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Sleep-disordered breathing is associated with depletion of circulating endothelial progenitor cells and elevation in pulmonary arterial pressure in patients with decompensated systolic heart failure

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Journal of Geriatric Cardiology 2015年第4期12卷 424-430页

作者： Han ZHANG Liu FENG Qi-Lin WAN Yan HONG Yan-Ming LI Guan-Chang CHENG Xin-Qiang HAN Department of Cardiology Huaihe Hospital of Henan University No.8 Baogonghu Road Kaifeng Henan China Department of Intensive Care Unit Huaihe Hospital of Henan University No.8 Baogonghu Road Kaifeng Henan China reid Hospital and Health Care Services Indiana University School of Medicine Richmond USA

Background Sleep-disordered breathing （SDB） is known to occur frequently in and may predict worsening progression of patients with congestive heart failure （CHF）. SDB is also known to play an important role in the development of idiopathic pulmonary arterial hyper- tension （PAH） via inducing endothelial dysfunction and vascular remodeling, a pathological process that can be significantly influenced by factors such as osteoprotegerin （OPG） and endothelial progenitor cells （EPCs）. The objective of this study is to determine if CHF with SDB is associated with changes in OPG, EPCs, and PAIl. Methods EPCs were isolated, cultured, and quantified from CHF patients with SDB （n = 52）, or without SDB （n - 68）. OPG and N-terminal pro-brain natriuretic peptide （NT-proBNP） from each group was analyzed and cor- related with EPCs and the mean pulmonary artery pressure （mPAP） measured by right heart catheterization. Results A significant decrease in circulating EPCs （29.30 ± 9.01 vs. 45.17 ± 10.51 EPCs/x 200 field; P 〈 0.05） was found in CHF patients with SDB compared to those without SDB. Both OPG （789.83 ±89.38 vs. 551.29 ± 42.12 pg/mL; P 〈 0.05） and NT-proBNP （5946.50 ± 1434.50 vs. 3028.60 ± 811.90 ng/mL; P 〈 0.05） were also significantly elevated in SDB CHF patients who also had significantly elevated mPAP （50.2 ± 9.5 vs. 36.4 ± 4.1 mm Hg; P 〈 0.05）. EPC numbers correlated inversely with the episodes of apnea and hypopnea per hour （RDI, r = -0.45, P = 0.037） and blood level of OPG （r =-0.53, P = 0.011）. Although NT-proBNP was also increased significantly in patients with SDB, it had no correlation with either EPCs or RD1. Conclusions SDBdue to hypoxemia from decompensated CHF is associated with （1） OPG elevation, （2） EPC depletion, and （3） mPAP elevation. The inverse relationship of circulating OPG with EPCs suggests a likely mechanism for hypoxemia and OPG in the development of pulmonary vascular dysfunction via depleting EPCs, thus worsening prognosis of CHF.

关键词： Congestive heart failure Endothelial progenitor cells Osteoprotegerin Sleep-disordered breathing

Geochemistry of the Rare Earth Elements in Natural Terrestrial Waters:A Review of What Is Currently Known

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Chinese Journal Of Geochemistry 1997年第1期16卷 20-42页

作者： KEVIN, H. JOHANNESSON ZHOU XIAOPING(Groundwater Chemistry Group,Harry reid Center for Environmental Studies,University of Nevada,Las Vegas,Nevada,89154-4009,U.S.A.) Groundwater Chemistry Group Harry Reid Center for Environmental Studies University of Nevada Las Vegas USA

The range of observed Chemical compositions of natural terrestrial waters varies greatly especially when compared to the essentially constant global composition of the *** concentrations of the REEs in natural terrestrial waters also exhibit more variation than what Was reported in seawater. In terrestrial waters, pH values span the range from acid up to alkaline. In addition, terrestrial waters can range from very dilute waters through to highly concentrated brines. The REE concentrations and their behavior. in natural terrestrial waters reflect these compositional ranges. Chemical weathering of rocks represents the source of the REEs to natural terrestrial waters and, consequently, the REE signature of rocks can impart their REE signature to associated waters. In addition, because of the typical low solubilities of the REEs, both surface and solution complexation can be important in fractionating REEs in aqueous solution. Both of these processes are important in all natural terrestrial waters, howev-er, their for relative importance varies as a function of the overall solution composition. In alkaline waters, for example, solution complexation of the REEs with carbonate ions appears to control their aqueous distributions whereas in acid waters, the REE signature of the labile fraction of the REEs is readily leached from the rocks. In circumneutral pH waters, both processes appear to be important and their relative significance has not yet been determined.

