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Protective Effects of Danmu Extract Syrup on Acute Lung Injury Induced by Lipopolysaccharide in Mice through Endothelial Barrier Repair

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Chinese Journal of Integrative Medicine 2024年第3期30卷 243-250页

作者： XU Han XU Si-cong LI Li-yan WU Yu-huang TAN Yin-feng CHEN Long LIU Pei LIANG Chang-fu HE Xiao-ning LI Yong-hui Hainan Provincial Key Lab of research&development on Tropic Herbs Hainan Medical UniversityHaikou571199China department of Stomatology the Second Affiliated Hospital of Hainan Medical UniversityHaikou571199China

Objective:To investigate the effects of Danmu Extract Syrup(DMS) on lipopolysaccharide(LPS)-induced acute lung injury(ALI) in mice and explore the mechanism.Methods:Seventy-two male Balb/C mice were randomly divided into 6 groups according to a random number table(n=12),including control(normal saline),LPS(5 mg/kg),LPS+DMS 2.5 mL/kg,LPS+DMS 5 mL/kg,LPS+DMS 10 mL/kg,and LPS+Dexamethasone(DXM,5 mg/kg) groups.After pretreatment with DMS and DXM,the ALI mice model was induced by LPS,and the bronchoalveolar lavage fluid(BALF) were collected to determine protein concentration,cell counts and inflammatory cytokines.The lung tissues of mice were stained with hematoxylin-eosin,and the wet/dry weight ratio(W/D) of lung tissue was calculated.The levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-1βin BALF of mice were detected by enzyme linked immunosorbent assay.The expression levels of Claudin-5,vascular endothelial(VE)-cadherin,vascular endothelial growth factor(VEGF),phospho-protein kinase B(p-Akt) and Akt were detected by Western blot analysis.Results:DMS pre-treatment significantly ameliorated lung histopathological changes.Compared with the LPS group,the W/D ratio and protein contents in BALF were obviously reduced after DMS pretreatment(P<0.05 or P<0.01).The number of cells in BALF and myeloperoxidase(MPO) activity decreased significantly after DMS pretreatment(P<0.05 or P<0.01).DMS pre-treatment decreased the levels of TNF-α,IL-6 and IL-1β(P<0.01).Meanwhile,DMS activated the phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) pathway and reversed the expressions of Claudin-5,VE-cadherin and VEGF(P<0.01).Conclusions:DMS attenuated LPS-induced ALI in mice through repairing endothelial barrier.It might be a potential therapeutic drug for LPS-induced lung injury.

关键词： Danmu Extract Syrup acute lung injury inflammatory factors vascular endothelial growth factor phosphoinositide 3-kinase/protein kinase B Chinese medicine Nauclea officinalis

Failure investigation and asset management of combined measuring instrument transformers

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High Voltage 2021年第1期6卷 61-70页

作者： ShengJi Tee Qiang Liu Zhongdong Wang Fikri Hafid Pierre Tournet department of Electrical&Electronic Engineering The University of ManchesterManchesterUK research&development Réseau de Transport d'ElectricitéParisFrance

Asset management of instrument transformers(ITs)has gained momentum in recent years due to their large population in the network and the potential adverse impacts of their increasing number of failures.This study investigates the failure cause of a family of combined measuring ITs via temperature profile simulations and consideration of moisture migration behaviour in an oil‐impregnated paper insulation system.The tem-perature difference experienced by an IT,particularly throughout summer,together with a relative saturation hysteresis phenomenon could have caused a lower dielectric strength that led to failures.The study also offers insights into factors influencing the probability of failures through analysis on the lifetime data from both graphical survival function plots and statistical Cox model.In‐service age,operating voltage level and environment appear to have an influence on failure rate.

