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Interleukin-1β:Friend or foe for gastrointestinal cancers

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1676-1682页

作者： Kullanat Khawkhiaw Jutatip Panaampon Thanit Imemkamon Charupong Saengboonmee Department of Biochemistry Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Center for Translational Medicine Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Cholangiocarcinoma research institute Khon Kaen UniversityKhon Kaen 40002Thailand Department of Medical Oncology Dana-Farber Cancer InstituteHarvard Medical SchoolBostonMA 02215United States Department of Medicine Harvard Medical SchoolBostonMA 02215United States Division of Hematopoiesis Joint Research Center for Human Retrovirus InfectionKumamoto UniversityKumamoto 860-0811Japan Department of Medicine Faculty of MedicineKhon Kaen UnivsersityKhon Kaen 40002Thailand

Gastrointestinal(GI)cancer is a malignancy arising in the digestive system and accounts for approximately a third of increasing global cancer-related mortality,especially in the colorectum,esophagus,stomach,and ***-1β(IL-1β)is a leukocytic pyrogen recognized as a tumor progression-related ***-1βsecretion and maturation in inflammatory responses could be regulated by nuclear factor-kappaB-dependent expression of NLR family pyrin domain containing 3,inflammasome formation,and activation of IL-1 converting *** studies have documented the pro-tumorigenic effects of IL-1β in tumor microenvironments,promoting proliferation and metastatic potential of cancer cells in vitro and tumorigenesis in *** application of IL-1β inhibitors is also promising for targeted therapy development in some cancer ***,as a leukocytic pro-inflammatory cytokine,IL-1β may also possess anti-tumorigenic effects and be type-specific in different *** editorial discusses the up-to-date roles of IL-1β in GI cancers,including underlying mechanisms and down-stream signaling *** and clarifying the roles of IL-1β would significantly benefit future therapeutic targeting and help improve therapeutic outcomes in patients suffering from GI cancer.

关键词： Cancer Gastrointestinal tract Inflammation Interleukin-1β Tumor microenvironment

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沁水盆地煤层气井排采水的地球化学特征及来源示踪

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天然气地球科学 2024年

作者：方鲁加陈碧莹能惠 Yuji Sano 徐胜 Marine Core research institute， Kochi University 天津大学地球系统科学学院

次生生物气与地下水之间存在一定的关系，特别是在煤层气等天然气储层中，了解地下水与次生生物成因甲烷之间的关系对于天然气勘探和开发具有重要意义。基于中国沁水盆地6个区块的57个煤层气井排采水和3个河水样品的化学组成、氢氧同位... 详细信息

次生生物气与地下水之间存在一定的关系，特别是在煤层气等天然气储层中，了解地下水与次生生物成因甲烷之间的关系对于天然气勘探和开发具有重要意义。基于中国沁水盆地6个区块的57个煤层气井排采水和3个河水样品的化学组成、氢氧同位素组成(δ18OH2O和δDH2O)和溶解无机碳(DIC)碳同位素组成(δ13CDIC和Δ14CDIC)，深入剖析了地下水与次生生物成因甲烷之间的复杂关系。研究结果表明：氢氧同位素分布在大气降水线附近，煤层气井排采水主要来源于大气降雨，硫酸盐微生物还原作用是郑庄和阳泉区块氘同位素富集的主要原因。研究区煤层气井排采水化学组成以Na-HCO3型为主，其变化受到水—岩相互作用、阳离子交换等过程的控制。沁水盆地6个研究区块煤层气井排采水的稳定碳同位素呈现高δ13CDIC值(-4.19‰～34.80‰，平均为16.51‰)、且与溶解无机碳含量呈明显正相关关系可能是微生物产甲烷作用的结果。煤层气井排采水中δ13CDIC与SO42-的负相关性以及δDH2O正漂移等指标也指向沁水盆地不同成熟度煤岩中次生生物成因甲烷的广泛存在。δ13CDIC与镜质体反射率(ROmax)的负相关性进一步表明沁水盆地不同成熟度煤层中广泛存在次生生物成因甲烷，且在浅埋藏和成熟度较低的煤层中最为显著。地球化学与微生物学的结合将会进一步阐明次生生物甲烷的形成途径和机制。

关键词：煤层气井排采水水化学特征碳同位素次生生物甲烷沁水盆地

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Equation of state for boron nitride along the principal Hugoniot to 16 Mbar

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Matter and Radiation at Extremes 2024年第5期9卷 77-86页

