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Impact of an Active Pharmacovigilance Program in a Third-Level Clinic in Barranquilla, Colombia

Journal of Pharmacy and Pharmacology 2016年第11期4卷 601-610页

作者： Jose Francisco Castro Bolivar Femando Martinez-Martinez Monica Ferrit-Martin Faculty of Chemistry and Pharmacy Universidad del Atlantico Barranquilla Colombia Research Group on Pharmaceutical Care from Universidad de Granada Granada 18010 Spain Pharmacy department Hospital Universitario Virgen de las Nieves Granada 18014 Spain

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Comparative effects of different types of exercise on health-related quality of life during and after active cancer treatment:A systematic review and network meta-analysis

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Journal of Sport and Health Science 2023年第6期12卷 726-738页

作者： Vicente Martínez-Vizcaíno Iván Cavero-Redondo Sara Reina-Gutiérrez Luis Gracia-Marco JoséJGil-Cosano Bruno Bizzozero-Peroni Fernando Rodriguez-Artalejo Esther Ubago-Guisado universidad de Castilla-La Mancha Health and Social Research CenterCuenca 16071Spain Facultad de Ciencias de la Salud Universidad Autónoma de ChileTalca 3460000Chile PROFITH(PROmoting FITness and Health through physical activity)research group Department of Physical Education and SportsFaculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18012Spain Higher Institute for Physical Education Universidad de la RepúblicaRivera 40000Uruguay department of Preventive Medicine and Public Health School of MedicineUniversidad Autónoma de MadridMadrid 28029Spain IdiPaz(Instituto de Investigación Sanitaria Hospital Universitario La Paz) Madrid 28029Spain g Epidemiology and Control of Chronic Diseases CIBER of Epidemiology and Public Health(CIBERESP)Madrid 28029Spain Cancer Registry of granada Escuela Andaluza de Salud PúblicaGranada 18011Spain Cancer Epidemiology group Instituto de Investigación BiosanitariaGranada 18012Spain

Background The positive influence of most types of exercise has been reported repeatedly,but what the most effective exercise approaches are for improving health-related quality of life(HRQoL)in people with cancer remains unknown.The aim of this systematic review and network meta-analysis was to synthesize the evidence from intervention studies to assess the effects of different types of exercise on HRQoL during and after cancer treatment.Methods MEDLINE,SPORTDiscus,the Cochrane Library,Web of Science,and Scopus were searched for randomized controlled trials aimed at testing the effects of exercise interventions meant to improve HRQoL in people with cancer.Separate analyses were conducted for HRQoL as measured by general and cancer-specific questionnaires.We also evaluated whether the effects of exercise were different during and after cancer treatment in both the physical and mental HRQoL domains.Results In total,93 studies involving 7435 people with cancer were included.Network effect size estimates comparing exercise intervention vs.usual care were significant for combined exercise(0.35,95%confidence interval(95%CI):0.14–0.56)for HRQoL as measured by general questionnaires,and for combined(0.31,95%CI:0.13–0.48),mind–body exercise(0.54,95%CI:0.18–0.89),and walking(0.39,95%CI:0.04–0.74)for HRQoL as measured by cancer-specific questionnaires.Conclusion Exercise programs combining aerobic and resistance training can be recommended to improve HRQoL during and after cancer treatment.The scarcity and heterogeneity of these studies prevents us from making recommendations about other exercise modalities due to insufficient evidence.

关键词： Cancer Exercise HRQoL Physical activityTagedend

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Drug Therapy Monitoring in Patients with Type 2 Diabetes and Hypertension

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Journal of Pharmacy and Pharmacology 2017年第4期5卷 169-178页

作者： Jose Francisco Castro Bolivar Femando Martinez-Martinez Monica Ferrit-Martin Faculty of Chemistry and Pharmacy Universidad del Atlantico Hospital Pharmacy and Pharmacology Research Group (GIFAF) Barranquilla 08003 Colombia pharmaceutical care research group Universidadde Granada Granada 18010 Spain Pharmacy department Virgen de las Nieves Universitario Hospital Granada 18014 Spain

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Inhaler Technique Questionnaire(InTeQ)in pediatric patients with asthma

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世界儿科杂志:英文版 2023年第8期19卷 798-804页

