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An equivariant index theorem on R~n in the context of continuous fields of C*-algebras

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Science China Mathematics 2025年

作者： Baiying Ren Hang Wang Zijing Wang research center for Operator Algebras School of Mathematical SciencesEast China Normal University

We prove an equivariant index theorem on the Euclidean space using a continuous field of C*-algebras. This generalizes the work of Elliott et al.（1996）, which is a special case of the algebraic index theorem by Nest and Tsygan （1995）. Using our formula, we see that the equivariant index of the Bott-Dirac operator on R2ncan be explicitly calculated.

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Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration

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Neural Regeneration research 2025年第12期20卷 3635-3648页

作者： Hui Xu Lining Cao Yuxi Chen Cuiping Zhou Jie Xu Zhuolin Zhang Xiangyu Li Lihua Liu Jianfeng Lu Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation center) Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Key Lab of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina

Inflammation plays a crucial role in the regeneration of fish and avian ***,how inflammation regulates Müller glia(MG)reprogramming remains ***,we used single-cell RNA sequencing to investigate the cell heterogeneity and interactions of MG and immune cells in the regenerating zebrafish *** first showed that two types of quiescent MG(resting MG1 and MG2)reside in the uninjured *** retinal injury,resting MG1 transitioned into an activated state expressing known reprogramming genes,while resting MG2 gave rise to rod *** further showed that retinal microglia can be categorized into three subtypes(microglia-1,microglia-2,and proliferative)and pseudotime analysis demonstrated dynamic changes in microglial status following retinal *** of cell–cell interactions indicated extensive crosstalk between immune cells and MG,with many interactions shared among different immune cell ***,we showed that inflammation activated Jak1–Stat3 signaling in MG,promoting their transition from a resting to an activated *** study reveals the cell heterogeneity and crosstalk of immune cells and MG in zebrafish retinal repair,and may provide valuable insights into future mammalian retina regeneration.

关键词： immune cells inflammation Jak1-Stat3 signaling microglia Müller glia regeneration reprogramming retina single-cell RNAseq zebrafish

Fault Diagnosis for Railway Point Machines Using VMD Multi-Scale Permutation Entropy and ReliefF Based on Vibration Signals

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Chinese Journal of Electronics 2025年第1期34卷 204-211页

作者： Yongkui Sun Yuan Cao Peng Li Shuai Su National Engineering research center of Rail Transportation Operation and Control System Beijing Jiaotong University School of Automation and Intelligence Beijing Jiaotong University Frontiers Science center for Smart High-speed Railway System Beijing Jiaotong University

The railway point machine plays an important part in railway systems. It is closely related to the safe operation of trains. Considering the advantages of vibration signals on anti-interference, this paper develops a novel vibration signal-based diagnosis approach for railway point machines. First, variational mode decomposition(VMD)is adopted for data preprocessing, which is verified more effective than empirical mode decomposition. Next, multiscale permutation entropy is extracted to characterize the fault features from multiple scales. Then ReliefF is utilized for feature selection, which can greatly decrease the feature dimension and improve the diagnosis accuracy. By experiment comparisons, the proposed approach performs best on diagnosis for railway point machines. The diagnosis accuracies on reverse-normal and normal-reverse processes are respectively 100% and 98.29%.

关键词： Vibrations Fault diagnosis Accuracy Data preprocessing Switches Feature extraction Rail transportation Entropy Maintenance Monitoring

Decoupling the roles of grain boundary strength and grain size hidden in grain-level electro-chemo-mechanical failure of solid-state electrolyte

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Journal of Energy Chemistry 2025年第2期101卷 685-691页

作者： Ming Xu Xuyang Wang Zhengqian Jin Xingxing Jiao Ya Gao Zhongxiao Song Xieyu Xu Kai Xi Yangyang Liu School of Chemistry Engineering Research Center of Energy Storage Materials and Devices Ministry of Education Xi'an Jiaotong University State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University research Institute of Frontier Science Southwest Jiaotong University School of Instrument Science and Technology Xi'an Jiaotong University

