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Journal of Integrative Plant Biology 2012年第1期54卷 15-32页

作者： Hamlet Avilés-Arnaut John Paul Délano-Frier Center of research and Advanced studies (Cinvestav) at Irapuato:Unit for Plant Biotechnology and Genetic Engineering

Tomato systemin is a bioactive peptide that regulates the systemic activation of wound-responsive genes. It is released from its 200 amino acid precursor called prosystemin. Initial tissue-localization and hormone-induced expression assays indicated that the tomato prosystemin gene （SIPS） accumulates mainly in floral tissues and in response to exogenous abscisic acid and methyl jasmonate （MeJA） treatments, respectively. Later, the promoter regions of the PS gene in tomato （Solanum lycopersicum L. cv. Castlemart）, pepper （Capsicum annuum） and potato （Solanum tuberosum） were isolated and an in silico analysis of the SIPS promoter revealed an over-representation of stress- and MeJA-responsive motifs. A subsequent 5＇ deletion analysis of the SIPS promoter fused to the/^-glucuronidase reporter （GUS） gene showed that the -221 to ＋40 bp proximal SIPS promoter region was sufficient to direct the stigma, vascular bundle-specific and MeJA-responsive expression of GUS in transgenic tobacco plants. Important ***-specific, light- and MeJA-responsive cis-elements were also present in this region. These findings provide relevant information regarding the transcriptional regulation mechanisms of the SIPS promoter operating in transgenic tobacco plants. They also suggest that its Ussue-specificity and inducible nature could have wide applicability in plant biotechnology.

关键词： cis-regulatory elements flower specific jasmonic acid methyl jasmonate promoter analysis prosystemin wound-responsive genes.

Mapping the trends and prospects of battery cathode materials based on patent landscape

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Frontiers in Energy 2023年第6期17卷 822-832页

作者： Chen YANG Xin-Yu MU School of Japanese Culture and Economy Xi’an International Studies UniversityXi’an 710128China The Northeast Asian research Center Xi’an International Studies UniversityXi’an 710128China

Advancing portable electronics and electric vehicles is heavily dependent on the cutting-edge lithium-ion (Li-ion) battery technology, which is closely linked to the properties of cathode materials. Identifying trends and prospects of cathode materials based on patent analysis is considered a kernel to optimize and refine battery related markets. In this paper, a patent analysis is performed on 6 popular cathode materials by comprehensively considering performance comparison, development trend, annual installed capacity, technology life cycle, and distribution among regions and patent assignees. In the technology life cycle, the cathode materials majorly used in electric vehicle have entered maturity stage, while the lithium cobalt oxide (LCO) cathode that is widely used in portable electronics is still in the growth stage. In global patent distributions, China holds more than 50% of total patents. In the top 10 patent assignees of 6 cathode materials, 2 institutes are from China with the rest being Japan (6) and Republic of Korea (2), indicating that the technology of cathode materials in China is relatively scattered while cathode research is highly concentrated in Japan and Republic of Korea. Moreover, the patent distribution has to consider practical issues as well as the impacts of core patents. For example, the high cost discourages the intention of applying international patents. This paper is expected to stimulate battery research, understand technical layout of various countries, and probably forecast innovative technology breakthroughs.

关键词： patent analysis cathode batteries technology life cycle

The effects of fire and seasonal variations on soil properties in Juniperus excelsa *** in the Alborz Mountains,Iran

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Journal of Forestry research 2022年第5期33卷 1471-1479页

作者： Nasim Bagheri Delijani Alireza Moshki Mohammad Matinizadeh Hooman Ravanbakhsh Elham Nouri Faculty of Desert studies Semnan UniversitySemnanIran Dep.of Forestry in Arid Regions Faculty of Desert StudiesSemnan UniversitySemnanIran Agricultural research Education and Extension Organization(AREEO)Research Institute of Forests and RangelandsTehranIran

