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贝伐珠单抗联合含氟尿嘧啶类化疗方案治疗晚期转移性结直肠癌的前瞻性、非干预性、全国多中心临床研究(react)

临床肿瘤学杂志 2016年第10期21卷 865-873页

作者：秦叔逵邓艳红毕锋刘天舒刘云鹏张苏展徐建明束永前徐农吴昌平王新钟海均冯继锋何裕隆杨建伟无解放军八一医院全军肿瘤中心 210002 中山大学附属第六医院肿瘤内科 510065 四川大学华西医院腹部肿瘤科 610041 复旦大学附属中山医院肿瘤内科 200032 中国医科大学附属第一医院肿瘤内科 110001 浙江大学医学院附属第二医院肿瘤中心 310009 解放军307医院消化肿瘤科 100071 江苏省人民医院肿瘤科 210006 浙江大学医学院附属第一医院肿瘤内科 310003 常州市第一人民医院生物诊疗中心 213003 第四军医大学西京医院消化科 710032 浙江省肿瘤医院化疗中心 310022 江苏省肿瘤医院肿瘤内科 210009 中山大学附属第一医院胃肠外科中心 510080 福建省肿瘤医院腹部肿瘤内科 350014 react研究协作组

背景和目的在欧美国家,贝伐珠单抗联合化疗业已成为治疗晚期转移性结直肠癌（m CRC）的标准方案。在我国,贝伐珠单抗的注册临床研究亦显示贝伐珠单抗联合化疗可以提高m CRC客观缓解率和显著改善生存预后。但是,缺乏贝伐珠单抗联合化疗... 详细信息

背景和目的在欧美国家,贝伐珠单抗联合化疗业已成为治疗晚期转移性结直肠癌（m CRC）的标准方案。在我国,贝伐珠单抗的注册临床研究亦显示贝伐珠单抗联合化疗可以提高m CRC客观缓解率和显著改善生存预后。但是,缺乏贝伐珠单抗联合化疗治疗国人m CRC的大样本资料,特别是安全性数据。为此,我们开展了上市后临床研究——react研究（REal world study of Avastin in Colorec Tal cancer;注册号：NCT 01319877）,系统观察和评价真实世界（real world）中贝伐珠单抗联合氟尿嘧啶类药物为基础的化疗方案治疗国人m CRC的安全性和有效性。方法本研究为一项前瞻性、非干预性、全国多中心的上市后临床研究。根据预设的入排标准,纳入m CRC一线或二线治疗患者,采用贝伐珠单抗联合氟尿嘧啶类药物为基础的常规化疗方案进行治疗。主要终点指标是评估治疗的安全性,次要终点指标为评估总体缓解率（ORR）、无进展生存期（PFS）、总生存期（OS）、KRAS突变状态和贝伐珠单抗用药周期（〈8或≥8周期）对疗效以及生活质量（Qo L）的影响。分别采用RECIST 1.1版和NCI-CTC AE 4.03版评价客观疗效和不良反应。结果自2011年3月至2013年12月,24家研究中心共纳入606例m CRC,中位年龄56.6岁（22-81岁）,ECOG PS 0-1占76.7%;其中,一线患者453例,二线患者153例。贝伐珠单抗中位用药周期为5.0个（3.0-8.0个）周期。安全性方面：有102例患者（16.8%）发生≥3级不良事件（AE）;66例（10.9%）发生≥3级可能与贝伐珠单抗有关的AE。特别关注的不良事件（AESI）为高血压（1.8%）、蛋白尿（0.8%）、胃肠穿孔（0.5%）、出血（3.3%）、动脉血栓栓塞（0.3%）、静脉血栓栓塞（1.0%）、肠瘘（0.8%）以及伤口愈合并发症（0.2%）。有效性方面：ORR为18.3%（95%CI：15.3%-21.6%）,一线患者和二线患者的ORR分别为21.0%（95%CI：17.3%-25.0%）和10.5%（95%CI：6.1%-16.4%）（P=0.0035）;中位无进展生存期（m PFS）为9.1个月（95%CI：8.1-9.8个月）;中位总生存期（m OS）为21.9个月（95%CI：17.1-25.7个月）。一线患者与二线患者的m PFS和m OS差异均无统计学意义（m PFS：P=0.6530;m OS：P=0.3695）。按治疗周期划分,应用贝伐珠单抗〈8周期患者的m PFS和m OS分别为7.8个月（95%CI：6.2-8.9个月）和17.6个月（95%CI：14.9-24.8个月）;用药≥8周期患者的m PFS和m OS分别为11.6个月（95%CI：10.9-14.4个月）和30.8个月（95%CI：21.3个月-未达）。用药≥8周期患者的生存获益明显优于〈8周期患者（m PFS：P=0.0001;m OS：P=0.001）。按KRAS突变状态划分,KRAS野生型和突变型患者的m PFS分别为9.8个月（95%CI：6.7-12.3个月）和8.6个月（95%CI：6.2-9.9个月）,差异无统计学意义（P=0.2784）。KRAS野生型和突变型患者的m OS分别为25.7个月（95%CI：16.9个月-未达）和14.3个月（95%CI：10.3-21.9个月）,差异无统计学意义（P=0.1015）。结论 react研究结果表明,贝伐珠单抗联合氟尿嘧啶类药物为基础的化疗,用于一线或二线治疗国人m CRC患者的总体安全性良好,临床获益明显;贝伐珠单抗联合含氟尿嘧啶类药物化疗使用时间长（≥8周期）的患者比使用时间短（〈8周期）的患者,具有更佳生存获益。这与欧美国家和中国注册临床研究的情况类似,值得临床上进一步推广应用。

