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Preparations of Mytilus edulis protein hydrolysate-iron complexes and their ameliorative effects on mice with iron deficiency anemia

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food Science and Human Wellness 2025年

作者： Guang Li Xuening Yu Shuling Zhou Xiaoyang Liu Fawen Yin Deyang Li Baocai Xu Dayong Zhou School of food and Biological Engineering， Hefei University of Technology SKL of Marine food processing & Safety Control， National Engineering research Center of Seafood， Collaborative Innovation Center of Seafood Deep processing， Liaoning Province Key Laboratory for Marine food Science and Technology， School of food Science and Technology， Dalian Polytechnic University

Iron is a fundamental trace element essential for the immune system， and current research on iron supplements is increasingly focusing on food-derived peptides capable of binding iron ions. The objectives of this study were to characterize the iron-chelating peptide (MEPH) derived from Mytilus edulis and to investigate the effects of MEPH-Fe complexes on mice with iron deficiency-induced anemia (IDA). MEPH and iron(II) sulfate heptahydrate successfully formed MEPH-Fe complexes under conditions of 4.5 mg/mL concentration， 45 ℃ temperature， and 60 minutes of incubation， utilizing both carboxyl and amino binding sites. Compared to MEPH alone， the MEPH-Fe complexes exhibited fluorescence quenching， ultraviolet shifts， reduced X-ray diffraction peak intensities， stabilization during in vitro digestion， microstructural changes， increased particle size， and decreased absolute values of zeta potential. In the IDA mouse model， the MEPH-Fe complexes were able to restore body weight， hematological indices， organ coefficients， iron content in organs， and antioxidant capacity to normal levels. Additionally， they demonstrated beneficial effects on IDA-induced colonic inflammation by normalizing tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) levels. The results indicated that MEPH-Fe complexes had more positive effects on IDA mice compared to ferrous sulfate. In conclusion， this study provides valuable insights into the potential of MEPH-Fe complexes as iron supplements.

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Degradation of gaseous hydrocarbons in aerated stirred bioreactors inoculated with Rhodococcus erythropolis:Effect of the carbon source and SIFT-MS method development

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Journal of Environmental Sciences 2025年第1期147卷 268-281页

作者： Paula Alejandra Lamprea Pineda Kristof Demeestere Allan Augusto Alvarado-Alvarado Frank Devlieghere Nico Boon Herman Van Langenhove Christophe Walgraeve research group EnVOC Department of Green Chemistry and TechnologyFaculty of Bioscience EngineeringGhent UniversityCoupure Links 6539000Ghent Belgium research group FMFP Department of Food TechnologySafety and HealthFaculty of Bioscience EngineeringGhent UniversityCoupure Links 6539000Ghent Belgium Center for Microbial Ecology and Technology-CMET Department of BiotechnologyFaculty of Bioscience EngineeringGhent UniversityCoupure Links 6539000Ghent Belgium

The study of microbial hydrocarbons removal is of great importance for the development of future bioremediation *** this study,we evaluated the removal of a gaseous mixture containing toluene,m-xylene,ethylbenzene,cyclohexane,butane,pentane,hexane and heptane in aerated stirred bioreactors inoculated with Rhodococcus erythropolis and operated under non-sterile *** the real-time measurement of hydrocarbons,a novel systematic approachwas implemented using Selected-Ion Flow TubeMass Spectrometry(SIFTMS).The effect of the carbon source(~9.5 ppmv)on(i)the bioreactors’performance(BR1:dosed with only cyclohexane as a single hydrocarbon versus BR2:dosed with a mixture of the 8 hydrocarbons)and(ii)the evolution of microbial communities over time were *** results showed that cyclohexane reached a maximum removal efficiency(RE)of 53%±4%in *** BR2,almost complete removal of toluene,m-xylene and ethylbenzene,being the most water-soluble and easy-to-degrade carbon sources,was *** below 32%were obtained for the remaining *** exposing the microbial consortium to only the five most recalcitrant hydrocarbons,REs between 45%±5%and 98%±1%were *** addition,we observed that airborne microorganisms populated the bioreactors and that the type of carbon source influenced the microbial communities *** abundance of species belonging to the genus Rhodococcus was below 10%in all bioreactors at the end of the *** work provides fundamental insights to understand the complex behavior of gaseous hydrocarbon mixtures in bioreactors,along with a systematic approach for the development of SIFT-MS methods.

