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Contribution of Water and Lipid Soluble Substances in the Relaxant Effects of Tymus Vulgaris Extract on Guinea pig Tracheal Smooth Muscle in Vitro

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Chinese Journal of Integrative Medicine 2016年第5期22卷 377-383页

作者： Rana Keyhanmanesh Mohammad Hossien Boskabady Mohammad Ali Ebrahimi Saadatloo Morteza Boskabady Drug Applied research center Tabriz University of Medical Sciences Tuberculosis and Lung research center Tabriz University of Medical Sciences Department of Physiology Tabriz University of Medical Sciences Department of Physiology School of MedicineMashhad University of Medical Sciences Neurogenic Inflammation research center Mashhad University of Medical Sciences Department of Basic sciences Islamic Azad University

Objective： To examine the relaxant effects of hydro-ethanolic, macerated aqueous （MA） and lipid- free macerated aqueous （LFMA） extract of Tymus vulgaris on tracheal chains of guinea pigs. Methods： The relaxant effects of five cumulative concentrations of each extract （0.4, 0.8, 1.2, 1.6 and 2.0 g/100 mL） were compared with saline as negative control and five cumulative concentrations of theophylline （0.1, 0.2, 0.4, 0.6 and 0.8 mmol/L） on precontracted tracheal smooth muscle of guinea pig with 60 mmol/L KCl （group 1） and 10 μmol/L methacholine （group 2, n=6 for each group）. Results： In group 1 all concentrations of theophylline, three higher concentrations of hydro-ethanolic, two concentrations of LFMA and last concentration of MA extracts showed significant relaxant effects compared with that of saline （P〈0.05 or P〈0.01）. Two lower concentrations of LFMA and all concentrations of MA except higher one caused contraction compared with saline （P〈0.05 or 0.01）. In group 2 experiments, all concentrations of theophylline, hydro-ethanolic, MA and LFMA extracts showed significant relaxant effects compared to that of saline （P〈0.05 or P〈0.01）. In both groups, the relaxant effect of all concentrations of hydro-ethanolic extract were significantly higher than most concentrations of others （P〈0.05 or P〈0.01）. The relaxant effect of different concentrations of three extracts were significantly greater in group 2 compared with group 1 experiments （all P〈0.01）. There were significantly positive correlations between the relaxant effects and concentrations for theophylline and all extracts in both groups （P〈0.05 or P〈0.01）. Conclusion： Hydro-ethanolic extract has a potent weaker relaxant effect for other extracts from Tymus vulgaris on tracheal chains of guinea pigs.

关键词： Tymus vulgaris hydro-ethanolic extract macerated aqueous extract lipid-free macerated aqueous extract relaxant effect guinea pig tracheal

Identification of genome regions and important variations associated with expression level of MYH genes and its correlation with meat quality traits in pigs

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Frontiers of Agricultural Science and Engineering 2015年第3期2卷 237-241页

作者： Ye HOU Lu JING Yunxia ZHAO Sheng WANG An LIU Shuhong ZHAO Xinyun LI Key Laboratory of Agricultural Animal Genetics Breeding and Reproduction of Ministry of Education of ChinaCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China The Cooperative Innovation center for Sustainable pig Production Wuhan 430070China

Meat quality is one of the most important economic traits in pig *** has been reported that the composition of type II muscle fibers is correlated with meat quality in *** II muscle fibers contain three isoforms,IIa,IIb and IIx,which contain specific myofibrillar proteins MYH2,MYH4 and MYH1,*** this study,the expression levels of MYH1,MYH2,and MYH4 genes in the Longissimus thoracis(LT)muscle were measured in 114 Yorkshire ***,the correlations between the expression level of MYH genes and the meat quality traits of intramuscular fat,drip loss,water-holding capacity and postmortem pH values were *** results showed that the expression level of MYH2 was positively correlated with the intramuscular fat(R=0.20,Ppigs.

