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Influence of abiotic factors on phytochemical diversity of Anacardium occidentale L.

Food Bioscience 2022年第5期49卷 1133-1143页

作者： Adrielle Rodrigues Costa Jailson Renato de Lima Silva Pedro Silvino Pereira Jos´e Weverton Almeida-Bezerra Maria Aurea Soares de Oliveira Paulo Riceli Vasconcelos Ribeiro Edy Sousa de Brito Marcos Antonio Drumond Jo˜ao Tavares Calixto Júnior Jean Paul Kamdem Antonia Eliene Duarte Luiz Marivando Barros Henrique Douglas Melo Coutinho researcher at the Structural and Molecular biology laboratory Center for Agricultural Sciences and Biodiversity Federal University of CaririCratoCEBrazil researcher at the biology and toxicology laboratory of the regional university of cariri CratoCEBrazil researcher at the Brazilian Agricultural Research Corporation-Embrapa Tropical Agribusiness FortalezaCEBrazil researcher at the Brazilian Agricultural Research Corporation-Embrapa Semiarid PetrolinaPEBrazil Department of Biological Sciences University of Regional Cariri(URCA)CEP63105-000CratoCEBrazil researcher at the laboratory of Microbiology and Molecular biology Regional University of CaririCratoCEBrazil

To understand the influence of environmental factors on the metabolic diversity of phytochemical compounds from extracts of leaves and bark of Anacardium occidentale,collected in two different geographic areas,ultra-performance liquid chromatography and mass spectrometry were used,as well as the composition of physicochemical properties of both soils at the collection site(“Lavras da Mangabeira”and“Crato”).It was possible to observe physicochemical differences between the soils of the two collection areas and some *** present granulometry with a sandy texture,with high values of total sand,with acid pH,and variation in porosity *** micronutrients with the highest accumulation in the soil,with emphasis on the predominance of P(Phosphorus)and Al(Aluminium)mainly in the 20-40 cm layer in ***-three phytochemical compounds were identified in the leaf and bark extracts,of which 28 were present in the leaves and 20 in the bark *** this total,13 were present in at least one of the parts of the plant(leaf or bark),and most were present in both Crato and Lavras da Mangabeira,presenting mainly phenolic acids,flavonoids and tannins in all extracts *** extracts showed similarities between the groups of *** together,this study may be relevant to assess environmental influences on the production of secondary metabolites.

关键词： LC/MS Anacardiaceae Cashew tree UPLC-QTOF Ground

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Metformin reduces testosterone level in type 2 diabetes mellitus patients and its therapy by traditional medicine

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 19-26页

作者： Gorika Tomar Mitushi Singh Isha Sharma Anuj Nautiyal Saurabh Aggarwal Subhash Chandra Havagiray R.Chitme Cassio Rocha Medeiros Micheline de Azevedo Lima Lucia Raquel de Lima Henrique Douglas Melo Coutinho Bhavna Kumar Department of Pharmacy Practice School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Medicine Shri MahantIndiresh HospitalSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmacology and toxicology Amity Institute of PharmacyAmity UniversitySector-125Noida 201313 UPGwaliorIndia CECAPE College Av.Padre Cícero3917-São JoséJuazeiro do Norte 63024-015CEBrazil Department of Molecular biology Federal University of Paraiba-UFPBJoao Pessoa 58051-900ParaibaBrazil Department of Biological Chemistry Regional University of Cariri-URCACrato 63105-000CEBrazil Department of Pharmaceutics DIT UniversityDehradun 248009UttarakhandIndia

Background:Type 2 Diabetes Mellitus(T2DM)is a chronic metabolic disorder characterized by insulin resistance and ***,a commonly prescribed treatment for T2DM,is known for its effectiveness in improving glycemic *** studies suggest that metformin may also influence testosterone levels in male patients,a hormone crucial for male reproductive health,muscle mass maintenance,and overall quality of *** plants were traditionally used for influencing the testosterone level in the body which may be given as a therapy for the side–effects of metformin ***:To assess the impact of metformin treatment on testosterone levels in male patients with T2DM compared to non-diabetic males,and to evaluate the potential implications of traditional medical treatments in managing the consequences of reduced testosterone ***:This study is a prospective observational investigation conducted among a total of 60 patients,divided into two groups:30 males taking metformin as a hyperglycaemic agent with T2DM and 30 males without any diabetic *** study was be carried out in different outpatient department of Shri Mahant Indiresh Hospital,Patel Nagar,Dehradun to assess the level of testosterone in male patients with T2DM taking metformin and in non-Diabetic *** on these findings,potential traditional medicines methods for reducing testosterone levels were ***:It was demonstrated that male patients with T2DM undergoing metformin treatment exhibited significant reduction in testosterone serum levels compared to non-diabetic *** plants were examinedand,and clinical studies were conducted on *** was discovered that these plants have been effective in increasingtestosterone level,suggesting their potential use as therapy for ***:This study shows reduction in the testosterone levels,which may lead to low sex drives and induction of low testosterone induced erectile dy

关键词： Type 2 diabetes mellitus Testosterone Metformin Erectile dysfunction Hyperglycaemia

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