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Sexual medicine disparities between Asia and North America： commentary on male sexual dysfunction in Asia

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Asian Journal of Andrology 2011年第4期13卷 605-606页

作者： Benjamin F Katz Doron S Stember Harris M Nagler Beth Israel Medical Center and the Albert Einstein College of Medicine of Yeshiva University 1300 Morris Park Avenue Bronx NY 10461 USA

In a recently published article in Asian Journal of Andrology, Ho et al.1 examine prevalence, attitudes, and treatment patterns related to sexual dysfunction in Asia and contrast them with those of Western society. They highlight the relative paucity of data with respect to erectile dysfunction （ED）, premature ejaculation, and hypogonadism in the Asian population.

关键词： Sexual North America

SeqSQC: A Bioconductor Package for Evaluating the Sample Quality of Next-generation Sequencing Data

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Genomics, Proteomics & Bioinformatics 2019年第2期17卷 211-218页

作者： Qian Liu Qiang Hu Song Yao Marilyn L. Kwan Janise M. Roh Hua Zhao Christine B. Ambrosone Lawrence H. Kushi Song Liu Qianqian Zhu Department of Biostatistics University at Buffalo SUNY Buffalo NY14260 USA Department of Biostatistics and Bioinformatics Roswell Park Comprehensive Cancer Center Buffalo NY14263 USA Department of Cancer Prevention and Control Roswell Park Comprehensive Cancer Center Buffalo NY14263 USA Division of Research Kaiser Permanente Northern California Oakland CA94612 USA Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX77030 USA

As next-generation sequencing (NGS) technology has become widely used to identify genetic causal variants for various diseases and traits,a number of packages for checking NGS data quality have sprung up in public domains. In addition to the quality of sequencing data,sample quality issues,such as gender mismatch,abnormal inbreeding coefficient,cryptic relatedness,and population outliers,can also have fundamental impact on downstream analysis. However,there is a lack of tools specialized in identifying problematic samples from NGS data,often due to the limitation of sample size and variant counts. We developed SeqSQC,a Bioconductor package,to automate and accelerate sample cleaning in NGS data of any scale. SeqSQC is designed for efficient data storage and access,and equipped with interactive plots for intuitive data visualization to expedite the identification of problematic samples. SeqSQC is available at http://bioconductor. org/packages/SeqSQC.

关键词： Next-generation sequencing Quality assessment 1000 Genomes Project Whole-exome sequencing Bioconductor package

Prediction of surgical complications in the elderly:Can we improve outcomes?

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Asian Journal of Urology 2017年第1期4卷 44-49页

作者： Preeya K.Mistry Geoffrey S.Gaunay David M.Hoenig The Smith Institute for Urology Northwell Health-Hofstra University School of MedicineNew Hyde ParkNYUSA

As the number of Americans aged 65 years and older continues to rise,there is projected to be a corresponding increase in demand for major surgeries within this ***,it is important to utilize accurate preoperative risk stratification techniques that are applicable to elderly ***,commonly used preoperative risk assessments are subjective and often do not account for elderly-specific syndromes that may pose a hazard for geriatric patients if not *** to accurately risk-stratify these patients may increase the risk of postoperative complications,morbidity,and ***,we aimed to identify and discuss the more objective and better-validated measurements indicative of poor surgical outcomes in the elderly with special focus on frailty,patient optimization,functional status,and cognitive ability.

关键词： Frailty Prediction Outcomes Surgical risks Complications

Percutaneous nephrolithotomy in octogenarians and beyond:How old is too old?

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Asian Journal of Urology 2015年第4期2卷 208-213页

作者： Bradley Morganstern Riccardo Galli Piruz Motamedinia David Leavitt Mohamed Keheila Eric Ghiraldi David Hoenig Arthur Smith Zeph Okeke The Smith Institute for Urology NorthShore-Long Island Jewish Health SystemNew Hyde ParkNYUSA

Objective:To specifically report perioperative characteristics and outcomes in patients 80 years and older undergoing percutaneous nephrolithotomy(PCNL).PCNL has been established as feasible in the elderly;however,to our knowledge no one has specifically reported feasibility in patients 80 years and ***:We retrospectively reviewed perioperative data of octogenarians who underwent PCNL at a high stone volume single institution,and matched them to patients<65 years of age by stone burden and *** demographics,perioperative outcomes and postoperative complications were ***:Thirty-three octogenarians(mean age 83.6 years)with 36 renal units were matched to 67 controls(mean age 48.6 years)with 72 renal *** had a higher mean American Society of Anesthesiologists(ASA)score,more comorbidities,and worse renal *** were no differences in operative characteristics,length of hospital stay or stone free *** the patients with preoperative urinary decompression(ureteral stent or nephrostomy tube)prior to PCNL,the elderly were more likely to have a history of *** did not experience more minor Clavien(Ⅰ-Ⅱ)or major Clavien(Ⅲa-Ⅳb)***:Octogenarians who undergo PCNL were more likely to have cardiovascular comorbidities and a prior history of *** these risk factors,in appropriately selected patients PCNL can be safely and successfully performed in octogenarians without increased perioperative complications relative to a younger cohort.