关键词： pig IMF pH MYH1 MYH2 MYH4

Micro ball-end milling of freeform titanium parts

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Advances in Manufacturing 2015年第4期3卷 263-268页

作者： Ali Mamedov Ismail Lazoglu Mechanical Engineering Department Manufacturing and Automation Research Center Koc University Istanbul 34450 Turkey

Micro machining has growing number of applications in various industries such as biomedical, automotive, aerospace, micro-sensor, micro-actuator and jewelry industries. Small-sized freeform titanium parts are frequently needed in the biomedical applications, especially in the implantations such as mini-blood pumps and mini left-ventricular assist devices, finger joint replacements and small bone implants. Most of the small-sized titanium parts with freeform geometries are machined using micro ball-end milling before polishing and other surface treatments. Decreasing the cycle time of the machining parts is important for the productivity. In order to reduce the cycle time of the roughing process in the micro ball-end milling, this paper investigates the imple- mentation of a previously developed force-based feedrate scheduling （FFS） technique on micro milling of freeform titanium parts. After briefly introducing the instantaneous micro milling forces in micro ball-end milling of titanium parts with freeform surfaces, the FFS technique is implemented in the rough machining of a freeform titanium surface to demonstrate the cycle time reduction potentials via virtual micro milling simulations.

关键词： Micro milling Roughing - Feedrate scheduling - Force model - Titanium - Ti-6Al-4V

Cytokines from the pig conceptus:roles in conceptus development in pigs

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Journal of Animal Science and Biotechnology 2015年第2期6卷 130-141页

作者： Rodney D Geisert Matthew C Lucy Jeffrey J Whyte Jason W Ross Daniel J Mathew Animal Sciences research center University of Missouri Department of Animal Science Iowa State University

Establishment of pregnancy in pigs involves maintaining progesterone secretion from the corpora lutea in addition to regulating a sensitive interplay between the maternal immune system and attachment of the rapidly expanding trophoblast for nutrient absorption. The peri-implantation period of rapid trophoblastic elongation followed by attachment to the maternal uterine endometrium is critical for establishing a sufficient placental-uterine interface for subsequent nutrient transport for fetal survival to term, but is also marked by the required conceptus release of factors involved with stimulating uterine secretion of histotroph and modulation of the maternal immune system. Many endometrial genes activated by the conceptus secretory factors stimulate a tightly controlled proinflammatory response within the uterus. A number of the cytokines released by the elongating conceptuses stimulate inducible transcription factors such as nuclear factor kappa B （NFKB） potentially regulating the maternal uterine proinflammatory and immune response. This review will establish the current knowledge for the role of conceptus cytokine production and release in early development and establishment of pregnancy in the pig.

关键词： Cytokines Embryo development Porcine conceptus Pregnancy Prostaglandins uterus

Challenges and strategies of chlorine inhibition in anode systems for seawater electrolysis

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Science China Chemistry 2024年第10期67卷 3198-3208页

作者： Chuqiang Huang Zhouzhou Wang Shaojun Cheng Yunpeng Liu Binglu Deng Shaoyi Xu Luo Yu Ying Yu School of Materials Science and Hydrogen Energy Foshan UniversityFoshan 528000China Institute of Nanoscience and Nanotechnology College of Physical Science and TechnologyCentral China Normal UniversityWuhan 430079China Department of Physics and Texas center for Superconductivity at the University of Houston(TcSUH) University of HoustonHoustonTX 77204USA Laboratory of Solar Fuel Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074China

Seawater electrolysis for green hydrogen production is one of the key technologies for achieving carbon ***,in anode systems,the chloride ions(Cl^(-))in seawater will trigger an undesired chlorine evolution reaction(CER)that competes with an oxygen evolution reaction(OER),resulting in inferior OER activity and ***,the corrosive Cl^(-)and its derivative products will corrode anodes during seawater electrolysis,leading to poor ***,great efforts have been devoted to developing efficient strategies for chlorine inhibition to improve the activity,selectivity,and stability of anode ***,focusing on chlorine inhibition,we present a mini review to comprehensively and concisely summarize the recent progress in anode systems for boosting seawater *** particular,two strategies of physical and chemical regulation to inhibit Cl^(-)are summarized in some representative ***,some challenges and future opportunities in anode systems for seawater electrolysis are *** mini review aims to shed light on designing highly efficient anode materials for seawater electrolysis.

