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Rapid range expansion predicted for the Common Grackle(Quiscalus quiscula)in the near future under climate change scenarios

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Avian Research 2021年第4期12卷 569-575页

作者： Peter Capainolo Utku Perktaş Mark DEFellowes Division of Vertebrate Zoology-Department of Ornithology American Museum of Natural HistoryCentral Park West@79th StreetNew YorkNY 10024-5192USA People and Wildlife Research Group School of Biological SciencesUniversity of ReadingWhiteknightsReading RG66ASUK Depart-ment of Biology(Zoology Section Biogeography Research Laboratory)Faculty of ScienceHacettepe UniversityBeytepe06800 AnkaraTurkey

Background:Climate change due to anthropogenic global warming is the most important factor that will affect future range distribution of species and will shape future biogeographic *** much effort has been expended in understanding how climate change will affect rare and declining species we have less of an understanding of the likely consequences for some abundant *** Common Grackle(Quiscalus quiscula;Linnaeus 1758),though declining in portions of its range,is a widespread blackbird(Icteridae)species in North America east of the Rocky *** study examined how climate change might affect the future range distribution of Common ***:We used the R package Wallace and six general climate models(ACCESS1-0,BCC-CSM1-1,CESM1-CAM5-1-FV2,CNRM-CM5,MIROC-ESM,and MPI-ESM-LR)available for the future(2070)to identify climatically suitable areas,with an ecological niche modelling approach that includes the use of environmental ***:Future projections suggested a significant expansion from the current range into northern parts of North America and Alaska,even under more optimistic climate change ***,there is evidence of possible future colonization of islands in the Caribbean as well as coastal regions in eastern Central *** most important bioclimatic variables for model predictions were Annual Mean Temperature,Temperature Seasonality,Mean Temperature of Wettest Quarter and Annual ***:The results suggest that the Common Grackle could continue to expand its range in North America over the next 50 *** research is important in helping us understand how climate change will affect future range patterns of widespread,common bird species.

关键词： Annual mean temperature Climate change Common Grackle Ecological niche modelling Range shift Seasonality

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Emerging roles of circular RNAs in retinal diseases

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Neural Regeneration Research 2022年第9期17卷 1875-1880页

作者： Aneliya Hanineva Karen Sophia park Joshua J.Wang Margaret M.DeAngelis Michael H.Farkas Sarah X.Zhang Department of Ophthalmology and Ross Eye Institute Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA Research Service Veterans Administration Western New York Healthcare SystemBuffaloNYUSA Department of Biochemistry Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA

Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the *** research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal *** this review,we explore a relatively new field of research involving circular RNAs,whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just *** knowledge of circular RNAs function is limited given its novelty,current evidence has highlighted their roles as modulators of microRNAs,regulators of gene transcription,and biomarkers of disease development and ***,we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy,glaucoma,proliferative vitreoretinopathy,and age-related macular ***,we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases.

关键词： age-related macular degeneration circular RNA diabetic retinopathy glaucoma microRNA proliferative vitreoretinopathy retina

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Novel Wavelet-Based Segmentation of Prostate CBCT Images with Implanted Calypso Transponders

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第3期6卷 336-343页

作者： Yingxia Liu Ziad Saleh Yulin Song Maria Chan Xiang Li Chengyu Shi Xin Qian Xiaoli Tang Shandong Communication and Media College Jinan China Medical Physics Department Memorial Sloan Kettering Cancer Center New York NY USA Radiation Oncology North Shore Long Island Jewish Health System New Hyde Park NY USA

Segmentation of prostate Cone Beam CT (CBCT) images is an essential step towards real-time adaptive radiotherapy (ART). It is challenging for Calypso patients, as more artifacts generated by the beacon transponders are present on the images. We herein propose a novel wavelet-based segmentation algorithm for rectum, bladder, and prostate of CBCT images with implanted Calypso transponders. For a given CBCT, a Moving Window-Based Double Haar (MWDH) transformation is applied first to obtain the wavelet coefficients. Based on a user defined point in the object of interest, a cluster algorithm based adaptive thresholding is applied to the low frequency components of the wavelet coefficients, and a Lee filter theory based adaptive thresholding is applied on the high frequency components. For the next step, the wavelet reconstruction is applied to the thresholded wavelet coefficients. A binary (segmented) image of the object of interest is therefore obtained. 5 hypofractionated Calypso prostate patients with daily CBCT were studied. DICE, Sensitivity, Inclusiveness and ΔV were used to evaluate the segmentation result.

