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Intraperitoneal injection but not oral administration of ellagic acid: A novel immunomodulator via targeting casein kinase 2 signaling pathway

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food Science and Human Wellness 2024年

作者： Wen-Hui Qi Bing Han Ting-Ting Cui Pei-Xin Shen Zhuo-Hua Zhao Ya-Ping Yan Li-Bin Wang Xin-Yu Lu Yuan Zhang Xing Li Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University)， The Ministry of Education College of Life Sciences， Shaanxi Normal University Department of Pharmacology， School of Pharmacy， Fourth Military Medical University The Nervous System Disease Diagnosis and Treatment Engineering technology research Center of Ningxia School of Medical technology， Xi'an Medical University

Immunosuppressants currently approved for the treatment of autoimmune diseases and organ transplant rejection present diverse adverse effects that impair the life quality of patients. Therefore， the development of novel immunomodulators with high efficiency and low toxicity is essential. Ellagic acid (EA)， a natural polyphenol compound widely distributed in berries， is metabolically transformed by gut microbiome to exert systemic health benefits. Here， we identified that intraperitoneal administration of EA with no cytotoxicity， beyond its well-known oral metabolic fate， effectively decreased clinical severity and CNS inflammation/demyelination in experimental autoimmune encephalomyelitis (EAE)， a mouse model of an autoimmune disease multiple sclerosis (MS). Interestingly， intraperitoneal EA administration at incredibly low doses (0.1 mg/kg/d) is dose-sparing with fingolimod (FTY720)， the first FDA-approved oral drug for MS. In addition， intraperitoneal EA also ameliorated the brain damage in a neuromyelitis optica (NMO) model， and significantly prevented the immune rejection of allograft skin graft. Evidence from pharmacological studies combined with RNA-seq indicate that prototype EA functions by a mechanism that involves direct inhibition of casein kinase II (CKII) to suppress the expression of IL-17 and promote the expression of Cpt1a to regulate Th17 differentiation. In conclusion， our study demonstrates that the prototype EA entering the blood circulation acts as a novel therapeutic immunomodulator for the treatment of autoimmune diseases and transplant rejection through the CKⅡ-mediated JAK/STAT/Cpt1a signaling pathway.

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High-Efficiency Photo-Induced Charge Transfer for SERS Sensing in N-Doped 3D-Graphene on Si Heterojunction

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Energy & Environmental Materials 2024年第2期7卷 268-276页

作者： Guanglin Zhang Jie Sun Genwang Wei Shan Zhang Zhengyi He Huijuan Wu Bingkun Wang Siwei Yang Guqiao Ding Zhiduo Liu Zhiwen Jin Caichao Ye Gang Wang Department of Microelectronic Science and Engineering School of Physical Science and TechnologyNingbo UniversityNingbo 315211China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesShenzhen UniversityShenzhen 518071China Academy for Advanced Interdisciplinary Studies&Department of Materials Science and Engineering Guangdong Provincial Key Laboratory of Computational Science and Material DesignSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081China School of Physical Science and technology&Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000China

Nitrogen-doped three-dimensional graphene(N-doped 3D-graphene)is a graphene derivative with excellent adsorption capacity,large specific surface area,high porosity,and optoelectronic ***,N-doped 3D-graphene/Si heterojunctions were grown in situ directly on silicon(Si)substrates via plasma-assisted chemical vapor deposition(PACVD),which is promising for surface-enhanced Raman scattering(SERS)substrates *** analyses of theoretical simulation,incorporating N atoms in 3D-graphene are beneficial to increase the electronic state density of the system and enhance the charge transfer between the substrate and the target *** enhancement of the optical and electric fields benefits from the stronger light-matter interaction improved by the natural nano-resonator structure of N-doped *** as-prepared SERS substrates based on N-doped 3D-graphene/Si heterojunctions achieve ultra-low detection for various molecules:10^(-8)M for methylene blue(MB)and 10^(-9)M for crystal violet(CRV)with rhodamine(R6G)of 10^(10)*** practical detected,10^(-8)M thiram was precisely detected in apple peel *** results indicate that N-doped 3D-graphene/Si heterojunctions based-SERS substrates have promising applications in low-concentration molecular detection and food safety.

