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Asian Journal of Urology 2024年第3期11卷 384-390页

作者： Abdul Wasay Mahmood Grace Harrington Zhe Jing Qiang Li Ahmed A.Hussein Khurshid A.Guru Department of Urology Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNew YorkNYUSA

Objective:We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures(UES)following robot-assisted radical cystectomy(RARC)and urinary ***:Retrospective review of our RARC database from November 2005 to August 2023 at Roswell park Comprehensive Cancer center was *** who developed UES and ultimately underwent robot-assisted uretero-enteric reimplantation(RUER)were *** method was used to compute the cumulative incidence recurrence rate of UES after RUER.A multivariable regression model was used to identify variables associated with UES ***:A total of 123(15%)out of 808 RARC patients developed UES,of whom 52 underwent reimplantation(45 patients underwent RUER[n=55 cases]and seven patients underwent open ureteroenteric reimplantation).The median time from RARC to UES was 4.4(interquartile range 3.0e7.0)months,and the median time between UES and RUER was 5.2(interquartile range 3.2e8.9)*** 3-year recurrence rate after RUER is about 29%.On multivariable analysis,longer hospital stay(hazard ratio 1.37,95%confidence interval 1.16e1.61,p<0.01)was associated with recurrent UES after ***:RUER for UES after RARC is feasible with durable outcomes although a notable subset of patients experienced postoperative complications and UES recurrence.

关键词： Stricture Cystectomy Reimplantation Robot-assisted

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKM2

RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 307-318页

作者： Lu Xu Zhi-Hao Xie Jun Li Shi Tao Fang-Li Ren Yin-Yin Wang Zhi-Jie Chang Xin-Bao Hao Department of Hematology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China State Key Laboratory of Membrane Biology School of MedicineTsinghua UniversityBeijing 100084China Heya Beijing Med-Biotech Inc. Beijing 100084China Department of Hematology Roswell Park Comprehensive Cancer CenterNY 14263USA

Objective:To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma(DLBCL)and its potential as a therapeutic ***:This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival *** vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and ***:RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor *** vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling ***:RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular *** RPRD1B may offer a novel therapeutic strategy for DLBCL,suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.

关键词： RPRD1B RNAPⅡ Diffuse large B-cell lymphoma NF-κB Apoptosis

Mesoscale interplay among composition heterogeneity,lattice deformation,and redox stratification in single-crystalline layered oxide cathode

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eScience 2024年第4期4卷 96-102页

作者： Zhichen Xue Feixiang Wu Mingyuan Ge Xiaojing Huang Yong SChu Piero Pianetta Yijin Liu School of Metallurgy and Environment Central South UniversityChangsha 410083China Stanford Synchrotron Radiation Lightsource SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA National Synchrotron Light Source II Brookhaven National LaboratoryBuilding 743 Ring RoadUptonNY 11973USA Walker Department of Mechanical Engineering The University of Texas at AustinAustinTX 78712USA

Single-crystalline layered oxide materials for lithium-ion batteries are featured by their excellent capacity retention over their polycrystalline counterparts,making them sought-after cathode *** capacity degradation,however,becomes more severe under high-voltage cycling,hindering many high-energy *** has long been speculated that the interplay among composition heterogeneity,lattice deformation,and redox stratification could be a driving force for the performance *** underlying mechanism,however,is not *** this study,we use X-ray microscopy to systematically examine single-crystalline NMC particles at the *** technique allows us to capture detailed signals of diffraction,spectroscopy,and fluorescence,offering spatially resolved multimodal *** on early high-voltage charging cycles,we uncover heterogeneities in valence states and lattice structures that are inherent rather than caused by electrochemical *** heterogeneities are closely associated with compositional variations within individual *** findings provide useful insights for refining material synthesis and processing for enhanced battery longevity and efficiency.

