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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 2036-2038页

作者： Pei Wu Yanjie Wang Honghai Sun Zhuoman Wen University of Chinese Academy of Sciences Beijing 100049and NIO Inc.Shanghai 200000China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

Dear Editor,In order to realize the pixel level light adjusting control of the binocular high dynamic light adjusting and imaging system, this letter proposed a novel self-calibration method. By analyzing the optical design of the system, the causes of the distortion are given and a distortion model is established. Then, a quick and accurate self-calibration method is designed. The experiments indicate that the method can calibrate the two image sensors of the system at the same time,the average pixel deviation of the calibrated system is less than 0.5pixels and the maximum deviation is less than 1 pixel.

关键词： Dynamic system deviation

Polycrystalline ZSM-5 Aggregates Induced by Seed and Catalytic Performance in Methanol to Hydrocarbon

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无机材料学报 2024年第8期39卷 945-954,I0010-I0013页

作者： WANG Xuchang JIAO Chuyu JI Zhuo JIAO Qirui QIN Bo DU Yanze ZHENG Jiajun LI Ruifeng Key Laboratory of Coal Science and Technology MOE Research Centre of Energy Chemical&Catalytic TechnologyTaiyuan University of TechnologyTaiyuan 030024China SINOPEC Dalian research Institute of Petroleum and Petrochemicals Co. Ltd.SINOPECDalian 116045China

Synthesis of ZSM-5 zeolite typically utilizes small molecule polyamines or quaternary ammonium salts as organic structure guiding agent(OSDA).By contrast,the OSDA-free hydrothermal synthesis system eliminates the use of organic templates and the subsequent calcination *** not only reduces the cost of synthesis,but also prevents environmental pollution from the combustion of organic templates,representing an eco-friendly *** this,literature suggests that even so-called template-free synthesis systems often involve trace amount of organic substances like *** the present work,a calcined commercial ZSM-5 zeolite was served as seed,with sodium aluminate as aluminum source and silica sol as silicon source,ensuring an entirely template-free synthesis *** ZSM-5 aggregates consisted of rod-like nanocrystals were successfully prepared in the completely OSDA-free *** of the Si/Al ratio in ZSM-5 seed,dosage and crystallization conditions such as crystallization temperature and crystallization time on ZSM-5 synthesis were *** results show that a highly crystallinity ZSM-5 aggregate consisting of primary nano-sized crystals less than 100 nm is produced from a gel precursor with 5.6%(in mass)seed after hydrothermal treatment for 48 ***,the Si/Al ratio in ZSM-5 seed has little effect on the topological structure and pore structure of the synthesized ***,the seeds with a low Si/Al ratio facilitate faster crystallization of zeolite and enhance the acidity,especially the strong acid centers,of the *** catalytic performance of the synthesized polycrystalline ZSM-5 was evaluated during dehydration of methanol and compared with a commercial reference *** results exhibit that as compared with the reference catalyst,the fabricated sample has a longer catalytic lifetime(16 h vs 8 h)attributed to its hierarchical pores derived from the loosely packed primary ***

关键词： ZSM-5 polycrystalline aggregate crystal seed structure guiding agent

Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： Luo-Xi XIAO Zi-Yu WANG Jiang-Tao LI Hai-Mei WANG Yi-Ming HAO Pan ZHOU Yu-Lin HUANG Qiu-Ju DENG Yong-Chen HAO Na YANG Li-Zhen HAN Zhao YANG Ping-Ping JIA Yue QI Jing LIU Center for Clinical and Epidemiologic research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

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Bone research 2024年第1期12卷 165-179页

