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Incense smoke(IS)inhalation exposure system:Physicochemical characterization,IS particle deposition and clearance in human airway using MPPD model

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Particuology 2024年第4期87卷 271-285页

作者： Vyas Kumar Hafsa Hashmi Anshita Nasreen Ghazi Ansari Jyotsna Singh Inhalation Toxicology Facility Regulatory Toxicology GroupCSR-Indian Institute of Toxicology ResearchLucknow22001UPIndi Academy of Scientific and Innovative Research(AcsSIR) Ghaziabad201002UPIndia Analytical Chemistry Regulatory Toxicology GroupCSIR-Indian Institute of Toxicology ResearchLucknow226001UPIndia

Incense smoke(IS)is source of indoor air pollution and key risk for diverse human *** in-formation is available regarding controlled IS rodent inhalation exposure system and IS particulate matter(PM)deposition in human *** aimed to demonstrate stable ISPM physicochemical parameters of 10 incense products inside the customized whole body inhalation exposure chamber(without animal)connected to smoke generation unit via aerosol mixing *** analyzed for size segregated PM emission,ISPM in vitro aerodynamics(MMAD and GSD determination),fine and ultrafine particle's SEM,SEM-EDX and PAH *** real life exposure scenario by utilizing MMAD,GSD and PM concentration after Tier 1 exposure assessment as key input parameters,ISPM dosimetry in infant(3 months)and adult(21 years male and female)human airways was calculated using multiple-path particle dosimetry(MPPD 3.04)*** median aerodynamic diameter(MMAD)and geo-metric standard deviation(GSD)ranged between 0.55 and 2.10μm and 1.22 to 1.77(polydisperse)***1.0 and PM0.1 showed multiple morphology and presence of heavy and trace *** like acenaphthylene,anthracene,fluorene,naphthalene and phenanthrene were detected(0.84-143.17μg/g).MPPD results showed higher ISPM deposition in pulmonary region and lowest in trachea bronchial *** deposition in tissue was higher in lower,peripheral lung as compared to upper and central lung *** body inhalation exposure system showed stable IS atmosphere(physi-cochemical parameters)indicating the device suitability in future inhalation *** ISPM deposition fraction and clearance data showed deep lung penetrating and retention behavior with higher risk in infant followed by female and then *** modeled particle deposition and clearance data may be useful in risk assessment analysis of IS.

关键词： Inhalation Incense smoke Multiple-path particle dosimetry(MPPD) Particle deposition Particulate matter(PM) Mass median aerodynamic diameter (MMAD) Human airway

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Detection of Novel BEST1 Variations in Autosomal Recessive Bestrophinopathy Using Third-generation Sequencing

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Current Medical Science 2024年第2期44卷 419-425页

作者： Jia-xun LI Ling-rui MENG Bao-ke HOU Xiao-lu HAO Da-jiang WANG Ling-hui QU Zhao-hui LI Lei ZHANG Xin JIN Department of Senior Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China Department of Ophthalmology the 74th Army Group HospitalGuangzhou 510318China

Objective:Autosomal recessive bestrophinopathy(ARB),a retinal degenerative disease,is characterized by central visual loss,yellowish multifocal diffuse subretinal deposits,and a dramatic decrease in the light peak on *** potential pathogenic mechanism involves mutations in the BEST1 gene,which encodes Ca2+-activated Cl−channels in the retinal pigment epithelium(RPE),resulting in degeneration of RPE and *** this study,the complete clinical characteristics of two Chinese ARB families were ***:Pacific Biosciences(PacBio)single-molecule real-time(SMRT)sequencing was performed on the probands to screen for disease-causing gene mutations,and Sanger sequencing was applied to validate variants in the patients and their family ***:Two novel mutations,c.202T>C(chr11:61722628,p.Y68H)and c.867+97G>A,in the BEST1 gene were identified in the two Chinese ARB *** novel missense mutation BEST1 c.202T>C(p.Y68H)resulted in the substitution of tyrosine with histidine in the N-terminal region of transmembrane domain 2 of *** novel variant,BEST1 c.867+97G>A(chr11:61725867),located in intron 7,might be considered a regulatory variant that changes allele-specific binding affinity based on motifs of important transcriptional ***:Our findings represent the first use of third-generation sequencing(TGS)to identify novel BEST1 mutations in patients with ARB,indicating that TGS can be a more accurate and efficient tool for identifying mutations in specific *** novel variants identified further broaden the mutation spectrum of BEST1 in the Chinese population.