关键词： charge transfer DFT simulation N-doped 3D-graphene SERS Thiram detection

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A triangular architectural relation model among sustainability,beauty,and power

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Frontiers of Architectural research 2024年第4期13卷 699-711页

作者： Ján Legény RobertŠpaček TomášHubinský Lucia Benkovičová Faculty of Architecture and Design Slovak University of Technology in BratislavaBratislavaSlovakia

Sustainability,beauty,and power are notions that hit our contemporary perception every ***,they have been an integral part of architecture and urban planning in various forms since the *** paper presents their fundamental descriptions,followed by an assessment of their mutual relations and impact on architecture through a triangular architectural relation model developed by the authors of the *** the theoretical thought experiment,it highlights eight boundary models along with their main characteristics,in particular,the implosion,explosion,shared-control,utilitarian,no-control,supremacy,inside-forced,and outside-forced architectural related *** models can help predict future events,explain past events,make decisions,and plan strategies,or reveal problems and propose new *** applications include determination of the causes of certain results or finding out the responsibility and mechanisms that led to *** authors are of the opinion that the mutual denominator of sustainability,beauty,and power represents ethics that should be forced in architectural education and practice.

关键词： Triangular architectural relation model Sustainability Beauty Power Thought experiment Interpretation

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Phosphorylation of PB2 at serine 181 restricts viral replication and virulence of the highly pathogenic H5N1 avian influenza virus in mice

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Virologica Sinica 2024年第1期39卷 97-112页

作者： Jiao Hu Zixiong Zeng Xia Chen Manyu Zhang Zenglei Hu Min Gu Xiaoquan Wang Ruyi Gao Shunlin Hu Yu Chen Xiaowen Liu Daxin Peng Xiufan Liu Animal Infectious Disease Laboratory School of Veterinary MedicineYangzhou UniversityYangzhou225009China Joint International research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou University225009China Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis Yangzhou UniversityYangzhou225009China Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agri-food Safety and Quality Ministry of Agriculture of China(26116120)Yangzhou UniversityYangzhou225009China

Influenza A virus(IAV)continues to pose a pandemic threat to public health,resulting a high mortality rate annually and during pandemic *** modification of viral protein plays a substantial role in regulating IAV ***,based on immunoprecipitation(IP)-based mass spectrometry(MS)and purified virus-coupled MS,a total of 89 phosphorylation sites distributed among 10 encoded viral proteins of IAV were identified,including 60 novel phosphorylation ***,for the first time,we provide evidence that PB2 can also be acetylated at site ***,the PB2 S181 phosphorylation site was consistently identified in both IP-based MS and purified virus-based *** S181 and K187 are exposed on the surface of the PB2 protein and are highly conserved in various IAV strains,suggesting their fundamental importance in the IAV life *** analysis results demonstrated that S181E/A and K187Q/R mimic mutations do not significantly alter the PB2 protein *** continuous phosphorylation mimicked by the PB2 S181E mutation substantially decreases viral fitness in mice,PB2 K187Q mimetic acetylation slightly enhances viral virulence in ***,PB2 S181E substantially impairs viral polymerase activity and viral replication,remarkably dampens protein stability and nuclear accumulation of PB2,and significantly weakens IAV-induced inflammatory ***,our study further enriches the database of phosphorylation and acetylation sites of influenza viral proteins,laying a foundation for subsequent mechanistic ***,the unraveled antiviral effect of PB2 S181E mimetic phosphorylation may provide a new target for the subsequent study of antiviral drugs.

