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Regulating Blood Clot Fibrin Films to Manipulate Biomaterial-Mediated Foreign Body Responses

research 2024年第2期2023卷 565-581页

作者： Yang Zou Zhengjie Shan Zongpu Han Jieting Yang Yixiong Lin Zhuohong Gong Lv Xie Jieyun Xu Runlong Xie Zhuofan Chen Zetao Chen Hospital of Stomatology Guanghua School of StomatologySun Yat-sen University and Guangdong Research Center for Dental and Cranial Rehabilitation and Material EngineeringGuangzhou 510055China

The clinical efficacy of implanted biomaterials is often compromised by host immune recognition and subsequent foreign body responses(FBRs).During the implantation,biomaterials inevitably come into direct contact with the blood,absorbing blood protein and forming blood *** studies have been carried out to regulate protein adsorption,thus manipulating ***,the role of clot surface fibrin films formed by clotting shrinkage in host reactions and FBR is often *** of the principle of fibrin film formation being relevant to fibrinogen or clotting factor absorption,it is feasible to manipulate the fibrin film formation via tuning the absorption of fibrinogen and clotting *** biological hydroxyapatite reserved bone architecture and microporous structure,the smaller particle size may expose more microporous structures and adsorb more fibrinogen or clotting ***,we set up 3 sizes(small,<0.2 mm;medium,1 to 2 mm;large,3 to 4 mm)of biological hydroxyapatite(porcine bone-derived hydroxyapatite)with different microporous structures to investigate the absorption of blood protein,the formation of clot surface fibrin films,and the subsequent *** found that small group adsorbed more clotting factors because of more microporous structures and formed the thinnest and sparsest fibrin *** thinnest and sparsest fibrin films increased inflammation and profibrosis of macrophages through a potential signaling pathway of cell adhesion-cytoskeleton-autophagy,leading to the stronger *** group adsorbed lesser clotting factors,forming the thickest and densest fibrin films,easing inflammation and profibrosis of macrophages,and finally mitigating ***,this study deepens the understanding of the role of fibrin films in host recognition and FBR and demonstrates the feasibility of a strategy to regulate FBR by modulating fibrin films via tuning the absorption of blood proteins.

关键词： Blood subsequent biomaterials

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Protein neddylation and its role in health and diseases

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1869-1904页

作者： Shizhen Zhang Qing Yu Zhijian Li Yongchao Zhao Yi Sun Department of Breast Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China Department of Thyroid Surgery Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of Head&Neck Cancer Translational research of Zhejiang Province Hangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Zhejiang University School of MedicineHangzhou 310029China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Zhejiang University Cancer Center Hangzhou 310029China Leading Innovative and Entrepreneur team Introduction Program of Zhejiang Hangzhou 310024China research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

NEDD8(Neural precursor cell expressed developmentally downregulated protein 8)is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation,catalyzed by the enzyme cascade,namely NEDD8 activating enzyme(E1),NEDD8 conjugating enzyme(E2),and NEDD8 ligase(E3).The substrates of neddylation are categorized into cullins and non-cullin *** of cullins activates CRLs(cullin RING ligases),the largest family of E3 ligases,whereas neddylation of non-cullin substrates alters their stability and activity,as well as subcellular ***,the neddylation pathway and/or many neddylation substrates are abnormally activated or over-expressed in various human diseases,such as metabolic disorders,liver dysfunction,neurodegenerative disorders,and cancers,among ***,targeting neddylation becomes an attractive strategy for the treatment of these *** this review,we first provide a general introduction on the neddylation cascade,its biochemical process and regulation,and the crystal structures of neddylation enzymes in complex with cullin substrates;then discuss how neddylation governs various key biological processes via the modification of cullins and non-cullin *** further review the literature data on dysregulated neddylation in several human diseases,particularly cancer,followed by an outline of current efforts in the discovery of small molecule inhibitors of neddylation as a promising therapeutic ***,few perspectives were proposed for extensive future investigations.

