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Attosecond Delays of High-Harmonic Emissions from Hydrogen Isotopes Measured by XUV Interferometer

Ultrafast Science 2022年第5期2卷 21-26页

作者： Mumta Hena Mustary Liang Xu Wanyang Wu Nida Haram Dane E.laban Han Xu Feng He R.T.Sang Igor V.Litvinyuk Centre for Quantum Dynamics Griffith UniversityBrisbaneQueensland 4111Australia Key Laboratory for Laser Plasmas(Ministry of Education)and School of Physics and Astronomy Collaborative Innovation Center for IFSA(CICIFSA)Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Lab of Modern Optical System University of Shanghai for Science and Technology200093 ShanghaiChina CAS center for Excellence in Ultra-Intense Laser Science Shanghai 201800China

High-harmonic spectroscopy can access structural and dynamical information on molecular systems encoded in the amplitude and phase of high-harmonic generation(HHG)***,measurement of the harmonic phase is a daunting ***,we present a precise measurement of HHG phase difference between two isotopes of molecular hydrogen using the advanced extreme-ultraviolet(XUV)Gouy phase *** measured phase difference is about 200 mrad,corresponding to~3 attoseconds(1 as=10−18 s)time delay which is nearly independent of harmonic *** measurements agree very well with numerical calculations of a four-dimensional time-dependent Schödinger *** simulations also reveal the effects of molecular orientation and intramolecular two-center interference on the measured phase *** technique opens a new avenue for measuring the phase of harmonic emission for different atoms and *** with isomeric or isotopic comparisons,it also enables the observation of subtle effects of molecular structures and nuclear motion on electron dynamics in strong laser fields.

关键词： equation harmonic precise

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Classifying Globular Clusters and Applying them to Estimate the mass of the Milky Way

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research in Astronomy and Astrophysics 2023年第1期23卷 127-152页

作者： GuangChen Sun Yougang Wang Chao Liu Richard J.Long Xuelei Chen Qi Gao Department of Physics College of ScienceTibet UniversityLhasa 850000China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Department of Astronomy Tsinghua UniversityBeijing 100084China Jodrell Bank Centre for Astrophysics Department of Physics and AstronomyThe University of ManchesterOxford RoadManchester M139PLUK Department of Physics College of SciencesNortheastern UniversityShenyang 110819China center of High Energy Physics Peking UniversityBeijing 100871China

We combine the kinematics of 159 globular clusters(GCs) provided by the Gaia Early Data Release 3(EDR3) with other observational data to classify the GCs,and to estimate the mass of the Milky Way(MW).We use the agemetallicity relation,integrals of motion,action space and the GC orbits to identify the GCs as either formed in situ(Bulge and Disk) or ex situ(via accretion).We find that 45.3% have formed in situ,while 38.4% may be related to known merger events:Gaia-Sausage-Enceladus,the Sagittarius dwarf galaxy,the Helmi streams,the Sequoia galaxy and the Kraken *** also further identify three new sub-structures associated with the *** remaining 16.3% of GCs are unrelated to the known mergers and thought to be from small accretion *** select 46 GCs which have radii 8.0

关键词： Galaxy kinematics and dynamics-Galaxy fundamental parameters-Galaxy halo-(Galaxy:)globular clusters general

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Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K /MMPs /Ln-5γ2 signaling pathway

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外科研究与新技术 2014年第1期3卷 59-59页

作者： ZHANG Jing-tao SUN Wei ZHANG Wen-zhong GE Chun-yan LIU Zhong-yan ZHAO Zhe-ming LU Xing-sui FAN Yue-zu Department of Surgery Tongji HospitalTongji University School of MedicineTongji University Department of Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineTongji University Department of Surgery Shanghai Pudong New Area People’s Hospital Department of Oncology Shanghai Yangpu Geriatric Hospital

Background:Vasculogenic mimicry(VM)is a novel tumor blood supply in some highly aggressive malignant ***,we reported VM existed in gallbladder carcinomas(GBCs)and the formation of the special passage through the activation of the PI3K/MMPs/Ln-5γ2 signaling *** is a highly aggressive malignant tumor with disappointing treatments and a poor ***(NCTD)has shown to have multiple antitumor activities against GBCs,etc;however the exact mechanism is not thoroughly *** this study,we firstly investigated the anti-VM activity of NCTD as a VM inhibitor for GBCs and its underlying ***:In vitro and in vivo experiments to determine the effects of NCTD on proliferation,invasion,migration,VM formation,hemodynamic and tumor growth of GBC-SD cells and xenografts were respectively done by proliferation,invasion,migration assays,HE staining and CD31-PAS double staining,optic/electron microscopy,tumor assay,and dynamic ***,immunohistochemistry,immunofluorescence,Western blotting and RT-PCR were respectively used to examine expression of VM signaling-related markers PI3-K,MMP-2,MT1-MMP and Ln-5γ2 in GBC-SD cells and xenografts in vitro and in ***:After treatment with NCTD,proliferation,invasion,migration of GBC-SD cells were inhibited;GBC-SD cells and xenografts were unable to form VM-like structures;tumor center-VM region of the xenografts exhibited a decreased signal in intensity;then cell or xenograft growth was *** all of untreated GBC-SD cells and xenografts formed VM-like structures with the same conditions;the xenograft center-VM region exhibited a gradually increased signal;and facilitated cell or xenograft growth(Figure 1-6).Furthermore,expression of MMP-2 and MT1-MMP products from sections/supernates of 3-D matrices and the xenografts,and expression of PI3-K,MMP-2,MM1-MMP and Ln-5γ2 proteins/mRNAs of the xenografts were all decreased in NCTD or TIMP-2 group(Figure 7-10;all P<0.0

