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China CDC weekly 2024年第18期6卷 385-389,I0001-I0004页

作者： Penghang Zhang Xiaochen Ma Yuzhu Liu Tongyu Wang Shuning Huo Xiaoai Zhang Beijing Key laboratory of diagnostic and Traceability Technologies for Food Poisoning Institute for Nutrition and Food HygieneBeijing Center for Disease Prevention and ControlBeijingChina Yanjing Medical College of Capital Medical University BeijingChina

Summary What is already known on this topic?Foodborne diseases present a substantial global health *** diagnostic methods have constraints,but advancements in molecular techniques,like quantitative polymerase chain reaction(qPCR),provide a hopeful *** is added by this report?We examined 1,011 stool samples from individuals suspected of foodborne illnesses.

关键词： solution. constraints advancement

Chemical composition and larvicidal activity of essential oil of Origanum majorana(Lamiaceae) cultivated in Morocco against Culex pipiens(Diptera:Culicidae)

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Asian Pacific Journal of Tropical Biomedicine 2014年第9期4卷 746-750页

作者： Fouad El-Akhal Abdelhakim El Ouali Lalami Yassine Ez Zoubi Hassane Greche Raja Guemmouh regional diagnostic laboratory epidemiological and environmental hygiene Regional Health DirectorateEL Ghassani HospitalFezMorocco Sidi Mohamed Ben Abdellah University Faculty of Sciences Dhar El MahrazLaboratory Analysis and Modelling of Ecosystems ContinentalsFezMorocco National Institute of Medicinal and Aromatic Plants Sidi Mohamed Ben Ahdellah University.FezMorocco

Objective:To evaluate the larvicidal activity of essential oil of Origanum mtijoruna(Lamiaceae)cultivated in Morocco against Culex pipiens(Diptera:Culicidae).Methods:The analysis and the identification of the various constituents of essential oil were carried out by gas chromatography coupled with mass *** test was performed according to a standard methodology inspired by the World Health Organization protocol with slight ***:This oil mainly consisted of monoterpene and *** majority compounds are 4-terpinene(28.96%),y-terpinene(18.57%),α-terpinene(12.72%) and sabinene(8.02%).The lethal concentrations(LC_(50) and LC_(90)) measured for the essential oil Origanum majorana,were respectively of the order of 258.71 mg/L and 580.49 mg/***:The results could be useful in search for newer,safer,and more effective natural larvicidal agents.

关键词： Essential oil Origanum majorana Culex pipiens Larvicidal activity Morocco Fez

Human bocavirus: Current knowledge and future challenges

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World Journal of Gastroenterology 2016年第39期22卷 8684-8697页

作者： Marcello Guido Maria Rosaria Tumolo Tiziano Verri Alessandro Romano Francesca Serio Mattia De Giorgi Antonella De Donno Francesco Bagordo Antonella Zizza laboratory of hygiene Department of Biological and Environmental Sciences and Technologies Faculty of Sciences University of Salento Institute of Clinical Physiology National Research Council laboratory of Physiology Department of Biological and Environmental Sciences and Technologies University of Salento Neuropathology Unit Institute of Experimental Neurology and Division of Neuroscience IRCCS San Raffaele Scientific Institute

Human bocavirus(HBoV) is a parvovirus isolated about a decade ago and found worldwide in both respiratory samples, mainly from early life and children of 6-24 mo of age with acute respiratory infection, and in stool samples, from patients with gastroenteritis. Since then, other viruses related to the first HBoV isolate(HBoV 1), namely HBoV 2, HBoV 3 and HBoV 4, have been detected principally in human faeces. HBo Vs are small nonenveloped single-stranded DNA viruses of about 5300 nucleotides, consisting of three open reading frames encoding the first two the non-structural protein 1(NS1) and nuclear phosphoprotein(NP1) and the third the viral capsid proteins 1 and 2(VP1 and VP2). HBoV pathogenicity remains to be fully clarified mainly due to the lack of animal models for the difficulties in replicating the virus in in vitro cell cultures, and the fact that HBo V infection is frequently accompanied by at least another viral and/or bacterial respiratory and/or gastroenteric pathogen infection. Current diagnostic methods to support HBoV detection include polymerase chain reaction, real-time PCR, enzymelinked immunosorbent assay and enzyme immunoassay using recombinant VP2 or virus-like particle capsid proteins, although sequence-independent amplification techniques combined with next-generation sequencing platforms promise rapid and simultaneous detection of the pathogens in the future. This review presents the current knowledge on HBoV genotypes with emphasis on taxonomy, phylogenetic relationship and genomic analysis, biology, epidemiology, pathogenesis and diagnostic methods. The emerging discussion on HBoV s as true pathogen or innocent bystander is also emphasized.