关键词： seawater electrolysis anode systems chlorine inhibition physical regulation chemical regulation

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Uptake and Speciation of Inorganic Arsenic with Cellulose Fibre Coated with Yttrium Hydroxide Layer as a Novel Green Sorbent

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Chinese Journal of Chemistry 2012年第9期30卷 2225-2231页

作者：安明日张晓星杨婷陈明丽王建华 research center for Analytical Sciences Northeastern UniversityBox 332ShenyangLiaoning 110819China

A novel adsorbent was developed by coating yttrium hydroxide precipitate layer on cellulose fibre. This material takes up ca. 98% of 5 μg·L 1 As（Ⅲ） and As（V） at low pH （pH〈7）, while a favorable selectivity for As（V） was achieved within pH 11--12. In practice, a mini-column packed with Y（OH）3 precipitate layer coated cellulose fibre particles was incorporated into a sequential injection system for selective uptake of arsenate at pH 11.5. The retained arsenate was afterwards recovered with 50μL of 0.8 mol.L l NaOH solution as eluent, followed by hydride generation in a reaction medium of 2.0 mol·L-1 HCl and 1.0% NaBH4 solution （W/V, in 0.5% NaOH） after pre-reduction of arsenate to arsenite by KI-ascorbic acid （5%, W/V）, with detection by atomic fluorescence spec- trometry. Total inorganic arsenic was quantitatively taken up at pH 6.0 by following the same procedure and arsenic speciation was performed by difference. With a sample volume of 1.0 mL, an enrichment factor of 16.4 was derived with a detection limit of 17 ng.L-1 within a linear range of 0.05--2.0μg.L ]. A relative standard deviation （RSD） of 2.6% （0.5 μg·L-1, n= 11） was achieved. The procedure was validated by analyzing arsenic in a certified refer- ence material GBW 09101 （human hair）, and speciation process requires no organic solvents, thus Y（OH）3 coated of inorganic arsenic in natural water samples. The entire cellulose fibre provides a green adsorbent.

关键词： yttrium hydroxide precipitate layer coated cellulose arsenic speciation hydride generation atomicfluorescence spectrometry

Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection

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World Journal of Hepatology 2022年第6期14卷 1053-1073页

作者： Iman Ibrahim Salama Hala M Raslan Ghada A Abdel-Latif Somaia I Salama Samia M Sami Fatma A Shaaban Aida M Abdelmohsen Walaa A Fouad Department of Community Medicine research National Research CenterGiza 12622DokkiEgypt Department of Internal Medicine National Research CenterGiza 12622DokkiEgypt Department of Child Health National Research CenterGiza 12622DokkiEgypt