关键词： H5N1 influenza virus PB2 Phosphorylation Acetylation Viral fitness Mice

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A low-profile dual-broadband dual-circularly-polarized reflectarray for K-/Ka-band space applications

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Frontiers of Information technology & Electronic Engineering 2024年第8期25卷 1145-1161页

作者： Xuanfeng TONG Zhi Hao JIANG Yuan LI Fan WU Lin PENG Taiwei YUE Wei HONG State Key Laboratory of Milimeter Waves School of Information Science and EngineeringSoutheast UniversityNanjing 210096China Purple Mountain laboratories Nanjing 21lllChina State Key Laboratory of Mobile Network and Mobile Multimedia technology ZTE CorporationShenzhen 518057China Apple Inc. One Apple Park WayCupertinoCA 95014USA

A low-profile dual-broadband dual-circularly-polarized(dual-CP)reflectarray(RA)is proposed and demonstrated,supporting independent beamforming for right-/left-handed CP waves at both K-band and *** functionality is achieved by incorporating multi-layered phase shifting elements individually operating in the K-and Ka-band,which are then interleaved in a shared aperture,resulting in a cell thickness of only about *** rotating the designed K-and Ka-band elements around their own geometrical centers,the dual-CP waves in each band can be modulated *** reduce the overall profile,planar K-/Ka-band dual-CP feeds with a broad band are designed based on the magnetoelectric dipoles and multi-branch hybrid *** planar feeds achieve bandwidths of about 32%and 26%at K-and Ka-band respectively with reflection magnitudes below-13 dB,an axial ratio smaller than 2 dB,and a gain variation of less than 1 dB.A proof-of-concept dual-band dual-CP RA integrated with the planar feeds is fabricated and characterized which is capable of generating asymmetrically distributed dual-band dual-CP *** measured peak gain values of the beams are around 24.3 and 27.3 dBic,with joint gain variation<1 dB and axial ratio<2 dB bandwidths wider than 20.6%and 14.6%at the lower and higher bands,*** demonstrated dual-broadband dual-CP RA with four degrees of freedom of beamforming could be a promising candidate for space and satellite communications.

关键词： Broadband Dual-band Dual-circularly-polarized Reflectarray Shared-aperture

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Multifunctional SnO_(2) QDs/MXene Heterostructures as Laminar Interlayers for Improved Polysulfide Conversion and Lithium Plating Behavior

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Nano-Micro Letters 2024年第11期16卷 156-169页

作者： Shungui Deng Weiwei Sun Jiawei Tang Mohammad Jafarpour Frank Nüesch Jakob Heier Chuanfang Zhang College of Materials Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China Laboratory for Functional Polymers Swiss Federal Laboratories for Materials Science and Technology(EMPA)Überlandstrasse 1298600 DübendorfSwitzerland Institute of Materials Science and Engineering Ecole Polytechnique Fédérale de Lausanne(EPFL)Station 121015 LausanneSwitzerland Key Laboratory of Quantum Materials and Devices of Ministry of Education School of PhysicsSoutheast UniversityNanjing 211189People’s Republic of China SEU‑FEI Nano‑Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096People’s Republic of China

Poor cycling stability in lithium–sulfur(Li–S)batteries necessitates advanced electrode/electrolyte design and innovative interlayer *** catalysis has emerged as a promising approach,leveraging the adsorption and catalytic performance on lithium polysulfides(LiPSs)to inhibit LiPSs shuttling and improve redox *** this study,we report an ultrathin and laminar SnO_(2)@MXene heterostructure interlayer(SnO_(2)@MX),where SnO_(2) quantum dots(QDs)are uniformly distributed across the MXene *** combined structure of SnO_(2) QDs and MXene,along with the creation of numerous active boundary sites with coordination electron environments,plays a critical role in manipulating the catalytic kinetics of sulfur *** Li–S cell with the SnO_(2)@MX-modified separator not only demonstrates superior electrochemical performance compared to cells with a bare separator but also induces homogeneous Li deposition during *** a result,an areal capacity of 7.6 mAh cm^(-2) under a sulfur loading of 7.5 mg cm^(-2) and a high stability over 500 cycles are *** work demonstrates a feasible strategy of utilizing a laminar separator interlayer for advanced Li–S batteries awaiting commercialization and may shed light on the understanding of heterostructure catalysis with enhanced reaction kinetics.