关键词： Human bocavirus Respiratory virus Molecular tests Gastrointestinal virus Pathogenesis Epidemiology Immunoassay methods

Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods：Association with particle constituents

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Journal of environmental Sciences 2016年第9期28卷 201-210页

作者： Bin Wang Ning Li Furong Deng Nicholas Buglak George Park Shu Su Aiguo Ren Guofeng Shen Shu Tao Xinbiao Guo Institute of Reproductive & Child Health/Ministry of Health Key laboratory of Reproductive Health School of Public Health Peking University Beijing 100192 China Department of Pathobiology & diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing 48824 USA Department of Occupational & environmental Health Sciences School of Public Health Peking University Beijing 100191 China laboratory for Earth Surface Processes College of Urban & Environmental Sciences Peking University Beijing 100871 China Jiangsu Provincial Academy of environmental Science Nanjing 210036 China

epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter（PM） *** presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM 〈 2.5 μm（PM2.5）pollution in China have led to serious concerns regarding the health effects of PM2.5during Asian *** investigated how changes in PM2.5composition,as the weather transitioned towards a sandstorm,affected human airway epithelial *** PM2.5samples covering two sandstorm events and their respective background and transition periods were collected in Baotou,an industrial city near the Gobi Desert in *** samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B,which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several *** PM samples potently increased the release of interleukin-6（IL-6） and interleukin-8（IL-8）.Endotoxin in all samples contributed significantly to the IL-6 response,with only a minor effect on *** was positively correlated with both IL-6 and IL-8 release,while Si was only associated with the increase of *** study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM.

关键词： Sandstorm particles Human bronchial epithelial cells Particle constituents Inflammation Local environmental surroundings

The role of gut microbiota in acute pancreatitis:new perspectives in pathogenesis and therapeutic approaches

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Journal of Pancreatology 2024年第1期7卷 61-71页

作者： Zu-Chao Du Guan-Qun Li Yan Luo Xue-Wei Bai Bei Sun Department of Pancreatic and Biliary Surgery the First Affiliated Hospital of Harbin Medical UniversityHarbinChina Key laboratory of Hepatosplenic Surgery Ministry of Educationthe First Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Hepatobiliary and Pancreatic Surgery Qunli Branchthe First Affiliated Hospital of Harbin Medical UniversityHarbinChina Key laboratory of Critical Care Research Qunli Branchthe First Affiliated Hospital of Harbin Medical UniversityHarbinChina

Acute pancreatitis(AP)is one of the most common acute abdomen diseases with increasing incidence and substantial healthcare *** microbiota disturbance,mucosal barrier failure,and bacterial translocation are identified as the dominant cause of infected pancreatic necrosis and high *** the advance of high-throughput sequencing,imbalance between beneficial and facultative pathogenic microorganisms with their metabolic activities in the development of AP has been increasingly recognized,whereas it remains unclear whether dysbacteriosis is the dominant cause of aggravating AP,or merely reflecting different epidemiological or environmental factors at the individual *** review discussed the alterations of the gut microbiota and their metabolites during AP with detailed molecular ***,it highlights microbiome-based medical therapies which influence gut barrier function and immune homeostasis to mitigate inflammatory responses in *** review will provide a novel roadmap of gastrointestinal microecology in AP progression,and contribute to the future development of microbiome-based diagnostic and therapeutic strategies in clinical practice.

关键词： Acute pancreatitis Immunity Metabolites Microbiome-based therapeutics Microbiota

Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1689-1698页

作者： Da Pan Gui-Ju Sun Ming Su Xin Wang Qing-Yang Yan Guang Song Yuan-Yuan Wang Deng-Feng Xu Nian-Nian Wang Shao-Kang Wang Key laboratory of environmental Medicine and Engineering of Ministry of Education Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Department of Chronic Disease Huai’an District Center for Disease Control and PreventionHuai’an 223200Jiangsu ProvinceChina

