cohort(n=798),the rate of LNM did not significantly differ between the two groups(small 12.3%vs large 10.9%,P=0.70).In addition,there were also no significant differences between the two groups in pathological factors such as histological grade,vascular invasion,or lymphatic *** Because there was no significant difference in the rate of LNM between small and large T1 colorectal cancers,the requirement for additional surgical resection should be determined according to pathological findings,regardless of tumor size.

关键词： Colorectal neoplasms Lymphatic metastasis Biological phenomena Polyps Colorectal cancers

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Eligibility of C-BIOPRED severe asthma cohort for type-2 biologic therapies

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Chinese Medical Journal 2023年第2期136卷 230-232页

作者： Zhenan Deng Meiling Jin Changxing Ou Wei Jiang Jianping Zhao Xiaoxia Liu Shenghua Sun Huaping Tang Bei He Shaoxi Cai Ping Chen Penghui Wu Yujing Liu Jian Kang Yunhui Zhang Mao Huang Jinfu Xu Kewu Huang Qiang Li Xiangyan Zhang Xiuhua Fu Changzheng Wang Huahao Shen Lei Zhu Guochao Shi Zhongmin Qiu Zhongguang Wen Xiaoyang Wei Wei Gu Chunhua Wei Guangfa Wang Ping Chen Lixin Xie Jiangtao Lin Yuling Tang Zhihai Han Kian Fan Chung Qingling Zhang Nanshan Zhong C-BIOPRED Consortium Pulmonary and Critical Care Medicine Guangzhou Institute of Respiratory HealthNational Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineState Key Laboratory of Respiratory DiseasesThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Department of respiratory Medicine Zhongshan HospitalShanghai 200433China Guangzhou Medical university GuangzhouGuangdong 510180China AstraZeneca Shanghai 200085China Department of respiratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of respiratory Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of respiratory Medicine The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China Department of respiratory Medicine Qingdao Municipal HospitalQingdaoShandong 266001China Department of respiratory Medicine Peking University Third HospitalBeijing 100191China Department of respiratory Medicine Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdong 510515China Department of respiratory Medicine General Hospital of Northern Theater CommandShenyangLiaoning 110016China Department of respiratory Medicine The First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of respiratory Medicine The First people’s Hospital of Yunnan ProvinceKunmingYunnan 363880China Department of respiratory Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of respiratory Medicine Shanghai Pulmonary HospitalShanghai 200433China Department of respiratory Medicine Beijing Chao-Yang HospitalBeijing 100020China Department of respiratory Medicine Shanghai General HospitalShanghai 200080China Department of respiratory Medicine Guizhou Province People’s HospitalGuiyangGuizhou 550002China Department of respiratory Medicine The Affiliated Hospital of Inner Mongolia Me

To the Editor:Patients with severe persistent asthma experience greater morbidity with more impairment in quality of life despite higher use of health care resources and being treated with existing asthma treatments such as inhaled corticosteroids and b-agonists,and sometimes oral corticosteroid(OCS)***-2(T2)high asthma has been identified as a phenotype that responds to targeted T2 biologic therapies such as anti-IgE,anti-interleukin(IL)5,or anti-IL5Ra and anti-IL4Ra monoclonal antibodies,which are currently available in Europe and North America,and are currently introduced in the rest of the world.[1]

关键词： asthma therapies impairment

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Artificial intelligence-assisted colonoscopy:A review of current state of practice and research

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World Journal of Gastroenterology 2021年第47期27卷 8103-8122页

作者： Mahsa Taghiakbari Yuichi Mori Daniel von Renteln Department of Gastroenterology CRCHUMMontreal H2X 0A9QuebecCanada Clinical Effectiveness Research Group University of OsloOslo 0450Norway Digestive disease center Showa University Northern Yokohama HospitalYokohama 224-8503Japan