关键词： NEDD8 attached attractive

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Multi-Scale X-Ray Imaging Technologies for Rechargeable Batteries

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Chinese Physics Letters 2024年第8期41卷 107-120页

作者： Zihan Xu Hanwen An Jiajun Wang MOE Engineering research Center for Electrochemical Energy Storage and Carbon Neutrality in Cold Regions School of Chemistry and Chemical EngineeringHarbin Institute of Technology Harbin 150001China State Key Laboratory of Space Power Sources Harbin Institute of TechnologyHarbin 150001China Chongqing research Institute of HIT Chongqing 401135China

The rapid advancement in electric vehicles and electrochemical energy storage technology has raised the demands placed on rechargeable *** is essential to comprehend the operational principles and degradation mechanisms of batteries across multiple scales to propel the research on rechargeable batteries for the next generation ***,phase information,and lattice of energy materials in both two dimensions and three dimensions can be intuitively obtained through the utilization of x-ray imaging ***,x-ray imaging technology is increasingly gaining attention due to its non-destructive nature and high penetrative capability,enabling in situ experiments and multi-scale spatial *** this review,we initially overview the basic principles and characteristics of several key x-ray imaging *** x-ray imaging technology is tailored to specific application ***,examples of multi-scale implementations of x-ray imaging technologies in the field of rechargeable batteries are *** review is anticipated to augment the comprehension of readers for x-ray imaging techniques as well as to stimulate the development of novel concepts and approaches in rechargeable battery research.

关键词： battery dimensions charge

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Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang Da-Wei Qiao Xiao-Shuai Chen Li-Zhi Wu Meng Tian Long Chen Yi Wei Liao-Yuan Song Jian Li Zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing Chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

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Polyzwitterionic cross-linked double network hydrogel electrolyte enabling high-stable Zn anode

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Nano research 2024年第6期17卷 5278-5287页

作者： Mengyu Shi Junlong Zhang Guochuan Tang Ben Wang Sen Wang Xiaoxian Ren Guojie Li Weihua Chen Chuntai Liu Changyu Shen State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China College of Chemistry and Green Catalysis Center Zhengzhou UniversityZhengzhou 450001China research Institute of Interdisciplinary Science and School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China

Zn metal anode suffers from dendrite issues and passive byproducts,which severely plagues the practical application of aqueous Zn metal ***,a polyzwitterionic cross-linked double network hydrogel electrolyte composed of physical crosslinking(hyaluronic acid)and chemical crosslinking(synthetic zwitterionic monomer copolymerized with acrylamide)is introduced to overcome these *** the one hand,highly hydrophilic physical network provides an energy dissipation channel to buffer stress and builds a H_(2)O-poor interface to avoid side *** the other hand,the charged groups(sulfonic and imidazolyl)in chemical crosslinking structure build anion/cation transport channels to boost ions’kinetics migration and regulate the typical solvent structure[Zn(H_(2)O)_(6)]^(2+)to R-SO_(3)^(−)[Zn(H_(2)O)_(4)]^(2+),with uniform electric field distribution and significant resistance to dendrites and parasitic *** on the above functions,the symmetric zinc cell exhibits superior cycle stability for more than 420 h at a high current density of 5 mA·cm^(−2),and Zn||MnO_(2)full cell has a reversible specific capacity of 150 mAh·g^(−1)after 1000 cycles at 2 C with this hydrogel ***,the pouch cell delivers impressive flexibility and cyclability for energy-storage applications.