BACKGROUND Helicobacter pylori(H. pylori) is a Gram-negative bacterium found in the upper digestive tract. Although H. pylori infection is an identified risk factor for gastric cancer, its role in esophageal squamous cell carcinoma(ESCC) remains a topic of much *** To evaluate the association between H. pylori infection and the risk of precancerous lesions of ESCC, and further explore the association between dietary factors and the risk of H. pylori *** Two hundred patients with esophageal precancerous lesions(EPL) aged 63.01 ± 6.08 years and 200 healthy controls aged 62.85 ± 6.03 years were included in this case-control study. epidemiological data and qualitative food frequency data were investigated. Enzyme-linked immunosorbent assay measuring serum immunoglobulin G antibodies was used to determine H. pylori seropositivity. An unconditional logistic regression model was used to assess the association between H. pylori infection and EPL risk dichotomized by gender, age, and the use of tobacco and alcohol, as well as the association between dietary factors and the risk of H. pylori *** A total of 47(23.5%) EPL cases and 58(29.0%) healthy controls had positive H. pylori infection. An inverse relation between H. pylori infection and the risk of EPL was found in the group of drinkers after adjustment for covariates [odds ratio(OR) = 0.32, 95% confidence interval(95%CI): 0.11-0.95]. Additionally, peanut intake was significantly associated with a decreased risk of H. pylori infection(OR = 0.39, 95%CI: 0.20-0.74).CONCLUSION Our study suggested that H. pylori infection may decrease the risk of EPL for drinkers in a rural adult Chinese population, and the consumption of peanut may reduce the risk of H. pylori infection. These findings should be framed as preliminary evidence, and further studies are required to address whether the mechanisms are related to the localization of lesions and alcohol consumption.

关键词： Helicobacter pylori Esophageal precancerous lesions Peanut consumption Esophageal squamous cell carcinoma

Studies on the Epidemiology and Etiology of Moldy Sugarcane Poisoning in China

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Biomedical and environmental Sciences 1992年第2期5卷 161-177页

作者： LIU XINGJIE,LUO XUEYUN, HU WENJUANInstitute of Nutrition and Food hygiene, Chinese Academy of Preventive Medicine, 29 Nan Wei Road, Beijing 100050, China Institute of Food Safety Control and Inspection, Ministry of Public Health, Panjiayao, Beijing 100021, China. Institute of Nutrition and Food hygiene Chinese Academy of Preventive Medicine Beijing.

Moldy sugarcane poisoning, an acute fatal food poisoning of unknown etiology, has occurred in 13 provinces in China. The epidemiological characteristics and clinical features were described. Evidence from laboratory studies indicates that 3-nitropropionic acid roduced by the fungus Arthrinium Spp. is the etiological factor of this food poisoning.

关键词： Studies on the Epidemiology and Etiology of Moldy Sugarcane Poisoning in China

Discovery of unique African Helicobacter pylori CagAmultimerization motif in the Dominican Republic

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World Journal of Gastroenterology 2020年第45期26卷 7118-7130页

作者： Takaaki Ono Modesto Cruz Hiroyuki Nagashima Phawinee Subsomwong Junko Akada Takashi Matsumoto Tomohisa Uchida Rumiko Suzuki Celso Hosking Jose A Jimenez Abreu Yoshio Yamaoka Department of environmental and Preventive Medicine Oita University Faculty of MedicineYufu 879-5593Japan Criminal Investigation laboratory Oita Prefectural Police HeadquartersOita 870-1117Japan Institute of Microbiology and Parasitology IMPAFaculty of ScienceAutonomous University of Santo DomingoSanto Domingo 10103Dominican Republic Department of Biomedical Research National Institute of Medicine and Diagnostic ImagingSanto Domingo 10107Dominican Republic Department of Gastroenterology Hokkaido Cancer CenterSapporo 003-0804Japan Department of Molecular Pathology Oita University Faculty of MedicineYufu 879-5593Japan Dominican-Japanese Digestive Disease Center Dr Luis E.Aybar Health and Hygiene CitySanto Domingo 10302Dominican Republic Department of Medicine Gastroenterology and Hepatology SectionBaylor College of MedicineHoustonTX 77030United States

BACKGROUND Helicobacter pylori(***)colonizes the human stomach and is a major cause of peptic ulcer disease and gastric ***,although the prevalence of *** is high in Africa,the incidence of gastric cancer is low,and this phenomenon is called to be African *** CagA protein produced by *** is the most studied virulence *** carcinogenic potential of CagA is associated with the Glu-Pro-Ile-Tyr-Ala(EPIYA)patterns and CagAmultimerization(CM)*** To better understand the EPIYA patterns and CM motifs of the cagA *** Gastric mucosal biopsy specimens were obtained from 258 patients with dyspepsia living in the Dominican Republic,from which 120 *** strains were *** the bacterial DNA extraction,the EPIYA pattern and CM motif genotypes were determined using a polymerase chain reaction-based *** population structure of the Dominican Republic strains was analyzed using multilocus sequence typing(MLST).Peptic ulcer disease and gastric cancer were identified via endoscopy,and gastric cancer was confirmed by *** scores of the gastric mucosa were evaluated using the updated Sydney *** All CagA-positive strains carried the Western-type CagA according to the identified EPIYA ***-seven kinds of CM motifs were *** the typical Western CM motif(FPLKRHDKVDDLSKVG)was observed most frequently,the typical East Asian CM motif(FPLRRSAAVNDLSKVG)was not ***,“FPLRRSAKVEDLSKVG”,similar to the typical East Asian CM motif,was found in 21 *** this type was significantly more frequent in strains classified as hpAfrica1 using MLST analysis(P=0.034),we termed it Africa1-CM(Af1-CM).A few hpEurope strains carried the Af1-CM motif,but they had a significantly higher ancestral Africa1 component than that of those without the Af1-CM motif(P=0.030).In 30 cagA-positive strains,the"GKDKGPE"motif was observed immediately upstream of the EPIYA motif in

