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Science China(Life Sciences) 2016年第7期59卷 678-685页

作者： Yanyan Li Xiuxiu Zhang Juan Gao Han Xiao Ming Xu Department of Cardiology Institute of Vascular MedicinePeking University Third HospitalKey Laboratory of Molecular Cardiovascular SciencesMinistry of EducationKey Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of Health and Beijing Key Laboratory of cardiovascular Receptors ResearchBeijing 100191China

Telocytes(TCs) are a novel type of interstitial cells that are thought to be involved in tissue regeneration and repair. However, the possible roles of TCs in vascular diseases remain unclear. In this study, we used a rat model of carotid artery balloon injury(CABI) to study the changes and potential roles of vascular TCs after vascular injury. Transmission electron microscopy(TEM) and CD34/vimentin immunolabeling were used to identify and quantify TCs in normal and injured carotid arteries. Quantitative immunofluorescence analysis revealed that, compared with the sham group, the number of TCs in the CABI group increased from 7.2±1.0 to an average of 20.4±1.8 per 1-mm^2 vascular area. The expression level of mi R-24 in TCs was three times higher than in vascular smooth muscle cells(VSMCs). The percentage of VSMCs in S phase and G2/M phase increased by approximately 5% when VSMCs were incubated with the supernatant of TCs. The antagomir of mi R-24 in TCs reduced the ratio of VSMCs in S phase and G2/M phase. This study illuminates the function of TCs in the proliferation of VSMCs.

关键词：血管平滑肌细胞血管损伤颈动脉增殖球囊大鼠透射电子显微镜免疫荧光分析

Cardiac Hypertrophy is Positively Regulated by MicroRNA-24 in Rats

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Chinese Medical Journal 2018年第11期131卷 1333-1341页

作者： Juan Gao Min Zhu Rui-Feng Liu Jian-Shu Zhang Ming Xu Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and regulatory Peptides Ministry of Health Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing Key Laboratory of Cardiovascular Receptors Research Beijing 100191 China

Background： MicroRNA-24 （miR-24） plays an important role in heart failure by reducing the efficiency of myocardial excitation-contraction coupling. Prolonged cardiac hypertrophy may lead to heart failure, but little is known about the role of miR-24 in cardiac hypertrophy. This study aimed to preliminarily investigate the function of miR-24 and its mechanisms in cardiac hypertrophy. Methods： Twelve Sprague-Dawley rats with a body weight of 50 ± 5 g were recruited and randonlly divided into two groups： a transverse aortic constriction （TAC） group and a sham surgery group. Hypertrophy index was measured and calculated by echocardiography and hematoxylin and eosin staining. TargetScans algorithm-based prediction was used to search for the targets of miR-24, which was subsequently confirmed by a real-time polymerase chain reaction and luciferase assay, lmmunofluorescence labeling was used to measure the cell surface area, and 3H-leucine incorporation was used to detect the synthesis of total protein in neonatal rat cardiac myocytes （NRCMs） with the overexpression of miR-24. In addition, flow cytometry was performed to observe the alteration in the cell cycle. Statistical analysis was carried out with GraphPad Prism v5.0 and SPSS 19.0. A two-sided P 〈 0.05 was considered as the threshold for significance. Results： The expression of miR-24 was abnormally increased in TAC rat cardiac tissue （ t =-2.938, P 〈 0.05）. TargetScans algorithm-based prediction demonstrated that CDKN 1B （p27, Kip 1 ）, a cell cycle regulator, was a putative target of miR-24, and was confirmed by luci ferase assay. The expression of p27 was decreased in TAC rat cardiac tissue （t = 2.896, P 〈 0.05）. The overexpression of miR-24 in NRCMs led to the decreased expression of p27 （t = 4.400, P 〈 0.01 ）, and decreased G0/G 1 arrest in cell cycle and cardiomyocylc hypertrophy. Conclusion： MiR-24 promotes cardiac hypertrophy partly by affecting the cell cycle through down-regulation of p27 expression.

