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Knowledge Graph Enhanced Transformers for Diagnosis Generation of Chinese Medicine

Chinese Journal of Integrative Medicine 2024年第3期30卷 267-276页

作者： WANG Xin-yu YANG Tao GAO Xiao-yuan HU Kong-fa School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing210023China School of Information Management Nanjing UniversityNanjing210023China Jiangsu Collaborative Innovation center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing210023China Jiangsu Province Engineering research center of tcm Intelligence Health Service Nanjing210023China

Chinese medicine(CM)diagnosis intellectualization is one of the hotspots in the research of CM *** traditional CM intelligent diagnosis models transform the CM diagnosis issues into classification issues,however,it is difficult to solve the problems such as excessive or similar *** the development of natural language processing techniques,text generation technique has become increasingly *** this study,we aimed to establish the CM diagnosis generation model by transforming the CM diagnosis issues into text generation *** semantic context characteristic learning capacity was enhanced referring to Bidirectional Long Short-Term Memory(BILSTM)with Transformer as the backbone ***,the CM diagnosis generation model Knowledge Graph Enhanced Transformer(KGET)was established by introducing the knowledge in medical field to enhance the inferential *** KGET model was established based on 566 CM case texts,and was compared with the classic text generation models including Long Short-Term Memory sequence-to-sequence(LSTM-seq2seq),Bidirectional and Auto-Regression Transformer(BART),and Chinese Pre-trained Unbalanced Transformer(CPT),so as to analyze the model ***,the ablation experiments were performed to explore the influence of the optimized part on the KGET *** results of Bilingual Evaluation Understudy(BLEU),Recall-Oriented Understudy for Gisting Evaluation 1(ROUGE1),ROUGE2 and Edit distance of KGET model were 45.85,73.93,54.59 and 7.12,respectively in this *** with LSTM-seq2seq,BART and CPT models,the KGET model was higher in BLEU,ROUGE1 and ROUGE2 by 6.00–17.09,1.65–9.39 and 0.51–17.62,respectively,and lower in Edit distance by 0.47–*** ablation experiment results revealed that introduction of BILSTM model and prior knowledge could significantly increase the model ***,the manual assessment indicated that the CM diagnosis results of the KGET model used

关键词： Chinese medicine diagnosis knowledge graph enhanced transformer text generation

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High-static-low-dynamic stiffness isolator based on an electromagnetic negative stiffness spring with long linear stroke

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Science China(Technological Sciences) 2024年第3期67卷 740-752页

作者： YUAN ShuJin WU YaJun SONG DaiPing PU HuaYan MOU LiSheng HOU Lei ZHAO JingLei LI XuePing LUO Jun WU Jie HUANG XiaoXu State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China China Aerodynamics research and development center Mianyang 621000China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Negative stiffness mechanisms can improve low-frequency vibration isolation performance and have been widely used in the vibration isolation of precision equipment. However, the negative stiffness mechanism usually introduces a nonlinear stiffness,resulting in a nonlinear response and worsening the vibration isolation performance, especially under large amplitude *** this paper, an electromagnetic spring with linear negative stiffness(ESLNS) is proposed, in which the antagonistic ampere forces of the energized coils are used to generate negative stiffness within a long linear stroke. The magnetic field distribution is improved through the design of the magnetic circuit, thereby increasing the stiffness generation efficiency. The stiffness can be adjusted bidirectionally by current within the range of positive and negative stiffness. An electromagnetic stiffness model was established based on the equivalent magnetic circuit method. Experimental measurements verified the accuracy of the model and proved the linearity of the electromagnetic spring. A vibration isolator with high static and low dynamic stiffness(HSLDS) based on the ESLNS is designed and tested. The experimental results prove that the introduction of the ESLNS can effectively expand the isolation frequency band without changing the equilibrium position. Moreover, the vibration isolator with ESLNS does not produce nonlinear response. The proposed electromagnetic spring with linear negative stiffness extends the application range of HSLDS isolators to a large amplitude vibration environment.

