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Science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang Juan Li Wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide

CoTCPP integrates with BiOBr microspheres for improved solar-driven CO_(2)reduction performance

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Green Energy & Environment 2025年第1期10卷 193-202页

作者： Lina Li Yi Zhang Gaopeng Liu Tiange Wei Junze Zhao Bin Wang Mengxia Ji Yuanbin She Jiexiang Xia Huaming Li School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu University301 Xuefu RoadZhenjiang212013China State Key Laboratory Breeding base of Green Chemistry-Synthesis Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

CO_(2) photoreduction into carbon-based chemicals has been considered as an appropriate way to alleviate the energy issue and greenhouse ***,the 5,10,15,20-tetra(4-carboxyphenyl)porphyrin cobalt(II)(CoTCPP)has been integrated with BiOBr microspheres and formed the CoTCPP/BiOBr *** as-prepared CoTCPP/BiOBr-2 composite shows optimized photocatalytic performance for CO_(2) conversion into CO and CH_(4) upon irradiation with 300 W Xe lamp,which is 2.03 and 2.58 times compared to that of BiOBr,*** introduced CoTCPP significantly enhanced light absorption properties,promoted rapid separation of photogenerated carriers and boosted the chemisorption of CO_(2) *** metal Co^(2+) at the center of the porphyrin molecules also acts as adsorption center for CO_(2) molecules,accelerating the CO_(2) conversion into CO and *** possible mechanism of CO_(2) photoreduction was explored by in-situ FT-IR *** work offers a new possibility for the preparation of advanced photocatalysts.

关键词： BiOBr CoTCPP CO_(2)photoreduction Carriers transfer CO_(2)adsorption-activation

Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells accelerate tooth extraction socket healing through the jaw vascular unit

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Science China Life Sciences 2025年

作者： Ruyu Wang Tianxiao Wang Ziyu Chen Jiandong Jiang Yifei Du Hua Yuan Yongchu Pan Yuli Wang Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical University State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University Department of Stomatology Chongzhou People's Hospital Medical Basic research Innovation Centre for Cardiovascular and Cerebrovascular Diseases Ministry of Education International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical University Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Department of Orthodontic The Affiliated Stomatological Hospital of Nanjing Medical University State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University

Delayed tooth extraction socket(TES) healing can cause failure of subsequent oral implantation and increase socioeconomic burden on patients. Excessive amounts of M1 macrophages, apoptotic neutrophils(ANs), and neutrophil extracellular traps(NETs) impair alveolar bone regeneration during TES healing. In the present study, we first discovered that conditioned medium(CM) collected from berberine-treated human bone marrow mesenchymal stem cells(BBR-HB-CM) accelerated TES healing. BBR-HB-CM contained bioactive materials that promoted the polarization of macrophages from M1 to M2, impeded the formation of ANs and NETs, and modulated M2 macrophage efferocytosis in vivo and in vitro. Mechanistically, BBR-HB-CM promoted bone formation by inhibiting macrophage-myofibroblast transition and reprogrammed macrophage polarization through p85/AKT/mTOR pathway-dependent autophagy. The 3-methyladenine abolished the therapeutic effects of BBR-HB-CM. Further studies revealed that BBR-HB-CM accelerated TES healing in rats with type 2 diabetes mellitus. Overall, our results demonstrated that BBR-HB-CM had high potential to promote rapid TES healing.

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research ON CATIONIC POLYMER WATER base DRILLING FLUIDS

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Journal of Wuhan University of Technology(Materials Science) 1997年第Z1期12卷 94-102页

作者：刘雨晴 research Institute of Petroleum Exploration and Development

Cationic polymer drilling fluid (CPDF) is a new water base drilling fluid in which high molecular weight (HMW) cationic polymer (CPAM) is an encapsulating and flocculating agent and organic quaternary ammonium compound (NW-1) acts as shale inhibitor. This paper describes the experimental results of cuttings recovery, particle size distribution layer spacing and Zeta potential, and discusses the inhibition of CPDF system and its major additives. The advantages of CPDF will be proved by its application in well LX-2.

关键词： cationic polymer drilling fluid high molecule encapsulating agent flocculating agent shale inhibitor application

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

A cyclic UH model for sand

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Earthquake Engineering and Engineering Vibration 2015年第2期14卷 229-238页

作者： Wan Zheng research Institute of base and Foundation China Academy of Building Research

A simple cyclic elastoplastic constitutive model for sand is proposed based on the UH model for overconsolidated clay. The proposed model has the following features. First, in order to describe the stress-induced anisotropy in sand, a rotational hardening rule is introduced for the evolution of the yield surface axis with development of plastic deviatoric strain in the principal stress space. Second, the relationship between the rotational axis and stress-induced anisotropy is modeled by introducing the slope of rotational axis into the yield function. The fl atness of the yield surface can be determined by the slope of rotational axis. Finally, a revised unifi ed hardening parameter is proposed to incorporate the stress-induced anisotropy. The model capability in describing the cyclic response of sand is verifi ed by comparing the simulations with available test results.