关键词： Cardiac Hypertrophy Cell Cycle MicroRNA MicroRNA-24 p27

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jun-Ping Liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan Zhang Wen-Yi Gu Xiao-Mei Xiang Yi Zhou Yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao Chun-Yan Liu Wei Yuan Xue Mei Jing Li Tao Li Rong-Jiong Zheng Xin-Yi Zhou Jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

A blockchain and IoT-based lightweight framework for enabling information transparency in supply chain finance

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Digital Communications and Networks 2022年第4期8卷 576-587页

作者： Lingling Guo Jingjing Chen Shihan Li Yafei Li Jinzhi Lu College of Chemical Engineering Zhejiang University of TechnologyHangzhou310014China School of Economics Fudan UniversityShanghai200433China Zhijiang College of Zhejiang University of Technology Shaoxing312030China School of Information Engineering Zhengzhou UniversityZhengzhou450001China ICT for Sustainable Manufacturing group Ecole Polytechnique Federale de LausanneSwitzerland

Supply Chain Finance(SCF)refers to the financial service in which banks rely on core enterprises to manage the capital flow and logistics of upstream and downstream *** adopts a self-testing and closed-loop credit model to control funds and *** key factor in a successful SCF service is the deployment of SCF businessoriented information systems that allow businesses to form partnerships efficiently and expedite cash flows throughout the supply *** Technology(BCT),featuring decentralization,tamper-proofing,traceability,which is usually paired with the Internet of Things(IoT)in real-world contexts,has been widely adopted in the field of finance and is perfectly positioned to facilitate innovative collaborations among participants in supply chain *** this paper,we propose a BCT and IoT-based information management framework(named BC4Regu),which works as the regulatory to improve the information transparency in the business process of *** BC4Regu,the operation cost of the whole supply chain can be significantly reduced through the coordination and integration of capital flow,information flow,logistics and trade flow in the supply *** contributions in this paper include:(1)proposing a novel information management framework which leverages Blockchain and IoT to solve the problem of information asymmetry in the trade of SCF;(2)proposing the technical design of BC4Regu,including the Blockchain infrastructure,distributed ledger-based integrated data flow service,and reshaped SCF process;and(3)applying BC4Regu to a group of scenarios and conducting theoretical analysis by introducing the principal-agent model to validate the BC4Regu.

关键词： Blockchain Supply chain finance Information asymmetry Information transparency Internet of things

Hypercholesterolemia,low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9

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The Journal of Biomedical Research 2015年第5期29卷 356-361页

作者： Hong-mei Gu Da-wei Zhang Departments of Pediatrics and Biochemistry Group on the Molecular and Cell Biology of LipidsUniversity of Alberta

Atherosclerotic cardiovascular disease is the main cause of mortality and morbidity in the world. Plasma levels of low density lipoprotein cholesterol （LDL-C） are positively correlated with the risk of atherosclerosis. High plasma LDL concentrations in patients with hypercholesterolemia lead to build-up of LDL in the inner walls of the arteries, which becomes oxidized and promotes the formation of foam cells, consequently initiating atherosclerosis. Plasma LDL is mainly cleared through the LDL receptor （LDLR） pathway. Mutations in the LDLR cause familiar hyperch- olesterolemia and increase the risk of premature coronary heart disease. The expression of LDLR is regulated at the transcriptional level via the sterol regulatory element binding protein 2 （SREBP-2） and at the posttranslational levels mainly through proprotein convertase subtilisin/kexin-type 9 （PCSK9） and inducible degrader of the LDLR （IDOL）. In this review, we summarize the latest advances in the studies of PCSK9.