作者： Luis F.de Castro Jarred M.Whitlock Zachary Michel Kristen Pan Jocelyn Taylor Vivian Szymczuk Brendan Boyce Daniel Martin Vardit Kram Rebeca Galisteo Kamran Melikov Leonid V.Chernomordik Michael T.Collins Alison M.Boyce Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membrane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Department of Plastic and Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics and Computational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dysplasia(FD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatment *** this study,we investigated the mechanisms underlying RANKL inhibition in FD tissue and its likely indirect effects on osteoprogenitors by evaluating human FD tissue pre-and post-treatment in a phase 2 clinical trial of denosumab(NCT03571191)and in murine in vivo and ex vivo preclinical *** analysis of human and mouse tissue demonstrated increased osteogenic maturation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in FD lesions after RANKL *** sequencing of human and mouse tissue supported these *** interaction between osteoclasts and mutant osteoprogenitors was further assessed in an ex vivo lesion model,which indicated that the proliferation of abnormal FD osteoprogenitors was dependent on *** results from this study demonstrated that,in addition to its expected antiosteoclastic effect,denosumab reduces FD lesion activity by decreasing FD cell proliferation and increasing osteogenic maturation,leading to increased bone formation within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of FD pathology and demonstrate a novel mechanism of action of denosumab in the treatment of bone disease.

关键词： dysplasia treatment finding

Enhanced fatigue resistance of ferroelectric Al0.65Sc0.35N deposited by physical vapor deposition

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Science China(Information Sciences) 2024年第5期67卷 335-336页

作者： Yang LI Danyang YAO Yan LIU Zhi JIANG Ruiqing WANG Xu RAN Jiuren ZHOU Qikun WANG Guoqiang WU Genquan HAN School of Microelectronics Xidian University Hangzhou Institute of Technology Xidian University Ultratrend Technologies inc. Emerging Device and Chip Laboratory Institute of Technological Sciences Wuhan University

Aluminum scandium nitride(AlScN), a Ⅲ-Ⅴ ternary semiconductor, has been recognized as an innovative and promising ferroelectric material in emerging research. Among the characteristics of ferroelectric material, fatigue resistance is a critical measure of the endurance of ferroelectric films and represents an inherent challenge in the pursuit of practical applications.

关键词： Physical vapor deposition

Potassium transporter OsHAK9 regulates seed germination under salt stress by preventing gibberellin degradation through mediating OsGA2ox7 in rice

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Journal of Integrative Plant Biology 2024年第4期66卷 731-748页

作者： Peng Zeng Ting Xie Jiaxin Shen Taokai Liang Lu Yin Kexin Liu Ying He Mingming Chen Haijuan Tang Sunlu Chen Sergey Shabala Hongsheng Zhang Jinping Cheng National Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization Jiangsu Collaborative Innovation Center for Modern Crop ProductionHainan Yazhou Bay Seed LabJiangsu Province Engineering Research Center of Seed Industry Science and TechnologyNanjing Agricultural UniversityNanjing 210095China International research Center for Environmental Membrane Biology Foshan UniversityFoshan 528000China School of Biological Sciences University of Western AustraliaCrawley WA 6009Australia

Soil salinity has a major impact on rice seed germination,severely limiting rice ***,a rice germination defective mutant under salt stress(gdss)was identified by using chemical *** GDSS gene was detected via MutMap and shown to encode potassium transporter *** analysis of complementation and mutant lines demonstrated that OsHAK9 was an essential regulator responsible for seed germination under salt ***9 is highly expressed in germinating seed *** contents and non-invasive micro-test technology results showed that OsHAK9 restricted K^(+)efflux in salt-exposed germinating seeds for the balance of K^(+)/Na^(+).Disruption of OsHAK9 significantly reduced gibberellin 4(GA4)levels,and the germination defective phenotype of oshak9a was partly rescued by exogenous GA_(3)treatment under salt *** sequencing(RNA-seq)and real-time quantitative polymerase chain reaction analysis demonstrated that the disruption of OsHAK9 improved the GA-deactivated gene OsGA2ox7 expression in germinating seeds under salt stress,and the expression of OsGA2ox7 was significantly inhibited by salt *** mutants of OsGA2ox7 created using clustered,regularly interspaced,short palindromic repeat(CRISPR)/CRISPR-associated nuclease 9 approach displayed a dramatically increased seed germination ability under salt ***,our results highlight that OsHAK9 regulates seed germination performance under salt stress involving preventing GA degradation by mediating OsGA2ox7,which provides a novel clue about the relationship between GA and OsHAKs in rice.