Colonoscopy is an effective screening procedure in colorectal cancer prevention programs;however,colonoscopy practice can vary in terms of lesion detection,classification,and *** intelligence(AI)-assisted decision support systems for endoscopy is an area of rapid research and *** systems promise improved detection,classification,screening,and surveillance for colorectal polyps and *** recently developed applications for AIassisted colonoscopy have shown promising results for the detection and classification of colorectal polyps and ***,their value for real-time application in clinical practice has yet to be determined owing to limitations in the design,validation,and testing of AI models under real-life clinical *** these current limitations,ambitious attempts to expand the technology further by developing more complex systems capable of assisting and supporting the endoscopist throughout the entire colonoscopy examination,including polypectomy procedures,are at the concept ***,further work is required to address the barriers and challenges of AI integration into broader colonoscopy practice,to navigate the approval process from regulatory organizations and societies,and to support physicians and patients on their journey to accepting the technology by providing strong evidence of its accuracy and *** article takes a closer look at the current state of AI integration into the field of colonoscopy and offers suggestions for future research.

关键词： Colonoscopy Adenoma Artificial intelligence Computational intelligence Endoscopy Surveillance

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Congenital tracheoesophageal fistula successfully diagnosed by CT esophagography

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World Journal of Gastroenterology 2006年第9期12卷 1476-1478页

作者： Koichi Nagata Yoshito Kamio Tamaki Ichikawa Mitsutaka Kadokura Akihiko Kitami Shungo Endo Haruhiro Inoue Shin-Ei Kudo Digestive disease center showa university northern yokohama hospital 35-1 Chigasaki-chuoTsuzuki-kuYokohama 224-8503 Japan respiratory disease center showa university northern yokohama hospital 35-1 Chigasaki-chuoTsuzuki-kuYokohama 224-8503Japan Department of Radiology showa university northern yokohama hospital 35-1 Chigasaki-chuoTsuzuki-kuYokohama 224-8503Japan Digestive disease center showa university northern yokohama hospital 35-1 Chigasaki-chuoTsuzuki-kuYokohama 224-8503Japan

Tracheoesophageal 管(TEF ) 或 bronchoesophageal 管可能对损伤先天、煽动性、肿瘤，或第二等。先天的 TEF 或 bronchoesophageal 管通常与食道的闭锁被联系并且乐意地在幼年期被诊断。但是如果它没与食道的闭锁被联系，它可以坚持直... 详细信息

Tracheoesophageal 管(TEF ) 或 bronchoesophageal 管可能对损伤先天、煽动性、肿瘤，或第二等。先天的 TEF 或 bronchoesophageal 管通常与食道的闭锁被联系并且乐意地在幼年期被诊断。但是如果它没与食道的闭锁被联系，它可以坚持直到成人生活。一些理论被建议了在诊断解释这延期。我们在场有先天的 TEF 的一个 70 岁的人的一个盒子。TEF 被 multidetector 排 CT esophagography 成功地诊断。

关键词：先天性气管疾病食管疾病 CT检查内窥镜

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Small invasive colon cancer with adenoma observed by endocytoscopy: A case report

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World Journal of Gastrointestinal Endoscopy 2020年第9期12卷 304-309页

作者： Yoshika Akimoto Shin-ei Kudo Katsuro Ichimasa Yuta Kouyama Masashi Misawa Tomokazu Hisayuki Toyoki Kudo Tetsuo Nemoto Digestive disease center Showa University Northern Yokohama HospitalYokohama 224-8503Japan Department of Pathology Showa University Northern Yokohama HospitalYokohama 224-8503Japan

Endocytoscopy is a next-generation endoscopic system that facilitates real-time histopathologic endoscopic diagnosis of colorectal lesions by virtue of its 520×maximum *** SUMMARY We present the case of a 63-year-old man with sigmoid colon cancer who was regularly referred for follow-up colonoscopy after endoscopic resection of T1 rectal *** revealed a 12 mm reddish polyp,including a depression and a flat area in the sigmoid *** observation showed unclear gland formation and agglomeration of distorted nuclei(depression),suggesting a submucosal invasive(T1)*** the flat area,slitlike smooth lumens and regular pattern of fusiform nuclei were found,suggesting an *** the basis of these endocytoscopic findings,we predicted this lesion as T1 cancer(depression)with adenoma(flat area)and performed endoscopic resection corresponding to the final histopathological *** We could perform an optical diagnosis of T1 sigmoid cancer with adenoma by using endocytoscopy before treatment.

关键词： Endocytoscopy T1 colorectal cancer Adenoma Optical diagnosis Case report

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