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Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

Current Medical Science 2024年第1期44卷 121-133页

作者： Ting-ting WEI Wen XU Bo TU Wan-xue ZHANG Xin-xin YANG Yiguo ZHOU Shan-shan ZHANG Jun-lian YANG Ming-zhu XIE Juan DU Wei-wei CHEN Qing-bin LU Department of epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of infectious Disease The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Laboratorial Science and Technology&Vaccine research Center School of Public HealthPeking UniversityBeijing 100191China Department of Health Policy and Management School of Public HealthPeking UniversityBeijing 100191China Global Center for infectious Disease and Policy research&Global Health and infectious diseases Group Peking UniversityBeijing 100191China Key Laboratory of epidemiology of Major diseases(Peking University) Ministry of EducationBeijing 100191China

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains *** the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were *** In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had *** samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted *** Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and *** metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid *** sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI *** and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

关键词： human adenovirus metabonomic lipids pneumonia upper respiratory tract infection

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Small mammal community composition impacts bank vole (Clethrionomys glareolus) population dynamics and associated seroprevalence of Puumala orthohantavirus

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Integrative Zoology 2024年第1期19卷 52-65页

作者： Felicitas Maria BUJNOCH Daniela REIL Stephan DREWES Ulrike MROSENFELD Rainer G.ULRICH Jens JACOB Christian IMHOLT Julius Kühn-Institute Federal Research Centre for Cultivated PlantsInstitute for Epidemiology and Pathogen DiagnosticsRodent ResearchMünsterGermany University of Münster Institute for Evolution and BiodiversityMünsterGermany Friedrich-Loeffler-Institut Federal Research Institute for Animal HealthInstitute of Novel and Emerging Infectious DiseasesGreifswald-Insel RiemsGermany

Rodents are important reservoirs for zoonotic pathogens that cause diseases in *** is hypoth-esized to be closely related to pathogen prevalence through multiple direct and indirect *** example,the presence of non-host species can reduce contact rates of the main reservoir host and thus reduce the risk of transmission(“dilution effect”).In addition,an overlap in ecological niches between two species could lead to increased interspecific competition,potentially limiting host densities and reducing density-dependent pathogen transmission *** this study,we investigated the relative impact of population-level regulation of direct and indirect drivers of the prevalence of Puumala orthohantavirus(PUUV)in bank voles(Clethrionomys glareolus)during years with high *** compiled data on small mammal community composition from four regions in Germany between 2010 and *** equation modeling revealed a strong seasonality in PUUV control mechanisms in bank *** abundance of shrews tended to have a negative relationship with host abundance,and host abundance positively influenced PUUV seroprevalence,while at the same time increasing the abundance of competing non-hosts like the wood mouse(Apodemus sylvaticus)and the yellow-neckedfield mouse(Apodemusflavicollis)were associated with reduced PUUV seroprevalence in the *** results indicate that for PUUV in bank voles,dilution is associated with increased interspecific *** pressures leading to the decline of Apodemus *** a specific habitat could lead to the amplification of mechanisms promoting PUUV transmission within the host populations.

关键词： bank vole biodiversity Puumala orthohantavirus small mammals

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Species-level Microbiota of Biting Midges and Ticks from Poyang Lake

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Biomedical and Environmental Sciences 2024年第3期37卷 266-277,I0001-I0003页

作者： GONG Jian WANG Fei Fei LIU Yang Qing PU Ji DONG Ling Zhi ZHANG Si Hui HUANG Zhen Zhou HUANG Yu Yuan LI Ya Ben YANG Cai Xin TAO Yuan Meihui ZHAO Li Jun JIN Dong LIU Li Yun YANG Jing LU Shan Department of epidemiology School of Public HealthShanxi Medical UniversityTaiyuan 030001ShanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Jiangxi Provincial Key Laboratory of Animal-Origin and Vector-Borne diseases Nanchang Center for Disease Control and PreventionNanchang 330038JiangxiChina research units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing 100730China

