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Additive Fault Tolerant Control Applied to Delayed Singularly Perturbed System

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Journal of Software Engineering and Applications 2012年第4期5卷 217-224页

作者： Nouceyba Abdelkrim Adel Tellili Mohamed Naceur Abdelkrim research unit Modeling Analysis and Control Systems (MACS) Gabes Tunisia

The additive fault tolerant control (FTC) for delayed system is studied in this work. To design the additive control, two steps are necessary;the first one is the estimation of the sensor fault amplitude using a Luenberger observer with delay, and the second one consists to generate the additive fault tolerant control law and to add it to the nominal control of delayed system. The additive control law must be in function of fault term, then, in the absence of fault the expression of additive control equal to zero. The generation of nominal control law consist to determinate the state feedback gain by using the Lambert W method. Around all these control tools, we propose an extension of the additive FTC to delayed singularly perturbed systems (SPS). So, this extension consists to decompose the delayed SPS in two parts: delayed slow subsystem (delayed SS) and fast subsystem (FS) without time delay. Next, we consider that the delayed SPS is affected at its steady-state, and we apply the principal of FTC to the delayed SS and finally we combine them with the feedback gain control of FS by using the principal of composite control.

关键词： Additive Fault Tolerant Control Composite Control Lambert W Function Order Reduction Sensor Fault Singularly Perturbed System

Resilient Control for Networked Control Systems Subject to Cyber/Physical Attacks

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International Journal of Automation and computing 2018年第3期15卷 345-354页

作者： Taouba Rhouma Karim Chabir Mohamed Naceur Abdelkrim Modeling Analysis and Control of Systems(MACS) Laboratory National Engineering School of Gabes (ENIG)University of Gabes

In this paper, we investigate a resilient control strategy for networked control systems（NCSs） subject to zero dynamic attacks which are stealthy false-data injection attacks that are designed so that they cannot be detected based on control input and measurement data. Cyber resilience represents the ability of systems or network architectures to continue providing their intended behavior during attack and recovery. When a cyber attack on the control signal of a networked control system is computed to remain undetectable from passive model-based fault detection and isolation schemes, we show that the consequence of a zero dynamic attack on the state variable of the plant is undetectable during attack but it becomes apparent after the end of the attack. A resilient linear quadratic Gaussian controller, having the ability to quickly recover the nominal behavior of the closed-loop system after the attack end, is designed by updating online the Kalman filter from information given by an active version of the generalized likelihood ratio detector.

关键词： Networked control systems (NCSs) cyber physical attacks Kahnan filtering resilient control anomaly detector.

Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therapy research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(macs)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCS and macs scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

New LMI Conditions for Reduced-order Observer of Lipschitz Discrete-time Systems: Numerical and Experimental Results

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International Journal of Automation and computing 2019年第5期16卷 644-654页

作者： Noussaiba Gasmi Assem Thabet Mohamed Aoun research Center for Automatic Control of Nancy CRAN-CNRS UMR 7039University of LorraineCosnes et Romain 54400France Modeling Analysis and Control of Systems(MACS)LaboratoryNational Engineering School of GabesUniversity of GabesGabes 6072Tunisia

The objective of this paper is to propose a reduced-order observer for a class of Lipschitz nonlinear discrete-time *** conditions that guarantee the existence of this observer are presented in the form of linear matrix inequalities(LMIs). To handle the Lipschitz nonlinearities, the Lipschitz condition and the Young′s relation are adequately operated to add more degrees of freedom to the proposed LMI. Necessary and sufficient conditions for the existence of the unbiased reduced-order observer are given. An extension to H_∞ performance analysis is considered in order to deal with H_∞ asymptotic stability of the estimation error in the presence of disturbances that affect the state of the system. To highlight the effectiveness of the proposed design methodology, three numerical examples are considered. Then, high performances are shown through real time implementation using the ARDUINO MEGA 2560 device.

关键词： Reduced-order observer discrete-time systems Lipschitz systems H_∞ ARDUINO MEGA 2560 device

On the gradient tracking problem for a bilinear reaction–diffusion equation excited by distributed bounded controls

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Journal of Control and Decision 2023年第3期10卷 365-373页

作者： El Hassan Zerrik Abderrahman Ait Aadi Mohamed Ouhafsaa macs Laboratory Faculty of SciencesMoulay Ismail UniversityMeknesMorocco Department of Sciences Ecole Normale SupérieureMoulay Ismail UniversityMeknesMorocco

This paper addresses a gradient tracking problem of a bilinear reaction–diffusion equation evolvingin a spatial domainΩ ⊂ Rn, n ≤ 3. Such an equation is excited with distributed and boundedcontrols. The problem is formulated by the minimisation of a functional constituted of the deviationbetween the desired gradient and the current one all over a time interval and the energyterm. Then we prove the existence of an optimal control that we characterise by an optimalitysystem. Moreover, we discuss two sets of particular controls: the set of time dependent controlsand the space dependent ones. A computational approach and illustrative simulations are alsogiven.