关键词： autosomal recessive bestrophinopathy BEST1 gene third-generation sequencing mutation

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A Review of 2023 Supervision Updates of Cosmetics in China

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China Detergent & Cosmetics 2024年第2期9卷 18-25页

作者： Li Neng Shanghai WEIPU Testing International group Co. Ltd.China

In 2023,multiple supporting documents of the Regulations on the Supervision and Administration of Cosmetics and regulatory requirements for toothpaste were successively *** article provides a detailed introduction to the updates of domestic cosmetics regulations in China in 2023,and sorts out the details of the 2023 unqualified cosmetics notification and flight inspection issued by regulatory authorities,analyzes the reasons,and helps cosmetics companies further understand regulatory requirements,implement the main responsibility of cosmetics quality and safety,and respond to changes in cosmetics regulatory policies,so as to avoid being notified of unqualified products,economic and reputation losses as much as possible.

关键词： cosmetic toothpaste regulatory status review

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Prophylactic treatment of Lacticaseibacillus paracasei K56 ameliorates asthma by regulating short-chain fatty acid production and Treg differentiation

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Food Science and Human Wellness 2024年

作者： Jiaqi Cui Yanfei Hong Wei-Hsien Liu Wen Zhao Xinmei Nan Xuekai Shang Yalan Li Haotian Feng Qiuyue Jiang Weilian Hung Guiying Peng Inner Mongolia Yili Industrial group Co. Ltd. Department of Immunology and Microbiology School of Life Sciences Beijing University of Chinese Medicine

Many studies have shown that the development of allergic asthma is associated with intestinal microbiota dysbiosis. Based on the gut-lung axis theory， probiotic intervention may be a potential strategy for respiratory diseases. Lacticaseibacillus paracasei K56 was reported to regulate gut microbiota in mice. However， its effect on allergic asthma has not been reported. In this study， we investigated the effect of the K56 on ovalbumin-induced asthma and its possible mechanisms. Our results showed that K56 reduced asthma symptoms and inflammatory cell infiltration in the lung of asthmatic mice. And K56 regulated the differentiation of helper T cells in the lung and intestine. Results from 16S rRNA gene sequencing showed that K56 prophylaxis significantly elevated the richness of Akkermansia and Burkholderia. Meanwhile， K56 abrogated the decrease in the levels of short-chain fatty acids (SCFAs) in the feces. In addition， a rebound in the mRNA expression of the SCFA receptors was observed after K56 prophylaxis. Notably， the regulatory T cell (Treg) frequencies and the FFAR3 levels were positively correlated. These results suggest that K56 could attenuate asthma， possibly by modulating the intestinal microbiota and regulating Treg differentiation through SCFA metabolized. Our study showed that K56 may be used as a probiotic to prevent pulmonary inflammation and dysbiosis of the intestinal microbiota in allergic asthma.

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Exploring the feasibility of prestressed anchor cables as an alternative to temporary support in the excavation of super-large-span tunnel

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Railway Engineering Science 2024年第3期32卷 344-360页

作者： Shunhua Zhou Yuyin Jin Zhiyao Tian Chunhua Zou Heming Zhao Zengrun Miao Shanghai Key Laboratory of Rail Infrastructure Durability and System Safety Tongji UniversityShanghai 201804China Key Laboratory of Road and Traffic Engineering of the Ministry of Education Tongji UniversityShanghai 201804China China Railway Construction Corporation Limited Beijing 100855China The 2nd Engineering Co. Ltd.of China Railway Construction Bridge Engineering Bureau GroupShenzhen 518083China China Railway Construction Bridge Engineering Bureau group Co. LtdTianjin 300300China

Excavating super-large-span tunnels in soft rock masses presents significant *** ensure safety,the sequential excavation method is commonly *** utilizes internal temporary supports to spatially partition the tunnel face and divide the excavation into multiple ***,these internal supports generally impose spatial constraints,limiting the use of large-scale excavation equipment and reducing construction *** address this constraint,this study adopts the“Shed-frame”principle to explore the feasibility of an innovative support system,which aims to replace internal supports with prestressed anchor cables and thus provide a more spacious working space with fewer internal *** evaluate its effectiveness,a field case involving the excavation of a 24-m span tunnel in soft rock is presented,and an analysis of extensive field data is conducted to study the deformation characteristics of the surrounding rock and the mechanical behavior of the support *** results revealed that prestressed anchor cables integrated the initial support with the shed,creating an effective“shed-frame”system,which successively maintained tunnel deformation and frame stress levels within safe regulatory ***,the prestressed anchor cables bolstered the surrounding rock effectively and reduced the excavation-induced disturbance zone *** summary,the proposed support system balances construction efficiency and *** field experiences may offer valuable insights into the popularization and further development of prestressed anchor cable support systems.