Objective The purpose of this study was to investigate the bacterial communities of biting midges and ticks collected from three sites in the Poyang Lake area,namely,Qunlu Practice Base,Peach Blossom Garden,and Huangtong Animal Husbandry,and whether vectors carry any bacterial pathogens that may cause diseases to humans,to provide scientific basis for prospective pathogen discovery and disease prevention and *** Using a metataxonomics approach in concert with full-length 16S rRNA gene sequencing and operational phylogenetic unit(OPU)analysis,we characterized the species-level microbial community structure of two important vector species,biting midges and ticks,including 33 arthropod samples comprising 3,885 individuals,collected around Poyang *** A total of 662 OPUs were classified in biting midges,including 195 known species and 373 potentially new species,and 618 OPUs were classified in ticks,including 217 known species and 326 potentially new ***,OPUs with potentially pathogenicity were detected in both arthropod vectors,with 66 known species of biting midges reported to carry potential pathogens,including Asaia lannensis and Rickettsia bellii,compared to 50 in ticks,such as Acinetobacter lwoffii and Staphylococcus *** found that Proteobacteria was the most dominant group in both midges and ***,the outcomes demonstrated that the microbiota of midges and ticks tend to be governed by a few highly abundant *** sp7 was predominant in biting midges,while Coxiella sp1 was enriched in ***,Coxiella spp.,which may be essential for the survival of Haemaphysalis longicornis Neumann,were detected in all tick *** identification of dominant species and pathogens of biting midges and ticks in this study serves to broaden our knowledge associated to microbes of arthropod *** Biting midges and ticks carry large numbers of known and potentially novel bacteria,and carry a wide

关键词： Biting midge Tick Microbiota Pantoea Coxiella

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Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2984-2998页

作者： Xin Wang Jie Zhang Maoshun Liu Yuanyuan Guo Peipei Guo Xiaonan Yang Bingli Shang Min Li Jinmin Tian Ting Zhang Xi Wang Ronghua Jin Jikun Zhou George F.Gao Jun Liu Department of epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China NHC Key Laboratory of Biosafety Research Unit of Adaptive Evolution and Control of Emerging VirusesChinese Academy of Medical SciencesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Beijing Key Laboratory of Emerging infectious diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Institute of infectious diseases Beijing 100015China National Center for infectious diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015P.R.China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China School of Ophthalmology&Optometry Wenzhou Medical UniversityWenzhou 325027China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Shijiazhuang Fifth Hospital Shijiazhuang 050011China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China

The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing ***,the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 to other human coronaviruses is not well *** our research,we assessed T cell responses to both conserved and nonconserved peptides shared by SARS-CoV-2 and SARS-CoV,identifying cross-reactive CD8^(+)T cell epitopes using enzyme-linked immunospot and intracellular cytokine staining ***,in vitro refolding and circular dichroism were performed to evaluate the thermal stability of the HLA/peptide ***,single-cell T cell receptor reservoir was analyzed based on tetramer ***,we discovered that cross-reactive T cells targeting SARS-CoV were present in individuals who had recovered from COVID-19,and identified SARS-CoV-2 CD8^(+)T cell epitopes spanning the major structural antigens.T cell responses induced by the nonconserved peptides between SARS-CoV-2 and SARS-CoV were higher and played a dominant role in the cross-reactivity in COVID-19 ***-T cell reactivity was also observed within the identified series of CD8^(+)T cell *** representative immunodominant peptide pairs,although the HLA binding capacities for peptides from SARS-CoV-2 and SARS-CoV were similar,the TCR repertoires recognizing these peptides were *** results could provide beneficial information for the development of peptide-based universal vaccines against coronaviruses.

关键词： immunity conserved assessed

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Evaluating short-term and long-term liver fibrosis improvement in hepatitis C patients after DAA treatment

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Journal of Biomedical research 2024年第5期38卷 464-472,I0001,I0002页

作者： Yifan Wang Xinyan Ma Yanzheng Zou Ming Yue Meiling Zhang Rongbin Yu Hongbo Chen Peng Huang Department of infectious Disease Jurong Hospital Affiliated to Jiangsu UniversityJurongJiangsu 212400China Department of epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of infectious diseases the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Despite achieving a high cure rate with the direct-acting antivirals(DAAs)in hepatitis C treatment,further research is needed to identify additional benefits of the DAA *** current study evaluated liver fibrosis improvement in 848 hepatitis C patients treated with DAAs,who also achieved sustained virologic *** the fibrosis-4(FIB-4)index,patients were categorized based on their baseline fibrosis levels,and the improvement in fibrosis was analyzed in both short-term(9-26 weeks)and long-term(≥36 weeks)*** results showed a significant decrease in the FIB-4 index,indicating an improvement in liver fibrosis,in 63.0%and 67.6%of the patients during the short-term and long-term follow-up,***-term improvement was associated with factors including ribavirin usage,blood cholinesterase levels,alanine transaminase levels,albumin levels,and the baseline FIB-4 index,while long-term improvement was associated with factors such as aspartate transaminase levels,total protein level,and the baseline FIB-4 *** current study emphasizes the importance of continuous assessment and post-treatment monitoring of liver fibrosis,which will provide crucial insights for enhancing patient care in hepatitis C management.