关键词： Hydrocarbons SIFT-MS Rhodococcus erythropolis Biodegradation Bioreactors

Integrated multi-omics analysis unveils metabolites-mediated microbial interactions: dynamic regulation and metabolic division of A. flavus SU-16 and S. cerevisiae HJ during co-fermentation

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food Science and Human Wellness 2025年

作者： Shuangping Liu Mingliang Li Hailong Sun Zhuoyue Zheng Yuezheng Xu Xiao Han Zhilei Zhou Jian Mao National Engineering research Center for Cereal Fermentation and food Biomanufacturing， State Key Laboratory of food Science and Technology， School of food Science and Technology， Jiangnan University Shaoxing Key Laboratory of Traditional Fermentation food and Human Health， Jiangnan University (Shaoxing) Industrial Technology research Institute National Engineering research Center of Huangjiu， Zhejiang Guyuelongshan Shaoxing Wine Co.， Ltd. Jiangsu Provincial Engineering research Center for Bioactive Product processing， Jiangnan University School of food Science and Technology， Shihezi University

This study aimed to gain insight into the interaction and metabolic mechanism between A. flavus SU-16 and S. cerevisiae HJ during co-fermentation. Despite the suppressed transcriptional activity of SU-16， its metabolites exerted a pivotal regulatory influence. The metabolites produced by SU-16 significantly increased the ethanol content to 17.0%. They also significantly increased the contents of crucial flavor substances， including amino acids (at least 5 times) and esters (up to 1100 mg/L). SU-16 produced 130 metabolites that may affect flavor compounds， while HJ mainly controlled the synthesis of 161 compounds. Metabolites of SU-16 with different molecular weights were observed to exert differential regulatory effects on the fermentation process and the metabolic pathway of HJ. The small molecule metabolites of SU-16 promote the growth of HJ significantly. In contrast， its macromolecular metabolites were found to mainly affect the expression of genes related to carbohydrate and amino acid metabolism in the HJ genome.

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Super-high bed sintering for iron ores:variation and optimization of bed resistance

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Journal of Iron and Steel research International 2025年第1期32卷 40-51页

作者： Liang-ping Xu Lin Xiong Hui-bo Liu Xi-duan Yang Ai-xiang Mao Pei-dun Chen Guang-hui Li School of Minerals processing and Bioengineering Central South UniversityChangsha410083HunanChina Central research Institute Baosteel Group Co.Ltd.Shanghai201900China Manufacturing Management Department Guangdong Zhongnan Iron and Steel Co.Ltd.Shaoguan512123GuangdongChina Technology and Development Center Shandong Taishan Iron and Steel Group Co.Ltd.Jinan271100ShandongChina

As the bed depth increases,sintering yield increases,but the productivity *** reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and combustion zone was analyzed in the *** results showed that the decreased porosity of mixture resulted in the increased bed resistance by 160.56%when the bed depth increased from 600 to 1000 *** improving porosity of 1%by adding loosening bars with optimized size and distribution,the bed resistance decreased,and the productivity increased by 5%.The increase in bed depth increased the thickness of the wet zone from 120 to 680 mm and the resistance from 1.56 to 8.83 *** using a three-stage intensive mixer and pre-adding water for granulation,the moisture of mixture was reduced by 0.6%,and the sintering productivity increased by 4%.Besides,the high bed resistance is mainly caused by the increase in the thickness of the combustion zone from 31.9 to 132.7 mm,and the bed resistance increased from 0.70 to 5.62 *** bed resistance of the combustion zone at 900 mm was increased by 90.51%compared to 700 *** optimization of the distribution of coke breeze,the thickness of combustion zone at the lower layer decreased from 132.7 to 106.84 mm and permeability improved significantly.