关键词： hypercholesterolemia low density lipoprotein receptor statin atherosclerosis proprotein convertasesubtilisin/kexin -type 9

Neuropathy experienced by colorectal cancer patients receiving oxaliplatin: A qualitative study to validate the Functional Assessment of Cancer Therapy/Gynecologic Oncology group-Neurotoxicity scale

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World Journal of Gastrointestinal Oncology 2020年第2期12卷 205-218页

作者： Karen Kaiser Madison Lyleroehr Sara Shaunfield Leilani Lacson Maria Corona Sheetal Kircher Malin Nittve David Cella Department of Medical Social Sciences Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States Project and regulatory Affairs PledPharma ABStockholm 11446Sweden

BACKGROUND Although oxaliplatin is widely established as a standard treatment in colorectal cancer(CRC),oxaliplatin-induced neuropathy has emerged as a prominent doselimiting side effect associated with quality of life *** monitoring and management of neuropathy is important for CRC patient quality of life and adherence to ***,a validated self-reported measure of neuropathy would aid in the management and assessment of oxaliplatininduced neuropathy in clinical practice and *** sought to evaluate the content validity of the 13-item Functional Assessment of Cancer Therapy/Gynecologic Oncology group-Neurotoxicity subscale(FACT/GOGNtx)for CRC patients receiving *** To understand the neuropathy experiences of CRC patients and assess content validity of the FACT/*** Semi-structured concept elicitation and cognitive debriefing interviews were conducted with 31 CRC patients experiencing peripheral neuropathy from current or previous oxaliplatin *** data were analyzed using a constant comparative approach,and data were mapped to the FACT/GOG-Ntx to assess content *** Mean age of the sample was 54(range 34-82).The sample was primarily Caucasian(84%)and consisted of nearly equal numbers of men and *** described 28 unique neuropathy symptoms;hand tingling(experienced by 87%of respondents);feet tingling(81%);hand numbness(68%);and feet numbness(84%)were most frequently *** symptoms occurring on the feet were most often identified as most bothersome by *** of the 13 FACT/GOG-Ntx items exhibited moderate to strong evidence of content *** items related to trouble hearing and ringing in the ears had weak support;however,these items represent severe neuropathy and could be useful for a patient reported outcome *** The FACT/GOG-Ntx represents the key neuropathy experiences of CRC patients treated with oxaliplatin.

关键词： Neuropathy Colorectal cancer Patient reported outcomes Quality of life

Stability Indicating RP-UPLC Method for Assay of Emtricitabine and Tenofovir Disoproxil Fumarate in Bulk and Dosage Forms

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American Journal of Analytical Chemistry 2015年第10期6卷 807-821页

作者： Bommakanti Valli Purnima Tummala Vijaya Bhaskara Reddy Yadlapalli Srinivas Rao Golkonda Ramu Dittakavi Ramachandran Department of Chemistry Acharya Nagarjuna University Guntur India Sir C. R. Reddy College for Women Eluru India regulatory Affair B & S Group Vadodara India Sir C. R. Reddy College of Engineering Eluru India

A simple, sensitive and rapid stability indicating reverse phase ultra performance liquid chromatography (RP-UPLC) method was developed and validated for the determination of Emtricitabine (EMT) and Tenofovir disoproxil fumarate (TDF) in pure and tablet dosage forms. The chromatographic separation was achieved by using Waters (Alliance) UPLC system equipped with auto-sampler and photo diode array detector. A volume of 5 μL of standard or test was injected into the column and the components were separated by using the mixture of 0.68% potassium dihydrogen orthophosphate buffer of pH = 6 and methanol in the ratio 45:55 v/v as mobile phase at a flow rate of 1.2 mL/min through BEH C18 (100 mm × 2.1, 1.8 μm) at ambient temperature and were detected at a wavelength of 261 nm. System suitable parameters such as plate count and tailing factor for EMT and TDF were found to be 2427 & 3685, 1.16 & 1.23 respectively, and resolution between EMT and TDF peaks was found to be 3.12. The chromatographic parameters like retention time, peak area and peak height of EMT and TDF were found to be 0.684 & 0.930, 694,200 & 8,778,000 and 272,881 & 3685 respectively. Percent of assay of EMT and TDF in bulk and dosage forms was determined and found to be 101.48 and 103.22 respectively. Study of degradation was examined and found that the drugs were stable under degradation conditions. The present method was developed keeping the principles of green chemistry by using eco-friendly solvent methanol in mobile phase. The developed method was found to be simple, rapid and applied for the analysis of Truvada;therefore the proposed method is recommended for the analysis of EMT and TDF in pure and tablet dosage forms in any quality control laboratories.

