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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina institute of Laboratory Animal center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Real-World Treatment Adherence to Smoking Cessation Medications and Association with Treatment Outcome—27 centers,China,2017–2022

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China CDC weekly 2024年第22期6卷 522-529,I0001-I0003页

作者： Anqi Cheng Zhao Liu Xinmei Zhou Zheng Su Dan Xiao Chen Wang the China national Tobacco Cessation Cohort Study(CNTCCS)Study Group Department of Tobacco Control and Prevention of respiratory Disease Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/National Center for Respiratory Medicine/National Clinical Research Center for Respiratory Diseases/Institute of Respiratory MedicineChinese Academy of Medical SciencesBeijingChina Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/China National Center for Respiratory Medicine/China National Clinical Research Center for Respiratory DiseasesBeijingChina Chinese Academy of medical Sciences and Peking Union medical College BeijingChina 不详

What is already known about this topic?Medication non-adherence significantly impedes smoking cessation *** effective smoking cessation medications are accessible in China,realworld adherence and its correlation with treatment outcomes remain largely *** is added by this report?From December 2017 to January 2022,1,120 participants were recruited from 27 centers in all seven geographical regions of *** revealed that only 38.2%of smokers adhered to the prescribed 12-week smoking cessation treatment and those with a higher education level were more likely to be *** addition,smokers with good adherence were more likely to successfully quit *** are the implications for public health practice?The data obtained could enhance our understanding of smoking cessation practices in *** adherence is a crucial strategy to enhance the effectiveness of smoking cessation treatments and management provided to smokers.

关键词： China smoke likely

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Food allergy and related risk factors in 2540 preschool children: an epidemiological survey in Guangdong Province, southern China

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World Journal of Pediatrics 2015年第3期11卷 219-225页

作者： Guang-Qiao Zeng Jia-Ying Luo Hui-Min Huang Pei-Yan Zheng Wen-Ting Luo Ni-Li Wei Bao-Qing Sun State Key Laboratory of respiratory Disease National Clinical Research Center for Respiratory DiseasesGuangzhou Institute of Respiratory DiseasesFirst Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina

Background:Although the number of studies on allergic diseases in the general population of southern China is increasing,only a few have addressed food allergy(FA)in children in this *** present study aimed to investigate the prevalence,clinical manifestations,spectrum of allergens,and related risk factors of FA in preschool children in Guangdong Province,southern ***:A random cluster-sampling method was used to select 24 kindergartens from 12 cities in Guangdong *** parents or guardians of the children were requested to complete a questionnaire on general information and data regarding FA diagnosis and symptoms in the children and their first-degree ***,the Chi-square test,multivariate regression analysis,and Spearman's rank-order correlation coefficient analysis were performed to identify statistically significant ***:Analysis of 2540 valid questionnaires revealed an FA prevalence rate of 4%.Adverse food reactions were due to the consumption of shrimp(4.4%),crab(3.2%),mango(2.3%),cow's milk and dairy products(1.9%),and eggs(1.4%).Logistic regression analysis indicated that a history of FA and a history of allergic rhinitis in the first-degree relatives were the major factors leading to FA in ***:The incidence of FA in children in Guangdong Province is higher than that commonly *** individual's genetic background is an important risk factor for ***,mitigation of the impact of lifestyle and environmental factors should be carefully considered to reduce the incidence of childhood FA.

关键词： allergic rhinitis eczema epidemiology food allergy questionnaire

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Long-term survival outcomes of video-assisted thoracic surgery for patients with non-small cell lung cancer

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Chinese Journal of Cancer Research 2014年第4期26卷 391-398页

作者： Wenlong Shao Xinguo Xiong Hanzhang Chen Jun Liu Weiqiang Yin Shuben Li Xin Xu Xin Zhang Jianxing He Department of Thoracic Surgery the First Affiliated Hospital of Guangzhou Medical University Department of Thoracic Surgery Guangzhou Institute of Respiratory Diseases Key cite of national Clinical Research center for respiratory diseases