关键词： chronic hepatitis C sustained virologic response direct-acting antivirals liver fibrosis

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Application of wastewater-based epidemiological monitoring of COVID-19 for disease surveillance in the city

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 81-87页

作者： Heng Chen Zhenhua Chen Liwen Hu Fengzhu Tang Dan Kuang Jiayi Han Yao Wang Xiao Zhang Yue Cheng Jiantong Meng Rong Lu Lan Zhang Chengdu Workstation for Emerging infectious Disease Control and Prevention Chinese Academy of Medical SciencesChengdu 610047China Chengdu Center for Disease Control and Prevention Chengdu 610047China National Key Laboratory of Intelligent Tracking and Forecasting for infectious diseases Beijing 100050China National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100050China

Wastewater-based surveillance serves as a supplementary approach to clinical surveillance of COVID-19 during the *** study aimed to track the prevalence of the disease and the viral genetic variability through wastewater-based surveillance in the post-epidemic *** January to December 2023,samples were collected from the influent lines of two wastewater treatment plants(WWTPs),concentrated using PEG8000,and subjected to detection of the target genes ORF 1ab and N of SARS-CoV-2 via reverse transcriptional quantitative PCR(RT-qPCR).For next-generation sequencing(NGS),high-quality samples from both wastewater and clinical patients were *** analysis were performed using R software to evaluate the correlation between the SARSCoV-2 RNA concentrations in wastewater and positive rate of reported cases,indicating a positive *** diversity patterns of SARS-CoV-2 in wastewater resembled those in the patient source based on Principal Coordinates Analysis(PCoA)with three clusters for different *** rise of RNA concentration in wastewater indicates the growth of cases and the emergence of new variants,serving as an early warning of potential viral mutations,disease outbreaks even possible ***,the genomic surveillance of wastewater could help identify new variants that may not be captured through population monitoring,especially when sample sizes are ***,surveillance of SARS-CoV-2 in municipal wastewater has emerged as a reliable,earlywarning monitoring system for COVID-19 in the post-epidemic era.

关键词： Wastewater-based epidemiology Monitoring COVID-19 Post-epidemic era

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Acute Effects of Exposure to Fine Particulate Matter and Its Constituents on Sex Hormone Among Postmenopausal Women — Beijing, Tianjin, and Hebei PLADs, China, 2018–2019

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China CDC weekly 2024年第13期6卷 249-253,I0001-I0004页

作者： Yanlin Tian Jiaonan Wang Jianlong Fang Chen Chen Feng Zhao Yi Zhang Peng Du Yawei Li Wanying Shi Yuanyuan Liu Enmin Ding Song Tang Xu Yue Xiaoming Shi Chinese research Academy of Environmental Sciences BeijingChina Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control(AEMPC)Nanjing University of Information Science&TechnologyNanjing CityJiangsu ProvinceChina China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Department of epidemiology and Health Statistics School of Public HealthCapital Medical Universityand Beijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for infectious diseases National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

What is already known on this topic?Exposure to fine particulate matter(PM_(2.5))was linked to endocrine hormone disruption in the reproductive ***,it was unclear which specific components of PM_(2.5) were primarily responsible for these *** is added by this report?The study presented the initial epidemiological evidence that brief exposure to PM_(2.5) can elevate estradiol levels in postmenopausal *** particle components had unique effects,with watersoluble ions and specific inorganic elements like Ag,As,Cd,Hg,Ni,Sb,Se,Sn,and Tl potentially playing significant roles in increasing estradiol *** are the implications for public health practice?The study established that the prevalence of air pollution,along with its specific components,has been recognized as a novel risk factor affecting the balance of sex hormones.