This study was conducted in Juniperus excels a stands on the southern slopes of Iran’s Alborz Mountains,to determine the effects of fire and seasonal variations on soil physicochemical properties and enzyme activities.A total of 64 composite soil s amples were randomly collected in the spring and fall from two burned and unburned sites at depths of 0-10 and 10-20 *** results of a two-way ANOVA analysis indicate that fire increased the organic carbon(OC),total nitrogen(TN),and available phosphorus(P_(ava)) contents of the soil by 16%,59%,and 53%,***,when burned sites were compared to unburned sites,the activities of acid phosphatase(ACP) and urease enzymes increased by 73% and 12%,***,fire did not affect soil texture,bulk density(BD),pH,electric conductivity(EC),exchangeable potassium(Kexc),or the activities of alkaline phosphatase(ALP) and *** to two-way ANOVA results,OC,TN,P_(ava),K_(exc),and EC values were significantly higher in the fall,whereas pH and ALP values were significantly higher in the ***,phosphorous and dehydrogenase activity were significantly different in selected soil factors at 0-10 and10-20 cm *** interaction of fire,season,and soil depth were significant for phosphorous and ***,the activity of ALP correlated well with pH(r=0.68),P(r=-0.74),OC(r=-0.53),and TN(r=-0.37),whereas the activity of ACP correlated significantly with OC(r=0.64) and TN(r=0.71).Two years after the fire,soil properties in *** a stands had either improved or remained unaffected,returning to pre-fire ***,soil chemical properties varied significantly across sampling seasons,which should be considered when comparing and interpreting soil data in future research.

关键词： Dehydrogenase Acid&alkaline phosphatases Seasonal variations Soil physicochemical properties Urease

Estimation of monthly global solar radiation over twelve major cities of Libya

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Energy and Built Environment 2024年第1期5卷 46-57页

作者： Alhassan Ali Teyabeen Najeya B.Elhatmi Akram A.Essnid F.Mohamed Libyan Center for Solar Energy research and studies TripoliLibya Libyan Authority of Scientific research TripoliLibya

This study aims to estimate monthly averaged daily horizontal global solar *** climatological data collected at twelve major cities located across Libya’s map were used to establish 7 different empirical *** empirical coefficients of the models were calculated using the least square *** accuracy of the models was evaluated using different statistical criteria such as Taylor diagram,mean absolute percentage error,MAPE,and root mean square error,*** results indicated that the sunshine duration-based models are more accurate than air temperature-based models,and the best performance was obtained by the quadratic regression model for all twelve Libyan ***,this regression model can be used for the prediction of monthly mean horizontal global solar radiation at a specific site across Libya’s regions with minimum ***,the results of the global solar irradiance produced by this method can be used for designing solar systems applications.

关键词： Monthly global solar radiation Clearness index Empirical models Performance evaluation Taylor diagram Libya

Calculus bovis in hepatocellular carcinoma:Tumor molecular basis,Wnt/β-catenin pathway role,and protective mechanism

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World Journal of Gastroenterology 2024年第35期30卷 3959-3964页

作者： Khaled Mohamed Mohamed Koriem Department of Medical Physiology Medical Research and Clinical Studies InstituteNational Research CentreGiza 12622Egypt

In this editorial,we comment on the recent article by Huang et *** editorial focuses specifically on the molecular mechanisms of hepatocellular carcinoma(HCC),mechanism of Wnt/β-catenin pathway in HCC,and protective mechanism of Calculus bovis(CB)in *** cancer is the fourth most common cause of cancer-related deaths *** most prevalent kind of primary liver cancer,HCC,is typically brought on by long-term viral infections(hepatitis B and C),non-alcoholic steatohepatitis,excessive alcohol consumption,and other conditions that can cause the liver to become chronically inflamed and *** is a wellknown traditional remedy in China and Japan and has been used extensively to treat a variety of diseases,such as high fever,convulsions,and *** in lipid metabolism,cholesterol metabolism,bile acid metabolism,alcohol metabolism,and xenobiotic detoxification lead to fatty liver disease and liver ***,which is a tricarboxylic acid cycle intermediate,is vital to energy production and mitochondrial *** is also thought to be a signaling molecule in metabolism and in the development and spread of liver *** Wnt/β-catenin pathway is made up of a group of proteins that are essential for both adult tissue homeostasis and embryonic *** is frequently caused by the dysregulation of the Wnt/β-catenin signaling *** HCC liver carcinogenesis,Wnt/β-catenin signaling is activated by the expression of downstream target *** between the liver and the gut exists via the portal vein,biliary tract,and systemic ***"gutliver axis"controls intestinal *** of the main factors contributing to the development,progression,and treatment resistance of HCC is the abnormal activation of the Wnt/β-Catenin signaling ***,understanding this pathway is essential to treating *** ingredients of CB,particularly oleanolic acid,ergosterol,and ursolic acid,have anti-p

关键词： Hepatocellular carcinoma MicroRNAs Wnt/β-catenin pathway Calculus bovis Apoptosis

Non-alcoholic fatty liver disease:Epidemiology,pathophysiology and an update on the therapeutic approaches