Hepatitis C virus(HCV)is a common cause of liver disease and is associated with various extrahepatic manifestations(EHMs).This mini-review outlines the currently available treatments for HCV infection and their prognostic effect on hepatic manifestations and ***-acting antiviral(DAA)regimens are considered pan-genotypic as they achieve a sustained virological response(SVR)>85%after 12 wk through all the major HCV genotypes,with high percentages of SVR even in advanced fibrosis and *** risk factors for DAA failure include old males,cirrhosis,and the presence of resistance-associated substitutions(RAS)in the region targeted by the received *** effectiveness of DAA regimens is reduced in HCV genotype 3 with baseline RAS like A30K,Y93H,and ***,the European Association for the Study of the Liver recommended the identification of baseline RAS for HCV genotype *** higher rate of hepatocellular carcinoma(HCC)after DAA therapy may be related to the fact that DAA regimens are offered to patients with advanced liver fibrosis and cirrhosis,where interferon was contraindicated to those *** change in the growth of pre-existing subclinical,undetectable HCC upon DAA treatment might be also a ***,after DAA therapy,the T cell-dependent immune response is much weaker upon HCV clearance,and the down-regulation of TNF-αor the elevated neutrophil to lymphocyte ratio might increase the risk of *** can result in reactivation of hepatitis B virus(HBV)in HCV coinfected *** are effective in treating HCV-associated mixed cryoglobulinemia,with clinical and immunological responses,and have rapid and high effectiveness in *** improve insulin resistance in 90%of patients,increase glomerular filtration rate,and decrease proteinuria,hematuria and articular *** clearance by DAAs allows a significant improvement in atherosclerosis and metabolic and immunological conditions,with a reduction of m

关键词： Hepatitis C virus Hepatic Extrahepatic Direct-acting antivirals Impact

Recent advances in droplet microfluidics for microbiology

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Chinese Chemical Letters 2022年第4期33卷 1729-1742页

作者： Ziyi He Hao Wu Xianghua Yan Wu Liu State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Interdisciplinary Sciences Institute Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Agricultural Microbiology College of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China The Cooperative Innovation center of Sustainable pig Production Wuhan 430070China Hubei Provincial Engineering Laboratory for pig Precision Feeding and Feed Safety Technology Wuhan 430070China Institute of Pharmaceutical Analysis School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Advances in microbiology rely on innovations in technology. Droplet microfluidics, as a versatile and powerful technique that allows high-throughput generation and manipulation of subnanoliter volume droplets, has become an indispensable tool shifting experimental paradigms in microbiology. Droplet microfluidics has opened new avenues to various microbiological research, from resolving single-cell heterogeneity to investigating spatiotemporal dynamics of microbial communities, from precise quantitation of microbiota to systematic decipherment of microbial interactions, and from isolating rare and uncultured microbes to improving genetic engineered strains. In this review, we present recent advances of droplet microfluidics in various fields of microbiology: i) microbial cultivation, ii) microorganism detection and characterization, iii) antibiotic susceptibility testing, iv) microbial interactions, v) microbial *** also provide our perspectives on the challenges and future directions for droplet microfluidic-based microbiology research.

关键词： Droplet microfluidics Microorganisms Antibiotic susceptibility testing Microbial interactions Microbial biotechnology

Continuous bending and straightening technology of Q345c slab based on high-temperature creep deformation

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Journal of Iron and Steel research International 2017年第6期24卷 595-600页

作者： Long Guo Xing-zhong Zhang Chang-xi Feng National Engineering research center for Equipment and Technology of Cold Strip Rolling Yanshan University Qinhuangdao 066004 Hebei China

A new continuous bending and straightening casting curve with the aim of full using of high-temperature creep deformation was proposed. The curvature of bending and straightening segment varies as sine law with arc length. The basic arc segment is shortened significantly so that the length of bending and straightening area can be extended and the time of creep behavior can be increased. The distance from so lidifying front in the slab was calculated at 1200 ℃ by finite element method. The maximum strain rate of new casting curve at different locations inside the slab is 6.39 × 10 ^-5 s ^-1 during the bending segment and it tends to be 3.70 × 10 ^-5 s ^-1 in the straightening segment. The minimum creep strain rate is 7.45× 10 ^-5 s ^-1 when the stress is 14 MPa at 1 200 ℃. The strain rate of new casting machine can be less than the mini mum creep strain rate. Thus, there is only creep deformation and no plastic deformation in the bending and straightening process of steel continuous casting. Deformation of slabs depending on creep behavior only comes true. It is helpful for the design of the new casting machine and improvement of old casting machine depending on high temperature creep property.

关键词： Steel continuous castingCreep strain rateStrain rateHigh-temperaturecreep behaviorContinuous bendingContinuous straightening