关键词：中国患者结直肠癌/晚期转移性贝伐珠单抗联合化疗/氟尿嘧啶类药物安全性/有效性

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Experimental Study on Hydrogenation of SiCl_4 to SiHCl_3 in a Stirred Bed reactor

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过程工程学报 2016年第5期16卷 767-773页

作者：李庆远李佩龙王铁峰 Beijing Key Lab.Green Chem.react.Eng.Technol. Dept.Chem.Eng.Tsinghua University

The hydrogenation of SiCl_4 to SiHCl_3 was studied in a stirred bed reactor with CuCl *** properties of the CuCl catalysts and silicon particles before and after the reaction were characterized by SEM,XRD and *** XRD showed that the active component of Cu3Si was formed during the reaction,and the EDX proved the molar ratio of Cu and Si on the region of *** valent of Cu was discussed by XPS before and after the hydrogen *** the effects of the reaction temperature,pressure,molar ratio of H2 to SiC l4,weight hourly space velocity(WHSV),and catalyst loading were *** results showed that the conversion rate of Si Cl4 was about 38%at WHSV of 190 Nm3/(t·h),temperature of 540℃,pressure of 1.8 MPa,catalyst loading of 0.9%(ω),and molar ratio of H2 to Si Cl4 1.7:*** on the experemental results,a reaction mechanism was proposed,which involved the continuous consumption of silicon(many apertures was showed on SEM image)and formation of new Cu3Si active component during the hydrogenation reaction.

关键词： silicon tetrachloride trichlorosilane hydrogenation stirred bed reactor

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Tuning SMSI to stabilize metallic Pd species:A case study on Pd/TiO_(2) for HCHO oxidation

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Chinese Chemical Letters 2024年第3期35卷 162-166页

作者： Chunying Wang Xiaofeng Liu Jingyi Wang Yaobin Li Shaohua Xie Fudong Liu Changbin Zhang Yuming Zheng Wenpo Shan Hong He Center for Excellence in Regional Atmospheric Environment Key Laboratory of Urban Pollutant ConversionInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control Ningbo Urban Environment Observation and Research StationChinese Academy of SciencesNingbo 315800China Department of Civil Environmentaland Construction Engineering(CECE)Catalysis Cluster for Renewable Energy and Chemical Transformations(REACT)Nano Science Technology Center(NSTC)University of Central FloridaOrlandoFL 32816USA State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China

