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Patterns, processes, and differentiation mechanisms of China's transition from old to new economic drivers

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Journal of Geographical Sciences 2024年第9期34卷 1697-1718页

作者： YAN Mingtao ZHAO Jianji YAN Mingyue Key research Institute of Yellow River Civilization and Sustainable Development Henan UniversityKaifeng 475001HenanChina Collaborative Innovation center on Yellow River Civilization Jointly Built by Henan Province and Ministry of Education Henan UniversityKaifeng 475001HenanChina College of Cultural and Tourism Henan UniversityKaifeng 475001HenanChina

Transition from old to new economic drivers(TONED) is of great significance for optimizing economic structures. Using a combination of methods including entropy weight technique for order preference by similarity to ideal solution, geospatial analysis, and optimal parameter geodetector, this study investigates the patterns and mechanisms of China's TONED in the prefecture-level cities from 2011 to 2020. The findings reveal that(1) the TONED exhibited a spatial distribution characterized by higher levels in the east and lower levels in the west, along with a pyramidal hierarchy of levels. The distribution of hot and cold spots roughly followed the Heihe-Yulin line.(2) The informatization levels, openness to the outside world, and urbanization played a dominant role in the TONED. The types of dual-factor interactions exhibited both dual-factor enhancement and non-linear enhancement effects.(3) The eastern and central regions were more likely to promote the TONED through enhanced informatization levels, whereas the western region relied more on increasing openness. This study finds that the TONED results from the combined effects of three geographical natures, each playing a distinct role. The recommendations provided can serve as a reference for China and other developing countries to implement the TONED in the context of deglobalization.

关键词： transition from old to new economic drivers pattern evolution differentiation mechanism geographical nature China

Inhibition mechanisms of CRISPR-Cas9 by AcrⅡA25.1 and AcrⅡA32

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Science China(Life Sciences) 2024年第9期67卷 1781-1791页

作者： Jianlin Zheng Yuwei Zhu Tengjin Huang Wenbo Gao Jiale He Zhiwei Huang HIT center for Life Sciences School of Life Science and TechnologyHarbin Institute of TechnologyHarbin 150080China Westlake center for Genome Editing Westlake Laboratory of Life Sciences and BiomedicineSchool of Life SciencesWestlake UniversityHangzhou 310024China

In the ongoing arms race between bacteria and bacteriophages,bacteriophages have evolved anti-CRISPR proteins to counteract bacterial CRISPR-Cas ***,AcrⅡA25.1 and AcrⅡA32 have been found to effectively inhibit the activity of Spy Cas9 both in bacterial and human ***,their molecular mechanisms remain ***,we report the cryo-electron microscopy structures of ternary complexes formed by AcrⅡA25.1 and AcrⅡA32 bound to Spy Cas9-sg *** structural analysis and biochemical experiments,we revealed that AcrⅡA25.1 and AcrⅡA32 recognize a novel,previously-unidentified anti-CRISPR binding site on Spy *** found that both AcrⅡA25.1 and AcrⅡA32 directly interact with the WED domain,where they spatially obstruct conformational changes of the WED and PI domains,thereby inhibiting Spy Cas9 from recognizing protospacer adjacent motif(PAM)and unwinding double-stranded *** addition,they may inhibit nuclease activity by blocking the dynamic conformational changes of the Spy Cas9 surveillance *** summary,our data elucidate the inhibition mechanisms of two new anti-CRISPR proteins,provide new strategies for the modulation of Spy Cas9 activity,and expand our understanding of the diversity of anti-CRISPR protein inhibition mechanisms.