关键词： Helicobacter pylori CagA CagA 3'region CagA-multimerization motif Glu-Pro-Ile-Tyr-Ala motif Dominican Republic

Screening of Serum Biomarkers for Distinguishing between Latent and Active Tuberculosis Using Proteome Microarray

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Biomedical and environmental Sciences 2018年第7期31卷 515-526页

作者： CAO Shu Hui CHEN Yan Qing SUN Yong LIU Yang ZHENG Su Hua ZHANG Zhi Guo LI Chuan You Department of Bacteriology and Immunology Beijing Key Laboratory on Drug-Resistant Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital Capital Medical University. Beijing 101149 China Department of laboratory Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Department of Clinical laboratory Beijing Tuberculosis and Thoracic Tumour Research Institute/Beijing Chest Hospital Capital Medical University Beijing 101149 China Department of epidemiological Research Beijing Tuberculosis and Thoracic Tumour Research lnstitute/Beijing Chest Hospital Capital Medical University Beijing 101149 China Institute of Tuberculosis Prevention and Control of District Changping Beijing 102200 China

Objective To identify potential serum biomarkers for distinguishing between latent tuberculosis infection（LTBI） and active tuberculosis（TB）. Methods A proteome microarray containing 4,262 antigens was used for screening serum biomarkers of 40 serum samples from patients with LTBI and active TB at the systems level. The interaction network and functional classification of differentially expressed antigens were analyzed using STRING 10.0 and the TB database, respectively. Enzyme-linked immunosorbent assays（ELISA） were used to validate candidate antigens further using 279 samples. The diagnostic performances of candidate antigens were evaluated by receiver operating characteristic curve（ROC） analysis. Both antigen combination and logistic regression analysis were used to improve diagnostic ability. Results Microarray results showed that levels of 152 Mycobacterium tuberculosis（Mtb）-antigenspecific IgG were significantly higher in active TB patients than in LTBI patients（P 〈 0.05）, and these differentially expressed antigens showed stronger associations with each other and were involved in various biological processes. Eleven candidate antigens were further validated using ELISA and showed consistent results in microarray analysis. ROC analysis showed that antigens Rv2031 c, Rv1408, and Rv2421 c had higher areas under the curve（AUCs） of 0.8520, 0.8152, and 0.7970, respectively. In addition, both antigen combination and logistic regression analysis improved the diagnostic ability. Conclusion Several antigens have the potential to serve as serum biomarkers for discrimination between LTBI and active TB.

关键词： LTBI Active TB Proteome microarray Serum biomarkers

environmental perspectives of COVID-19 outbreaks:A review

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World Journal of Gastroenterology 2021年第35期27卷 5822-5850页

作者： Palas Samanta Apurba Ratan Ghosh Department of environmental Science Sukanta MahavidyalayaUniversity of North BengalDhupguri 735210West BengalIndia Department of environmental Science The University of BurdwanBurdwan 713104West BengalIndia

The coronavirus disease 2019(COVID-19)pandemic,caused by the novel virus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in December 2019 in China and has led to a global public health ***,it was known as 2019-nCoV and caused disease mainly through respiratory *** COVID-19 outbreak is ranked third globally as the most highly pathogenic disease of the twenty-first century,after the outbreak of SARS-CoV and Middle East respiratory syndrome in 2002 and 2012,***,laboratory,and diagnostic methodology have been demonstrated in some observational *** systematic reviews on COVID-19 have been published regarding the integration of COVID-19 outbreaks(monitoring,fate and treatment)with environmental and human health ***,this review systematically addresses environmental aspects of COVID-19 outbreak such as the origin of SARS-CoV-2,epidemiological characteristics,diagnostic methodology,treatment options and technological advancement for the prevention of COVID-19 ***,we integrate COVID-19 outbreaks(monitoring,fate and treatment)with environmental and human health *** believe that this review will help to understand the SARS-CoV-2 outbreak as a multipurpose document,not only for the scientific community but also for global *** should adopt emergency preparedness such as prepare human resources,infrastructure and facilities to treat severe COVID-19 as the virus spreads rapidly globally.

关键词： COVID-19 SARS-CoV-2 virus environmental perspectives epidemiological characteristics Public health Emergency preparedness