检索结果-南通市图书馆

Commentary:Mammokine directs beige adipocytes to reserve energy for milk production in breast

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第3期14卷 1472-1476页

作者： Lina Tang Jianping Ye metabolic disease research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Beige/brown adipocytes play a crucial role in regulating the body’s overall energy *** thermogenic function is under the influence of various tissues,including the brain,muscles,and ***,the breast tissue is not in th... 详细信息

关键词： Beige Breast Epitheliail cells scRNA-seq Thermogenesis

NASTCNN: a spatio-temporal convolutional neural network with non-local attention mechanism for image-induced brain activity pattern recognition

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2025年

作者： TAN Xiangxin SHAO Mingxiong ZENG Ke GU Yue School of Computer Science and Engineering， Tianjin University of Technology Engineering research Center of Learning-Based Intelligent System (Ministry of Education)， Tianjin University of Technology Krembil research institute， University Health Network

Deciphering the brain’s visual processing mechanisms has always been a hot topic. Using neural signal patterns to predict the corresponding external visual stimuli is crucial in understanding the interaction of real visual scenes. There are some challenges in the study of image-induced brain activity pattern recognition based on electroencephalogram (EEG)， e.g. how to fully utilize the effective features of EEG signals to improve the classification， and how the frequency and the length of EEG effect the model performance. We design an experimental paradigm that minimizes the interaction between visual stimuli， and propose a spatio-temporal convolutional neural network with non-local attention mechanism (NASTCNN) for image-induced brain activity pattern recognition. The framework utilizes non-local feature extraction operations to realize global information interaction between EEG signals over long distances and enhance the feature expression of some important information. Our model achieves the best performance on both MNIST-EEG and ImageNet-EEG datasets. The classification results are 24.00% and 50.10% respectively， higher than the random probability. We also analyze the effects of different EEG frequency bands and time subsequences of different lengths on the classification performance and which brain regions are activated over time. The results show that when full frequency band and entire length sequence are selected， the classification result is optimal. The occipital region is essential for processing visual tasks， and the temporal region and some frontal regions also play important role in the later stage of visual decoding. This research can help us better understand the visual processing mechanism of the brain.

关键词：

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric research institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

Commentary:Gut microbiota reduce the risk of hyperuricemia and gout in the human body

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第1期14卷 433-435页

作者： Lin Wang Jianping Ye metabolic disease research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Gout,a prevalent and painful metabolic disease often associated with obesity and aging,is caused by the deposition of urate crystals in joints,bones,or soft *** is an intermediate metabolite within the purine degradation pathway,predominantly derived from uric acid under physiological pH *** occurs due to excessive uric acid production or insufficient excretion2,which is associated with various chronic diseases,including type 2 diabetes.

关键词： Uric acid Gout Microbiota Gut Uricase

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen Yu Han Jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Activation energy

Synergistic antitumor activity of artesunate and HDAC inhibitors through elevating heme synthesis via synergistic upregulation of ALAS1 expression

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2019年第5期9卷 937-951页

作者： Cai-Ping Chen Kun Chen Zhiqi Feng Xiaoan Wen Hongbin Sun Jiangsu Key Laboratory of Drug Discovery for metabolic disease State Key Laboratory of Natural MedicinesChina Pharmaceutical University

Artemisinin and its derivatives(ARTs) were reported to display heme-dependent antitumor activity. On the other hand, histone deacetylase inhibitors(HDACi) were known to be able to promote heme synthesis in erythroid cells. Nevertheless, the effect of HDACi on heme homeostasis in nonerythrocytes remains unknown. We envisioned that the combination of HDACi and artesunate(ARS)might have synergistic antitumor activity through modulating heme synthesis. In vitro studies revealed that combination of ARS and HDACi exerted synergistic tumor inhibition by inducing cell death. Moreover, this combination exhibited more effective antitumor activity than either ARS or HDACi monotherapy in xenograft models without apparent toxicity. Importantly, mechanistic studies revealed that HDACi coordinated with ARS to increase 5-aminolevulinate synthase(ALAS1) expression, and subsequent heme production, leading to enhanced cytotoxicity of ARS. Notably, knocking down ALAS1 significantly blunted the synergistic effect of ARS and HDACi on tumor inhibition, indicating a critical role of ALAS1 upregulation in mediating ARS cytotoxicity. Collectively, our study revealed the mechanism of synergistic antitumor action of ARS and HDACi. This finding indicates that modulation of heme synthesis pathway by the combination based on ARTs and other heme synthesis modulators represents a promising therapeutic approach to solid tumors.

关键词： Artesunate HDAC inhibitor Heme ALAS1 Antitumor

Interplay between diet and genetic susceptibility in obesity and related traits

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2018年第6期12卷 601-607页

作者： Tiange Wang Min Xu Yufang Bi Guang Ning State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of HealthNational Clinical Research Center for Metabolic DiseasesShanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrine and Metabolic DiseasesRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.

关键词： diet genetic susceptibility interaction obesity

Current developments in pharmacological therapeutics for chronic constipation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2015年第4期5卷 300-309页

作者： Chunhuan Jiang Qinglong Xu Xiaoan Wen Hongbin Sun State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for metabolic disease China Pharmaceutical University

Chronic constipation is a common gastrointestinal disease severely affecting the patient's quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-EF1'1 receptor modulators velusetrag and naronapride, the guanylate cy-clase C agonist plecanatide and die deal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field. (C) 2015 Chinese Pharmaceutical Association and institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/by-ne-rid/4.0/).

关键词： Chronic constipation Prokinetic agent 5-HT1 receptor Prosecretory agent

IN VIVO MAPPING BRAIN MICROCIRCULATION BY LASER SPECKLE CONTRAST IMAGING:A MAGNETIC RESONANCE PERSPECTIVE OF THEORETICAL FRAMEWORK

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2008年第2期1卷 239-256页

作者： ZHENG WANG Center for Functional and metabolic Mapping Robarts research institute Department of Medical Biophysics The University of Western Ontario LondonCanada

The fundamental limitations of most vascular-based functional neuroimaging techniques are placed by the fact how fine the brain regulates the blood supply *** vivo mapping of the cerebral microcirculation with high resolution and sensitivity hence becomes unprecedentedly *** paper reviews the theoretical background of the laser speckle contrast imaging(LSCI)technique and attempts to present a complete framework stemming from a simple biophysical *** the sensitivity analysis,more insights into the tool optimization are attained for in vivo *** questions of the technical aspects are discussed within this unified ***,it concludes with a brief perspective of future research in a way analogous to the magnetic resonance imaging(MRI)*** exploration could catalyze their development and initiate a technological fusion for precise assessment of blood flow across various spatial scales.

关键词： Laser speckle contrast imaging brain microcirculation functional neuroimaging magnetic resonance imaging