关键词： Percutaneous nephrolithotomy Elderly Percutaneous stone extraction complications Clavien Octogenarians Percutaneous stone extraction

Multi-parametric MRI of the prostate:Factors predicting extracapsular extension at the time of radical prostatectomy

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Asian Journal of Urology 2017年第1期4卷 31-36页

作者： Geoffrey S.Gaunay Vinay Patel Paras Shah Daniel Moreira Ardeshir R.Rastinehad Eran Ben-Levi Robert Villani Manish A.Vira The Smith Institute for Urology Hofstra Northwell School of MedicineNew Hyde ParkNYUSA Department of Urology Mayo ClinicRochesterMNUSA Department of Urology Icahn School of Medicine at Mount SinaiNew YorkNYUSA Department of Radiology Hofstra Northwell School of MedicineNew Hyde ParkNYUSA

Objective:Extracapsular extension(ECE)of prostate cancer is a poor prognostic factor associated with progression,recurrence after treatment,and increased prostate cancer-related *** staging prior to radical prostatectomy is crucial in avoidance of positive margins and when planning nerve-sparing ***-parametric magnetic resonance imaging(mpMRI)of the prostate has shown promise in this regard,but is hampered by poor *** sought to identify additional clinical variables associated with pathologic ECE and determine our institutional accuracy in the detection of ECE amongst patients who went on to radical ***:mpMRI studies performed between the years 2012 and 2014 were cross-referenced with radical prostatectomy *** properties of ECE as well as additional clinical and biochemical variables to identify pathology-proven prostate cancer ECE were ***:The prevalence of ECE was 32.4%,and the overall accuracy of mpMRI for ECE was 84.1%.Overall mpMRI sensitivity,specificity,positive predictive value,and negative predictive value for detection of ECE were 58.3%,97.8%,93.3%,and 81.5%,*** mpMRI characteristics predictive of pathologic ECE included primary lesion size((20.73±9.09)mm,mean±SD,p<0.001),T2 PIRADS score(p=0.009),overall primary lesion score(p<0.001),overall study suspicion score(p=0.003),and MRI evidence of seminal vesicle invasion(SVI)(p=0.001).

关键词： Prostate cancer Magnetic resonance imaging Staging Prostatectomy Extracapsular extension

Emergency department utilization for gastrointestinal care and patient characteristics associated with hospital admission in a national cohort

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Gastroenterology Report 2023年第1期11卷 566-568页

作者： Kelly Suchman Nina Kohn Arvind J.Trindade Division of Gastroenterology Zucker School of Medicine at Hofstra/NorthwellLong Island Jewish Medical CenterNew Hyde ParkNYUSA Institute of Health Innovations and Outcomes Research Feinstein Institutes for Medical ResearchNorthwell HealthManhassetNYUSA

Introduction Gastrointestinal diseases and care in the USA account for a significant amount of healthcare resources and spending,recently totaling>$119 billion dollars annually[1].In addition to ambulatory sites and clinics,a substantial portion of gastrointestinal care occurs through the emergency department(ED).Though the overall rate of ED visits in the USA has remained stable over the past 10 years[2],the number of visits for gastrointestinal complaints has been increasing[1,3],contributing to rising healthcare costs.

关键词： gastrointestinal diseases ambulatory

Imprinting at the KBTBD6 locus involves species-specific m ternal methylation and monoallelic expression in livestock animals

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Journal of Animal Science and Biotechnology 2024年第1期15卷 127-145页

作者： Jinsoo Ahn In-Sul Hwang Mi-Ryung park Seongsoo Hwang Kichoon Lee Department of Animal Sciences The Ohio State UniversityColumbusOH 43210USA Animal Biotechnology Division Rural Development AdministrationNational Institute of Animal ScienceJeonbuk 55365Republic of Korea Columbia Center for Translational Immunology Columbia University Irving Medical CenterColumbia UniversityNew YorkNY 10032USA Animal Welfare Research Team National Institute of Animal ScienceRDA1500Kongjwipatjwi‑roJeollabuk‑do 55365Republic of Korea