关键词： Truvada Emtricitabine Tenofovir DF Validation Assay

A Wearable Dual-Band Dielectric Patch Antenna for LTE and WLAN

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Journal of Electromagnetic Analysis and Applications 2012年第7期4卷 305-309页

作者： Mohamed Ali Soliman Taha ElsayedTaha Wael Elsayed Swelam Ali MohamedGomaa Faculty of Electronic Engineering Menoufia University Menouf Egypt National Telecom regulatory Authority Cairo Egypt RF/Microwave and Photonics group Dep. of ECE University of WaterlooWaterloo Ontario Canada Shobraa Faculty of Engineering Benha University Cairo Egypt

In this paper, a dual-band microstrip patch array antenna for both the Multiple Input Multiple Output (MIMO) 4G Long-Term Evolution (LTE) and the Wireless Local Area Network (WLAN) systems is developed. Design simulation and optimization processes are carried out with the aid of the Advanced Design System (ADS) electromagnetic simula-tor that uses the full–wave Method of Moment (MoM) numerical technique [1]. Rectangular microstrip patch antenna constructed from Multi-Walled Carbon Nanotubes (MWCNT) ink with electrical conductivity of 2.2 × 104 S/m and relative permittivity of 5-j1 is used as the conductor patch [2]. The patch is deposited on Rogers substrate RT-Durid 5880 single substrate with (εr = 2.2) and thickness of 62 mil. U-shape slot is used to provide the dual-band. The pro-posed antenna operates at 3.5 GHz for LTE and 5 GHz for WLAN. The proposed antenna parameters are compared with published result of copper patch [3,4] for the same application. Great enhancement in antenna size, matching, and frequency band width are achieved for the proposed antenna at the expense of gain and antenna efficiency compared with copper one. The proposed MWCNT dielectric antenna size is 18.4 mm × 27 mm compared with size of 27 mm × 37 mm for copper one respectively. The gain is better than 7dBi with antenna efficiency of 87.29% at 3.5GHz for cop-per patch antenna and is better than 1.692 dBi with antenna efficiency of 27.05% at 3.5GHz for MWCNT respectively.

关键词： U-Slotted Patch Antenna MWCNT Dielectric Antenna and ADS

Effects of Bushen Yiqi Huoxue Decoction in Treatment of Patients with Diminished Ovarian Reserve:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第3期28卷 195-201页

作者： ZHOU Jing PAN Xin-yao LIN Jin ZHOU Qi LAN Li-kun ZHU Jun DUAN Ru WANG Lan SUN Yan WANG Ling Laboratory for Reproductive Immuno logy Hospital&Institute of Obstetrics and Gyn ecologyShan ghai Medical CollegeFudan UniversityShanghai(200000)China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai(200000)China Academy of Integrative Medicine of Fudan University Shanghai(200000)China Yangpu Hospital of Traditional Chinese Medicine Shanghai(200000)China Second Affiliated Hospital of Hexi University ZhangyeGansu Province(743000)China Department of Obstetrics and Gyn ecology Wenling People's HospitalWenzhou Medical UniversityWenzhouZhejiang Provinee(325000)China regulatory Commissi on Office of the New Cooperative Medical Scheme Eryuan CountyDaliYunnan Province(671000)China

