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Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma

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Oncology research 2024年第4期32卷 679-690页

作者： XINFENG ZHANG SHUANG LI MEIRU SONG YUE CHEN LIANGZHENG CHANG ZHERUI LIU HONGYUAN DAI YUTAO WANG GANGQI YANG YUN JIANG YINYING LU The PLA 307 Clinical College of Anhui Medical University The Fifth Clinical Medical College of Anhui Medical UniversityHefei230032China Liver Tumor Diagnosis and research Center 5th Medical Center of the PLA General HospitalBeijing100039China Department of Infection Diseases Guizhou Medical UniversityGuiyang550025China 4302 Clinical Medical School Peking UniversityBeijingChina Cell and Gene Therapy innovation Center Beijing Lotuslake BiomedicalScience and Technology ParkBeijing102206China State Key Laboratory of Chemical Oncogenomics and the institute of Biopharmaceutical and Health Engineering(iBHE) Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China

Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality *** and recurrence primarily contribute to the high mortality rate of liver *** carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and ***,the efficacy of FAK phosphorylation inhibitors is currently ***,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC *** study examined the correlation between FAK expression and the prognosis of ***,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor *** expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying *** results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in *** expression of E-cadherin and decreased expression of vimentin indicated that EMT was ***,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs.

关键词： Hepatocellular carcinoma(HCC) Focal adhesion kinase(FAK) Proteolytic targeting chimera technology(PROTAC) Epithelial-mesenchymal transformation(EMT) Metastasis

Study on the Fine Configuration of Reservoir in River Facies Oilfield in Bohai Sea Area

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Open Journal of Applied Sciences 2024年第2期14卷 391-397页

作者： Jianmin Zhang Xijie Wang Pengfei Mu Shicong Lyu Jun Xie Bohai Oilfield research institute Tianjin Branch of CNOOC Ltd. Tianjin China

The geological conditions of offshore shallow water delta oil reservoirs were complex, with limited well data and large well spacing. Taking A Oilfield in the Bohai Sea Area, China as an example, the target sand body was formed in a shallow water delta sedimentary environment, with well-developed underwater distributary channels and frequent branching and diversion. The reservoir was strong non-uniformity and uneven plane water cut pressure. To this end, based on the existing work of predecessors, combined with seismic, logging, and production dynamics data, and based on the genesis mechanism of shallow water delta reservoirs, the boundary of composite river channels was identified through seismic facies, and logging facies were used to subdivide them into single river levels within the composite river channels. Then, seismic waveform characteristics were applied to track and characterize the plane distribution of single river channels, guiding the efficient development of offshore shallow water delta oil fields and achieving increased storage and production in Bohai Oilfield, China.

关键词： Shallow Water Delta Reservoir Configuration Seismic Facies Single Channel Dominant Channel

Traceable ring signature schemes based on SM2 digital signature algorithm and its applications in the data sharing scheme

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Frontiers of Computer Science 2024年第2期18卷 251-253页

作者： Yongxin ZHANG Hong LEI Bin WANG Qinghao WANG Ning LU Wenbo SHI Bangdao CHEN Qiuling YUE R&D Department SSC Holding CompanyLtd.Chengmai 571924China School of Cyberspace Security(School of Cryptography) Hainan UniversityHaikou 570228China College of Computer Science and Engineering Northeastern UniversityShenyang 110819China School of Computer Science and Technology Xidian UniversityXi'an 710071China Blockchain research Group Oxford-Hainan Blockchain Research InstituteChengmai 571924China

1 Introduction Identity privacy concerns hinder data sharing by casting doubt on the safeguarding of personal information,eroding trust,and impeding the willingness of individuals and organizations to exchange their data[1,2].The traceable ring signatures(TRSs)addresses the contradiction between identity privacy and regulation[3],no scheme has been developed thus far that is based on SM2,the Chinese cryptographic public key algorithm standard,without relying on centralized trust.