关键词： Single-crystalline layered oxide cathode Composition heterogeneity Lattice deformation Redox stratification

Quantification and visualization of spatial distribution of dendrites in solid polymer electrolytes

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eScience 2024年第1期4卷 114-122页

作者： Tiancheng Yi Enyue Zhao Yuping He Tianjiao Liang Howard Wang Spallation Neutron Source Science Center Dongguan 523803China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Neutron Science Platform Songshan Lake Materials LaboratoryDongguan 523808China Institute for Materials Research and Department of Mechanical Engineering Binghamton UniversityBinghamtonNY 13902USA Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742USA

Integrating lithium metal anodes with polymer electrolytes is a promising technology for the next generation high-energy-density rechargeable *** the progress is often hindered by the dendrite growth upon cycling,quantifying three-dimensional(3D)microstructures of dendrites in polymer electrolytes is essential to better understanding of dendrite formation for the development of mitigation *** for 3D quantification and visualization of dendrites,especially those with low Li contents,are rather *** study reports quantitative measurements of the spatial distribution of Li dendrites grown in solid polymer electrolytes using 3D tomographic neutron depth profiling(NDP)with improved spatial resolution,compositional range,and data *** reveal heterogeneous distribution of Li over length scales from tens nanometers to *** most dendrites grow from the plating toward the stripping electrode with dwindling Li quantities,dendrites apparently grown from the Li-stripping electrode are also *** discovery is only possibly due to the unique combination of the high specificity and high sensitivity of the neutron activation analysis of Li isotope.

关键词： Li metal battery Solid polymer electrolytes 3D tomographic neutron depth profiling Lithium dendrite

Can ChatGPT be used to generate scientific hypotheses?

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Journal of Materiomics 2024年第3期10卷 578-584页

作者： Yang Jeong park Daniel Kaplan Zhichu Ren Chia-Wei Hsu Changhao Li Haowei Xu Sipei Li Ju Li Department of Nuclear Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02139USA Institute of New Media and Communications Seoul National University1 Gwanak-roGwanak-guSeoul08826Republic of Korea Department of Condensed Matter Physics Weizmann Institute of ScienceRehovot7610001Israel Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02139USA Global Technology Applied Research JPMorgan Chase237 Park AveNew YorkNY10017USA

We investigate whether large language models can perform the creative hypothesis generation that human researchers regularly *** the error rate is high,generative AI seems to be able to effectively structure vast amounts of scientific knowledge and provide interesting and testable *** future scientific enterprise may include synergistic efforts with a swarm of“hypothesis machines”,challenged by automated experimentation and adversarial peer reviews.

关键词： large language models scientific hypothesis generation generative AI GPT-4

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读书 1996年第2期 146-147页

作者：潘互美国rego park

一九九五年十月号《读书》登了一篇燕继荣的文章《政治冷漠是不是坏事?》,读后甚觉惊异。作者断言:“自由主义给我们的启示是:极少数人捣鼓政治机器,绝大多数人过自己的生活,那才是社会良性发展的常态。”不知这是哪一家的自由主义? 燕... 详细信息

一九九五年十月号《读书》登了一篇燕继荣的文章《政治冷漠是不是坏事?》,读后甚觉惊异。作者断言:“自由主义给我们的启示是:极少数人捣鼓政治机器,绝大多数人过自己的生活,那才是社会良性发展的常态。”不知这是哪一家的自由主义? 燕继荣的逻辑是:因为自由主义主张“管得最少的政府就是最好的政府”,所以,“老百姓不大过问的政治,才是最好的政治”。在这里,燕继荣把“政府”和“政治”混为一谈。其实,自由主义所极力反对的

关键词：燕继荣良性发展自由主义政治

Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine

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Cell Research 2005年第7期15卷 523-531页

作者： Chien Chung CHANG,Soldano FERRONE Department of Immunology Roswell park Cancer Institute Buffalo.ny 14263 USA Department of Immunology Roswell park Cancer Institute Buffalo.ny 14263 USA