Background The primary differentially methylated regions(DMRs) which are maternally hypermethylated serve as imprinting control regions(ICRs) that drive monoallelic gene expression, and these ICRs have been investigated due to their implications in mammalian development. Although a subset of genes has been identified as imprinted, in-depth comparative approach needs to be developed for identification of species-specific imprinted genes. Here, we examined DNA methylation status and allelic expression at the KBTBD6 locus across species and tissues and explored potential mechanisms of *** Using whole-genome bisulfite sequencing and RNA-sequencing on parthenogenetic and normal porcine embryos, we identified a maternally hypermethylated DMR between the embryos at the KBTBD6 promoter Cp G island and paternal monoallelic expression of KBTBD6. Also, in analyzed domesticated mammals but not in humans, non-human primates and mice, the KBTBD6 promoter Cp G islands were methylated in oocytes and/or allelically methyl-ated in tissues, and monoallelic KBTBD6 expression was observed, indicating livestock-specific imprinting. Further analysis revealed that these Cp G islands were embedded within transcripts in porcine and bovine oocytes which coexisted with an active transcription mark and DNA methylation, implying the presence of transcription-dependent *** In this study, our comparative approach revealed an imprinted expression of the KBTBD6 gene in domesticated mammals, but not in humans, non-human primates, and mice which implicates species-specific evolution of genomic imprinting.

关键词： Differentially methylated region Domesticated mammal Imprinting KBTBD6 Parthenogenetic

Kohn-Sham Density Matrix and the Kernel Energy Method

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物理化学学报 2018年第6期34卷 656-661页

作者： POLKOSNIK Walter MASSA Lou The Graduate Center of the City University of New York Physics Department 365 5th Avenue New York NY 10016 USA. Hunter College of the City University of New York Chemistry Department 695 Park Avenue New York NY 10065 USA. The Graduate C

The kernel energy method(KEM) has been shown to provide fast and accurate molecular energy calculations for molecules at their equilibrium *** breaks a molecule into smaller subsets,called kernels,for the purposes of *** results from the kernels are summed according to an expression characteristic of KEM to obtain the full molecule energy.A generalization of the kernel expansion to density matrices provides the full molecule density matrix and *** this study,the kernel expansion for the density matrix is examined in the context of density functional theory(DFT) Kohn-Sham(KS) calculations.A kernel expansion for the one-body density matrix analogous to the kernel expansion for energy is defined,and is then converted into a normalizedprojector by using the Clinton *** normalized projectors are factorizable into linear combination of atomic orbitals(LCAO) matrices that deliver full-molecule Kohn-Sham molecular orbitals in the atomic orbital *** straightforward KEM energies and energies from a normalized,idempotent density matrix obtained from a density matrix kernel expansion to which the Clinton algorithm has been applied are compared to reference energies obtained from calculations on the full system without any kernel *** were performed both for a simple proof-of-concept system consisting of three atoms in a linear configuration and for a water cluster consisting of twelve water *** the case of the proof-of-concept system,calculations were performed using the STO-3 G and6-31 G(d,p) bases over a range of atomic separations,some very far from *** water cluster was calculated in the 6-31 G(d,p) basis at an equilibrium *** normalized projector density energies are more accurate than the straightforward KEM energy results in nearly all *** the case of the water cluster,the energy of the normalized projector is approximately four times more accurate than the straightforwa

关键词： Kohn Sham density matrix Kernel energy method N-representability Quantum crystallography Watercluster

Adaptive dynamic programming for finite-horizon optimal control of linear time-varying discrete-time systems

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Control Theory and Technology 2019年第1期17卷 73-84页

作者： Bo PANG Tao BIAN Zhong-Ping JIANG Control and Networks (CAN) Lab Department of Electrical and Computer Engineering Tandon School of Engineering New York University Brooklyn NY 11201 U.S.A. Bank of America Merrill Lynch One Bryant Park New York NY 70036 U.S.A.

This paper studies data-driven learning-based methods for the finite-horizon optimal control of linear time-varying discretetime systems. First, a novel finite-horizon Policy Iteration (PI) method for linear time-varying discrete-time systems is presented. Its connections with existing in finite-horizon PI methods are discussed. Then, both data-drive n off-policy PI and Value Iteration (VI) algorithms are derived to find approximate optimal controllers when the system dynamics is completely unknown. Under mild conditions, the proposed data-driven off-policy algorithms converge to the optimal solution. Finally, the effectiveness and feasibility of the developed methods are validated by a practical example of spacecraft attitude control.

关键词： Optimal control time-varying system adaptive dynamic programming policy iteration (PI) value iteration(VI)