关键词： CBCT Prostate Segmentation Wavelets MWDH

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Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion

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Bone Research 2021年第4期9卷 571-581页

作者： Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun park-Min Arthritis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterNew YorkNYUSA Tissue Engineering Regeneration and RepairHospital for Special SurgeryNew YorkNYUSA Department of Cell and Developmental Biology Weill Cornell Medical CollegeNew YorkNYUSA BCMB allied program Weill Cornell Graduate School of Medical SciencesNew YorkNYUSA Hanyang University Institute for Rheumatology Research SeoulKorea Department of Rheumatology Hanyang University Hospital for Rheumatic DiseasesSeoulKorea Rheumatology College of MedicineKorea UniversitySeoulKorea Department of Medicine Weill Cornell Medical CollegeNew YorkNYUSA

Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone *** colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely ***,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)*** levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory ***,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis *** FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein ***,targeting the MNK1/2 pathway diminished arthritic bone *** results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion.

关键词： osteoclast stimulating 1/2

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Now decision theory

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Probability, Uncertainty and Quantitative Risk 2023年第3期8卷 391-416页

作者： Dilip B.Madan Wim Schoutens King Wang Robert H.Smith School of Business University of MarylandCollege ParkMD.20742USA Department of Mathematics K.U.LeuvenLeuven3000 LeuvenBelgium Derivative Product Strats Morgan Stanley1585 Broadway5th floorNew YorkNY 10036USA

The spirit of now in nowcasting suggests expanding the current to include the near *** theory is then developed by incorporating the consequences of actions into the *** the future falling into the present discounting it is no longer *** functions are then observed to be determinate only up to scale and shift that are then locked down by fixing values arbitrarily in two selected states,much like declaring water to freeze and boil at zero and a hundred degrees *** locked down value functions associated policy functions are seen to exist in decision contexts in where the only time is *** are studied in univariate and multivariate dimensions for the decision state space and the dimension of shocks delivering state *** policy functions are expanded from realisitic training sets to the full state space using Gaussian Process *** are implemented on real data with reported performances.

关键词： State dependent discounting Bilateral gamma process Probability distortion Measure distortion Gamma discounted averaging Multivariate bilateral gamma model

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Lack of proper reimbursement is hampering adoption of minimally invasive gastrointestinal endoscopy in North America

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World Journal of Gastrointestinal Endoscopy 2020年第1期12卷 49-52页

作者： Shahzad Iqbal Aman Ali Arham Razzaq Eman Shahzad Department of Gastroenterology Good Samaritan HospitalWest IslipNY 11795United States Department of Gastroenterology Lancaster General HospitalLancasterPA 17602United States Herricks High School New Hyde ParkNY 11040United States

Endoscopic submucosal dissection(ESD)and related procedures are minimally invasive and cost-effective alternates to ***,there is no approved or listed current procedural terminology(CPT)for *** aimed to review the current reimbursement process hurdles for ESD procedures in private practice model in United *** reviewed the data of two advanced endoscopists(one in New York and other in Pennsylvania State)performing ESD in their private practice *** found the reimbursement process was complex,with number of refusals varied from 0-9 for ESD *** was not paid at all in 8.3%of cases by the medical *** mucosal resection,which is considered inferior as compared to ESD,but has a listed CPT,was denied in only 0.83%*** data highlights the billing hurdles by the endoscopists to adopt ESD-related procedures in private practice model.

关键词： Endoscopic submucosal dissection Lack of reimbursement Current procedural terminology Minimally invasive gastrointestinal endoscopy North America

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Rylene Dielectrophores for Capacitive Energy Storage

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Materials Sciences and Applications 2018年第6期9卷 534-541页

作者： Andrey Borzenko Carine Edder Lev Mourokh Pavel Lazarev Capacitor Sciences Inc. Menlo Park USA Department of Physics Queens College of the City University of New York Flushing USA The Graduate Center of CUny New York NY USA

Main design principles of the potent rylene-based class of dielectrophores are established in the present article. The proposed class of dielectrophores comprises polarizable aromatic core, conjugated with aromatic subunits, and bears resistive groups on the periphery. The aromatic subunits might comprise donor and acceptor groups for the desired level of polarizability of the molecule. Appropriate positions for donor and acceptor groups are established by quantum chemistry modeling. The design principles are demonstrated on the molecular design of an efficient rylene-based dielectrophore.