关键词： Super-high bed sintering Bed resistance Permeability Productivity Wet zone Combustion zone

Structural analysis of a neutral polysaccharide ATP-1 from the red seaweed Asparagopsis taxiformis and its immunomodulatory effects on RAW264.7 macrophages

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food Science and Human Wellness 2025年

作者： Kun Yang Baojun Xu Wei Hu Yifan Tang Amy Hui-Mei Lin Saiyi Zhong College of food Science and Technology， Guangdong Ocean University， Guangdong Provincial Key Laboratory of Aquatic Product processing and Safety，Guangdong Province Engineering Laboratory for Marine Biological Products， Guangdong Provincial Engineering Technology research Center of Seafood Guangdong Provincial Engineering Technology research Center of Prefabricated Seafood processing and Quality Control food Science and Technology Program， Department of Life Sciences， BNU-HKBU United International College Singapore Institute of food and Biotechnology Innovation (SIFBI) Shenzhen research Institute， Guangdong Ocean University

As a seaweed supplement， the powdered， entire herb of Asparagopsis taxiformis can effectively promote immune response in animals. However， the active factors responsible for this effect are currently unknown. A novel polysaccharide， ATP-1， was isolated and purified from the red alga A. taxiformis， and its structural and immunomodulatory properties were determined. ATP-1 is a neutral polysaccharide with a molecular weight of 307.978 kDa and is primarily composed of galactose (94.07%)， glucose (1.27%)， and xylose (4.66%). Scanning electron microscopy and atomic force microscopy revealed that ATP-1 had an amorphous structure and was composed of molecular chain entanglement and intramolecular hydrogen bonding interactions. The microstructure of ATP-1 exhibited asymmetric sheet–like cracks and pores. Results from immunomodulatory activity showed that ATP-1 promoted inducible nitric oxide (NO) synthase and cyclooxygenase (COX)-2 protein expression in RAW264.7 macrophages， improved macrophage phagocytic ability， and stimulated cytokine production (NO， tumor necrosis factor [TNF]-α， and interleukin [IL]-6). Quantitative proteome analysis identified 178 differentially expressed proteins (70 upregulated and 108 downregulated) that were involved in various molecular pathways， among which， TNF was one of the 20 most common and significant signaling pathways in inflammation and immunoregulation. Western blotting indicated that ATP-1 significantly upregulated the expression of IKKα， IKKβ， COX-2， and TNF-α proteins in the TNF pathway. In contrast， ATP-1 downregulated the expression of IκBα， Fas， and AIPI. Results from molecular docking suggested that hydrogen bonding predominantly contributed to the affinity between TNF-α and galactose， glucose， and xylose. These findings indicated that ATP-1 may play an immunomodulatory role by activating the TNF signaling pathway. ATP-1 enhanced macrophage phagocytic capacity and stimulated the production of cytokines NO， TNF-α， and IL-6， thereb

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Punicalagin alleviates hypercholesterolemia in mice through modulating farnesoid X receptor signaling and modulating gut microbiota

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food Science and Human Wellness 2025年第1期14卷 175-189页

作者： Huanhuan Liu Hongli Liu Chunhong Yan Jiaxiu Liu Yu Cao Guopeng Li Xiaodong Xia State Key Laboratory of Marine food processing and Safety Control National Engineering Research Center of SeafoodSchool of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Beijing Advanced Innovation Center for food Nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Punicalagin has been demonstrated to exhibit anti-oxidant and anti-inflammatory properties,but whether and how it could impact hypercholesterolemia remains not fully *** aim of this study was to investigate the influence of punicalagin on hypercholesterolemia in mice and its related *** 6 weeks'intervention,punicalagin significantly reduced serum total cholesterol and low-density lipoprotein cholesterol(LDL-C)levels in mice fed a high-fat high-cholesterol(HFHC)***,punicalagin supplementation lowered hepatic cholesterol level,which corresponded to the down-regulation of cholesterol synthesis genes(Fdps,Cyp51)and up-regulated bile acid synthesis genes(Cyp7a1,Cyp27a1).In addition,bile acid reabsorption was retarded in punicalagin-fed mice through down-regulating ileal apical sodium-dependent BA transporter(ASBT).Furthermore,intestinal farnesoid X receptor(FXR)-fibroblast growth factor 15(Fgf15)pathway was inhibited while hepatic FXR-small heterodimeric partner(SHP)pathway was activated in punicalagin *** analysis and targeted metabolomics showed that punicalagin decreased the abundance of bile-salt hydrolase(BSH)-producing bacteria(Clostridiaceae and Bifidobacteriaceae)and the ratio of primary BAs to secondary *** conclusion,the cholesterol-lowering effect of punicalagin partly through down-regulating cholesterol synthesis and increasing cholesterol catabolism,which could be achieved by regulating gut microbiota,altering bile acid composition and modulating FXR signaling *** findings indicate the potential application of punicalagin-related products as an alternative strategy for hypercholesterolemia prevention and mitigation.