关键词： SM2 signature scheme

A three-way electrolyte with ternary solvents for high-energy-density and long-cycling lithium-sulfur pouch cells

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SusMat 2024年第2期4卷 1-12页

作者： Zheng Li Legeng Yu Chen-Xi Bi Xi-Yao Li JinMa Xiang Chen Xue-Qiang Zhang Aibing Chen Haoting Chen Zuoru Zhang Li-Zhen Fan Bo-Quan Li Cheng Tang Qiang Zhang Tsinghua Center for Green Chemical Engineering Electrification Beijing Key Laboratory of Green Chemical Reaction Engineering and TechnologyDepartment of Chemical EngineeringTsinghua UniversityBeijingChina School of Materials Science and Engineering Beijing Institute of TechnologyBeijingChina institute of Advanced Materials and Technology University of Science and TechnologyBeijingChina Shanxi research institute for Clean Energy Tsinghua UniversityTaiyuanChina Center for Next-Generation Energy Materials and School of Chemical Engineering Sungkyunkwan UniversityJangan-GuSuwon-SiGyeonggi-DoRepublic of Korea College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuangChina Ordos Carbon Neutral research and Application Co. Ltd.Kangbashi DistrictOrdos CityInner MongoliaChina institute for Carbon Neutrality Tsinghua UniversityBeijingChina

Lithium–sulfur(Li–S)batteries promise high-energy-density potential to exceed the commercialized lithiumion batteries but suffer from limited cycling lifespan due to the side reactions between lithium polysulfides(LiPSs)and Li metal ***,a three-way electrolyte with ternary solvents is proposed to enable high-energy-density and long-cycling Li–S pouch ***,ternary solvents composed of 1,2-dimethoxyethane,di-isopropyl sulfide,and 1,3,5-trioxane are employed to guarantee smooth cathode kinetics,inhibit the parasitic reactions,and construct a robust solid electrolyte interphase,*** cycling lifespan of Li–S coin cells with 50μm Li anodes and 4.0 mg cm^(−2) sulfur cathodes is prolonged from88 to 222 cycles using the three-way ***-heterogeneous solvation structure of LiPSs and organic-rich solid electrolyte interphase are identified to improve the cycling stability of Li metal ***,a 3.0 Ah-level Li–S pouch cell with the three-way electrolyte realizes a high energy density of 405 Wh kg^(−1) and undergoes 27 *** affords a three-way electrolyte recipe for suppressing the side reactions of LiPSs and inspires rational electrolyte design for practical high-energy-density and long-cycling Li–S batteries.

关键词： lithium metal anodes lithium-sulfur batteries pouch cells solid electrolyte interphase three-way electrolyte

Angioinvasive mucormycosis in burn intensive care units:A case report and review of literature

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World Journal of Critical Care Medicine 2024年第1期13卷 76-84页

作者： Atul Parashar Chandra Singh Plastic Surgery Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

BACKGROUND Mucormycosis is a rare,rapidly progressive and often fatal fungal *** rarity of the condition lends itself to unfamiliarity,delayed treatment,and poor *** of fungal infections early enough to enable appropriate treatment occurs in less than half of affected *** SUMMARY An 11-year-old girl with a history of 15%total body surface area scald burns involving both lower limbs progressed to develop angioinvasive *** further led to a thrombosis of the right external iliac artery and vein and rapidly progressive necrosis of surrounding soft *** also had dextrocardia and patent foramen ovale.A right hip disarticulation and serial aggressive debridements were performed but she went on to develop systemic sepsis with multisystem involvement and succumbed to the *** revealed mucor species with extensive vascular *** This case highlights the importance of maintaining vigilance for mycotic infections and acting appropriately when there are signs of fulminant wound infection.

关键词： Angioinvasiveness Mucormycosis Burn sepsis Femoral artery thrombosis Case report

Wireless sequential dual light delivery for programmed PDT in vivo

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Light(Science & Applications) 2024年第6期13卷 1047-1061页

作者： Jiayi Liu Bowen Sun Wenkai Li Han-Joon Kim Shu Uin Gan John S.Ho Juwita Norasmara Bte Rahmat Yong Zhang Department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore Department of Mechanical Engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore Department of Electrical and Computer Engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The N.1 institute for Health National University of SingaporeSingapore117456Singapore institute for Health innovation and Technology National University of SingaporeSingapore119276Singapore Department of Biomedical Engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