关键词： linear negative stiffness mechanism low-frequency vibration isolation electromagnetic spring vibration control

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Iterative Model Predictive Control for Automatic Carrier Landing of Carrier-Based Aircrafts Under Complex Surroundings and Constraints

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Journal of Shanghai Jiaotong university(Science) 2024年第4期29卷 712-724页

作者： ZHANG Xiaotian HE Defeng LIAO Fei College of Information Engineering Zhejiang University of TechnologyHangzhou310023China Aerospace Technology Institute China Aerodynamics Research and Development CenterMianyang621000SichuanChina

This paper considers the automatic carrier landing problem of carrier-based aircrafts subjected to constraints,deck motion,measurement noises,and unknown *** iterative model predictive control(MPC)strategy with constraints is proposed for automatic landing control of the ***,the long short-term memory(LSTM)neural network is used to calculate the adaptive reference trajectories of the *** the Sage-Husa adaptive Kalman filter and the disturbance observer are introduced to design the composite ***,an iterative optimization algorithm is presented to fast solve the receding horizon optimal control problem of MPC based on the Lagrange’s ***,some sufficient conditions are derived to guarantee the stability of the landing system in a closed loop with the ***,the simulation results of F/A-18A aircraft show that compared with the conventional MPC,the presented MPC strategy improves the computational efficiency by nearly 56%and satisfies the control performance requirements of carrier landing.

关键词： automatic carrier landing model predictive control(MPC) long short-term memory(LSTM)neural network stability computational efficiency

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China's Path Towards Consumption-Led Growth in the New Era

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China Forex 2024年第1期 20-27页

作者： WANG Wei WANG Nian development research center of the State Council

Consumption is the mainstay of an economy's aggregate demand,the fundamental driver of large economies,and a cornerstone of a secure,wellmanaged,and resilient economic ***'s new strategic priority is to effectively ex... 详细信息

关键词： Consumption corners aggregate

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Accclerating thc Devclopmcnt of New Quality Productive Forces with a Focus on High-Quality development

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Qiu Shi 2024年第3期16卷 41-50页

作者： Zhang Laiming development research center of the State Council

Gaining a sound understanding of new quality productive forces and accelerating their development holds important theoretical and practical significance for high-quality development.

关键词： Focus holds Quality

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Bionic Design and Experimental Validation of a Robotic Airship Inspired by the Physalia physalis

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Journal of Bionic Engineering 2024年第2期21卷 740-753页

作者： Yueneng Yang Lili Chen Zhiyang Liu Shifeng Zhang College of Aerospace Science and Engineering National University of Defense TechnologyNo.109Deya RoadKaiFu DistrictChangsha410073China Aerospace Technology Institute China Aerodynamics Research and Development CenterMianyang621000China

The robotic airship is one of the most unique and promising green aircraft,however,as a“lighter-than-air aircraft”and“thermal aircraft”,its long-endurance flight has great difficulties in decreasing drag and controlling buoyancy and pressure under thermal *** this work,we reported a robotic airship inspired by the Physalia physalis,imitating its morphology,physiological structure,and biological *** hull is designed by imitating the morphology of the Physalia physalis,and the gasbags including a helium balloon,two ballonets,and a thermoregulation gasbag are designed by imitating the physiological structure and biological behaviors of the pneumatophore,bladder,and gland of the Physalia physalis,*** results show that the bionic airship has an increase of about 40%in lift-to-drag and decreases the pressure in helium balloon by 47.5%under thermal effects,and has better aerodynamic performances and thermoregulation performances than conventional airships.