关键词： anti-CRISPR cryo-EM Spy Cas9 AcrⅡA25.1 AcrⅡA32 inhibiton

Substitutions of stem-loop subdomains in internal ribosome entry site of Senecavirus A:Impacts on rescue of sequence-modifying viruses

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Journal of Integrative Agriculture 2024年第7期23卷 2391-2406页

作者： Qianqian Wang Jie Wang Lei Zhang Xiaoxiao Duan Lijie Zhu Youming Zhang Yan Li Fuxiao Liu College of Veterinary Medicine Qingdao Agricultural UniversityQingdao 266109China College of Veterinary Medicine Inner Mongolia Agricultural UniversityHuhhot 010018China Shandong new Hope Liuhe Group Co. Ltd.Qingdao 266100China Qingdao center for Animal Disease Control&Prevention Qingdao 266199China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

Senecavirus A(SVA)has a positive-sense,single-stranded RNA *** 5´untranslated region harbors an internal ribosome entry site(IRES),comprising 10 larger or smaller stem-loop structures(including a pseudoknot)that have been demonstrated to be well ***,it is still unclear whether each stem-loop subdomain,such as a single stem or loop,is also highly *** clarify this issue in the present study,a set of 29 SVA cDNA clones were constructed by site-directed mutagenesis(SDM)on the *** SDM-modified scenarios included:(1)stem-formed complementary sequences exchanging with each other;(2)loop transversion;(3)loop transition;and(4)point *** cDNA clones were separately transfected into cells for rescuing viable viruses,whereas only four SVAs of interest could be recovered,and were genetically stable during 20 *** progeny grew significantly slower than the other three *** dual-luciferase reporter assay showed that none of the SDM-modified IRESes significantly inhibited the IRES *** previous study indicated that a single motif from any of the ten stem structures,if completely mutated,would cause the failure of virus ***,our present study revealed three stem structures,whose individual complementary sequences could exchange with each other to rescue sequence-modifying ***,one apical loop was demonstrated to have the ability to tolerate its own full-length transition,also having no impact on the recovery of sequence-modifying *** present study suggested that not every stem-loop structure was strictly conserved in its conformation,while the full-length IRES itself was well *** provides a new research direction on interaction between the IRES and many factors.

关键词： SVA HCV IRES HCV-like IRES stem-loop structure cDNA clone virus rescue mutation

Recent progress of radionuclides separation by porous materials

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Science China Chemistry 2024年

作者： Yinghui Xie Long Yu Long Chen Cheng Chen Li Wang Fenglei Liu Yun Liao Peng Zhang Tao Chen Yihui Yuan Yuexiang Lu Boyang Huang Hui Yang Suhua Wang Shuao Wang Lijian Ma Feng Luo Yunhai Liu Baowei Hu Hongqing Wang Duoqiang Pan Wenkun Zhu Ning Wang Zhe Wang Liang Mao Shengqian Ma Xiangke Wang State Key Laboratory of Marine Resource Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology Hainan University Institute of Nuclear and new Energy Technology Tsinghua University State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University Department of Chemistry University of North TexasDenton Guangdong Provincial Key Laboratory for Green Agricultural Production and Intelligent Equipment School of Environmental Science and Engineering Guangdong University of Petrochemical Technology School of Life Science Shaoxing University College of Environmental Science and Engineering North China Electric Power University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University College of Chemistry Sichuan University School of Chemistry and materials Science East China University of Technology School of Chemistry and Chemical Engineering University of South China Frontiers Science center for Rare Isotopes Lanzhou University State Key Laboratory of Environment-friendly Energy materials National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety Sichuan Civil-military Integration Institute School of National Defence & Nuclear Science and TechnologySouthwest University of Science and Technology

The separation of radionuclides is critical for the sustainable development of nuclear energy. It is urgent to design and prepare functionalized materials for efficient radionuclides separation. Porous materials are considered excellent candidates for the separation of radionuclides under complex conditions due to their high specific surface areas, tunable pore structures and controllable functionalities. In this review, we summarized the design, preparation and functionalization of porous materials and their application for separation of radionuclides in the past five years, discussed the separation performance and analyzed the structure-activity relationship between various radionuclides and porous materials, and systematically clarified their characterization and mechanism of different type porous materials. We also introduced the detection, irradiation and chemical toxicity of different reflective radionuclides.