关键词： Dielectrophore Polarization Capacitor Molecular Dielectrics Molecular Design

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Molecular Materials for Energy Storage

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Materials Sciences and Applications 2018年第6期9卷 517-525页

作者： Lev Mourokh Carine Edder Wolfgang Mack Pavel Lazarev Capacitor Sciences Inc. Menlo Park USA Department of Physics Queens College of the City University of New York Flushing USA The Graduate Center of CUny New York NY USA

We map the requirements and design rules for dielectric materials that target large scale energy storage applications of electrostatic capacitors. The molecular unit (dielectrophore) must contain three main components: a polarizable subunit having large electric dipole, an isolating subunit which prevents current leakage, and a structural element that promotes self-assembly of molecules in solution and in mesophase and promotes crystallization in the process of film formation. This structural subunit is necessary for high molecular density and enhanced resistivity of film. The process engineering steps required for the supramolecular assembly and crystal film formation (cascade crystallization) are addressed.

关键词： Capacitor Molecular Dielectrics Molecular Design Polarization Induced Electric Dipole

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Loss of Notch signaling in skeletal stem cells enhances bone formation with aging

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Bone Research 2023年第4期11卷 737-750页

作者： Lindsey H.Remark Kevin Leclerc Malissa Ramsukh Ziyan Lin Sooyeon Lee Backialakshmi Dharmalingam Lauren Gillinov Vasudev V.Nayak Paulo El Parente Margaux Sambon Pablo J.Atria Mohamed A.E.Ali Lukasz Witek Alesha B.Castillo Christopher Y.park Ralf H.Adams Aristotelis Tsirigos Sophie M.Morgani Philipp Leucht Department of Orthopaedic Surgery NYU Robert I.Grossman School of MedicineNew YorkNYUSA Applied Bioinformatics Laboratories NYU Grossman School of MedicineNew YorkNYUSA Institute of Comparative Molecular Endocrinology Ulm UniversityUlmGermany Max Planck Institute for Molecular Biomedicine Department of Tissue Morphogenesisand University of MünsterFaculty of MedicineD-48149 MünsterGermany Department of Biochemistry and Molecular Biology University of Miami Miller School of MedicineMiamiFLUSA Department of Pathology NYU Robert I.Grossman School of MedicineNew YorkNYUSA Biomaterials Division New York University College of DentistryNew YorkNYUSA Hansjörg Wyss Department of Plastic Surgery NYU Grossman School of MedicineNew York UniversityNew YorkNYUSA Department of Biomedical Engineering Tandon School of EngineeringNew York UniversityBrooklynNYUSA Department of Cell Biology NYU Robert I.Grossman School of MedicineNew YorkNYUSA

Skeletal stem and progenitor cells(SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental transformation are largely unknown. Single-cell RNA sequencing revealed that Notch signaling becomes elevated in SSPCs during aging. To examine the role of increased Notch activity, we deleted Nicastrin, an essential Notch pathway component, in SSPCs in vivo. Middle-aged conditional knockout mice displayed elevated SSPC osteo-lineage gene expression, increased trabecular bone mass, reduced bone marrow adiposity, and enhanced bone repair. Thus, Notch regulates SSPC cell fate decisions, and moderating Notch signaling ameliorates the skeletal aging phenotype, increasing bone mass even beyond that of young mice. Finally, we identified the transcription factor Ebf3 as a downstream mediator of Notch signaling in SSPCs that is dysregulated with aging, highlighting it as a promising therapeutic target to rejuvenate the aged skeleton.

关键词： Notch skeletal elevated

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Investigation of the role of Ca(OH)2 in the catalytic Alkaline Thermal Treatment of cellulose to produce H2 with integrated carbon capture

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Journal of Energy Chemistry 2017年第5期26卷 984-1000页

作者： Maxim R.Stonor Nicholas Ouassil Jingguang G.Chen Ah-Hyung Alissa park Department of Chemical Engineering Columbia UniversityNYUSA Department of Earth and Environmental Engineering Columbia UniversityNYUSA Lenfest Center for Sustainable Energy Columbia UniversityNYUSA

The Alkaline Thermal Treatment(ATT)of biomass is one of the few biomass conversion processes that has a potential for BECCS(bio-energy with carbon capture and storage).Combining in-situ carbon capture withcreates a carbon-neutral process that has the potential to be *** study has shown that the conversion of cellulose tosuppressedcan be achieved through the reforming of gaseous intermediates in a fixed bed of 10%Ni/*** occurs at low temperatures≤773 K,which could allow for improved sustainability.

关键词： Hydrogen Biomass Alkaline Thermal Treatment Calcium hydroxide Calcium carbonate Carbon capture utilization storage Nickel Heterogeneous catalysis Catalytic reforming

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