Garnet lithium lanthanum zirconium oxide(Li7La3Zr2O12,LLZO) is a benchmark solid-state electrolyte（SSE） material receiving considerable attention owing to its high conductivity and chemical stability against Li *** its electro-chemo-mechanical failure mechanisms have been much investigated,the equivocal roles of grain boundary strength and grain size of LLZO remain under-explored,hindering further performance *** we decoupled the effects of grain size and grain boundary strength of polycrystalline LLZO via the combination of electrochemical kinetics and the cohesive zone *** discovered that the disintegration of LLZO is initiated by the accumulation of local displacements,which strongly relates to the changes in both grain size and grain boundary ***,variations in grain boundary strength affect the diffusion and propagation pathways of damage,while the failure of LLZO is determined by the grain *** LLZO grains facilitate transgranular damage under low grain boundary strength,which can alter local chemo-mechanics within the bulk of LLZO,leading to more extensive damage *** results showcase the structure optimization pathways by preferentially controlling the growth of lithium dendrites at grain boundaries and their penetration in garnet-type SSE.

关键词： Electro-chemo-mechanics Grain boundary Growth of lithium metal Solid-state electrolyte

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

Advances in neoadjuvant therapy for resectable intrahepatic cholangiocarcinoma: An invited commentary

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Oncology and Translational Medicine 2025年第1期11卷 1-4页

作者： Ruyu Han Peipei Song Wei Tang Tianqiang Song Lu Chen Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerNational Key Laboratory of Druggability Evaluation and Systematic Translational MedicineTianjin Key Laboratory of Digestive CancerTianjin’s Clinical Research Center for CancerTianjinChina Department of Hepatobiliary Cancer Liver Cancer Research CenterTianjin Medical University Cancer Institute and HospitalTianjinChina National center for Global Health and Medicine TokyoJapan

Intrahepatic cholangiocarcinoma(ICC)poses a significant threat to human health owing to its high malignancy rate and poor ***-gery is the most effective treatment option for ***,the prognosis remains unfavorable even after surgical ***,neo-adjuvant therapy has emerged as a potential treatment option for patients with *** therapy can improve patient prognosis by reducing the tumor size and eliminating tiny lesions that are not visible to the naked ***,specific treatment options for neoad-juvant therapy are *** review summarizes the studies on neoadjuvant therapy for ICC in the last decade,including chemotherapy,radiotherapy,interventional therapy,targeted therapy,and immunotherapy,with the aim of providing suggestions for the selection of clinical treatment options for patients with *** reports suggest that chemotherapy is the most effective neoadjuvant treatment ***-ever,radiotherapy and interventional therapies require further investigation to obtain conclusive *** targeted thera-pies and immunotherapies have been studied less extensively,several ongoing clinical trials are investigating these promising approaches.

关键词： Intrahepatic cholangiocarcinoma Resectable Neoadjuvant therapy

Facile and gram-scale synthesis of single-crystal hydrogen-bonded organic frameworks as iodine adsorbents for synthesis of β-iodoethers

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Science China Chemistry 2025年

作者： Zhiye Zheng Qiuyuan Lin Shunfeng Peng Yuxuan Zhang Shuting Xu Hui Zhang Hongyu Wang Department of Chemistry College of Science Center for Supramolecular Chemistry & Catalysis Shanghai University Laboratory for Microstructures Instrumental Analysis and Research Center Shanghai University

The facile synthesis of single-crystal hydrogen-bonded organic frameworks（HOFs） on a gram scale remains a significant challenge but is crucial for practical applications. Herein, we report a novel strategy to prepare two three-dimensional（3D）single-crystal HOFs at ambient temperature and pressure with gram-scale products. The imine-linked oligomers were synthesized using ionic liquids as catalysts, which self-assembled in situ to form large single crystals. The optimal material, H1,exhibited iodine uptake capacities of 6.02 and 4.44 g g-1from vapor and aqueous solutions, respectively, ranking among the highest reported HOFs. For the first time, the iodine-adsorbed H1 was used as an iodine source for synthesizing β-iodoethers,achieving excellent yields comparable to those obtained using iodine as the reactant. This study not only presents a simple method for the scalable synthesis of single-crystal HOFs but also explores a potential application of iodine-adsorbed materials in organic synthesis.