作者： Huan Zhang Yutong Yang Weimin Yang Zanyang Guan Xiaoxi Duan Mengsheng Yang Yonggang Liu Jingxiang Shen Katarzyna Batani Diluka Singappuli Ke Lan Yongsheng Li Wenyi Huo Hao Liu Yulong Li Dong Yang Sanwei Li Zhebin Wang Jiamin Yang Zongqing Zhao Weiyan Zhang Liang Sun Wei Kang Dimitri Batani National Key Laboratory of Plasma Physics Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900China HEDPS Center for Applied Physics and Technologyand College of PhysicsPeking UniversityBeijing 100871China HEDPS Center for Applied Physics and Technologyand School of EngineeringPeking UniversityBeijing 100871China institute of Plasma Physics and Laser Microfusion Hery 2301-497 WarszawaPoland Universitéde Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications)UMR 5107F-33405 TalenceFrance institute of Applied Physics and Computational Mathematics Beijing 100094China

The thermodynamic properties of boron nitride under extreme pressures and temperatures are of great interest and importance for materials science and inertial confinement fusion physics,but they are poorly understood owing to the challenges of performing experiments and realizing ab initio ***,we report the first shock Hugoniot data on hexagonal boron nitride at pressures of 5–16 Mbar,using hohlraum-driven shock waves at the SGIII-p laser facility in *** density functional theory molecular dynamics calculations closely match experimental data,validating the equations of state for modeling the shock response of boron nitride and filling a crucial gap in the knowledge of boron nitride properties in the region of multi-Mbar pressures and eV *** results presented here provide fundamental insights into boron nitride under the extreme conditions relevant to inertial confinement fusion,hydrogen–boron fusion,and high-energy-density physics.

关键词： boron Hugoniot extreme

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Marine Predators Algorithm with Deep Learning-Based Leukemia Cancer Classification on Medical Images

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 893-916页

作者： Sonali Das Saroja Kumar Rout Sujit Kumar Panda Pradyumna Kumar Mohapatra Abdulaziz S.Almazyad Muhammed Basheer Jasser Guojiang Xiong Ali Wagdy Mohamed Department of Computer Science&Engineering Gandhi Institute for TechnologyBPUTBhubaneswar752054India Department of Information Technology Vardhaman College of Engineering(Autonomous)Hyderabad501218TelanganaIndia Department of Electronic&Communication Engineering Vedang Institute of TechnologyBhubaneswar752010India Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Department of Computing and Information Systems School of Engineering and TechnologySunway UniversityJalan UniversitiBandar SunwaySelangor Darul Ehsan47500Malaysia research Centre for Human-Machine Collaboration(HUMAC) School of Engineering and TechnologySunway UniversityJalan UniversitiBandar SunwaySelangor Darul Ehsan47500Malaysia Guizhou Key Laboratory of Intelligent Technology in Power System College of Electrical EngineeringGuizhou UniversityGuiyang550025China Operations research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied Science research Center Applied Science Private UniversityAmman11931Jordan

In blood or bone marrow,leukemia is a form of cancer.A person with leukemia has an expansion of white blood cells(WBCs).It primarily affects children and rarely affects *** depends on the type of leukemia and the extent to which cancer has established throughout the *** leukemia in the initial stage is vital to providing timely patient *** image-analysis-related approaches grant safer,quicker,and less costly solutions while ignoring the difficulties of these invasive *** can be simple to generalize Computer vision(CV)-based and image-processing techniques and eradicate human *** researchers have implemented computer-aided diagnosticmethods andmachine learning(ML)for laboratory image analysis,hopefully overcoming the limitations of late leukemia detection and determining its *** study establishes a Marine Predators Algorithm with Deep Learning Leukemia Cancer Classification(MPADL-LCC)algorithm onMedical *** projectedMPADL-LCC system uses a bilateral filtering(BF)technique to pre-process medical *** MPADL-LCC system uses Faster SqueezeNet withMarine Predators Algorithm(MPA)as a hyperparameter optimizer for feature ***,the denoising autoencoder(DAE)methodology can be executed to accurately detect and classify leukemia *** hyperparameter tuning process using MPA helps enhance leukemia cancer classification *** results are compared with other recent approaches concerning various measurements and the MPADL-LCC algorithm exhibits the best results over other recent approaches.

关键词： Leukemia cancer medical imaging image classification deep learning marine predators algorithm

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Novel Blasting-Like Lubricating Process for Cold Extrusion

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 322-329页

作者：陈海棠胡成亮龚爱军施卫兵赵震 institute of Forming Technology&Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200030China National Engineering research Center of Die and Mold CAD Shanghai Jiao Tong UniversityShanghai 200030China Jiangsu Sunway Precision Forging Co. Ltd.Yancheng 224100JiangsuChina

A blasting-like lubricating process(combination of shot blasting and lubricating processes)is *** this process,the specimens to be treated,alloy shots,and solid lubricating powder are rotated together in a *** surface pockets formed due to the impact by the shots can store lubricants,and the lubricant can also adhere to the specimen surface by *** effects of process parameters,including rolling time,rotational speed,mass of alloy shots,and the diameter of shots,on the surface topography of the steel specimen are investigated using 13 experimental *** distribution ratio and average depth of surface pockets on the defined areas of the specimen are quantitatively *** selected schemes with the MoS_(2) solid lubricating powder are further carried out to lubricate the cylindrical billets,and the lubricating effect is evaluated using the steady combined forward and backward extrusion *** indicated friction factor of the novel blasting-like process is smaller than that of the conventional phosphate-soap coating process.