关键词： Punicalagin Hypercholesterolemia Farnesoid X receptor Bile acid metabolism Gut microbiota

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Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang Chenyang Zhang Linlin Wu Wei Sun Hongliang Zhang Jianhua Chen Yong Pei Songjiang Li Engineering research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

Mitochondria-targeted nanoparticles for encapsulating astaxanthin:exploring the reason for alleviating oxidative damage

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food Science and Human Wellness 2025年第1期14卷 124-133页

作者： Yannan Chen Siyuan Fei Lijuan Zhang Mingqian Tan Academy of food Interdisciplinary Science School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China National Engineering research Center of Seafood Dalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep processing Dalian Polytechnic UniversityDalian 116034China

Oxidative stress is considered as a critical factor in the process of pathological diseases,and mitochondria are considered as vital target organelles for disease *** purpose of this study was aimed to evaluate the antioxidant efficacy of mitochondria-targeted astaxanthin nanoparticle on hydrogen peroxideinduced oxidative *** expected,mitochondria-targeted nanoparticle showed excellent mitochondria co-localization ability with higher Pearson's correlation coefficient(r=0.88).In vitro experiments suggested that the mitochondria-targeted astaxanthin nanoparticle could promote cell viability and increase antioxidantrelated enzyme ***,metabolomics analysis indicated that mitochondria-targeted astaxanthin nanoparticle could alleviate oxidative stress by regulating amino acid metabolism and energy ***,all these results strongly confirmed the mitochondria-targeted strategy for astaxanthin delivery could relieve oxidative stress and had great promise in the application of disease intervention.

关键词： Oxidative stress Mitochondria-targeted Astaxanthin Antioxidant Metabolism

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Expression and characterization of a novel GH128 laminarinase OUC-Bs Lam26 harboring both hydrolyzing and transferring activities

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food Science and Human Wellness 2025年第1期14卷 134-143页

作者： Yueyang Dong Yongyi Quan Hong Jiang Hamed I.Hamouda Zewei Lu Yimiao Chen Chengqiang Li Xiangzhao Mao State Key Laboratory of Marine food processing and Safety Control College of Food Science and EngineeringOcean University of ChinaQingdao 266404China Qingdao Key Laboratory of food Biotechnology Qingdao 266404China Key Laboratory of Biological processing of Aquatic Products China National Light IndustryQingdao 266404China Sanya Ocean research Institute Ocean University of ChinaSanya 572025China Processes Design and Development Department Egyptian Petroleum Research InstituteCairo 11727Egypt Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China

Laminarin oligosaccharides(LOSs)with a specific degree of polymerization prepared through the laminarin degradation via laminarinase present more significant nutritional functions and application *** intestinal bacteria are promising potential producers of novel carbohydrate-active enzymes with unique ***,a novel glycoside hydrolase family 128(GH128)laminarinase OUC-BsLam26 from the intestinal bacterium Bacteroides ***7301 was heterologously expressed and *** recombinant OUC-BsLam26 with a molecular mass of 49.86 kDa exhibits highest activity(6.60 U/mg)at 45℃ and pH 6.0,which shows noticeable temperature and pH *** purified OUC-BsLam26 could degrade laminarin via an endo-type mode with the generation of laminaripentaose,laminaritetraose,laminaritriose,and laminaribiose,among them,laminaritetraose is the principal product,which accounts for 45.25% of the total products,which is significantly different from the reported GH128 *** minimum recognition substrate of OUC-BsLam26 is ***,OUC-BsLam26 also could catalyze the transglycosylation process with the production of some novel ***,the intestinal bacterium Bacteroides ***7301 contains laminarinase with unique product composition and OUC-BsLam26 is a hopeful bio-catalyst with the potential to produce laminaritetraose and some novel glycosides.

关键词： Laminarinase Expression Laminarin oligosaccharides Hydrolytic pattern Novel glycosides

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