关键词：地球化学 REE 稀土元素地表水化学组成海水 pH值

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竖向餐厅Jidori日式餐厅

室内设计与装修 2018年第10期 16-17页

作者：无秋落(编译) Giles reid Architects 不详

本案的业主想要将位于伦敦的一栋六层高的乔治亚式联排房屋改造成一个名为Jidori的日本餐厅。由于建筑每一层面积都较小，所以功能空间必须叠加起来，即每层都有一个功能：一楼有用餐区域，后面有一个小酒吧；二楼还有两个用餐空间，前... 详细信息

本案的业主想要将位于伦敦的一栋六层高的乔治亚式联排房屋改造成一个名为Jidori的日本餐厅。由于建筑每一层面积都较小，所以功能空间必须叠加起来，即每层都有一个功能：一楼有用餐区域，后面有一个小酒吧；二楼还有两个用餐空间，前面和后面都有房间；厨房在三楼，盥洗在四楼，厕所在地下室。三层以上每层楼都只有一个房间，而员工办公室被挤进了屋顶。现有的楼梯蜿蜒穿过整栋大楼，厨房和餐厅则由一部新的服务电梯连接。

关键词：餐厅竖向日式功能空间房屋改造地下室办公室用餐

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ARS技术在乙烯装置改造中的应用

乙烯工业 1998年第4期10卷 55-62页

作者： Kenneth E Bush 雷正香王明耀 John A reid Stone & Webster Engineering Corporation

ARS(Advanced Recovery System)技术是Mobil化工公司和S＆W公司特别为消除乙烯装置冷分离区瓶颈的改造而设计的(美国专利No.4900347)。ARS技术是建立在高效的传质/传热设备与分散精馏系统组合应用的基础上的,其核心是分凝分馏器(De-phle... 详细信息

ARS(Advanced Recovery System)技术是Mobil化工公司和S＆W公司特别为消除乙烯装置冷分离区瓶颈的改造而设计的(美国专利No.4900347)。ARS技术是建立在高效的传质/传热设备与分散精馏系统组合应用的基础上的,其核心是分凝分馏器(De-phlegmator)。

关键词：乙烯装置技术改造 ARS技术

Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients

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Burns & Trauma 2021年第1期9卷 642-651页

作者： Lincoln M.Tracy Peter A.Cameron Yvonne Singer Arul Earnest Fiona Wood Heather Cleland Belinda J.Gabbe School of Public Health and Preventive Medicine Monash University553 St Kilda RoadMelbourneVictoria3004Australia Emergency and Trauma Centre The Alfred HospitalCommercial RoadMelbourneVictoria3004Australia Victorian Adult Burns Service Alfred Hospital55 Commercial RoadMelbourneVictoria3004AustraliaAustralia Registry Sciences Unit Department of Epidemiology and Preventive MedicineMonash University553 St Kilda RoadMelbourneVictoria3004Australia Biostatistics Unit Department of Epidemiology and Preventive MedicineMonash University553 St Kilda RoadMelbourneVictoria3004Australia Burn Injury Research Unit University of Western Australia35 Stirling HighwayPerthWestern Australia6009Australia Health Data Research UK Swansea University Medical SchoolSwansea UniversitySingleton ParkSwanseaUK

Background:Patients with burn injuries are considered to have an increased risk of venous thromboembolism(VTE).While untreated VTEs can be fatal,no studies have examined chemoprophylaxis *** study aimed to quantify the variation in prevalence of VTE prophylaxis use in patients in Australian and New Zealand burns units and whether prophylaxis use is associated with in-hospital outcomes following burn ***:Admission data for adult burns patients(aged≥16 years)admitted between 1 July 2016 and 31 December 2018 were extracted from the Burns Registry of Australia and New *** effects logistic regression modelling investigated whether VTE prophylaxis usewas associated with the primary outcome of in-hospital ***:There were 5066 admissions over the study *** these patients,81%(n=3799)with a valid response to the VTE prophylaxis data field received some form of VTE *** of VTE prophylaxis ranged from 48.6%to 94.8%of patients between ***-hospital death was recorded in<1%of patients(n=33).After adjusting for confounders,receiving VTE prophylaxis was associated with a decrease in the adjusted odds of in-hospital mortality(adjusted odds ratio=0.21;95%CI,0.07–0.63;p=0.006).Conclusions:Variation in the use of VTE prophylaxis was observed between the units,and prophylaxis use was associated with a decrease in the odds of *** findings provide an opportunity to engage with units to further explore differences in prophylaxis use and develop future best practice guidelines.

关键词： Burn injury Venous thromboembolism Prophylaxis Australia New Zealand

Surfactant protein A (SP-A) binds to phosphatidylserine and competes with annexin V binding on late apoptotic cells

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Protein & Cell 2010年第2期1卷 188-197页

作者： Anne Jäkel Kenneth B.M.reid Howard Clark Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK University of Southampton MP 803 Level FSouth BlockSouthampton General HospitalSouthampton SO166YDUK

The role of surfactant protein A(SP-A)in the recognition and clearance of apoptotic cells is well established,but to date,it is still not clear which surface molecules of apoptotic cells are involved in the *** we present evidence that phosphatidylserine(PS)is a relevant binding molecule for human *** binding is Ca^(2+)-dependent and is not inhibited by mannose,suggesting that the sugar-binding site of the carbohydrate recognition domain(CRD)of SP-A is not *** cytometry studies on apoptotic Jurkat cells revealed apparent inhibition of annexin V binding by increasing concentrations of SP-A in late apoptotic but not early apoptotic cells,and this was consistent for Jurkat cells and *** these data,confocal microscopy results show a co-localisation of annexin V and SP-A in late apoptotic but not early apoptotic ***,we cannot conclude that this inhibition is exclusively due to the binding of SP-A to PS on the cell surface,as annexin V is not wholly specific for PS and SP-A also interacts with other phospholipids that might become exposed on the apoptotic cell surface.