The non-classical HLA class I antigen HLA-G is an immune modulator which inhibits the functions of T cells, NK cells, and the Dendritic cells (DC). As a result, HLA-G expression in malignant cells may provide them with a mechanism to escape the immune surveillance. In melanoma, HLA-G antigen expression has been found in 30% of surgically removed lesions but in less than 1% of established cell lines. One possible mechanism underlying the differential HLA-G expression in vivo and in vitro is that the HLA-G gene is epigenetically repressed in melanoma cells in vitro. To test this hypothesis, we treated the HLA-G negative melanoma cell line OCM-1A with the DNA methyltransferase inhibitor 5-aza-2'-deoXycytidine (5-AC) and analyzed whether HLA-G expression can be restored. Our data strongly suggest that HLA-G is silenced as a result of CpG hypermethylation within a 5' regulatory region encompassing 220 bp upstream of the start codon. After treatment, HLA-G mRNA expression was dramatically increased. Western blot and flow cytometry showed that HLA-G protein was induced. Interestingly, HLA-G cell surface expression on the 5-AC treated OCM-1 A cells is much less than that on the HLA-G positive JEG-3 cells while a similar amount of total HLA-G was observed. Possible mechanisms for the difference were analyzed in the study such as cell cold-treatment, peptide loading and antigen processing machinery components (APM) as well as β2 microglobulin (β2-m) expression. Data revealed that the APM component calreticulin might be involved in the lower HLA-G surface expression on OCM-1 A cells. Taken together, our results indicated that DNA methylation is an important epigenetic mechanism by which HLA-G antigen expression is modulated in melanoma cells in vitro. Furthermore, to the first time, we hypothesized that the deficiency of calreticulin might be involved in the low HLA-G surface expression on the 5-AC treated OCM-1 A cells.

关键词： HLA-G methylation 5-aza-2’-deoxycytidine APM.

Foregut duplication cysts:A report of two cases with emphasis on embryogenesis

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World Journal of Gastroenterology 2011年第1期17卷 130-134页

作者： Thaer Khoury Louis Rivera Department of Pathology Roswell Park Cancer InstituteBuffaloNY 14263United States Surgical Oncology Roswell Park Cancer InstituteBuffaloNY 14263United States

Duplication cyst of the stomach with a pseudostratifie columnar ciliated epithelium is extremely *** de scribe two cases of these cysts,with emphasis on the immunophenotype and *** first patien was a 29-year-old man who presented with crampin abdominal pain in his left lower *** secon patient was a 26-year-old woman who had a history over several years,of chronic epigastric abdominal pai radiating to her *** lesions were surgically re *** showed the same *** cysts were lined by a pseudostratified respiratory ep thelium with ciliated *** first cyst was connecte to the stomach,while the second cyst was not connect *** cysts expressed thyroid transcription factor(TTF-1) and *** this report,we explore th possible embryogenesis of these lesions in the light o TTF-1 and surfactant expression.

关键词： Duplication cyst Stomach Thyroid transcription factor-1 Surfactant Embryogenesis

Enhancing the electrochemical performance of Na metal anodes via local eutectic melting in porous Al-Cu alloy hosts

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Nano Research 2024年第7期17卷 6111-6118页

作者： Tao Hu Qiang Wu Cheng Wang Jialu Chen Fu Su Zibo Chen Yizhou Wang Jianyu Chen Yanwen Ma Jin Zhao State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Suzhou Vocational Institute of Industrial Technology 1 Zhineng AvenueSuzhou International Education ParkSuzhou 215104China

Sodium(Na)metal batteries(SMBs)have emerged as promising alternatives to lithium metal batteries for large-scale energy storage applications,owing to their cost-effectiveness,abundance,and favorable redox ***,the practical implementation of SMBs faces several challenges associated with the Na metal anode,including the formation of dendrites,low Coulombic efficiency,and capacity ***,we propose a novel approach to enhance the electrochemical performance of Na metal anodes through a porous Al-Cu alloy host(PAC)fabricated by a local eutectic melting *** local eutectic melting facilitates the development of a conductive network,offering mechanical support,and the porous structure provides abundant channels for the diffusion of Na ions and accommodates volume fluctuations in the Na metal during charge–discharge ***,the PAC exhibits a high average Coulombic efficiency of 99.8%at 1 mA·cm^(−2)for 1 mAh·cm^(−2)and a low voltage polarization of 19 mV during 500 *** study provides valuable insight into the design and fabrication of highperformance Na metal anodes,which hold significant promise for the advancements of next-generation energy storage systems.

关键词： Na metal anode porous Al-Cu alloy porous current collector local eutectic melting