关键词： Infinite dimensional systems bilinear systems reaction–diffusion equation controllability optimal control

METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2176-2192页

作者： Yue-fan Wang Wen-li Zhang Zhi-xuan Li Yue Liu Jian Tan Hao-zan Yin Zhi-chao Zhang Xian-jie Piao Min-hao Ruan Zhi-hui Dai Si-jie Wang Chen-yang Mu Ji-hang Yuan Shu-han Sun Hui Liu Fu Yang The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University200438 ShanghaiChina The Department of Medical Genetics Naval Medical University200433 ShanghaiChina Translational Medicine research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital100048 BeijingChina The Department of Pharmaceutical Analysis School of PharmacyNaval Medical University200433 ShanghaiChina Key Laboratory of Biosafety Defense Ministry of Education200433 ShanghaiChina Shanghai Key Laboratory of Medical Biodefense 200433 ShanghaiChina

Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and even hepatocellular ***,the molecular mechanisms that control progressive MAFLD have yet to be fully ***,we unraveled that the expression of the N6-methyladenosine(m6A)methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD,whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation,liver injury,and ***,hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet(HFD).Notably,in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner,which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1^(+)Ccr2^(+)monocyte-derived macrophages(Mo-macs).In detail,Cx3cr1^(+)Ccr2^(+)Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells(HSCs)to promote liver *** experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1^(+)Ccr2^(+)*** of METTL14 or GLS2,or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and *** together,these findings indicate potential therapies for the treatment of MAFLD progression.

关键词： S100A4 MyD88 metabolism

Morphology and phylogeny of root-endophytic fungus Periconia igniaria

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Studies in Fungi 2019年第1期4卷 274-281页

作者： D’Souza MA Rana S Singh SK Department of Botany St.Xavier’s CollegeMapusaGoa-403507India National Fungal Culture Collection of India Biodiversity and Palaeobiology GroupMACS'Agharkar Research InstituteGG Agarkar Road411004 PuneIndia

Periconia igniaria,isolated as an endophytic fungus from roots of Cheilocostus speciosus from Calangute,Bardez,Goa,India was described in this *** identity of the endophytic isolate was based on asexual-morphs,cultural characteristics and phylogenetic analyses of internal transcribed spacer rDNA sequence *** our knowledge,this is the first report of this taxon as root endophyte of Cheilocostus speciosus from Western Ghats forests,Goa,India.

关键词： Cheilocostus speciosus Goa Taxonomy Western Ghats

Autotrophic potential in mesophilic heterotrophic bacterial isolates from Sino-Pacific marine sediments

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Acta Oceanologica Sinica 2017年第2期36卷 69-77页

作者： CAO Wenrui DAS Anindita SAREN Gaowa JIANG Mingyu ZHANG Hongjie YU Xinke Key laboratory of Marine Geology and Environment (MAGE) Institute of Oceanology Chinese Academy of Sciences (IO-CAS) Qingdao 266071 China Institute of Biophysics Chinese Academy of Sciences (IBP-CAS) Beijing 100101 China Council of Scientific and Industrial research (CSIR) National Institute of Oceanography Dona Paula Panaji 403004 India Maharashtra Association for the Cultivation of Science (macs) Agharkar Research Institute Pune 411004 India

Microbial carbon fixation is a paramount process in the ocean especially below the photic zone both in water and sedimentary ecosystems. Autotrophic microbes that fix carbon dioxide are renowned. However, the question whether heterotrophs can also fix carbon is intriguing. Ten heterotrophically grown, identified bacterial isolates from the Sino-Pacific marine sediments were tested for autotrophic uptake potential with and without addition of electron donors. Nine of the ten isolates showed carbon uptake capacity without addition of any substrate at very low rates in the order of 10^（-8） to 10^（-4） fmol/（cell·h）. The addition of manganese and ammonium at 1 mmol/L final concentration enhanced the uptake potential. Addition of 1 mmol/L final concentrations of reduced iron（10^（-6） to10^（-5） fmol/（cell·h） and sulfide（10^（-5） fmol/（cell·h） decreased the uptake potential significantly at p〈0.1. Bacterial tolerance to formaldehyde suggested propensities of anaplerotic chemical reactions that form metabolic intermediates of C-1 metabolism pathways. The isolates displayed high metabolic flexibility. With the changes in electron donors, the isolates metabolically toggled between relatively anoxic reductive iron/sulfur cycles and the oxidative cycles of manganese/ammonium and vice-versa. This property makes these microbes successful survivors in the highly dynamic Sino-Pacific sediments.

关键词： autotrophy bacteria mesophiles heterotrophs Sino-Pacific

Elaboration of Materials with Functionality Gradients by Assembly of Chitosan-Collagen Microspheres Produced by Microfluidics

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Journal of Renewable Materials 2018年第3期6卷 314-324页

作者： David Azria Raluca Guermache Sophie Raisin Sébastien Blanquer Frédéric Gobeaux Marie Morille Emmanuel Belamie ICGM-macs UMR 5253 CNRS-ENSCM-UMCharles Gerhardt Institute Montpellier8 rue de l’Ecole normale34296 Montpellier cedex 5France Ecole Pratique des Hautes Etudes PSL Research University75014 ParisFrance LIONS-NIMBE CEA CNRSUniversity of Paris-SaclayCEA Saclay91191 Gif-sur-YvetteFrance

Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications,among which are their hydrophilicity,biocompatibility and *** many cases,functional recovery of an injured tissue or organ requires oriented cell outgrowth,which is particularly critical for nerve ***,there is a growing interest for the elaboration of materials exhibiting functionalization gradients able to guide ***,we explore an original way of elaborating such gradients by assembling particles from a library of functionalized *** propose a simple process to prepare chitosan-collagen hybrid microspheres by micro-and milli-fluidics,with adaptable dimensions and narrow size *** adhesion and survival rate of PC12 cells on hybrid microspheres were compared to those on pure chitosan ***,functionalized microspheres were assembled into membranes exhibiting a functionalization gradient.

关键词： Hybrid microspheres biomaterials chitosan collagen functionality gradient nerve regeneration microfluidics