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Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury

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research 2024年第1期2023卷 17-32页

作者： Bolin Zheng Yijing He Shuai Yin Xu Zhu Qing Zhao Huiyi Yang Zhaojie wang Rongrong Zhu Liming Cheng Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration Ministry of EducationDepartment of OrthopedicsTongji HospitalSchool of MedicineTongji UniversityShanghai 200092China Frontier science center for Stem Cell research School of Life Science and TechnologyTongji UniversityShanghai 200092China Clinical center for Brain and Spinal Cord research Tongji UniversityShanghai 200092China

Spinal cord injury triggers complex pathological cascades,resulting in destructive tissue damage and incomplete tissue *** formation is generally considered a barrier for regeneration in the central nervous ***,the intrinsic mechanism of scar formation after spinal cord injury has not been fully ***,we report that excess cholesterol accumulates in phagocytes and is inefficiently removed from spinal cord lesions in young adult ***,we observed that excessive cholesterol also accumulates in injured peripheral nerves but is subsequently removed by reverse ***,preventing reverse cholesterol transport leads to macrophage accumulation and fibrosis in injured peripheral ***,the neonatal mouse spinal cord lesions are devoid of myelin-derived lipids and can heal without excess cholesterol *** found that transplantation of myelin into neonatal lesions disrupts healing with excessive cholesterol accumulation,persistent macrophage activation,and *** internalization suppresses macrophage apoptosis mediated by CD5L expression,indicating that myelin-derived cholesterol plays a critical role in impaired wound *** together,our data suggest that the central nervous system lacks an efficient approach for cholesterol clearance,resulting in excessive accumulation of myelin-derived cholesterol,thereby inducing scar formation after injury.

关键词： healing Spinal impaired

data as a Factor of Production Promoting the Deep Integration of the Digital economy and the Real economy:Theoretical Logic and Analysis Framework

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2024年第2期19卷 129-153页

作者： OUYANG Rihui China center for Internet economy research Central University of Finance and EconomicsBeijing 100081China

data is the primary factor of production in the digital economy,playing a role in promoting the deep integration of the digital economy and the real economy and smoothing the national economic *** entering the circulation system of the real economy,data is rapidly integrated into production,circulation,consumption,distribution,and other *** optimizes resource allocation,unblocks circulation channels,promotes accurate matching of supply and demand,stimulates emerging demand,and forms a virtuous circle of digital technology application,traditional physical enterprise transformation,and technological *** development is an important feature of the digital *** promotes the integration of factors of production,products,enterprises,industries,and markets,which fosters a circular system with deep integration of the digital economy and the real *** promote the deep integration of the digital economy and the real economy,the government and business entities should take measures to improve the circular efficiency of the digital economy and the real *** measures include attaching importance to the role of data-driven development,improving data capacity,data development,and utilization in enterprises,exploring diverse circulation models of enterprise data,and creating typical application scenarios and industrial data spaces.

关键词： data data as a factor of production(data factor) digital economy real economy integrated development

Genome-wide CRISPR screening reveals key genes and pathways associated with 20-hydroxyecdysone signal transduction in the silkworm(Bombyx mori)

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Insect science 2024年第1期31卷 47-58页

作者： Hao Sun Jingya Chen Ruolin Wang Dan Liu Na Zhang Tong Zhang Ling Jia Sanyuan Ma Qingyou Xia State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqingChina Biological science research center Southwest UniversityChongqingChina