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Asian Pacific Journal of Tropical Biomedicine 2022年第3期12卷 99-114页

作者： Rehab F.Abdel-Rahman Department of Pharmacology Medical Research and Clinical Studies InstituteNational Research Centre12622-DokkiGizaEgypt

Non-alcoholic fatty liver disease(NAFLD)denotes a spectrum of fatty liver disease in individuals without significant alcohol *** is set to be the most common etiology of serious liver diseases in numerous nations when accompanied by obesity and type 2 *** is further histologically categorized into the non-alcoholic fatty liver(NAFL;steatosis without hepatocellular injury)and non-alcoholic steatohepatitis(NASH)which is characterized by the coexistence of hepatic steatosis and inflammation and is accompanied by hepatocyte injury(ballooning),either with or without *** is considered the benign and reversible stage arising from the excessive accumulation of triglycerides in ***,NASH is a more progressive stage of NAFLD,due to the increased risks of evolving more serious diseases such as cirrhosis,hepatocellular *** concept,however,has been lately challenged by a hypothesis of multiple parallel hits of NAFLD,in which steatosis and NASH are separate entities rather than two points of the NAFLD spectrum,not only from a set of histological patterns but also from a pathophysiological *** current review highlights the epidemiology and pathophysiology of NAFLD,and its progression towards steatohepatitis,with special focus on the novel imminent therapeutic approaches targeting the molecular aspects and the pathogenic pathways involved in the development,and progression of NAFLD.

关键词： Non-alcoholic fatty liver disease Steatosis Insulin sensitizers Glucagon-like peptide-1 analogues Dipeptidyl peptidase-4 inhibitors Farnesoid X receptor agonists

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin Lu National Engineering research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

Context-dependent role of sirtuin 2 in inflammation

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Neural Regeneration research 2025年第3期20卷 682-694页

作者： NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta Department of Pharmaceutical Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Navarra Institute for Health research(IdiSNA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2

Study of ππ production in two-photon collisions at Belle

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Chinese Physics C 2008年第6期32卷 499-503页

作者： S.Uehara IPNS-KEK Institute of Particle and Nuclear StudiesHigh Energy Accelerator Research OrganizationTsukubaJapan

We have measured the cross section for π^＋π^- production in two-photon collisions using a data sample with an integrated luminosity of 85.9 fb^-1 collected with the Belle detector. The f0（980） resonance is observed as a peak in the energy spectrum of the cross section. We also report preliminary results for γγ→ π^0π^0 with two-photon center-of-mass energies ranging from 0.6 to 4.0 GeV, based on a 95 fb-1 data sample. We find at least four resonant structures including a peak from f0（980）. In addition, there is evidence for Xc0 production. We also make a preliminary discussion of the angular dependence and cross section ratio of γγ →π^＋π^- and γγ→π^oπ^o.

关键词： two-photon collisions pion cross section resonances charmonia

The history and development of the theory and practice of cybercartography

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International Journal of Digital Earth 2010年第1期3卷 2-15页

作者： D.R.Fraser Taylor Stephanie Pyne Department of Geography and Environmental studies Geomatics and Cartographic Research CentreCarleton UniversityOttawaONCanada

This paper describes the development of cybercartography since the introduction of the term in *** the origins of cybercartography were largely conceptual in nature,the evolution of cybercartography to date has been an iterative process reflecting the creative interplay between theory and practice.A major step forward was made in 2002 when the Geomatics and Cartographic research Centre at Carleton University received a$2.5 million grant from the Social Sciences and Humanities research Council of Canada to explore the utility of cybercartography to what was described as the New *** 2006,the interaction between theory and practice had led to considerable advances in cybercartography as a holistic,location-based concept and two new cybercartographic products,the Cybercartographic Atlas of Antarctica and the Cybercartographic Atlas of Canada’s Trade with the World,were *** 2006 and 2009,cybercartography was further developed as a result of interaction with indigenous communities,especially in Canada’s north and new interactive atlases such as the Kitikmeot Place Names Atlas and the Community Atlas of Arctic Bay were created in cooperation with the communities *** Nunaliit Cybercartographic Atlas Framework,built using open source software and open specifications and standards,was developed to facilitate direct input to these *** is now entering a new phase in both theory and practice building on a recently completed prototype atlas of Indigenous Perspectives and Knowledge.

关键词： cybercartography cybercartographic atlases indigenous mapping cybercartographic atlas framework iteration theory and practice