关键词： Super-large-span tunnel Construction safety Sequential excavation method Shed-frame principle Prestressed anchor cables

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A review of the interaction between diet composition and gut microbiota and its impact on associated disease

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未来食品学报(英文) 2024年第3期4卷 221-232页

作者： Zhaoxi Liu Meihua Liu Jing Meng Lushan Wang Min Chen State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China Qingdao Center Medical group Qingdao 266200China Jinan Maternity and Child Care Hospital Jinan 250000China

Dietary intake has an impact on the development of gut *** require carbohydrates,protein,fat,and other nutrients on a daily basis to provide energy for the growth,maintenance,and repair of body *** nutrition-induced changes in gut microbiota may be used to alter host physiology,including disease development and progression,such as obesity and *** research is needed to fully understand how diet influences microbiota and how microbiota influence host *** pathways of carbohydrate,protein,and fat metabolism,as well as their interactions and regulatory mechanisms,are described in this review,as well as how diet shapes the microbiota,how dietary-microbiome crosstalk may affect disease development and progression,and how this information could be used to maintain intestinal health.

关键词： Gut microbiota Carbohydrates Amino acids Short-chain fatty acids Prebiotics

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Phage lytic proteins: a natural approach to agro-food safety

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Food Science and Human Wellness 2024年

作者： Seila Agún Lucía Fernández Ana Rodríguez Pilar García Instituto de Productos Lácteos de Asturias (IPLA-CSIC). DairySafe group.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)

Sustainability is a leading trend in the context of food production. Additionally， consumers increasingly demand safer and less-processed products. Among the different technologies used to maintain the quality and extend the shelf-life of fresh and minimally-processed food， natural antimicrobial agents offer a promising strategy to replace conventional compounds. In this regard， phage lytic proteins or lysins， such as endolysins and virion-associated peptidoglycan hydrolases (VAPGHs)， have been proposed as a viable option for the avoidance and elimination of undesirable bacteria within the food production chain. Even when applied exogenously， these proteins can degrade the bacterial cell wall maintaining their lytic activity. This feature， alongside their modular structure， which can be exploited for bioengineering， provides significant biotechnological potential. However， despite the promising properties of lysins， the main obstacle for their commercialization is the limited legal information regulating their use. This challenge underscores the need to navigate complex regulatory pathways. The primary objective of this review is to address this crucial gap and summarize the many prospective applications of endolysins during the different stages of food production. By doing so， we aim to provide clarity and insight into the regulatory challenges that must be overcome for the successful utilization of lysins.

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Large‑scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1466-1481页

作者： Di Zhao Ranran Liu Xiaodong Tan Huimin Kang Jie Wang Zheng Ma Haiquan Zhao Hai Xiang Zhengfen Zhang Hua Li Guiping Zhao Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding School of Life Science and EngineeringFoshan UniversityFoshanChina State Key Laboratory of Animal Biotech Breeding Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijingChina Guangdong Tinoo’s Foods group Co. Ltd.QingyuanChina

Background Carcass traits are crucial indicators of meat production ***,the molecular regulatory mechanisms associated with these traits remain *** In this study,we conducted comprehensive transcriptomic and genomic analyses on 399 Tiannong partridge chickens to identify key genes and variants associated with carcass traits and to elucidate the underlying regulatory *** on association analyses with the elastic net(EN)model,we identified 12 candidate genes(AMY1A,AP3B2,CEBPG,EEF2,EIF4EBP1,FGFR1,FOXD3,GOLM1,LOC107052698,PABPC1,SERPINB6 and TBC1D16)for 4 carcass-related traits,namely live weight,dressed weight,eviscerated weight,and breast muscle ***6 was identified as the only overlapping gene by 3 analyses,EN model analysis,weighted gene co-expression network analysis and differential expression ***-level experiments confirmed that SERPINB6 promotes the proliferation of chicken DF1 cells and primary *** expression genome-wide association study and association analysis indicated that rs317934171 is the critical site that enhances SERPINB6 ***,a dual-luciferase reporter assay proved that gga-miR-1615 targets the 3′UTR of *** Collectively,our findings reveal that SERPINB6 serves as a novel gene for chicken carcass traits by promoting fibroblast and myoblast ***,the downstream variant rs317934171 regulates SERPINB6 *** results identify a new target gene and molecular marker for the molecular mechanisms of chicken carcass traits.