关键词： stress-induced anisotropy sand unifi ed hardening

Vulnerability analysis for airport networks based on fuzzy soft sets: From the structural and functional perspective

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Chinese Journal of Aeronautics 2015年第3期28卷 780-788页

作者： Li Shanmei Xu Xiaohao Air Traffic Management research base Civil Aviation University of China

Abstract Recently, much attention has been paid to the reliability and vulnerability of critical infrastructure. In air traffic systems, the vulnerability analysis for airport networks can be used to guide air traffic administrations in their prioritization of the maintenance and repair of airports, as well as to avoid unnecessary disturbances in the planning of flight schedules. In this paper, the evaluation methods of airport importance and network efficiency arc established. Firstly, the evaluation indices of airport importance are proposed from both the topological and functional perspectives. The topological characteristics come from the structure of airport network and the functional features stem from the traffic flow distribution taking place inside the network. Secondly, an integrated evaluation method based on fuzzy soft set theory is proposed to identify the key airports, which can fuse together importance indices over different time intervals. Thirdly, an airport network efficiency method is established for the purpose of assessing the accuracy of the evaluation method. Finally, empirical studies using real traffic data of US and China＇s airport networks show that the evaluation method proposed in this papcr is the most accuratc. Thc vulucrability of US and China＇s airport networks is compared. The similarities and differences between airport geography distribution and airport importance distribution are discussed here and the dynamics of airport importance is studied as well.

关键词： Air traffic Airport network Complex networkFuzzy soft sets Key node

The Hazard and Risk Science base at Beijing Normal University—Enhancing Disciplinary research and Education Capacity in China

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International Journal of Disaster Risk Science 2010年第1期1卷 46-47页

作者： Wei Xu Juan Du Hazard and Risk Science base State Key Laboratory of Earth Surface Processes and Resource Ecology/Academy of Disasters Reduction and Emergency ManagementBeijing Normal UniversityBeijing 100875 China

Jointly initiated in 2005 by the Ministry of Education and the State Administration of Foreign Experts Affairs,China,the Expertise-Introduction Project for Disciplinary Innovation of Universities,also known as the"111 Project"in China,is an ambitious national program that aims to draw about I000leading overseas scholars and researchers from the top 100 leading universities and research institutions in the world to build 100 innovative bases for disciplinary development and research in China(1000-100-100,thus the nickname“111 Project”).

关键词： bases initiated Disciplinary

Topological Structure of US Flight Network based on Complex Network Theory

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Transactions of Nanjing University of Aeronautics and Astronautics 2015年第5期32卷 555-559页

作者：李善梅徐肖豪王飞王兴隆 Air Traffic Management research base Civil Aviation University of China

US flight network,composed of 285airports(nodes)and 3 971flights(edges)is studied.A static network model and a dynamic network model of US flight network are ***,the characteristics of static network are *** finds that such a network is a″small-world″and″scale-free″*** cumulative degree distributions of weighted network and unweighted network follow″Double Pareto Law″.And the degree exponent of weighted network is smaller than unweighted *** average shortest-path length is 2.368 9,which is smaller than previous *** clustering coefficient of unweighted network is 0.637 1and of weighted network is 0.653 6,which are both bigger than previous *** correlation of degree,unweighted clustering coefficient and weighted clustering coefficient are also ***,the characteristics of dynamic network are *** structure of flight network is changing as the time goes by on a *** rush hours,the network′s character of″scale-free″is stronger than other *** then the relationships of topological structures and congestion effects are addressed.

关键词： complex network scale-free small-world congestion effect

Secure beamforming and deployment design for rate-splitting multiple access-based UAV communications

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Science China(Information Sciences) 2025年第1期68卷 342-356页

作者： Bing WANG Xiaofeng TAO Shujun HAN Huici WU Kai YANG Zhu HAN National Engineering research Center of Mobile Network Technologies Beijing University of Posts and Telecommunications Peng Cheng Laboratory Department of Electrical and Computer Engineering University of Houston

Rate-splitting multiple access(RSMA) has recently gained attention as a potential robust multiple access(MA)scheme for upcoming wireless networks. Given its ability to efficiently utilize wireless resources and design interference management strategies, it can be applied to unmanned aerial vehicle(UAV) networks to provide convenient services for large-scale access ground users. However, due to the line-of-sight(LoS) broadcast nature of UAV transmission, information is susceptible to eavesdropping in RSMA-based UAV networks. Moreover, the superposition of signals at the receiver in such networks becomes complicated. To cope with the challenge, we propose a two-user multi-input single-output(MISO) RSMA-based UAV secure transmission framework in downlink communication networks. In a passive eavesdropping scenario, our goal is to maximize the sum secrecy rate by optimizing the transmit beamforming and deployment location of the UAV-base station(UAV-BS),while considering quality-of-service(QoS) constraints, maximum transmit power, and flight space limitations. To address the non-convexity of the proposed problem, the optimization problem is first decoupled into two subproblems. Then, the successive convex approximation(SCA) method is employed to solve each subproblem using different propositions. In addition, an alternating optimization(AO)-based location RSMA(L-RSMA) beamforming algorithm is developed to implement joint optimization to obtain the suboptimal solution. Numerical results demonstrate that(1) the proposed L-RSMA scheme yields a28.97% higher sum secrecy rate than the baseline L-space division multiple access(SDMA) scheme;(2) the proposed L-RSMA scheme improves the security performance by 42.61% compared to the L-non-orthogonal multiple access(NOMA) scheme.

关键词： rate-splitting multiple access UAV communication precoding optimization deployment location physical layer security

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