Metamorphosis is a complex developmental process involving multiple pathways and a large number of genes that are regulated by juvenile hormone(JH)and 20-hydroxyecdysone(20E).Despite important progress in understanding various aspects of silkworm biology,the hormone signaling pathway in the silkworm remains poorly ***-wide screening using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)-based libraries has recently emerged as a novel method for analyzing genome function,enabling further research into essential genes,drug targets,and virus-host ***,we constructed a genome-wide CRISPR/Cas9-based library of the silkworm(Bombyx mori)and successfully revealed the genes involved in biotic or abiotic stress factor *** this study,we used our silkworm CRISPR library and large-scale genome-wide screening to analyze the key genes in the silkworm 20E signaling pathway and their mechanisms of *** annotation showed that 20E regulates key proteins in processes that mainly occur in the cytoplasm and *** enrichment analysis showed that 20E can activate phosphorylation and may affect innate immunity,interfere with intracellular nutrition and energy metabolism,and eventually cause cell *** screening results were experimentally validated by generating cells with knockout alleles of the relevant genes,which had increased tolerance to *** findings provide a panoramic overview of signaling in response to 20E in the silkworm,underscoring the utility of genome-wide CRISPR mutant libraries in deciphering hormone signaling pathways and the mechanisms that regulate metamorphosis in insects.

关键词： CRISPR/Cas9 CRISPR library screening ecdysone 20E signal transduction silkworm whole genome editing

Ghost Module Based Residual Mixture of Self-Attention and Convolution for Online Signature Verification

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Computers, Materials & Continua 2024年第4期79卷 695-712页

作者： Fangjun Luan Xuewen Mu Shuai Yuan Department of Computer Technology School of Computer Science and EngineeringShenyang Jianzhu UniversityShenyang110168China Liaoning Province Big data Management and Analysis Laboratory of Urban Construction Shenyang Jianzhu UniversityShenyang110168China Shenyang Branch of National Special Computer Engineering Technology research center Shenyang Jianzhu UniversityShenyang110168China

Online Signature Verification (OSV), as a personal identification technology, is widely used in various ***, it faces challenges, such as incomplete feature extraction, low accuracy, and computational heaviness. Toaddress these issues, we propose a novel approach for online signature verification, using a one-dimensionalGhost-ACmix Residual Network (1D-ACGRNet), which is a Ghost-ACmix Residual Network that combines convolutionwith a self-attention mechanism and performs improvement by using Ghost method. The Ghost-ACmix Residualstructure is introduced to leverage both self-attention and convolution mechanisms for capturing global featureinformation and extracting local information, effectively complementing whole and local signature features andmitigating the problem of insufficient feature extraction. Then, the Ghost-based Convolution and Self-Attention(ACG) block is proposed to simplify the common parts between convolution and self-attention using the Ghostmodule and employ feature transformation to obtain intermediate features, thus reducing computational ***, feature selection is performed using the random forestmethod, and the data is dimensionally reducedusing Principal Component Analysis (PCA). Finally, tests are implemented on the MCYT-100 datasets and theSVC-2004 Task2 datasets, and the equal error rates (EERs) for small-sample training using five genuine andforged signatures are 3.07% and 4.17%, respectively. The EERs for training with ten genuine and forged signaturesare 0.91% and 2.12% on the respective datasets. The experimental results illustrate that the proposed approacheffectively enhances the accuracy of online signature verification.

关键词： Online signature verification feature selection ACG block ghost-ACmix residual structure

Security and Privacy in Solar Insecticidal Lamps Internet of Things:Requirements and Challenges

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 58-73页

作者： Qingsong Zhao Lei Shu Kailiang Li Mohamed Amine Ferrag Ximeng Liu Yanbin Li the College of Artificial Intelligence Nanjing Agricultural UniversityNanjing 210031 the State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023 the State Key Laboratory of Cryptology Beijing 100878China IEEE the School of Engineering University of LincolnLincoln LN67TSUK the Artificial Intelligence and Digital science research center Technology Innovation InstituteMasdar City 9639UAE the College of Computer and data science Fuzhou UniversityFuzhou 350108China