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A surfactant-modified composite separator for high safe lithium ion battery

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Journal of Energy Chemistry 2023年第1期76卷 398-403,I0010页

作者： Botao Yuan Niandong He Yifang Liang Liwei Dong Jipeng Liu Jiecai Han Weidong He Yuanpeng Liu National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080HeilongjiangChina MIIT Key Laboratory of Critical materials Technology for new Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150080HeilongjiangChina Chongqing research Institute Harbin Institute of TechnologyChongqing 401151China

Separators have been gaining increasing attention to improve the performance of lithium ion batteries(LIBs),especially for high safe and long cycle ***,commercial polyolefin separators still face the problems of rapid capacity decay and safety issues due to the poor wettability with electrolytes and low thermal ***,a novel composite separator is proposed by introducing a surfactant of sodium dodecyl thiosulfate(SDS)into the polytetrafluoroethylene(PTFE)substrate with the binder of polyacrylic acid(PAA)through the suction filtration *** introduction of PAA/SDS enhances the adsorption energy between PTFE substrate and electrolyte through density functional theory calculations,which improves wettability and electrolyte uptake of the separator *** asachieved composite separator enables the LIBs to own high Li^(+)conductivity(0.64×10^(-3)S cm^(-1))and Li^(+)transference number(0.63),further leading to a high capacity retention of 93.50%after 500 cycles at 1 *** addition,the uniform and smooth surface morphology of Li metal employed the composite separator after cycling indicates that the lithium dendrites can be successfully *** work indicates a promising route for the preparation of a novel composite separator for high safe LIBs.

关键词： Composite separator PTFE Surfactant High safe Lithium ion batteries

Self-powered and broadband germanium/PEDOT:PSS heterojunction photodetectors for near-infrared biomedical imaging applications

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Science China(Technological Sciences) 2021年第11期64卷 2523-2531页

作者： WU QiuYue LIU YuJin HUANG XinYue ZHENG Xu HE JieZhong JI Zhong MAI WenJie Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsDepartment of PhysicsJinan UniversityGuangzhou 510632China

To develop high-performance photodetectors(PDs) as near-infrared(NIR) imaging sensors, researchers have either proposed new photoelectric materials, introduced complicated interface-processing steps, or created complex optical structures. In this study, we introduce a solution-processed organic material, PEDOT:PSS(PEDOT corresponds to a polymer of 3,4-ethylene dioxythiophene(EDOT), and PSS corresponds to a polystyrene sulfonate), to germanium(Ge) wafers using a convenient spincoating method to improve the photoresponse performance of Ge-based PDs. The Ge wafers and PEDOT:PSS form a heterojunction that reduces the dark current when compared with the Ge Schottky PD(Au/Ge/Ag PD). The experimental results show that the Au/PEDOT:PSS/Ge/Ag heterojunction PD with a bias voltage of 0 V at 1550 nm exhibits a responsivity(R) of 0.26 A/W,a detectivity(D*) of 6.5×1011 Jones, a linear dynamic range(LDR) of 124 d B, and a bandwidth(-3 dB) of 10 k Hz. This implies that the performance of the PD is comparable to that of previously reported Ge-based PDs. Subsequently, a biomedical imaging application of the PD is successfully demonstrated through foreign-body detection. Therefore, it is expected that the selfpowered Au/PEDOT:PSS/Ge/Ag PD will be highly suitable for NIR imaging.

关键词： gemanium photodetectors PEDOT:PSS heterojunction self-powered photodetectors near-infrared biomedical imaging

HIGH-SPEED FLOW EROSION ON A new ROLLER COMPACTED CONCRETE DAM DURING CONSTRUCTION

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Journal of Hydrodynamics 2012年第1期24卷 32-38页

作者： WANG Xin LUO Shao-ze HU Ya-an YUAN Qiang WANG He-sheng ZHAO Lan-hao hydraulic Engineering Department Nanjing Hydraulic Research InstituteNanjing 210029China State Key Laboratory of Hydrology-Water Resources and hydraulic Engineering -Nanjing 210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China