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An ionic liquid functionalized sericin hydrogel for drug-resistant bacteria-infected diabetic wound healing

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Chinese Chemical Letters 2025年第2期36卷 307-313页

作者： Jiajia Wang XinXin Ge Yajing Xiang Xiaoliang Qi Ying Li Hangbin Xu Erya Cai Chaofan Zhang Yulong Lan Xiaojing Chen Yizuo Shi Zhangping Li Jianliang Shen National Engineering research center of Ophthalmology and Optometry Eye HospitalWenzhou Medical University School of Chemical Engineering Nanjing University of Science&Technology School&Hospital of Stomatology Wenzhou Medical University Zhejiang Engineering research center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of Sciences The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital

Diabetic wound healing is often complicated due to bacterial infections that intensify inflammation. Employing hydrogel dressings with inherent antibacterial properties can significantly reduce reliance on antibiotics for treating infected wounds in diabetics. Traditional hydrogels typically rely on the infiltration of bacteria into their porous structure to manifest antibacterial effects. However, this infiltration process is not only prolonged but can also exacerbate inflammation, further delaying the healing of the ***, promptly capturing and eliminating bacteria is crucial for enhancing the antibacterial efficiency of the hydrogel. In this context, we present a multifunctional hydrogel dressing, termed SIP, designed to tackle drug-resistant bacterial infections in diabetic wounds. This dressing integrates ionic liquid functional groups into a sericin-based matrix: phenylboronic acid for the immobilization of bacteria and imidazole for their subsequent annihilation. Expectedly, the SIP system demonstrates potent antibacterial activity against methicillin-resistant Staphylococcus aureus, verified through in vitro and in vivo experiments. As a result, SIP emerges as a promising candidate in the realm of hydrogel dressings with innate antibacterial properties, showcasing considerable potential for addressing diabetic wounds plagued by drug-resistant bacterial infections.

关键词： Diabetic wound healing Hydrogels Ionic liquids Methicillin-resistant Staphylococcus aureus infection Sericin

Annual Optimal Performance Analysis of Micro Heat Pipe PV/T under Different Angles in Northwest China

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Journal of Thermal Science 2025年第02期 400-412页

作者： LIU Xiaomin WU Qingbai LI Jinping Vojislav NOVAKOVIC School of Energy and Power Engineering Lanzhou University of Technology Collaborative Innovation center for Supporting Technology of Northwest Low-Carbon Towns Gansu Key Laboratory of Complementary Energy System of Biomass and Solar Energy Gansu natural Energy research Institute Department of Energy and Process Engineering Norwegian University of Science and Technology

The exploitation of photovoltaic/thermal（PV/T） systems,which facilitate concurrent conversion of solar radiation into electrical and heat energies,presents substantial potential in the solar-abundant northwestern zone of *** investigation endeavors to evaluate the efficacy of a micro heat pipe（M-HP） PV/T system via exhaustive experimental analysis conducted in *** improve the performance of M-HP-PV/T system,a comparison was made between the optimal angles for each day and the entire *** system inside greenhouse exhibited an average photovoltaic conversion efficiency（PCE） and thermal conversion efficiency（TCE） of12.32% and 42.81%.The system of external environment registered average PCE and TCE values of 12.99% and21.08%.To further understand the system's operational results,a mathematical model was constructed through the integration of experimental data,exhibiting good agreement between the simulated outcomes and empirical *** average solar irradiance of daily optimum angle was 728.3 W/m2;the annual optimum angle was 29° with an average solar irradiance of 705.6 W/*** average annual total powers at the optimal angle outside the greenhouse and inside the greenhouse were 448.0 W and 398.7 *** average annual total efficiencies at the optimal angle outside the greenhouse and inside the greenhouse were 40.8% and 56.9%.The total power in the greenhouse was lower by 49.3 W,while total efficiency in the greenhouse was higher by 16.1%.

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