关键词： Robotic airship Bionic design Aerodynamic performances Thermoregulation Physalia physalis

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Improvement in hydrogen storage performance of MgH_(2) by vanadium doped with ZIF-8 derived a single-atom catalyst V-N-C

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Rare Metals 2024年第6期43卷 2623-2635页

作者： Fei-Fan Hong Wei-Tao Shi Ruo-Lin Zhao Yi Fan Zi-Qi Liu Si-Zhi Ding Hai-Zhen Liu Wen-Zheng Zhou Jin Guo Zhi-Qiang Lan Guangxi Novel Battery Materials research center of Engineering Technology and center on Nanoenergy research Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationCarbon Peak and Neutrality Science and Technology Development InstituteSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China Nanning Engineering Technology research center for Power Transmission System of New Energy Vehicle Transportation CollegeNanning UniversityNanning 530200China

Herein,the successful preparation of a singleatom catalyst V-N-C using vanadium-doped zeolitic imidazolate framework(ZIF)-8 as a precursor is *** experimental results showed that the V-N-C had a good promoting effect on the hydrogen storage performance of MgH_(2),and the optimal addition amount of V-N-C was 10wt%.The hydrogenation and dehydrogenation apparent activation energies of 10 wt%V-N-C-catalyzed MgH_(2)were reduced by 44.9 and 53.5 kJ·mol^(-1),respectively,compared to those of additive-free MgH_(2).The 10 wt%V-N-C-catalyzed MgH_(2)could reabsorb 5.92 wt%of hydrogen in 50 min at 150℃,with a capacity retention rate of 99.1%after 30 cycles of hydrogen absorption and *** analysis showed that V-N-C was partially transformed into VN and metallic V when it was milled with MgH_(2);the in-situ-formed VN and metallic V played an important role in improving the hydrogen storage performance of MgH_(2).This approach provides a potential solution for obtaining high-performance Mg-based hydrogen storage materials through synergistic interactions between V,N and C.

关键词： MgH_(2) Hydrogen storage materials Catalyst Hydrogen storage perormance

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High performance photodegradation resistant PVA@TiO_(2)/carboxyl-PES self-healing reactive ultrafiltration membrane

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Chinese Journal of Chemical Engineering 2024年第2期66卷 31-39页

作者： Yu Liang Yuanfang Fan Zhongmin Su Mingxin Huo Xia Yang Hongliang Huo Chi Wang Zhi Geng College of Environment Engineering Research Center of Low-Carbon Treatment and Green Development of Polluted Water in Northeast ChinaMinistry of EducationNortheast Normal UniversityChangchun 130117China School of Science Hainan UniversityHaikou 570225China

The occurrence of ultrafiltration(UF)membrane fouling frequently hampers the sustainable advancement of UF *** self-cleaning UF membranes can effectively alleviate the problem of membrane ***,the self-cleaning process may accelerate membrane *** these concerns,we present an innovative design concept for composite self-healing materials based on self-cleaning UF *** begin,TiO_(2)nanoparticles were incorporated into the polymer molecular structure via molecular design,resulting in the synthesis of TiO_(2)/carboxyl-polyether sulfone(PES)hybrid ***,the nonsolvent-induced phase inversion technique was employed to prepare a novel of UF ***,a polyvinyl alcohol(PVA)hydrogel coating was applied to the hybrid UF membrane surface to create PVA@TiO_(2)/carboxyl-PES self-healing reactive UF *** establishing a covalent bond,the TiO_(2)nanoparticles were effectively and uniformly dispersed within the UF membrane,leading to exceptional self-cleaning ***,the water-absorbing and swelling properties of PVA hydrogel,along with its capacity to form hydrogen bonds with water molecules,resulted in UF membranes with improved hydrophilicity and active self-healing *** results demonstrated that the water contact angle of PVA@5%TiO_(2)/carboxyl-PES UF membrane was 43.1°.Following a 1-h exposure to simulated solar exposure,the water flux recovery ratio increased from 48.16%to 81.03%.Moreover,even after undergoing five cycles of 12-h simulated sunlight exposure,the UF membranes exhibited a consistent retention rate of over 97%,thus fully demonstrating their exceptional self-cleaning,antifouling,and selfhealing *** anticipate that the self-healing reactive UF membrane system will serve as a pioneering and comprehensive solution for the self-cleaning antifouling challenges encountered in UF membranes while also effectively mitigating the aging effects of reactive