A new roller compacted concrete dam of Fengman Hydropower Station is to be built in the toe of the old dam,which was identified as a dangerous *** new dam during construction would be influenced by the high-speed flow discharged from the old dam,which is an important problem to be considered for the first time in China,and which would affect the construction of the whole ***,a series of erosion experiments were conducted in this article.A high-speed flow erosion test apparatus was developed for the erosion experiments of the new dam *** maximum jet velocity goes up to 40 m/s and the section area of the nozzle is 0.0025 *** the process of experiments,the equipment shows a good *** wear tests for two types of materials used in the new dam,a roller compacted concrete and a distorted concrete with four kinds of ages were carried out with the flow velocity in the range of 30 m/s-35 m/*** parameters and erosion laws for the two types of concretes with different ages were determined,and a general relationship between the erosion rate and the flow velocity is obtained as：,with the velocity exponent between 3.33 and *** is concluded that the erosion resistance of the distorted concrete is better than that of the roller compacted concrete and the mechanical properties of the concretes of over 14 d age are influenced slightly by the water *** test results might serve as a practical technique guide for the safety of this project during its construction in the flood season.

关键词： high-speed flow impact apparatus erosion test roller compacted concrete hydraulic structures

Cyclic behavior test of a new double-arch steel gate

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第11期8卷 1731-1739页

作者： LUO Yao-zhi ZHU Shi-zhe CHEN Xi Space structures research center Zhejiang University Hangzhou 310027 China School of Landscape Architecture and Art Zhejiang Forestry University Hangzhou 311300 China

A new double-arch structure for the gate used as tidal barrage and sluice was adopted in Caoe River Dam in China. It was a spatial structure made up of the right arch, the invert arch, the chord, etc., and was designed to bear bilateral loads. To research the cyclic behavior of the new double-arch structure, a scale-model cyclic test was conducted. First, the test setup and test method were presented in detail, and according to the test results, the cyclic behavior and failure characteristics of this structure were discussed. Then by analyzing the test cyclic envelope curve, it was found the curve was divided into three stages: the elastic stage, the local plastic stage and the failure stage at the local yield point and structural yield point. The gate model has local yield strength and structural yield strength, with both their values being bigger than that of the designing load. Therefore, the gate is safe enough for the projects. At last, dynamic property of the gate was analyzed considering additional mass of the water. It was found that the tidal bore shock would not cause resonance vibration of the gate.

关键词： Double-arch steel gate Cyclic behavior test Cyclic envelope curve Dynamic property

Experimental Study on Wave Attenuation Performance of A new Type of Floating Breakwater with Twin Pontoons and Multi Porous Vertical Plates

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China Ocean Engineering 2022年第3期36卷 384-394页

作者： SHEN Yu-sheng PAN Jun-ning ZHOU Yi-ren WANG Xing-gang River and Harbour Engineering Department Nanjing Hydraulic Research InstituteNanjing 210029China State Key Laboratory of Hydrology-Water Resources and hydraulic Engineering Nanjing 210024China

A floating breakwater(FB)has extensive potential applications in the fields of coastal,offshore,and ocean engineering owing to its advantages such as eco-friendliness,low cost,easy and rapid construction,and quick dismantling and *** FB composed of twin pontoons and multi-porous vertical plates is proposed to improve the wave attenuation *** wave attenuation performance is investigated for different FB structures and vertical plate types under different incident wave heights and periods using 2D wave physical model tests in a wave *** results demonstrate that the proposed FB has a better performance than that of the conventional single pontoon-type *** reduces the wave transmission due to its enhanced wave reflection and energy *** wave transmission coefficient of the proposed FB decreases with an increase in the number of layers and relative draft depth of the vertical ***,a further decrease in the wave transmission coefficient is not observed when the number of porous vertical plates is increased from 4 to 5 *** equation has been derived to predict the wave transmission of the proposed FB based on the experimental results.

关键词： Floating breakwater twin pontoons porous vertical plates layer numbers relative draft wave attenuation performance experimental model test