关键词： instrument gained insulation

Investigational treatments for neurodegenerative diseases caused by inheritance of gene mutations:lessons from recent clinical trials

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Neural Regeneration research 2023年第8期18卷 1679-1683页

作者： Bruno P.Imbimbo Viviana Triaca Camillo Imbimbo Robert Nisticò department of research&development Chiesi FarmaceuticiParmaItaly Institute of Biochemistry and Cell Biology National Research CouncilRomeItaly department of Brain and Behavioral Sciences University of PaviaPaviaItaly School of Pharmacy Department of BiologyUniversity of Tor Vergataand European Brain Research Institute(EBRI)RomeItaly

We reviewed recent major clinical trials with investigational drugs for the treatment of subjects with neurodegenerative diseases caused by inheritance of gene mutations or associated with genetic risk factors.Specifically,we discussed randomized clinical trials in subjects with Alzheimer's disease,Huntington's disease and amyotrophic lateral sclerosis bearing pathogenic gene mutations,and glucocerebrosidase-associated Parkinson's disease.Learning potential lessons to improve future therapeutic approaches is the aim of this review.Two long-term,controlled trials on three anti-β-amyloid monoclonal antibodies(solanezumab,gantenerumab and crenezumab)in subjects carrying Alzheimer's disease-linked mutated genes encoding for amyloid precursor protein or presenilin 1 or presenilin 2 failed to show cognitive or functional benefits.A major trial on tominersen,an antisense oligonucleotide designed to reduce the production of the huntingtin protein in subjects with Huntington's disease,was prematurely interrupted because the drug failed to show higher efficacy than placebo and,at highest doses,led to worsened outcomes.A 28-week trial of tofersen,an antisense oligonucleotide for superoxide dismutase 1 in patients with amyotrophic lateral sclerosis with superoxide dismutase 1 gene mutations failed to show significant beneficial effects but the 1-year open label extension of this study indicated better clinical and functional outcomes in the group with early tofersen therapy.A trial of venglustat,a potent and brain-penetrant glucosylceramide synthase inhibitor,in Parkinson's disease subjects with heterozygous glucocerebrosidase gene mutations revealed worsened clinical and cognitive performance of patients on the enzyme inhibitor compared to placebo.We concluded that clinical trials in neurodegenerative diseases with a genetic basis should test monoclonal antibodies,antisense oligonucleotides or gene editing directed against the mutated enzyme or the mutated substrate without dramatically affecting physiological wild-type var

关键词： Alzheimer's disease amyotrophic lateral sclerosis amyloid precursor protein glucocerebrosidase huntingtin Huntington's disease Parkinson's disease presenilin 1 presenilin 2 superoxide dismutase 1

Effect of seed orientations on crystallographic texture control in faceted Al2O3/YAG eutectic ceramic during directional solidification

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Journal of Materials Science & Technology 2023年第15期146卷 86-101页

作者： Yuan Liu Haijun Su Zhonglin Shen Di Zhao Yinuo Guo Shanding Li Min Guo Lin Liu Hengzhi Fu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China research&development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

Crystallographic texture control is a major challenge in directionally solidified multiphase eutectic ceramics with complex faceted growth characteristics.In this study,the Czochralski(CZ)technique is proposed to prepare eutectic single crystal ceramic with large size(30 mm×125 mm).A highly oriented and unique texture of Al_(2)O_(3)/Y_(3)Al_(5)O_(12)(YAG)eutectic ceramic is formed via the 112¯0Al_(2)O_(3) single crystal seed induction based on crystallographic orientation tailoring.The orientations of Al_(2)O_(3)/YAG eutectic are more strictly constrained by single crystal seed induction on the basis of the minimum interface energy principle,resulting in a defined single orientation relationship along the solidification direction.In particular,the single crystallographic orientation can be obtained in a short competitive solidification distance under the influence of epitaxial solidification from single crystal seed.Therefore,it has been confirmed that the orientations of 112¯0Al_(2)O_(3) and 111YAG are preferentially stabilized with the minimum under-cooling during directional solidification.Crystallographic orientation disturbances and instabilities due to polycrystalline crystal seed are avoided.Finally,the successful texture control inducted by 112¯0Al_(2)O_(3) single crystal seed can provide a promising orientation design pathway for faced oxide eutectic solidification.