关键词：胆囊癌肿瘤治疗方法临床分析

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Representation Learning with Deconvolution for Multivariate Time Series Classification and Visualization

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国际计算机前沿大会会议论文集 2020年第1期 310-326页

作者： Wei Song Lu Liu Minghao Liu Wenxiang Wang Xiao Wang Yu Song Henan Academy of Big Data Zhengzhou UniversityZhengzhou 450001China Department of Computational Linguistics University of WashingtonSeattleWA 98195USA School of Information Engineering Zhengzhou UniversityZhengzhou 450001China Network Management center Zhengzhou UniversityZhengzhou 450001China

We propose a new model based on the convolutional networks and SAX(Symbolic Aggregate Approximation)discretization to learn the representation for multivariate time *** deep neural networks has excellent expressiveness,which is fully exploited by the convolutional networks with means of unsupervised *** design a network structure to obtain the cross-channel correlation with means of convolution and deconvolution,the pooling operation is utilized to perform the dimension reduction along each position of the *** which based on the Symbolic Aggregate Approximation is applied on the feature vectors to extract the bag of *** collect two different representations from the convolutional networks,the compression from bottle neck and the last convolutional *** show how these representations and bag of features can be useful for *** provide a full comparison with the sequence distance based approach on the standard datasets to demonstrate the effectiveness of our *** further build the Markov matrix according to the discretized representation abstracted from the deconvolution,time series is visualized to complex networks through Markov matrix visualization,which show more class-specific statistical properties and clear structures with respect to different labels.

关键词： Multivariate time-series Deconvolution Symbolic aggregate approximation Deep learning Markov matrix Visualization

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Construction and Application of in vitro Alveolar Models Based on 3D Printing Technology

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Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers) 2022年第2期1卷 58-65页

作者： Tiankun Liu Chang Zhou Yongchun Shao Zhuo Xiong Ding Weng Yuan Pang Wei Sun Department of Mechanical Engineering Biomanufacturing CenterTsinghua UniversityBeijing100084China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Beijing100084China State Key Laboratory of Tribology School of Mechanical EngineeringTsinghua UniversityBeijing100084China Department of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104USA

Increasing lung diseases,mutating coronaviruses,and the development of new compounds urgently require biomimetic in vitro lung models for lung pathology,toxicology,and *** current construction strategies for lung models mainly include animal models,2D cell culture,lung-on-a-chip,and lung ***,current models face difficulties in reproducing in vivo-like alveolar size and vesicle-like structures,and are unable to contain multiple cell *** this study,a strategy for constructing alveolar models based on degradable hydrogel microspheres is *** microspheres,200-250μm in diameter,were prepared using a self-developed printing technique driven by alternating viscous and inertial *** were further constructed using a coacervation-based layer-by-layer technique and core *** types of cells were inoculated and co-cultured on hydrogel capsules based on optimized microcapsule surface treatment ***,an in vitro three-dimensional endothelial alveolar model with a multicellular composition and vesicle-like structure with a diameter of approximately 230μm was successfully *** in the constructed alveolar model maintained a high survival *** LD_(50)values of glutaraldehyde based on the constructed models were in good agreement with the reference values,validating the potential of the model for future toxicant and drug detection.

关键词： 3D printing Lung model Hydrogel beads Microcapsule Toxicity test

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从磷酸酯化学刍议各类磷酸酶和三磷酸核苷酶的生物化学转化与机制

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化学教育（中英文） 2023年第8期44卷 19-29页

作者：王志鹏蒋振雄 Maggie Chen 张璇马新雨车子良 Division of Genetics Department of MedicineBrigham and Women's HospitalDepartment of Biological Chemistry and Molecular PharmacologyHarvard Medical SchoolBostonMA 02115USA Department of Chemistry Texas A&M UniversityCollege StationTX77840USA 清华大学化学系北京100084 Department of Biology Texas A&M UniversityCollege StationTX 77840USA Computational Biology and Bioinformatics Program Duke Center for Genomics and Computational BiologyDuke University School of MedicineDurhamNC 27705USA Department of Microbiology Miami UniversityOxfordOH 45056USA Department of Chemistry and Chemical Biology Harvard UniversityCambridgeMA02138US 清华大学生命学院北京100084 Department of Mathematics Harvard UniversityMA 02138 Citadel Securities LLC131 SouthDearborn St.Chicago Illinois 60603USA

磷作为一切生物体的必需元素,参与了包括生命体能量代谢、结构调控、遗传信息传递等在内的必要过程,其重要性不言而喻。然而,在国内基础学科教学过程中,基于酶促反应的调控机制和反应机理被拆分到众多生化专业相关的课程中,并未能得到... 详细信息

磷作为一切生物体的必需元素,参与了包括生命体能量代谢、结构调控、遗传信息传递等在内的必要过程,其重要性不言而喻。然而,在国内基础学科教学过程中,基于酶促反应的调控机制和反应机理被拆分到众多生化专业相关的课程中,并未能得到系统性的剖析与讲解。本文从基础磷酸酯和磷酸酐的化学结构及反应特性入手,分别讨论了生物体中磷酸酯相关的调控酶类,并对最重要的一类磷酸酐——三磷酸腺苷在生物体内的转化关系做了系统性的讲解及分析。作为对磷元素相关的生命化学过程的梳理归纳,希望对化学及生命科学的教学与科研实验设计有所助益。

关键词：磷化学磷酸酯酶促反应激酶三磷酸腺苷

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