关键词： Lithium-sulfur battery Heterogeneous catalysis Heterostructure Redox kinetics Lithium dendrites

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A healable, mechanically robust and ultrastretchable ionic conductive elastomer for durably wearable sensor

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Nano research 2024年第4期17卷 3369-3378页

作者： Guoxian Zhang Chunmei Li JiaoJun Tan Mingqi Wang Yafeng Ren Feijie Ge Qiuyu Zhang Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi'an 710072China College of Bioresources Chemical and Materials Engineering National Demonstration Center for Experimental Light Chemistry Engineering EducationShaanxi University of Science&TechnologyXi’an 710021China

The ionic conductive elastomers show great promise in multifunctional wearable electronics,but they currently suffer from liquid leakage/evaporation or mechanical *** ionic conductive elastomers integrating non-volatility,mechanical robustness,superior ionic conductivity,and ultra-stretchability remains urgent and ***,we developed a healable,robust,and conductive elastomer via impregnating free ionic liquids(ILs)into the ILs-multigrafted poly(urethane-urea)(PUU)elastomer networks.A crucial strategy in the molecular design is that imidazolium cations are largely introduced by double-modification of PUU and centipede-like structures are obtained,which can lock the impregnated ILs through strong ionic *** this system,the PUU matrix contributes outstanding mechanical properties,while the hydrogen bonds and ionic interactions endow the elastomer with self-healing ability,conductivity,as well as non-volatility and *** fabricated ionic conductive elastomers show good conductivity(3.8×10^(-6) S·cm^(-1)),high mechanical properties,including tensile stress(4.64 MPa),elongation(1470%),and excellent healing ability(repairing efficiency of 90%after healing at room temperature for 12 h).Significantly,the conductive elastomers have excellent antifatigue properties,and demonstrate a highly reproducible response after 1000 uninterrupted extension-release *** work provides a promising strategy to prepare ionic conductive elastomers with excellent mechanical properties and stable sensing capacity,and further promote the development of mechanically adaptable intelligent sensors.

关键词： ionic conductive elastomers poly(urethane-urea)(PUU) ionic interactions centipede-like self-healing

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Biodegradable,strong,and clear wood package for plastic alternative

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Nano research 2024年第9期17卷 8531-8541页

作者： Jianfu Tang Xueqin Fan Haozhou Huang Xiaofei Dong Xueqi Li Peiru Wang Ran Yin Yanjun Xie Jian Li Gang Tan Zhenqian Pang Wentao Gan Key Laboratory of Bio-based Material Science&technology(Ministry of Education) Northeast Forestry UniversityHarbin 150040China Department of Architecture College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou 310027China Smart Materials for Architecture research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China Heilongjiang Key Laboratory of Complex Traits and Protein Machines in Organisms Northeast Forestry UniversityHarbin 150040China

Using biodegradable material derived from renewable resources as petroleum-based plastics replacement is a promising way towards sustainable ***,the insufficient mechanical properties and complex manufacturing process of bioplastics still need to be improved for high-quality food ***,we report a top-down strategy to transform natural wood into a clear wood packaging film through scalable delignification and polyvinyl alcohol(PVA)*** wood packaging film demonstrates a laminated structure with completely collapsed cell walls and PVA intertwined together after energy-saving air drying,resulting in high light transmittance with low haze,good mechanical performance,and high barrier performance for oxygen and water *** dynamics simulations reveal the underlying fracture mechanism between cellulose and PVA,which effectively enhances the Young’s modulus and strength of the wood packaging *** findings contribute to the development of biodegradable and strong packaging materials,as well as other food-related applications,using sustainable wood.