关键词： surfactant proteins phosphatidylserine apoptotic cells

Catheter Ablation of Atrial Fibrillation:Where Are We?

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Cardiovascular Innovations and Applications 2017年第B2期2卷 203-227页

作者： Xinqiang Han Jianming Li reid Health Indiana University School of MedicineRichmondIN 47374USA Minneapolis VA Medical Center University of Minnesota School of MedicineMinneapolisMN 55417USA

Atrial fibrillation(AF)is the commonest cardiac arrhythmia,with significant morbidity and *** than half of patients with AF are still symptomatic despite adequate anticoagulation and rate *** antiarrhythmic drugs are ineffective or poorly tolerated,AF patients are then typically treated with catheter ablation to restore sinus *** the past 20 years,AF ablation has developed from a specialized,experimental procedure into a common treatment in the cardiovascular *** ablation techniques and mapping technologies have been described and are continuing to evolve for increased safety and *** incomplete list of such techniques and technologies would include focal and segmental,circumferential and linear,complex fractionated atrial electrogram,ganglionated plexus,focal impulse and rotor modulation,body surface potential mapping–guided,real-time MRI–guided,cryoballoon,visually guided laser balloon,radiofrequency hot balloon,contact force sensing catheter,multielectrode catheter,and hybrid *** review examines the history of invasive AF treatment and its evolution into catheter ablation but mainly focuses on the discussion of various ablation techniques and technologies leading to our current understanding of the ablation therapy of this most common arrhythmia.

关键词： Atrial fibrillation Catheter ablation Invasive cardiology Cardiac arrhythmia

Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D

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Protein & Cell 2010年第6期1卷 563-572页

作者： Anne Jäkel Howard Clark Kenneth B.M.reid Robert B.Sim Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK University of Southampton School of MedicineDivision of Infection Inflammation&ImmunitySouthampton General HospitalSouthampton SO166YDUK MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK

Surfactant proteins A(SP-A)and D(SP-D),both members of the collectin family,play a well established role in apoptotic cell recognition and *** in vitro data show that SP-A and SP-D interact with apoptotic neutrophils in a distinct ***-A and SP-D bind in a Ca^(2+)-dependent manner to viable and early apoptotic neutrophils whereas the much greater interaction with late apoptotic neutrophils is Ca^(2+)-*** surface molecules on the apoptotic target cells responsible for these interactions had not been identified and this study was done to find candidate target ***(MPO),a specific intracellular defense molecule of neutrophils that becomes exposed on the outside of the cell upon apoptosis,was identified by affinity purification,mass-spectrometry and western blotting as a novel binding molecule for SP-A and *** confirm its role in recognition,it was shown that purified immobilised MPO binds SP-A and SP-D,and that MPO is surface-exposed on late apoptotic ***-A and SP-D inhibit binding of an anti-MPO monoclonal Ab to late apoptotic *** microscopy confirmed that anti-MPO mAb and SP-A/SP-D colocalise on late apoptotic *** was identified as a further potential ligand for SP-A,and neutrophil defensin as a target for both proteins.

关键词： SP-A SP-D myeloperoxidase neutrophils flow cytometry mass spectrometry

全球化、亚洲移民及西方的东南亚研究──来自加利福尼亚一个正在变化的前景

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南洋问题研究 2001年第1期 11-22页

作者：安东尼.里德沈燕清廖大珂 (Anthony reid):美国加利福尼亚大学伯克利分校东南亚研究中心

冷战结束以后，西方的东南亚研究曾一度走向衰退。然而由于全球化的发展，以及亚洲人，特别是东南亚人的移民浪潮冲击着美国这个“民族熔炉”，使其出现“多样化”的趋势，尤其是美国西海岸成了亚裔和东南亚裔美国人聚居的地区。因此，... 详细信息

冷战结束以后，西方的东南亚研究曾一度走向衰退。然而由于全球化的发展，以及亚洲人，特别是东南亚人的移民浪潮冲击着美国这个“民族熔炉”，使其出现“多样化”的趋势，尤其是美国西海岸成了亚裔和东南亚裔美国人聚居的地区。因此，加利福尼亚大学成为研究亚裔美国人的中心。这一系列的变化也为西方的亚洲研究带来了新的挑战。

关键词：亚洲移民全球化东南亚研究加利福尼亚