Solar insecticidal lamps(SIL) can effectively control pests and reduce the use of pesticides. Combining SIL and Internet of Things(IoT) has formed a new type of agricultural IoT,known as SIL-IoT, which can improve the effectiveness of migratory phototropic pest control. However, since the SIL is connected to the Internet, it is vulnerable to various security *** issues can lead to serious consequences, such as tampering with the parameters of SIL, illegally starting and stopping SIL,etc. In this paper, we describe the overall security requirements of SIL-IoT and present an extensive survey of security and privacy solutions for SIL-IoT. We investigate the background and logical architecture of SIL-IoT, discuss SIL-IoT security scenarios, and analyze potential attacks. Starting from the security requirements of SIL-IoT we divide them into six categories, namely privacy, authentication, confidentiality, access control, availability,and integrity. Next, we describe the SIL-IoT privacy and security solutions, as well as the blockchain-based solutions. Based on the current survey, we finally discuss the challenges and future research directions of SIL-IoT.

关键词： Challenges Internet of Things(IoT) privacy and security security requirements solar insecticidal lamps(SIL)

Experimental and computational optimization of Prussian blue analogues as high-performance cathodes for sodium-ion batteries:A review

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Journal of Energy Chemistry 2024年第6期93卷 627-662,I0015页

作者： Gwangeon Oh Junghoon Kim Shivam Kansara Hyokyeong Kang Hun-Gi Jung Yang-Kook Sun Jang-Yeon Hwang Department of Energy Engineering Hanyang UniversitySeoul 04763Republic of Korea Energy Storage research center Clean Energy Research DivisionKorea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Energy science Sungkyunkwan UniversitySuwon 16419Republic of Korea KIST-SKKU Carbon-Neutral research center Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Battery Engineering Hanyang UniversitySeoul 04763Republic of Korea

In this review,we discuss the electrochemical properties of Prussian blue(PB)for Na^(+)storage by combining structural engineering and electrolyte *** integrated experimental data and density functional theory(DFT)in sodium-ion battery(SIB)research to refine the atomic arrangements and crystal lattices and introduce substitutions and *** changes affect the lattice stability,intercalation,electronic and ionic conductivities,and electrochemical *** unraveled the intricate structure-electrochemical behavior relationship by combining experimental data with computational models,including first-principles *** holistic approach identified techniques for optimizing PB and Prussian blue analog(PBA)structu ral properties for *** also discuss the tuning of electrolytes by systematically adjusting their composition,concentration,and additives using a combination of molecular dynamics(MD)simulations and DFT *** review offers a comprehensive assessment of strategies for enhancing the electrochemical properties of PB and PBAs through structural engineering and electrolyte modifications,combining experimental insights with advanced computational simulations,and paving the way for next-generation energy storage systems.

关键词： Prussian blue analogs(PBAs) Sodium ion batteries(SIBs) Structural engineering Electrolyte modifications Experiments Density functional theory(DFT)

Handgrip Strength and Low Muscle Strength Rate in Chinese Adults-China,2020

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China CDC weekly 2024年第32期6卷 821-824,I0004-I0006页

作者： Jiarong Zhu Jingjing Wang Chaoqun Fan Dongming Wu Qiang Feng Department of National Fitness and Scientific Exercise research center China Institute of Sport ScienceBeijingChina

Summary What is already known on this topic?Handgrip strength(HS)serves as a diagnostic marker for low muscle strength rate(LMSR)and reflects the level of skeletal *** the past two decades,global data indicate a downward trend in HS across various *** is added by this report?According to the latest national data,the mean HS among Chinese adults aged 20 years and older was recorded at 40.4 kg for males and 25.1 kg for females in 2020.A decline in HS was observed with increasing age,particularly among ***,lower HS values were reported in rural areas,whereas LMSR was more prevalent in these *** are the implications for public health practice?The analysis of HS and LMSR among Chinese adults is essential for the development and implementation of targeted interventions aimed at improving HS prevalence *** analysis is highly significant for public health,contributing to increased public awareness of LMSR and the promotion of preventative measures.