关键词： Carcass traits Chicken Genome SERPINB6 Transcriptome

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Hearing loss and tinnitus associated with COVID-19 vaccines:An analysis from the national pharmacovigilance database in Malaysia

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Asian Pacific Journal of Tropical Medicine 2023年第7期16卷 289-295,I0002-I0004页

作者： Sing Chet Lee Wee Kee Wo Hee Sheong Yeoh Sim Mei Choo Azuana Ramli National Pharmaceutical regulatory Agency(NPRA) Ministry of HealthMalaysia

Objective:To compare the reporting pattern of hearing loss and tinnitus across different vaccines brands used in Malaysia(BNT162b2,CoronaVac,ChAdOx1,***2-S and BBIBP-CorV).Methods:This retrospective study included all reports of hearing loss and tinnitus occurring after COVID-19 vaccination that were received in the national pharmacovigilance database,QUEST,from February 24,2021 through July 31,*** given causality consistent or indeterminate were ***:There were 21 cases of hearing loss,with overall reporting rate of 0.29 cases per million *** rate was similar across BNT162b2,CoronaVac and *** tinnitus,35 cases were reported,with the overall reporting rate of 0.49 cases per million doses,and the highest rate was reported for *** both events,most cases aged 30 to 49 *** gender disparity was *** events were mainly reported to have occurred after the primary doses,with a median time-to-onset of two *** were no statistically significant differences in the reporting patterns for both events across BNT162b2,CoronaVac and ChAdOx1 by age group,gender,race,and dose ***:Despite the low reporting rates and insufficient evidence to confirm its relationship,hearing loss and tinnitus following vaccinations should not be ignored due to its disabling potential and impact on one’s quality of *** reporting is encouraged for better signal characterization in the future.

关键词： COVID-19 vaccines Hearing loss Tinnitus Adverse events following immunization

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Diagnostic and prognostic role of LINC01767 in hepatocellular carcinoma

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World Journal of Hepatology 2024年第6期16卷 932-950页

作者： Li Zhang Tong-Xing Cui Xiang-Zhi Li Chong Liu Wen-Qin Wang Department of Thyroid and Breast Surgery The Affiliated People Hospital of Second Medical UniversityWeifang 266010Shandong ProvinceChina Department of General Surgery Qingdao Municipal Hospital GroupQingdao 266237Shandong ProvinceChina School of Life Sciences Shandong University(Qingdao)Qingdao 26637Shandong ProvinceChina School of Medicine Tsinghua UniversityBeijing 100084China

BACKGROUND Hepatocellular carcinoma(HCC)is a primary contributor to cancer-related mortality on a global ***,the underlying molecular mechanisms are still poorly *** noncoding RNAs are emerging markers for HCC diagnosis,prognosis,and therapeutic *** study of LINC01767 in HCC was *** To conduct a multi-omics analysis to explore the roles of LINC01767 in HCC for the first *** DESeq2 Package was used to analyze different gene *** operating characteristic curves assessed the diagnostic ***-Meier univariate and Cox multivariate analyses were used to perform survival *** least absolute shrinkage and selection operator(LASSO)-Cox was used to identify the prediction *** to the validation of LINC01767 expression in HCC fresh frozen tissues through quantitative real time polymerase chain reaction,next generation sequencing was performed following LINC01767 over expression(GSE243371),and Gene Ontology/Kyoto Encyclopedia of Genes and Genomes/Gene Set Enrichment Analysis/ingenuity pathway analysis was carried *** vitro experiment in Huh7 cell was carried *** LINC01767 was down-regulated in HCC with a log fold change=1.575 and was positively correlated with the cancer ***01767 was a good diagnostic marker with area under the curve(AUC)[0.801,95% confidence interval(CI):0.751-0.852,P=0.0106]and an independent predictor for overall survival(OS)with hazard ratio=1.899(95%CI:1.01-3.58,P=0.048).LINC01767 nomogram model showed a satisfied *** top-ranked regulatory network analysis of LINC01767 showed the regulation of genes participating various *** regression identified the 9-genes model showing a more satisfied performance than 5-genes model to predict the OS with AUC>***01767 was down-expressed obviously in tumor than para-tumor tissues in our cohort as well as in cancer cell line;the over expression of LINC01767 inhibit cell prolifer

关键词： Hepatocellular carcinoma LINC01767 Multi-omics analysis GSE243371 Cell proliferation Clone formation

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