关键词： wood food package mechanical enhancement plastic replacement biodegradability

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有前景的石墨炔基纳米材料用于环境污染物控制（英文）

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Science China Materials 2024年第11期67卷 3456-3467页

作者：潘传奇何倩丽李超凡 College of Environmental Engineering Henan University of Technology Institute of Quality Standard and Testing technology for Agro-Products Chinese Academy of Agricultural Sciencesand Key Laboratory of Agro-Food Safety and QualityMinistry of Agriculture and Rural Affairs Institute of Chemistry Henan Academy of Sciences Henan Academy of Sciences

环境污染物,包括气相污染物、液体有机污染物、重金属离子和致病细菌,对我们的生态环境和人类健康构成了严重威胁.有效解决这些污染物已成为当下最紧迫的问题之一.石墨炔作为一种新兴的二维碳材料,具有独特的炔键和丰富的孔洞结构,同时... 详细信息

环境污染物,包括气相污染物、液体有机污染物、重金属离子和致病细菌,对我们的生态环境和人类健康构成了严重威胁.有效解决这些污染物已成为当下最紧迫的问题之一.石墨炔作为一种新兴的二维碳材料,具有独特的炔键和丰富的孔洞结构,同时具有的sp/sp2杂化碳原子结构赋予其可调谐的电子结构和优异的物理化学性能.本文综述了石墨炔基纳米材料在环境污染控制中的应用,包括一氧化碳（CO）氧化、臭氧（O3）分解、重金属离子检测和吸附、有机污染物降解以及细菌灭活.此外,本文分析了石墨炔基纳米材料的构性关系,指出了其在环境修复领域存在的问题和挑战.

关键词： graphdiyne CO oxidation O3 decomposition heavy metal ion detection and adsorption organic pollutant degradation bacterial inactivation

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Association of physical activity with risk of chronic kidney disease in China:A population-based cohort study

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Journal of Sport and Health Science 2024年第2期13卷 204-211页

作者： Kexiang Shi Yunqing Zhu Jun Lv Dianjianyi Sun Pei Pei Huaidong Du Yiping Chen Ling Yang Bing Han Rebecca Stevens Junshi Chen Zhengming Chen Liming Li Canqing Yu China Kadoorie Biobank collaborative group Department of Epidemiology&Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Medical research Council Population Health research Unit at the University of Oxford Oxford OX37LFUK NCDs Prevention and Control Department Henan Center for Disease Control and PreventionZhengzhou 450016China China National Center for food Safety Risk Assessment Beijing 100022China 不详

Background:Information on the association between physical activity(PA)and the risk of chronic kidney disease(CKD)is *** aimed to explore the associations of total,domain-specific,and intensity-specific PA with CKD and its subtypes in ***:The study included 475,376 adults from the China Kadoorie Biobank aged 30-79 years during 2004-2008 at *** interviewer-administered questionnaire was used to collect the information about PA,which was quantified as metabolic equivalent of task hours per day(MET-h/day)and categorized into 4 groups based on *** regression was used to analyze the association between PA and CKD ***:During a median follow-up of 12.1 years,5415 incident CKD cases were documented,including 1159 incident diabetic kidney disease(DKD)cases and 362 incident hypertensive nephropathy(HTN)*** PA was inversely associated with CKD risk,with an adjusted hazard ratio(HR,95%confidence interval(95%CI))of 0.83(0.75-0.92)for incident CKD in the highest quartile of total PA as compared with participants in the lowest *** results were observed for risk of DKD and HTN,and the corresponding HRs(95%CIs)were 0.75(0.58-0.97)for DKD risk and 0.56(0.37-0.85)for HTN *** nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA were significantly associated with a decreased risk of CKD,with HRs(95%CIs)of 0.80(0.73-0.88),0.85(0.77-0.94),and 0.85(0.76-0.95)in the highest quartile,***:PA,including nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA,was inversely associated with the risk of CKD,including DKD,HTN,and other CKD,and such associations were dose dependent.

关键词： Chronic kidney disease Domain Intensity Physical activity

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