Background： Video-assisted thoracic surgery （VATS） has been shown to be a safe alternative to conventional thoracotomy for patients with non-small cell lung cancer （NSCLC）. However, popularization of this relatively novel technique has been slow, partly due to concerns about its long-term outcomes. The present study aimed to evaluate the long-term survival outcomes of patients with NSCLC after VATS, and to determine the significant prognostic factors on overall survival. Methods： Consecutive patients diagnosed with NSCLC referred to one institution for VATS were identified from a central database. Patients were treated by either complete-VATS or assisted-VATS, as described in previous studies. A number of baseline patient characteristics, clinicopathologic data and treatment-related factors were analyzed as potential prognostic factors on overall survival. Results： Between January 2000 and December 2007, 1,139 patients with NSCLC who underwent VATS and fulfilled a set of predetermined inclusion criteria were included for analysis. The median age of the entire group was 60 years, with 791 male patients （69%）. The median 5-year overall survival for Stage Ⅰ, Ⅱ, Ⅲ and Ⅳ disease according to the recently updated TNM classification system were 72.2%, 47.5%, 29.8% and 28.6%, respectively. Female gender, TNM stage, pT status, and type of resection were found to be significant prognostic factors on multivariate analysis. Conclusions： VATS offers a viable alternative to conventional open thoracotomy for selected patients with clinically resectableNSCLC

关键词： Non-small cell lung cancer (NSCLC) video-assisted thoracoscopic surgery (VATS) overall survival

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Use of endoscopic ultrasound-based techniques in tumor of the guts and beyond

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Chinese Journal of Cancer Research 2014年第6期26卷 644-646页

作者： Chu Pei Guangqiao Zeng State Key Laboratory of respiratory Disease National Clinical Center for Respiratory Diseases Guangzhou Institute of Respiratory Diseases FirstAffiliated Hospital Guangzhou Medical University Guangzhou 510120 China

Endoscopic techniques in gastroenterology have been developing rapidly over the past two *** in minimally invasive endoscopic techniques allow for the detection and treatment of more gastrointestinal（GI）diseases tha... 详细信息

关键词： speaking endoscopy miniature advent manner guided beyond radiofrequency disciplines epoch

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Molecular Epidemiology of Echovirus 18 Circulating in China's Mainland from 2015 to 2016

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Virologica Sinica 2019年第1期34卷 50-58页

作者： Xiangpeng Chen Tianjiao Ji Jiayun Guo Wei Wang Wenbo Xu Zhengde Xie Key Laboratory of Major diseases in Children Ministry of EducationNational Clinical Research Center for Respiratory DiseasesBeijing Key Laboratory of Pediatric Respiratory Infection DiseasesVirology LaboratoryBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health WHO WPRO regional Polio Reference Laboratory and Key Laboratory of medical Virology and Viral diseases National Health and Family Planning Commission of ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention

Echovirus 18(E18), a serotype of Enterovirus B(EV-B) species, is an important pathogen in aseptic meningitis. E18 had rarely been detected in China's Mainland, but became the predominant pathogen associated with viral encephalitis(VE) and meningitis in Hebei province for the first time in 2015. To investigate the molecular epidemiology and genetic characteristics of E18 in China's Mainland, sixteen E18 strains from patient throat swabs with hand, foot, and mouth disease(HFMD) in six provinces in China collected between 2015 and 2016, and four E18 strains isolated from 18 patient cerebrospinal fluid specimens with VE in Hebei Province in 2015 were obtained and sequenced. Combined with the sequences from the GenBank database, we performed an extensive genetic analysis. Phylogenetic analysis of VP1 gene sequences revealed that all E18 strains from China's Mainland after 2015 belonged to subgenotype C2. There were no obvious specific differences in phylogenetic and variation analyses of E18 genome sequences between HFMD and VE/meningitis strains. Potential multiple recombination may have occurred in the 50-untranslated region and in the P2 and P3 nonstructural protein-encoding regions of E18 strains from China. The current E18 strains were potential multiplerecombinant viruses. Overall, these findings supported that E18 caused HFMD, VE, and meningitis, although there were no significant associations between clinical features and viral genomic characteristics.