Advances in multi-scale design and fabrication processes for thick electrodes in lithium-ion batteries

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Energy Reviews 2024年第2期3卷 14-30页

作者： Xiuxue Liu Yubin Zeng Wei Yuan Guanhua Zhang Huai Zheng Zhongxue Chen Key Laboratory of Hydraulic Machinery Transients Ministry of EducationSchool of Power and Mechanical EngineeringWuhan UniversityWuhan430072China School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510640GuangdongChina State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Greater Bay Area institute for innovation Hunan UniversityGuangzhou511300China

In the contemporary era,lithium-ion batteries have gained considerable attention in various industries such as 3C products,electric vehicles and energy storage systems due to their exceptional *** the rapid progress in the energy storage sector,there is a growing demand for greater energy density in lithium-ion *** the use of thick electrodes is a straightforward and effective approach to enhance the energy density of battery,it is hindered by the sluggish reaction dynamics and insufficient mechanical ***,we comprehensively review recent advances in the field of thick electrodes for lithium-ion batteries to overcome the bottlenecks in the development of thick electrodes and achieve efficient fabrication for high-performance lithium-ion ***,a systematic analysis is performed to identify the factors affecting the performance of the thick *** correlation between electrode materials,structural parameters,and performance is also ***,the viable strategies for constructing thick electrodes with improved properties are summarize,including high throughput,high conductivity and low tortuosity,in both material development and structural *** addition,recent advances in efficient fabrication methods for thick electrode fabrication are reviewed,with a comprehensive assessment of their merits,limitations,and applicable ***,a comprehensive overview of the multiscale design and manufacturing process for thick electrodes in lithium-ion batteries is provided,accompanied by valuable insights into design considerations that are crucial for future advances in this area.

关键词： Lithium-ion battery Thick electrode High energy density Electrode structure Multi-scale design Material development

Few-shot image recognition based on multi-scale features prototypical network

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High Technology Letters 2024年第3期30卷 280-289页

作者： LIU Jiatong DUAN Yong School of Information Science Engineering Shenyang University of TechnologyShenyang 110870P.R.China Shenyang Key Laboratory of Advanced Computing and Application innovation Shenyang 110870P.R.China

In order to improve the model􀆳s capability in expressing features during few-shot learning,a multi-scale features prototypical network(MS-PN)algorithm is *** metric learning algo-rithm is employed to extract image features and project them into a feature space,thus evaluating the similarity between samples based on their relative distances within the metric *** sufficiently extract feature information from limited sample data and mitigate the impact of constrained data vol-ume,a multi-scale feature extraction network is presented to capture data features at various scales during the process of image feature ***,the position of the prototype is fine-tuned by assigning weights to data points to mitigate the influence of outliers on the *** loss function integrates contrastive loss and label-smoothing to bring similar data points closer and separate dissimilar data points within the metric *** evaluations are conducted on small-sample datasets mini-ImageNet and *** method in this paper can achieve higher classification ***,in the 5-way 1-shot experiment,classification accuracy reaches 50.13%and 66.79%respectively on these two ***,in the 5-way 5-shot ex-periment,accuracy of 66.79%and 85.91%are observed,respectively.

关键词： few-shot learning multi-scale feature prototypical network channel attention label-smoothing

MRE11 lactylation:a linker between Warburg effect and DNA repair

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Life Metabolism 2024年第3期3卷 6-8页

作者： Pingyu Liu Hongbin Ji Fuming Li Human Phenome institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China institute of Metabolism and Integrative Biology State Key Laboratory of Cell BiologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China School of Life Science and Technology Shanghai Tech UniversityShanghai 200120China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China

Lysine lactylation is a recently discovered post-translational modification with emerging roles in both physiology and disease.A recent study published in Cell shows that lactate-induced lactylation of the homologous recombination(HR)protein meiotic recombination 11 results in HR hyperactivation and chemoresistance in cancer cells,establishing a previously unrecognized link between cellular metabolism and deoxyribonucleic acid(DNA)damage repair and providing new insights into how altered glucose metabolism can impact DNA damage response in cancer.

关键词： metabolism damage establishing