关键词： blasting-like process lubricating surface pocket friction factor cold extrusion

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Is Yang-Mills theory unitary in fractional spacetime dimensions?

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 59-64页

作者： Qingjun Jin Ke Ren Gang Yang Rui Yu Graduate School of China Academy of Engineering Physics Beijing 100193China School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Hangzhou 310024China School of Physical Science and Technology Inner Mongolia UniversityHohhot 010021China Beijing Computational Science research Center Beijing 100193China

We present concrete evidence that Yang-Mills theory exhibits non-unitarity in non-integer spacetime *** violation of unitarity stems from evanescent operators that,while vanishing in four dimensions,are non-zero in general d *** demonstrate that these evanescent operators lead to the emergence of both negative-norm states and complex anomalous dimensions.

关键词： gauge field theories field theories in dimensions other than four renormalization

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Strategies for improving crop comprehensive benefits via a decision-making system based on machine learning in the rice‒rape,rice‒wheat and rice‒garlic rotation systems in Southwest China

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Journal of Integrative Agriculture 2024年第9期23卷 2970-2988页

作者： Xinrui Li Xiafei Li Tao Liu Huilai Yin Hao Fu Yongheng Luo Yanfu Bai Hongkun Yang Zhiyuan Yang Yongjian Sun Jun Ma Zongkui Chen Crop Ecophysiology and Cultivation Key Laboratory of Sichuan Province/Rice research institute/State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China/Sichuan Agricultural University Chengdu 611130China College of Grassland Science and Technology Sichuan Agricultural UniversityChengdu 611130China College of Agronomy Sichuan Agricultural UniversityChengdu 611130China

Rice‒rape,rice‒wheat and rice‒garlic rotations are common cropping systems in Southwest China,and they have played a significant role in ensuring ecological and economic benefits(EB)and addressing the challenges of China’s food security in the ***,the crop yields in these rotation systems are 1.25‒14.73%lower in this region than the national *** decision-making with machine learning can analyze the key factors for obtaining better benefits,but it has rarely been used to enhance the probability of obtaining such benefits from rotations in Southwest ***,we used a data-intensive approach to construct an intelligent decision‒making system with machine learning to provide strategies for improving the benefits of rice-rape,rice-wheat,and rice-garlic rotations in Southwest *** results show that raising the yield and partial fertilizer productivity(PFP)by increasing seed input under high fertilizer application provided the optimal benefits with a 10%probability in the rice-garlic *** high yields and greenhouse gas(GHG)emissions by increasing the N application and reducing the K application provided suboptimal benefits with an 8%probability in the rice-rape *** N and P to enhance PFP and yield provided optimal benefits with the lowest probability(8%)in the rice‒wheat *** on the predictive analysis of a random forest model,the optimal benefits were obtained with fertilization regimes by reducing N by 25%and increasing P and K by 8 and 74%,respectively,in the rice-garlic system,reducing N and K by 54 and by 36%,respectively,and increasing P by 38%in rice-rape system,and reducing N by 4%and increasing P and K by 65 and 23%in rice-wheat *** strategies could be further optimized by 17‒34%for different benefits,and all of these measures can improve the effectiveness of the crop rotation systems to varying ***,these findings provide insights into optimal agricultural inputs for higher be

关键词： rice rotation agricultural management greenhouse gas emissions comprehensive benefits fertilizer management

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Intermittent disturbance mechanical behavior and fractional deterioration mechanical model of rock under complex true triaxial stress paths

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International Journal of Mining Science and Technology 2024年第1期34卷 117-136页

作者： Zhi Zheng Hongyu Xu Kai Zhang Guangliang Feng Qiang Zhang Yufei Zhao State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationCollege of Civil Engineering and ArchitectureGuangxi UniversityNanning 530004China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing 100080China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China

Mechanical excavation,blasting,adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass,leading to further fracture of damaged surrounding rock in three-dimensional high-stress and even causing ***,a novel complex true triaxial static-dynamic combined loading method reflecting underground excavation damage and then frequent intermittent disturbance failure is *** triaxial static compression and intermittent disturbance tests are carried out on *** effects of intermediate principal stress and amplitude on the strength characteristics,deformation characteristics,failure characteristics,and precursors of monzogabbro are analyzed,intermediate principal stress and amplitude increase monzogabbro strength and tensile fracture *** increases in microseismic parameters during rock loading can be precursors for intermittent rock *** on the experimental result,the new damage fractional elements and method with considering crack initiation stress and crack unstable stress as initiation and acceleration condition of intermittent disturbance irreversible deformation are proposed.A novel three-dimensional disturbance fractional deterioration model considering the intermediate principal stress effect and intermittent disturbance damage effect is established,and the model predicted results align well with the experimental *** sensitivity of stress states and model parameters is further explored,and the intermittent disturbance behaviors at different f are *** study provides valuable theoretical bases for the stability analysis of deep mining engineering under dynamic loads.