Objective:To explore the therapeutic effect of Bushen Yiqi Huoxue Decoction BYHD)in patients with diminished ovarian reserve(DOR).Methods:A total of 180 patients with DOR diagnosed from December2013 to December 2014 were equally assigned into progynova and duphaston(E+D)group,Zuogui Pill group and BYHD group with 60 cases in each by computerized *** received E+D,Zuogui Pill or BYHD for 12 months,*** stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),anti-Mullerian hormone(AMH),antral follicle count(AFC),ovarian volume,endometrial thickness,and the resistance indices(Rls)of ovarian arteries and uterine arteries were observed before and after ***:Nine women(4 from the E+D group,3 from the Zuogui Pill group,and 2 from the BYHD group)withdrew from the *** 6 months,Zuogui Pill and BYHD significantly decreased FSH and LH and increased endometrial thickness and AMH(all Pgroups(all Pgroup(all P<0.01).However,E+D only significantly increased endometrial thickness(P<0.01)and no significant improvements were observed in the RI of uterine arteries in the three ***:BYHD had a favorable therapeutic effect in patients with DOR by rebalancing hormone levels,promoting ovulation,and repairing the thin *** combination of tonifying Shen(Kidney),benefiting qi and activating blood circulation may be a promising therapeutic strategy for DOR.

关键词： Bushen Yiqi Huoxue Decoction diminished ovarian reserve randomized controlled trial Chinese medicine

Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease

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Journal of Geriatric Cardiology 2014年第1期11卷 57-62页

作者： Li-Yun HE Jun-Feng ZHAO Jiang-Li HAN Shan-Shan SHEN Xu-Jiao CHEN Department of Cardiology Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry ofHealth Beijing 100191 China Department of Emergency the Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310005 Zhejiang Province China Department of Geriatrics Zhejiang Hospital Hangzhou 310013 Zhejiang Province China

ObjectivesTo 调查在浆液之间的关系免费的丰满的酸(船边交货)层次和在有冠的心疾病( CAD )的老病人的冠的动脉损害的严厉经历了冠的 angiography 的 172 个老病人全部的 .MethodsA 被划分成 CAD 组( n = 128 )并且非CAD 组( n = 44 )... 详细信息

ObjectivesTo 调查在浆液之间的关系免费的丰满的酸(船边交货)层次和在有冠的心疾病( CAD )的老病人的冠的动脉损害的严厉经历了冠的 angiography 的 172 个老病人全部的 .MethodsA 被划分成 CAD 组( n = 128 )并且非CAD 组( n = 44 )根据冠的 angiography 的结果。浆液船边交货和类脂化合物层次被测量， Gensini 分数是 *** 物质年龄，性和 statins 的用法之间的差别，在船边交货层次没有统计意义(P >；0.05 ) 。以 Gensini 分数，它比在病人 60-69 岁在 70-79 年的病人是更高的[15.00 (5.00， 34.00 ) 对 10.00 (2.00， 24.00 ) ， P <；0.05 ] ，在男人更高比女人[14.00 (4.00， 34.00 ) 对 7.00 (2.50， 19.75 ) ， P <；0.05 ] ，并且在 statins 上的病人更高[13.50 (4.25， 33.50 ) 对 6.50 (2.00， 18.00 ) ， P <；0.05 ] 。浆液船边交货层次[449.50 (299.00， 624.75 ) mEq/L 对 388.00 (258.50， 495.25 ) mEq/L， P <；0.05 ] 并且 Gensini 分数[17.50 (8.00， 41.75 ) 对 1.00 (0， 5.00 ) ， P <；0.05 ] 比在非 CAD 组在 CAD 组是更高的。在 CAD 组，在在有 diseased 的不同数字的病人之中的船边交货层次没有统计意义冠的容器(P >；0.05 ) 。而且，船边交货层次断然与 Gensini 分数被相关(r = 0.394， P = 0.005 ) 。回归分析证明船边交货层次在调整因为另外的风险 *** 浆液船边交货层次与 CAD 在老病人与 Gensini 分数被联系以后独立地与 Gensini 分数有关。它可能作为预言冠的动脉损害的严厉的 biomarker 显示船边交货。

关键词：冠状动脉造影游离脂肪酸心脏疾病患者酸水血清老年评分