关键词： GDSS gibberellins potassium transporter rice salt tolerance seed germination

Few-Shot Graph Classification with Structural-Enhanced Contrastive Learning for Graph Data Copyright Protection

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Tsinghua Science and Technology 2024年第2期29卷 605-616页

作者： Kainan Zhang DongMyung Shin Daehee Seo Zhipeng Cai Department of Computer Science Georgia State UniversityAtlantaGA 30303USA LSWare inc. Seoul 08504Republic of Korea College of Intelligence Information Engineering Sangmyung UniversitySeoul 03016Republic of Korea

Open-source licenses can promote the development of machine learning by allowing others to access,modify,and redistribute the training ***,not all open-source licenses may be appropriate for data sharing,as some may not provide adequate protections for sensitive or personal information such as social network ***,some data may be subject to legal or regulatory restrictions that limit its sharing,regardless of the licensing model ***,obtaining large amounts of labeled data can be difficult,time-consuming,or expensive in many real-world ***-shot graph classification,as one application of meta-learning in supervised graph learning,aims to classify unseen graph types by only using a small amount of labeled ***,the current graph neural network methods lack full usage of graph structures on molecular graphs and social network *** structural features are known to correlate with molecular properties in chemistry,structure information tends to be ignored with sufficient property information ***,the common binary classification task of chemical compounds is unsuitable in the few-shot setting requiring novel ***,this paper focuses on the graph classification tasks of a social network,whose complex topology has an uncertain relationship with its nodes'*** two multi-class graph datasets with large node-attribute dimensions constructed to facilitate the research,we propose a novel learning framework that integrates both meta-learning and contrastive learning to enhance the utilization of graph topological *** experiments demonstrate the competitive performance of our framework respective to other state-of-the-art methods.

关键词： few-shot learning contrastive learning data copyright protection

Lightweight Super-Resolution Model for Complete Model Copyright Protection

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Tsinghua Science and Technology 2024年第4期29卷 1194-1205页

作者： Bingyi Xie Honghui Xu YongJoon Joe Daehee Seo Zhipeng Cai Department of Computer Science Georgia State UniversityAtlantaGA 30303USA LSWare inc. Seoul 08504Republic of Korea College of Intelligence Information Engineering Sangmyung UniversityRepublic of KoreaSeoul 03016

Deep learning based techniques are broadly used in various applications, which exhibit superior performance compared to traditional methods. One of the mainstream topics in computer vision is the image super-resolution task. In recent deep learning neural networks, the number of parameters in each convolution layer has increased along with more layers and feature maps, resulting in better image super-resolution performance. In today’s era, numerous service providers offer super-resolution services to users, providing them with remarkable convenience. However, the availability of open-source super-resolution services exposes service providers to the risk of copyright infringement, as the complete model could be vulnerable to leakage. Therefore, safeguarding the copyright of the complete model is a non-trivial concern. To tackle this issue, this paper presents a lightweight model as a substitute for the original complete model in image super-resolution. This research has identified smaller networks that can deliver impressive performance, while protecting the original model’s copyright. Finally, comprehensive experiments are conducted on multiple datasets to demonstrate the superiority of the proposed approach in generating super-resolution images even using lightweight neural networks.

关键词： lightweight adversarial learning image super-resolution copyright protection

Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer

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Cancer Biology & Medicine 2024年第1期21卷 83-103页