关键词： strength promotion analysis

Benefit of aerosol reduction to winter wheat during China's clean air action:A case study of Henan Province

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Journal of Environmental sciences 2024年第7期141卷 90-101页

作者： Yang Bai Pengfei Zhao Xueyang Chen Lijun Wang Wenjuan Chang Jianzhong Guo Jiayao Wang College of Geography and Environmental science Henan UniversityKaifeng 475004China Henan Industrial Technology Academy of Spatio-Temporal Big data Henan UniversityZhengzhou 475000China Henan Technology Innovation center of Spatio-Temporal Big data Henan UniversityZhengzhou 450046China Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of EducationKaifeng 475000China

A strongly declining aerosol radiative effect has been observed in China since 2013 after implementing the clean air action,yet its impact on wheat(Triticum aestivum L.)production remains *** use satellite measures and a biophysical crop model to assess the impact of aerosol-induced radiative perturbations on winter wheat production in the agricultural belt of Henan province from 2013 to *** calibrating parameters with the extended Fourier Amplitude Sensitivity Test(EFAST)and the generalized likelihood uncertainty estimation(GLUE)method,the DSSAT CERES-Wheat model was able to simulate crop biomass and yield more *** found that the aerosol negatively impacted wheat biomass by 21.87%and yield by 22.48%from 2006 to 2018,and the biomass effects from planting to anthesis were more significant compared to anthesis to *** to the strict clean air action,under all-sky conditions,the surface solar shortwave radiation(SSR)in 2018 increased by about 7.08%over 2006-2013 during the wheat growing *** a result of the improvement of crop photosynthesis,winter wheat biomass and yield increased by an average of 5.46%and 2.9%,*** findings show that crop carbon uptake and yield will benefit from the clean air action in China,helping to ensure national food and health security.

关键词： Haze pollution Clean air action Aerosol-induced radiative perturbation Wheat production DSSAT model

Systematic investigation of nucleon optical model potentials in(p,d)transfer reactions

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Chinese Physics C 2024年第7期48卷 168-175页

作者：陈思璐刘子旋张智续瑞瑞庞丹阳许祎萍 School of Nuclear science and Engineering North China Electric Power UniversityBeijing 102206China China Nuclear data center China Institute of Atomic EnergyBeijing 102413China School of Physics Beihang UniversityBeijing 100191China

The consistent three-body model reaction methodology(TBMRM)proposed by *** et al.[***.C 69,064313(2004);***.C 73,044608(2006);***.C 75,064320(2007)],which includes adopting the simple zero-range adiabatic wave approximation,constraining the single-particle potentials using modern Hartree-Fock calculations,and using global nucleon optical model potential(OMP)geometries,are widely applied in systematic studies of transfer *** this study,we investigate the influence of different nucleon OMPs in extracting spectroscopic factors(SFs)from(p,d)*** study covers 32 sets of angular distribution data of(p,d)reactions on four targets and a large range of incident energies(20-200 MeV/nucleon).This study uses two semi-microscopic nucleon OMPs,i.e.,Jeukenne,Lejeune,and Mahaux(JLM)[***.C 16,80(1977);***.C 58,1118(1998)]and CTOM[***.C 94,034606(2016)],and a pure microscopic nucleon potential,i.e.,WLH[***.127,182502(2021)].The results are compared with those using the phenomenological global optical potential KD02[***.A 713,231(2003)].We find that the incident energy dependence of spectroscopic factors extracted from(p,d)reactions is evidently suppressed when microscopic OMPs are employed for ^(12)C,^(28)Si,and *** addition,spectroscopic factors extracted using the systematic microscopic optical potential CTOM based on the Dirac-Brueckner-Hartree-Fock theory are more in line with the results obtained from(e,e′p)measurements,except for 16O and ^(40)Ca at high energies(>100 MeV),necessitating an exact treatment of double-magic *** results obtained by using the pure microscopic optical potential,WLH,based on the EFT theory show the same trend as those of CTOM but are generally *** JLM potential,which relies on simplified nuclear matter calculations with old-fashioned bare interactions,produces results that are very similar to those of the phenomenological potential *** results indicate that modern

关键词： optical model potentials transfer reactions spectroscopic factors