关键词： True triaxial static and disturbance test Mechanical properties Failure mechanism and precursor Intermittent disturbance effect Fractional mechanical model

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Evaluation of Four Anthropogenic Activity Impacts on Heavy Metal Quality of the Kumba River in the South West Region of Cameroon

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Journal of Water Resource and Protection 2024年第5期16卷 361-380页

作者： Martin Keghe Nkobe Barthelemy Ndongo Kanouo Boris Merlain Djousse Salomon Nyasse institute of Agricultural research for Development (IRAD) Yaound&#233 Cameroon Faculty of Agronomy and Agricultural Sciences (FASA) University of Dschang Dschang Cameroon

Anthropogenic activities have contributed to pollution of water bodies through deposition of diverse pollutants amongst which are heavy metals. These pollutants, which at times are above the maximum concentration levels recommended, are detrimental to the quality of the water, soil and crops (plant) with subsequent human health risks. The objective of the work was to evaluate the impacts of human-based activities on the heavy metal properties of surface water with focus on the Kumba River basin. Field observations, interviews, field measurements and laboratory analyses of different water samples enabled us to collect the different data. The results show four main human-based activities within the river basin (agriculture, livestock production, domestic waste disposal and carwash activities) that pollute surface water. Approximately 20.61 tons of nitrogen and phosphorus from agricultural activities, 156.48 tons of animal wastes, 2517.5 tons of domestic wastes and 1.52 tons of detergent from carwash activities were deposited into the river each year. A highly significant difference at 1% was observed between the upstream and downstream heavy metal loads in four of the five heavy metals tested except for copper that was not significant. Lead concentrations were highest in all the activities with an average of 2.4 mg∙L−1 representing 57.81%, followed by zinc with 1.596 mg∙L−1 (38.45%) and manganese with 0.155 mg∙L−1 (3.74%) for the different anthropogenic activities thus indicating that these activities highly lead to pollution of the Kumba River water. The level of zinc and manganese was significantly influenced at ρ 005 by anthropogenic activities though generally the variations were in the order: carwash (3.196 mg∙L−1) −1) −1) −1) r

关键词： Metal Properties Human-Based Activities Kumba River Basin Surface Water

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Atmospheric chemistry of 2-nitrobenzaldehyde:Initiated by photo-excitation,OH-oxidation,and small TiO_(2) clusters adsorption catalysis

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Journal of Environmental Sciences 2024年第5期139卷 123-137页

作者： Feng-Yang Bai Xiang-Huan Liu Ting-Ting Meng Zhou Yu Yi-Chen Wang Shuang Ni Zhen Zhao institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034China

The fate of 2-nitrobenzaldehyde(2-NBA)is of interest in atmospheric chemistry as it is a semi-volatile organic compound with high *** study presents a quantum chemical study of the gas-phase reactions of 2-NBA photo-excitation and OH-oxidation in the absence and presence of small TiO_(2) *** further understand the unknown photolysis mechanism,the photo-reaction pathways of ground singlet state and the lying excited triplet state of 2-NBA were investigated including the initial and subsequent reactions of proton transfer,direct CO,NO_(2),and HCO elimination routes in the presence of O_(2) and ***,the OH-mediated degradation of 2-NBA proceeded via five H-extraction and six OH-addition channels by indirect mechanism,which follows a succession of reaction steps initiated by the formation of weakly stable intermediate *** H-extraction from the-CHO group was the dominant pathway with a negative activation energy of-1.22 kcal/*** calculated rate coefficients at 200–600 K were close to the experimental data in literature within 308-352 K,and the kinetic negative temperature independence was found in both experimental literature and computational ***,2-NBA was favored to be captured onto small TiO_(2) clusters via six adsorption configurations formed via various combination of three types of bonds of Ti…O,Ti…C,and O…H between the molecularly adsorbed 2-NBA and TiO_(2) *** indicted that the chemisorptions of aldehyde oxygen have largest *** results suggested adsorption conformations have a respectable impact on the catalysis *** study is significant for understanding the atmospheric chemistry of 2-nitrobenzaldehyde.

关键词： 2-nitrobenzaldehyde OH radical oxidation Rate coefficient Photolysis mechanism Adsorption catalysis

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