作者： Yumei Wang Haiyan Wang Wei Shao Yuhui Chen Yu Gui Chao Hu Xiaohong Yi Lijun Huang Shasha Li Dong Wang School of Basic Medical Sciences State Key Laboratory of Southwestern Chinese Medicine ResourcesChengdu University of Traditional Chinese MedicineChengdu 611137China Department of Pathology School of MedicineQinghai UniversityXining 810001China Omics Biosciences inc Beijing 100871China Laboratory of Integrative Medicine Clinical Research Center for BreastState Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China State Key Laboratory of Southwestern Chinese Medicine Resources School of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of Diabetology&Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity ResearchMedical Center for Comprehensive Weight ControlThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Objective:Epigenetic abnormalities have a critical role in breast cancer by regulating gene expression;however,the intricate interrelationships and key roles of approximately 400 epigenetic regulators in breast cancer remain *** is important to decipher the comprehensive epigenetic regulatory network in breast cancer cells to identify master epigenetic regulators and potential therapeutic ***:We employed high-throughput sequencing-based high-throughput screening(HTS^(2))to effectively detect changes in the expression of 2,986 genes following the knockdown of 400 epigenetic ***,bioinformatics analysis tools were used for the resulting gene expression signatures to investigate the epigenetic regulations in breast ***:Utilizing these gene expression signatures,we classified the epigenetic regulators into five distinct clusters,each characterized by specific *** discovered functional similarities between BAZ2B and SETMAR,as well as CLOCK and ***,we observed that CLOCK functions in a manner opposite to that of HDAC8 in downstream gene ***,we constructed an epigenetic regulatory network based on the gene expression signatures,which revealed 8 distinct modules and identified 10 master epigenetic regulators in breast ***:Our work deciphered the extensive regulation among hundreds of epigenetic *** identification of 10 master epigenetic regulators offers promising therapeutic targets for breast cancer treatment.

关键词： Epigenetic regulators breast cancer regulatory network HTS^(2)

Delphi study for developing a checklist of adverse events associated with acupotomy

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Journal of Integrative Medicine 2024年第5期22卷 579-587页

作者： Hyungsun Jun Haebeom Lee Sang-Hoon Yoon Chan-Young Kwon Damin Jeon Jun-Hwan Lee Jungtae Leem Department of Diagnostics College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea 7Days inc. Seoul 06247Republic of Korea Chung-Yeon Korean Medicine Clinic Seoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-Eui University College of Korean MedicineBusan 47227Republic of Korea Chonnam National University Hwasun Hospital Hwasun 58128Republic of Korea KM Science research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Korean Convergence Medical Science KIOM SchoolUniversity of Science&Technology(UST)Daejeon 34054Republic of Korea Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation HospitalHarvard Medical SchoolBostonMA 02115USA research Center of Traditional Korean Medicine College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea

Background Acupotomy,a more invasive procedure than acupuncture,involves the use of a thicker needle with an integrated knife at the tip,necessitating safety *** aimed to define relevant adverse events(AEs)and create a standardized form of the ACUPOtomy-related AEs CHECKlist(ACUPOCHECK).Methods Before conducting the Delphi process,a systematic review and pilot prospective study were conducted to gather information on previously reported *** these data,pilot versions of the ACUPOCHECK and Delphi questionnaires were *** Delphi questionnaire involved selecting types of AE for inclusion,establishing separate criteria for acupotomy-related AEs,and achieving a consensus on AE *** Korean doctors with experience in acupotomy or AE research were recruited to participate in each Delphi *** was considered to have been reached if the critical value for the content validity ratio met or exceeded *** The final ACUPOCHECK was developed using four rounds of the Delphi method and one face-to-face consensus *** included 12 local AEs(pain,hemorrhage,bruise,hematoma,edema,pruritus,rash,infection,nerve damage,dysesthesia,movement impairment,and pneumothorax)and 14 systemic AEs(disease aggravation,needle fatigue,sleepiness,procedural nausea,procedural vomiting,procedural headache,procedural dizziness,sweating,procedural shock,syncope,dyspnea,procedural pain,sleep disorder,and postprocedural infection).Separate criteria were established for pain,hemorrhage and bruising:pain was defined as pain that occurrs during daily activities and persists for longer than 72 h,hemorrhage as bleeding that continues for≥3 min despite pressure application,and bruising as having a bruise with a diameter of≥3 ***-ended descriptions were allowed for AEs not covered by the checklist,and severity and causality were assessed using the Common Terminology Criteria for Adverse Events and modified World Health Organization-Uppsala Monitoring C

关键词： Acupotomy Delphi technique Patient safety Safety management Adverse event