关键词： Zn anode dendrites parasitic reactions polyzwitterion double network hydrogel electrolyte

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Stable ultraviolet ultrafast laser based on all-polarizationmaintaining fiber femtosecond laser

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Chinese Optics Letters 2024年第3期22卷 76-82页

作者：田昊朱喆林巍李子豪温俊鹏修昊范怡衡韦池一韦小明杨中民 School of Physics and Optoelectronics/State Key Laboratory of Luminescent Materials and Devices Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and DevicesGuangdong Provincial Key Laboratory of Fiber Laser Materials and Applied TechniquesSouth China University of TechnologyGuangzhou 510640China research Institute of Future Technology South China Normal UniversityGuangzhou 510006China

We report a high-stability ultrafast ultraviolet(UV)laser source at 352 nm by exploring an all-fiber,all-polarizationmaintaining(all-PM),Yb-doped femtosecond fiber laser at 1060 *** output power,pulse width,and optical spectrum width of the fiber laser are 6 W,244 fs,and 17.5 nm,*** UV ultrashort pulses at a repetition rate of 28.9 MHz are generated by leveraging single-pass second-harmonic generation in a 1.3-mm-long BiB_(3)O_(6)(BIBO)and sum frequency generation in a 5.1-mm-long *** maximum UV output power is 596 *** root mean square error of the output power of UV pulses is 0.54%.This laser,with promising stability,is expected to be a nice source for frontier applications in the UV wavelength window.

关键词： all-polarization-maintaining fiber ultrafast fiber laser UV laser

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Gradient microstructure and superior strength-ductility synergy of AZ61 magnesium alloy bars processed by radial forging with different deformation temperatures

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Journal of Materials Science & Technology 2024年第3期170卷 65-77页

作者： Jingfeng Zou Lifeng Ma Yanchun Zhu Ling Qin Yuan Yuan School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Heavy Machinery Engineering research Center of the Ministry Education Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Engineering University of HullCottingham RdHull HU67RXUK National Engineering research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

Gradient microstructure modification is a cost-efficient strategy for high strength without compromising ductility,which is urgently needed in the fundamental science of engineering *** this study,heterogeneous structures of AZ61 alloy bars with anisotropic gradients(with different grain size distributions from the surface to the center)were observed to exhibit strong strength-ductility synergies under different deformation tem *** results reveal that the grain refinement process under mediumlow temperature deformation conditions(≤350℃)consists of four transition stages along the radial direction,i.e.,twin activations and deformation band formations,dislocation cells and pile-ups,ultrafine sub-grains,and randomly orientated quasi-micron *** deformation temperatures have a great influence on twin activations and deformation band formations,and the high temperature can easily provoke the initiation of non-basal *** deformation bands were determined as a primary nucleation site due to their highly unstable dislocation hindrance *** in combination with the Radial forging(RF)deformation process,the differences of dynamic precipitates can be attributed to microstructural difference and solubility limit of Al at different tem *** summarizing the tensile test results,the sample forged at 350℃exhibited the best strength-ductility synergy,exhibiting the highest elongation(EL)of 23.2%with a 251 MPa yield strength(YS)and 394 MPa ultimate tensile strength(UTS)in center region,and combined with the highest strength value of 256 MPa YS and 420 MPa UTS in the center region,while the EL was slightly degraded to 19.8%.

关键词： Gradient microstructure Radial forging Strength-ductility synergy Magnesium alloy Strengthening mechanism

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Optimized new Shengmai powder(优化新生脉散方) inhibits myocardial fibrosis in heart failure by regulating the rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular regulated protein kinases signaling pathway

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Journal of Traditional Chinese Medicine 2024年第3期44卷 448-457页

作者： ZHANG Zeyu JIA Zhuangzhuang SONG Yuwei ZHANG Xuan WANG Ci WANG Shuai ZHANG Peipei REN Qiuan WANG Xianliang MAO Jingyuan Department of Cardiovascular the First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion

OBJECTIVE: Exploring the effect of Optimized New Shengmai powder(优化新生脉散方, ONSMP) on myocardial fibrosis in heart failure(HF) based on rat sarcoma(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase kinase(MEK)/extracellular regulated protein kinases(ERK) signaling pathway. METHODS: Randomized 70 Sprague-Dawley rats into sham(n = 10) and operation(n = 60) groups, then established the HF rat by ligating the left anterior descending branch of the coronary artery. We randomly divided the operation group rats into the model, ONSMP [including low(L), medium(M), and high(H) dose], and enalapril groups. After the 4-week drug intervention, echocardiography examines the cardiac function and calculates the ratios of the whole/left heart to the rat's body weight. Finally, we observed the degree of myocardial fibrosis by pathological sections, determined myocardium collagen(COL) Ⅰ and COL Ⅲ content by enzyme-linked immunosorbent assay, detected the m RNA levels of COL Ⅰ, COL Ⅲ, α-smooth muscle actin(α-SMA), and c-Fos proto-oncogene(c-Fos) by universal real-time, and detected the protein expression of p-RAS, p-RAF, p-MEK1/2, p-ERK1/2, p-ETS-like-1 transcription factor(p-ELK1), p-c-Fos, α-SMA, COL Ⅰ, and COL Ⅲ by Western blot. RESULTS: ONSMP can effectively improve HF rat's cardiac function, decrease cardiac organ coefficient, COL volume fraction, and COL Ⅰ/Ⅲ content, down-regulate the m RNA of COL Ⅰ/Ⅲ, α-SMA and c-Fos, and the protein of p-RAS, p-RAF, p-MEK1/2, p-ERK1/2, p-ELK1, c-Fos, COL Ⅰ/Ⅲ, and α-SMA. CONCLUSIONS: ONSMP can effectively reduce myocardial fibrosis in HF rats, and the mechanism may be related to the inhibition of the RAS/RAF/MEK/ERK signaling pathway.

关键词： extracellular regulated protein kinases heart failure mitogen-activated protein kinases myocardial fibrosis optimized new Shengmai powder rapidly accelerated fibrosarcoma sarcoma

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Room-temperature phonon-coupled single-photon emission in hexagonal boron nitride

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 109-114页

作者： Jia-Min Lai Qing-Hai Tan Feilong Song Haonan Chang Yanpei Lv Xue-Lu Liu Jinghua Teng Weibo Gao Ping-Heng Tan Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education&research Institute of Materials Science Shanxi Normal UniversityTaiyuan 030000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute of Materials research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore

Photon-lattice(phonon)coupling is fundamental to light-matter interaction,particularly when it reaches the quantum limit of the phonon-coupled single-photon emission,which holds great potential for quantum manipulation and quantum information ***,we report single defect state-phonon coupling in hexagonal boron nitride(h BN)at room *** ultrabroad spectrum of single-photon emissions can be achieved by selecting the excitation *** photoluminescence excitation spectroscopy,we observe single-phonon-assisted resonance-enhanced single-photon emission,along with multiple phonon replicas that herald the creation of phonon Fock *** also develop a transition model to gain insight into the physical process behind the single defect state-phonon *** work sets the stage for manipulating electron-phonon coupling state with single quantum-level precision at room temperature.

关键词： temperature phonon hexagonal

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BArcherFuzzer:An Android System Services Fuzzier via Transaction Dependencies of BpBinder

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Intelligent Automation & Soft Computing 2024年第3期39卷 527-544页

作者： Jiawei Qin Hua Zhang Hanbing Yan Tian Zhu Song Hu Dingyu Yan The State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100080China The National Computer Network Emergency Response Technical team/Coordination Center of China Beijing100012China

By the analysis of vulnerabilities of Android native system services,we find that some vulnerabilities are caused by inconsistent data transmission and inconsistent data processing logic between client and *** existing research cannot find the above two types of vulnerabilities and the test cases of them face the problem of low *** this paper,we propose an extraction method of test cases based on the native system services of the client and design a case construction method that supports multi-parameter mutation based on genetic algorithm and priority *** on the above method,we implement a detection tool-BArcherFuzzer to detect vulnerabilities of Android native system *** experiment results show that BArcherFuzzer found four vulnerabilities of hundreds of exception messages,all of them were confirmed by Google and one was assigned a Common Vulnerabilities and Exposures(CVE)number(CVE-2020-0363).

关键词： Android OS vulnerability detection binder fuzz testing genetic algorithm

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