关键词： pollution Particulate primarily

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Advances in technology for the laboratory diagnosis of individuals with HIV/AIDS coinfected with Mycobacterium tuberculosis

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Biosafety and Health 2024年第3期6卷 133-142页

作者： Jin Sun Xiaoxu Han Hongxia Yan Xin Zhang Taiyi Jiang Tong Zhang Hao Wu Grigory Kaminskiy Yingmin Ma Eduard Karamov Bin Su Beijing Key Laboratory for HIV/AIDS research Clinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing 100069China State Health Organization Tula Regional Center for Control and Prevention of AIDS and infectious diseases Tula 300002Russia Department of Respiratory and Critical Care Medicine Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Gamaleya National research Centre for epidemiology and Microbiology of the Ministry of Health of the Russian Federation Moscow 123098Russia

The high morbidity and mortality rate of individuals with human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS)coinfected with Mycobacterium tuberculosis(MTB)is a tough challenge for current global tuberculosis prevention and control ***/MTB coinfection is more complex than a single infection,and the interaction between the two diseases aggravates the deterioration caused by the disease,resulting in increased hospitalizations and *** screening and early diagnosis facilitate the timely initiation of anti-tuberculosis treatment in HIV/MTB coinfected individuals,thereby reducing transmission and the incidence of adverse *** date,pathogenic detection has remained the gold standard for diagnosing tuberculosis,but its sensitivity and specificity are greatly affected by the body's immune status,which limits its application in the diagnosis of HIV/MTB ***,immunology and molecular detection technology has developed *** detection technologies,such as interferon-γ release assays,interferon-gamma inducible protein 10,and GeneXpert MTB/RIF assay have overcome the limitations of traditional detection methods,significantly improved the sensitivity and specificity of tuberculosis diagnosis,and brought new hope to the detection of HIV/MTB *** this article,the principle,scope of application,and latest research progress of relevant detection methods are reviewed to provide a reference for the early diagnosis of HIV/MTB coinfection.

关键词： Human immunodeficiency virus(HIV) Mycobacterium tuberculosis(MTB)coinfection Mycobacterium tuberculosis(MTB) Early diagnosis

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Prematurity and the burden of influenza and respiratory syncytial virus disease

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世界儿科杂志:英文版 2016年第1期12卷 8-18页

作者： Bernhard Resch Stefan Kurath-Koller Monika Eibisberger Werner Zenz research unit for neonatal infectious diseases and epidemiology Division of NeonatologyDepartment of Pediatrics and Adolescent MedicineMedical University of GrazAustria research unit for neonatal infectious diseases and epidemiology Medical University of GrazAustria research unit for infectious diseases and Vaccinology Division of General PediatricsDepartment of Pediatrics and Adolescent MedicineMedical University of GrazAustria

Background:Respiratory morbidity of former preterm infants and especially those with bronchopulmonary dysplasia(BPD)is high during infancy and early *** sources:We performed a review based on a literature search including EMBASE,MEDLINE,and CINAHL databases to identify all relevant papers published in the English and German literature on influenza and respiratory syncytial virus infection associated with preterm infant,prematurity,and BPD between 1980 and ***:Recurrent respiratory symptoms remain common at preschool age,school age and even into young *** viral respiratory tract infections due to different pathogens cause significant morbidity and necessitate rehospitalizations during the fi rst years of *** uenza virus infection plays a minor role compared to respiratory syncytial virus(RSV)associated respiratory tract infection during infancy and early ***,particular morbidity to both viruses is ***:The particular burden of both viral diseases in preterm infants is dominated by RSV and its associated rehospitalizations during the fi rst two years of *** measures include vaccination against influenza virus of family members and caregivers and active immunization starting at the age of 6 months,and monthly injections of palivizumab during the cold season to avoid severe RSV disease and its sequelae.

关键词： bronchopulmonary dysplasia infl uenza preterm infant respiratory infectious disease respiratory syncytial virus

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Genomic investigation and nationwide tracking of pediatric invasive nontyphoidal Salmonella in China

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mLife 2024年第1期3卷 156-160页

作者： Yefang Ke Lin Teng Zhe Zhu Wenbo Lu Wenyuan Liu Haiyang Zhou Qi Yu Lina Ye Pan Zhu Guoping Zhao Min Yue Deparment of Clinical Laboratory Ningbo Women and Children's HospitalNingboChina Department of Veterinary Medicine Zhejiang University Cllege of Animal SciencesHangzhouChina Department of Blood Transfusion Ningbo No.2 HospitalNingboChina Office of Screening Ningbo Women and Children's HospitalNingboChina neonatal Intensive Care unit Ningbo Women and Children's HospitalNingboChina School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouChina CAS Key Laboratory of Synthetic Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina Department of Microbiology and Microbial Engineering School of Life SciencesFudan UniversityShanghaiChina State Key Laboratory for Diagnosis and Treatment of infectious diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina Hainan Institute of Zhejiang University SanyaChina

Impact Statement。Invasive nontyphoidal Salmonella(iNTS)causes significant concern with~15%morbidity,affecting populations mainly in African countries.

关键词： pediatric nationwide morbidity

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