作者： Catalina Lizano‑Barrantes Olatz Garin Alexandra Lelia Dima Karina Mayoral Angels Pont Eva María Ortiz María Araceli Caballero‑Rabasco Manuel Praena‑Crespo Laura Valdesoiro‑Navarrete María Teresa Guerra Alberto Bercedo‑Sanz Gimena Hernández Camila Maroni Inés de Mir MaríaÁngeles Carrasco Marta Ortega Alberto Servan JoséAntonio Castillo Eva Tato Montse Ferrer Health Services research group IMIM(Hospital del Mar Medical Research Institute)Barcelona Biomedical Research ParkDoctor Aiguader8808003 BarcelonaSpain department of Medicine and Life Sciences Universitat Pompeu FabraBarcelonaSpain department of pharmaceutical care and Clinical Pharmacy Faculty of PharmacyUniversidad de Costa RicaSan JoseCosta Rica Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública CIBERESP MadridSpain research and development Unit Institut de Recerca Sant Joan de DéuBarcelonaSpain department of Pediatrics Obstetrics and Gynaecology and Preventive MedicineUniversitat Autònoma de BarcelonaBarcelonaSpain Pediatric Allergy and Pulmonology Unit Pediatric ServiceHospital del MarBarcelonaSpain Pediatric Allergy and Pulmonology Unit Pediatric ServiceHospital Universitari Parc TaulíSabadellSpain Centro de Salud La Candelaria Servicio Andaluz de SaludSevilleSpain Grupo de Vías Respiratorias de La Asociación Española de Pediatras de Atención Primaria(AEPAP) MadridSpain Centro de Salud Jerez Sur Servicio Andaluz de SaludSevilleSpain Centro de Salud La Sagrera BarcelonaSpain Centro de Salud Los Castros CantabriaSpain Facultat de Medicina Universitat Autònoma de BarcelonaBarcelonaSpain Pediatric Allergy and Pulmonology and Cystic Fibrosis UnitHospital Universitari Vall d’HebronBarcelonaSpain Consultorio Sevilla la Nueva MadridSpain Centro de Salud Dos de Mayo MadridSpain Hospital Miguel Servet ZaragozaSpain Hospital Universitario Araba Vitoria-GasteizSpain departamento de Farmacologia Pediatría y RadiologíaUniversidad de SevillaSevilleSpain Institut d’Investigaciói InnovacióParc Taulí SabadellSpain

Asthma in school-aged children is a major public health problem worldwide[1,2].Inhaled medications are the mainstay of its pharmacological management[2],but only 8%-22%of children with asthma use their inhalers correc... 详细信息

关键词： asthma pediatric patients

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急诊科反复喘息婴幼儿需要住院并接受呼吸支持治疗的预测因素

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中国当代儿科杂志 2021年第5期23卷 438-444页

作者： Jefferson Antonio Buendía Ranniery Acuña-Cordero Carlos E Rodriguez-Martinez department of Pharmacology and Toxicology School of MedicineResearch Group in Pharmacology and Toxicology(INFARTO)Universidad de AntioquiaMedellínColombia

目的反复喘息患者多为2岁以下的婴幼儿。在热带国家,对该人群住院期间接受呼吸支持治疗的风险的临床预测模型研究较少。该研究旨在评估就诊于哥伦比亚急诊科的反复喘息婴幼儿需要住院并接受呼吸支持治疗的临床预测因素。方法该研究是一... 详细信息

目的反复喘息患者多为2岁以下的婴幼儿。在热带国家,对该人群住院期间接受呼吸支持治疗的风险的临床预测模型研究较少。该研究旨在评估就诊于哥伦比亚急诊科的反复喘息婴幼儿需要住院并接受呼吸支持治疗的临床预测因素。方法该研究是一项回顾性队列研究,纳入了2019年1~12月期间在哥伦比亚Rionegro的两个三级中心医院就诊的所有患有2次或2次以上喘息发作的婴幼儿(年龄均小于2岁)。主要结局指标是住院加呼吸支持治疗。采用多因素logistic回归模型确定需要住院并接受呼吸支持治疗的独立预测因素。结果共85名婴幼儿住院并接受呼吸支持治疗,其中34名(40%)予以高流量鼻导管吸氧,2名(2%)予以无创通气,6名(7%)予以机械通气,43名(51%)予以常规氧疗。多因素logistic回归模型分析显示,早产(OR=1.79,95%CI:1.04~3.10)、喂养困难(OR=2.22,95%CI:1.25~3.94)、鼻煽和/或咕噜声(OR=4.27,95%CI:2.41~7.56)和既往有1次以上喘息发作需要住院治疗(OR=3.36,95%CI:1.86~7.08)是需要住院并接受呼吸支持治疗的预测因素。该模型特异度高(99.6%),鉴别度中等,曲线下面积为0.70(95%CI:0.60~0.74)。结论该研究表明,早产、喂养困难、鼻煽和/或呼噜声,以及有1次以上需要住院治疗的喘息发作史,是急诊科就诊的反复喘息婴幼儿需要住院并接受呼吸支持治疗的独立预测因素。然而,还需收集更多的其他热带国家的证据来验证这个结论。

关键词：喘息呼吸支持风险预测因素婴幼儿

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Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

Assessment of Lung Cancer Risk on the Basis of a Biomarker P...

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2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青...