关键词： Seeding method Directional solidification Al_(2)O_(3)/YAG eutectic single crystal ceramic Crystallographic orientation

Formation and Evolution of Surface Morphology in Overhang Structure of IN718 Superalloy Fabricated by Laser Powder Bed Fusion

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金属学报:英文版 2023年第9期36卷 1433-1453页

作者： Haotian Zhou Haijun Su Yinuo Guo Yuan Liu Di Zhao Peixin Yang Zhonglin Shen Le Xia Min Guo State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072China research&development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518057China

Controlling the overhang surface quality is still a formidable challenge in manufacturing the components with complex structures during laser powder bed fusion(LPBF).This study systematically uncovers the effects of the volume energy density(VED)and overhang angle on the evolution of surface morphology and corresponding surface roughness(Ra)of top and down-skin surfaces of IN718 superalloy samples.The results show that balling,Plateau-Rayleigh instability,open pore and humping caused by the material stacking are the main factors contributing to the apparent deterioration of top surface quality.When the VED is 80–100 J/mm^(3),the high down-skin surface roughness is attributed to the serious dross caused by recoil pressure and sinking of the melt pool.Using insufficient VED(15–50 J/mm^(3))can easily lead to poor metallurgical bonding and material spalling on the down-skin surface.In addition,overhang angle also significantly affects down-skin surface roughness due to the stair effect and the adhered unmelted powders.An improvement in the surface quality of down-skin surface is observed when the overhang angle increases.Based on the finding of this investigation,an optical VED(59.5 J/mm^(3))significantly improves the top and down-skin surface quality and porosity of overhang samples.This study provides an insight into synergy ascension of the top and down-skin surface quality in the overhang structure.

关键词： Laser powder bed fusion IN718 superalloy Surface roughness Overhang structure

A Review of Emerging Metallic System for High-Energy Beam Additive Manufacturing: Al–Co–Cr–Fe–Ni High Entropy Alloys

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Acta Metallurgica Sinica(English Letters) 2022年第9期35卷 1407-1423页

作者： Yinuo Guo Haijun Su Peixin Yang Yong Zhao Zhonglin Shen Yuan Liu Di Zhao Hao Jiang Jun Zhang Lin Liu Hengzhi Fu research&development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518057China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072China

Al–Co–Cr–Fe–Ni high entropy alloy(HEA) system is a newly developed category of metallic materials possessing unique microstructure, mechanical and functional properties, which presents many promising industrial applications. In recent years, additive manufacturing technology has given rise to a great potential for fabricating HEA parts of ultra-fine grains and geometrical complexity, thereby attracting great interest of researchers. Herein, a comprehensive review emphasizes on the recent developments in high-energy beam additive manufacturing of Al–Co–Cr–Fe–Ni HEA, in the aspects of their printing processes, microstructures, properties, defects, and post treatments. The technical characteristics of three typical high-energy beam additive manufacturing technologies for printing HEA, namely, selective laser melting(SLM), selective electron beam melting(SEBM), and directed energy deposition(DED) are systematically summarized. Typical crystal structure, grain, microstructure, as well as corresponding properties of Al–Co–Cr–Fe–Ni HEA manufactured by those technologies are primarily presented and discussed. It also elaborates the formation mechanisms of harmful defects related to the rapid solidification and complex thermal cycle during high-energy beam additive manufacturing. Furthermore, several kinds of post treatments with an aim to improve performance of HEA are illustrated. Finally, future research directions for HEA by additive manufacturing are outlined to tackle current challenges and accelerate their applications in industrial fields.

关键词： High entropy alloy Additive manufacturing Microstructures Properties Defects Post treatments

Synthesis of β,β＇-Porphyrin Dimer Linked by Vinylene

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Chinese Journal of Chemistry 2012年第2期30卷 405-408页

作者： Jiang,Xuliang Li,Panli Wang,Yucheng Shen,Qi Tao,Jingchao Shi,Weimin department of Chemistry Zhengzhou UniversityNew Drug Research&Development CenterZhengzhou UniversityZhengzhouHenan 450052China

一篇小说的合成， -tetraalkylporphyrin 更暗淡由 vinylene 连接了是 discribed，在哪个更暗淡乐意地经由 Wittig 反应从导出卟啉的 Wittig 试剂和 mono-formylated 卟啉被准备。在二枚卟啉戒指之间的变化形式都不是 obserbed，并且更... 详细信息