关键词： Ultrafiltration membrane Self-cleaning Self-healing Poly(aryl ether sulfone)

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Chalcone derivatives as novel,potent and selective inhibitors against human Notum:Structure–activity relationships and biological evaluations

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Chinese Chemical Letters 2024年第3期35卷 321-325页

作者： Jin-Hui Shi Bei Zhao Li-Lin Song Yu-Qing Song Meng-Ru Sun Tian Tian Hong-Yu Chen Yun-Qing Song Jian-Ming Sun Guang-Bo Ge Shanghai Frontiers Science center of tcm Chemical Biology Institute of Interdisciplinary Integrative Medicine research Shanghai University of Traditional Chinese MedicineShanghai 201203China Dalian Engineering research center for Carbohydrate Agricultural Preparations Liaoning Provincial Key Laboratory of CarbohydratesDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137China

Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal ***,two series of chalcone derivatives were designed and synthesized aiming to find selective and potent hNotum ***–activity relationship(SAR)studies showed that 2-methoxyl and 5-bromine substitutions on A-ring significantly enhanced anti-hNotum effect,while 4’-ethoxyl and 3’-alkyl substitutions on B-ring were beneficial for hNotum *** all tested chalcones,B11 displayed the most potent anti-Notum effect(IC_(50)=3.6 nmol/L),good selectivity,excellent chemical stability and suitable metabolic *** investigations showed that B11 acted as a competitive inhibitor of hNotum,while this agent(5μmol/L)significantly weaken the migration abilities of colorectal cancer ***,this study deciphers the SARs of chalcones as hNotum inhibitors and reports a novel and potent hNotum inhibitor with the anti-migration effect on colorectal cancer cells,which offers a promising lead compound to develop novel anti-cancer agents.

关键词： Human notum(hNotum) Chalcone Computer-assisted drug discovery Structure–activity relationship(SAR) Anti-colorectal cancer agent

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Pathological progression of osteoarthritis:a perspective on subchondral bone

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Frontiers of Medicine 2024年第2期18卷 237-257页

作者： Xuefei Li Wenhua Chen Dan Liu Pinghua Chen Shiyun Wang Fangfang Li Qian Chen Shunyi Lv Fangyu Li Chen Chen Suxia Guo Weina Yuan Pan Li Zhijun Hu Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai200032China research and development center of Chinese Medicine Resources and Biotechnology Shanghai University of Traditional Chinese MedicineShanghai201203China

Osteoarthritis(OA)is a degenerative bone disease associated with *** rising global aging population has led to a surge in OA cases,thereby imposing a significant socioeconomic *** have been keenly investigating the mechanisms underlying *** studies have suggested that the disease starts with synovial inflammation and hyperplasia,advancing toward cartilage ***,subchondral-bone collapse,sclerosis,and osteophyte formation *** progression is deemed as“top to bottom.”However,recent research is challenging this perspective by indicating that initial changes occur in subchondral bone,precipitating cartilage *** this review,we elucidate the epidemiology of OA and present an in-depth overview of the subchondral bone’s physiological state,functions,and the varied pathological shifts during OA *** also introduce the role of multifunctional signal pathways(including osteoprotegerin(OPG)/receptor activator of nuclear factor-kappa B ligand(RANKL)/receptor activator of nuclear factor-kappa B(RANK),and chemokine(CXC motif)ligand 12(CXCL12)/CXC motif chemokine receptor 4(CXCR4))in the pathology of subchondral bone and their role in the“bottom-up”progression of *** vivid pattern maps and clinical images,this review highlights the crucial role of subchondral bone in driving OA progression,illuminating its interplay with the condition.

关键词： osteoarthritis subchondral bone OPG/RANKL/RANK CXCL12/CXCR4

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