作者： sun,nan Florence,Guida Bantis,LeonidasE. Muller,DavidC. Li,Peng Taguchi,Ayumu Dhillon,Dilsher Kundnani,deepaliL. Patel,NikulJ. Yan,Qingxiang Byrnes,Graham Moons,KarelG.M. Tj?nneland,Anne Panico,Salvatore Claudia ,Agnoli Vineis,Paolo Palli,Domenico Bueno-de-Mesquita,Bas Peeters,PetraH. Agudo,Antonio Huerta,JoseM. Dorronsoro,Miren Barranco,MiguelRodriguez Ardanaz,Eva Travis,RuthC. Byrne,KarlSmith Boeing,Heiner Steffen,Annika Kaaks,Rudolf Hüsing,Anika Trichopoulou,Antonia Lagiou,Pagona LaVecchia,Carlo Severi,Gianluca Boutron-Ruault,Marie-Christine Sandanger,TorkjelM. Weiderpass,Elisabete N?st,ThereseH. Tsilidis,Kostas Riboli,Elio Grankvist,Kjell Johansson,Mikael Goodman,GaryE. Feng,Ziding Brennan,Paul Johansson,Mattias Hanash,Samir M. The University of Texas MD Anderson Cancer Center Genetic Epidemiology group International Agency for Research on Cancer department of Biostatistics The University of Texas MD Anderson Cancer Center department of Epidemiology and Biostatistics Imperial College London School of Public Health Laboratory of Population Health Max Planck Institute for Demographic Research department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Environment and Radiation Section International Agency for Research on Cancer department of Epidemiology Julius Center for Health Sciences and Primary CareUniversity Medical Center Unit of Diet Genesand EnvironmentDanish Cancer Society Research Center department of Clinical Medicine and Surgery Federico Ⅱ University Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Molecular and Genetic Epidemiology Unit Human Genetics Foundation Cancer Risk Factors and Life-Style Epidemiology Unit Cancer Research and Prevention Institute-Istituto per lo Studio ela Prevenzione Oncologica department for determinants of Chronic Diseases National Institute for Public Health and the Environment Unit of Nutirition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of OncologyBellvitge Institute for Biomedical Research (IDIBELL)L’Hospitalet de Llobregat department of Epidemiology Murcia Regional Health Council Biomedical Research Institute of Murcia(IMIB-Arrixaca) Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP) Public Health Direction and Biodonostia research Institute-CIBERESP Escuela Andaluza de Salud Pública Instituto de Investigación Biosanitaria Hospitales Universitarios de granada/universidad de granada Epidemiology Preventionand Promotion Health ServiceNavarra Public Health Institute Instituto de Investigación Sanitaria de Navarra (IdiSNA) Navarra Institute for Health Research Cancer Epidemiology Unit Nuffield Department of Population HealthUniversity of Oxford department of Epidemi

IMPORTANCE:There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of cases.OBJECTIVE:To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria.

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Breast Cancer Risk Genes-Association Analysis in More than 113,000 Women

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四川生理科学杂志 2021年第1期43卷 7-7页

作者： Leila Dorling The authors' affiliations are as follows: the Centre for Cancer Genetic Epidemiology Departments of Public Health and Primary Care (L.D. S. Carvalho J.A. K.A.P. Q.W. M.K.B. J.D. B.D. N. Mavaddat K. Michailidou A.C.A. P.D.P.P. D.F.E.) and Oncology (C.L. P.A.H. C. Baynes D.M.C. L.F. V.R. M. Shah P.D.P.P. A.M.D. D.F.E.) University of Cambridge Cambridge the Centre for Genomic and Experimental Medicine MRC Institute of Genetics and Molecular Medicine (A. Campbell D.J.P.) and the Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology (D.J.P.) University of Edinburgh the Cancer Research UK Edinburgh Centre (D.A.C. J.F.) and the Usher Institute of Population Health Sciences and Informatics University of Edinburgh Medical School (A. Campbell J.F.) Edinburgh the Divisions of Informatics Imaging and Data Sciences (E.F.H.) Cancer Sciences (A. Howell) Population Health Health Services Research and Primary Care (A. Lophatananon K. Muir) and Evolution and Genomic Sciences School of Biological Sciences (W.G.N. E.M.V. D.G.E.) University of Manchester the NIHR Manchester Biomedical Research Unit (E.F.H.) and the Nightingale Breast Screening Centre Wythenshawe Hospital (E.F.H. H.I.) Academic Health Science Centre and North West Genomics Laboratory Hub and the Manchester Centre for Genomic Medicine St. Mary's Hospital Manchester University NHS Foundation Trust (W.G.N. E.M.V. D.G.E.) Manchester the School of Cancer and Pharmaceutical Sciences Comprehensive Cancer Centre Guy's Campus King's College London London (E.J.S.) the Institute of Cancer and Genomic Sciences University of Birmingham Birmingham (I.T.) and the Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre University of Oxford Oxford (I.T.) - all in the United Kingdom the Human Genotyping-CEGEN Unit Human Cancer Genetic Program (A.G.-N. M.R.A. N.Á. B.H. R.N.-T.) and the Human Genetics Group (V.F. A.O. J.B.) Spanish National Cancer Research

Background:Genetic testing for breast cancer susceptibility is widely used,but for many genes,evidence of an association with breast cancer is weak,underlying risk estimates are imprecise,and reliable subtype-specific risk estimates are lacking.Methods:We used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women with breast cancer and 53,461 controls.In separate analyses for protein-truncating variants and rare missense variants in these genes,we estimated odds ratios for breast cancer overall and tumor subtypes.We evaluated missense-variant associations according to domain and classification of pathogenicity.

关键词： cancer Breast Cancer

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