关键词： Genetic characteristics Echovirus 18 (E18) Genome Enterovirus Recombination

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Endobronchial ultrasound-guided transbronchial needle aspiration： unraveling myths of mass in the chest

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Chinese Journal of Cancer Research 2014年第6期26卷 732-734页

作者： Rui Wang Guangqiao Zeng State Key Laboratory of respiratory Disease National Clinical Center for Respiratory Diseases Guangzhou Institute of Respiratory Diseases FirstAffiliated Hospital Guangzhou Medical University Guangzhou 51012 0 China

Lung cancer is one of the most common neoplasms worldwide and a major cause of cancer *** diagnosis and accurate staging for patients with suspected lung cancer are essential to appropriate ***,many of submucosal or p... 详细信息

关键词： submucosal guided neoplasms aspiration staging needle chest malignancy despite alone

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Safety and feasibility of video-assisted thoracoscopic surgery for stage IIIA lung cancer

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Chinese Journal of Cancer Research 2014年第4期26卷 418-422页

作者： Wenlong Shao Jun Liu Wehua Liang Hanzhang Chen Shuben Li Weiqiang Yin Xin Zhang Jianxing He Department of Thoracic Surgery The First Affiliated Hospital of Guangzhou Medical University Department of Thoracic Surgery Guangzhou Institute of Respiratory Diseases Key cite of national Clinical Research center for respiratory diseases

Objective： The current study was prospectively designed to explore the application of video-assisted thoracoscopic surgery （VATS） radical treatment for patients with stage ⅢA lung cancer, with the primary endpoints being the safety and feasibility of this operation and the second endpoints being the survival and complications after the surgery. Methods： A total of 51 patients with radiologically or mediastinoscopically confirmed stage ⅢA lung cancer underwent VATS radical treatment, during which the standard pulmonary lobectomy and mediastinal lymph node dissection were performed after pre-operative assessment. The operative time, intraoperative blood loss/ complications, postoperative recovery, postoperative complications, and lymph node dissection were recorded and analyzed. This study was regarded as successful if the surgical success rate reached 90% or higher. Results： A total of 51 patients with non-small cell lung cancer （NSCLC） were enrolled in this study from March 2009 to February 2010. The median post-operative follow-up duration was 50.5 months. Of these 51 patients, 41 （80.4%） had N2 lymph node metastases. All patients underwent the thoracoscopic surgeries, among whom 50 （98%） received pulmonary lobectomy and mediastinal lymph node dissection completely under the thoracoscope, 6 had their incisions extended to about 6 cm due to larger tumor sizes, and 1 had his surgery performed using a 12 cm small incision for handling the adhesions between lymph nodes and blood vessels. No patient was converted to conventional open thoracotomy. No perioperative death was noted. One patient received a second surgery on the second post-operative day due to large drainage （〉1,000 mL）, and the postoperative recovery was satisfactory. Up to 45 patients （88.2%） did not suffer from any perioperative complication, and 6 （11.8%） experienced one or more complications. Conclusions： VATS radical treatment is a safe and feasible treatment for stage ⅢA lung cancer.

关键词： Lung cancer video-assisted thoracoscopic surgery (VATS) systematic node dissection (SND)

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Early screening of lung cancers:an effort arduous but worthwhile

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Chinese Journal of Cancer Research 2015年第6期27卷 617-618页

作者： Chu Pei Lawrence Grouse Guangqiao Zeng State Key Laboratory of respiratory Disease National Clinical Center for Respiratory Diseases Guangzhou Institute of Respiratory Diseases First Affiliated Hospital of Guangzhou Medical University University of Washington School of Medicine

Cancers are a concerning health catastrophe worldwide that may become the end of lifetime for many of us--they overwhelmingly exhaust medical resources, lead to huge economic burdens, and separate people from their beloved ones. Fewer and fewer insurance agencies are willing to include primary cancers on their general health insurance plan, just because cancers have been so flummoxingly usual in our daily life that many primary cancer claims would give rise to much less profits.

关键词： lung Early screening of lung cancers

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Updated consensus statement for pulmonary rehabilitation of patients with coronavirus disease 2019 (2023)

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中华医学杂志(英文版) 2024年第21期137卷 2024 Sep 27页

作者： Wang Wenqiao Wang Ye Li Danye Ma Xinqi Dong Tairan Zhao Qing Zhao Hongmei Wang Chen national center for respiratory Medicine State Key Laboratory of respiratory Health and Multimorbidity national Clinical Research center for respiratory diseases institute of respiratory Medicine Chinese Academy of Medical Sciences Department of Pulmonary and Critical Care Medicine Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China institute of Basic medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences Beijing China

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