一篇小说的合成， -tetraalkylporphyrin 更暗淡由 vinylene 连接了是 discribed，在哪个更暗淡乐意地经由 Wittig 反应从导出卟啉的 Wittig 试剂和 mono-formylated 卟啉被准备。在二枚卟啉戒指之间的变化形式都不是 obserbed，并且更暗淡在 trans 形式。

关键词：卟啉环合成乙炔 Wittig反应 Wittig试剂链接二聚体共轭

Unveiling the dynamic instability mechanism of microstructure transformation in faceted oxide eutectic composite ceramics

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Journal of Materials Science & Technology 2023年第13期144卷 224-234页

作者： Haijun Su Yuan Liu Qun Ren Zhonglin Shen Min Guo Xi Li Jun Zhang Lin Liu Hengzhi Fu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China research&development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China department of Material Science and Engineering Shanghai UniversityShanghai 200072China

Microstructure control is a great challenge in the high-temperature gradient directional solidification of eutectic composite ceramics due to the complex solidification behavior.Herein,the microstructure trans-formation of faceted Al_(2)O_(3)/Er_(3)Al_(5)O_(12) thermal emission eutectic composite ceramics is explored over wide ranges of compositions(13.5 mol%-22.5 mol%Er_(2)O_(3))and solidification rates(2-200μm/s).Entirely cou-pled eutectics with primary phases suppressed are fabricated and the coupled zone is broadened in a wide range of 15.5 mol%-22.5 mol%Er_(2)O_(3) at low solidification rates.The competitive growth between eutectic and dendrite is evaluated on the basis of the maximum interface temperature criterion.In ad-dition,the mechanisms of irregular eutectic spacing selection and adjustment under different solidifi-cation rates are revealed based on Magnin-Kurz model.A successful prediction of lamellar to rod-like eutectics is achieved associated with the dynamic instability of lamellar eutectic and the corresponding enlarged coexistence region is mapped based on the interface undercooling.According to the well mi-crostructure tailoring,the flexural strength of Al_(2)O_(3)/Er_(3)Al_(5)O_(12) eutectic composite ceramics has improved from 508 MPa up to 1800 MPa due to the refined eutectic spacing with low fluctuation.The eutectic composite ceramics show strong selective optical absorption and the intensity increases with the refin-ing microstructure.The as-designed Al_(2)O_(3)/Er_(3)Al_(5)O_(12) composites with microstructural tailoring have great potential as integrations of structural and functional materials.

关键词： Directional solidification Laser floating zone melting Al_(2)O_(3)/Er_(3)Al_(5)O_(12)eutectic composite ceramics Eutectic growth mechanism Microstructure transformation

Free Vibration Analysis of FG-CNTRC Cylindrical Pressure Vessels Resting on Pasternak Foundation with Various Boundary Conditions

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Computers, Materials & Continua 2020年第3期62卷 1001-1023页

作者： Mohammad Arefi Masoud Mohammadi Ali Tabatabaeian Timon Rabczuk department of Solid Mechanic Faculty of Mechanical EngineeringUniversity of KashanKashan 87317-51167Iran Duy Tan University Institute of Research&Development3 Quang TrungDanangVietnam

This study focuses on vibration analysis of cylindrical pressure vessels constructed by functionally graded carbon nanotube reinforced composites(FG-CNTRC).The vessel is under internal pressure and surrounded by a Pasternak foundation.This investigation was founded based on two-dimensional elastic analysis and used Hamilton’s principle to drive the governing equations.The deformations and effective-mechanical properties of the reinforced structure were elicited from the first-order shear theory(FSDT)and rule of mixture,respectively.The main goal of this study is to show the effects of various design parameters such as boundary conditions,reinforcement distribution,foundation parameters,and aspect ratio on the free vibration characteristics of the structure.

关键词： FG-CNTRC cylindrical pressure vessel first-ordershear deformation theory free vibration Pasternak’s foundation rule of mixture