Pretreatment of the carrier for supported catalysts can effectively improve the strong metal-support interaction(SMSI)and increase the dispersion of precious metals,which are critical to many important catalytic *** this work,we tuned SMSI on Pd/TiO_(2)catalysts through inducing surface defects of TiO_(2)by pretreated with different atmospheres(H_(2)/N_(2),N_(2),O_(2)/N_(2))at the high temperature(800℃).Multiple characterization results illustrated that surface defects anchored Pd species and thus enhanced their *** reduction,Ti^(3+)species formed and transferred onto the metallic Pd species and then induced SMSI,which effectively stabilize Pd species in the metallic *** stronger MSI,the more stability of Pd *** a case,Pd/TiO_(2)–800H_(2),with strongest MSI,displayed the best HCHO oxidation performance at low temperature(10℃).

关键词： Pd/TiO_(2) Surface defects SMSI Formaldehyde Stability of Pd species

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Macro-scale pseudo-particle modeling for particle-fluid systems

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Chinese Science Bulletin 2001年第18期46卷 1503-1507,1585页

作者： Wei Ge Jinghai Li Chinese Acad Sci Inst Proc Engn Multiphase React Lab Beijing 100080 Peoples R China

Pseudo-particle modeling (PPM) is a particle method (PM) proposed in 1996. Though it is effective for the simulation of microscopic particle-fluid systems, its application to practical systems is still limited by computational cost. In this note, we speed up the computation by using a combination of weighted averaging with finite difference techniques to upgrade the particle interactions to a fluid element level, which conforms to the Navier-Stokes equation. The approach, abbreviated to MaPPM, is then applied to the problem of one-dimensional Poiseuille flow with a quantitative comparison to the results of another related PM--smoothed particle hydrodynamics (SPH), where the accuracy and efficiency of MaPPM is found to be much better than that of SPH. Flows around a cylinder and multiple freely moving particles are also simulated with the new model, resulting in reasonable flow pattern and drag coefficient. The convergence and robustness of the algorithm prove promising.

关键词： smoothed particle hydrodynamics computational fluid dynamics particle method multi-phase flow pseudo-particle modeling.

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Laser induced photoemission electron and the generation of high Rydberg states of atoms and molecules

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Chinese Science Bulletin 1998年第19期43卷 1616-1620页

作者： Li Wang Haiyang Li Jiling Bai Richang Lu Acad Sinica Dalian Inst Chem Phys State Key Lab Mol React Dynam Dalian 116023 Peoples R China

Laser induced photoemission electron was produced by directing 532 nm and/or 355 nm onto stainless steel plate on a time of flight mass spectrometer. Multiple charged ions and high Rydberg states of atoms or molecules were successfully generated by impacts of the photoemission electrons. The high Rydberg states ( n ～40-100) thus produced were separated from ions, produced by direct electron impact ionization, by a 3 V DC electric field and then ionized by a delayed pulsed HV electric field in a ZEKE-PFI manner. Relationship between generation/property of high Rydberg states of atoms/molecules and experimental conditions could be investigated. Relationship between the electron accelerating voltage and high Rydberg states of Ar was described.

关键词： photoemission electron multiple charged ions high Rydberg states.

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CeO_(2) doping boosted low-temperature NH3-SCR activity of FeTiOx catalyst:A microstructure analysis and reaction mechanistic study

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Frontiers of Environmental Science & Engineering 2022年第5期16卷 69-81页

作者： Wei Tan Shaohua Xie Wenpo Shan Zhihua Lian Lijuan Xie Annai Liu Fei Gao Lin Dong Hong He Fudong Liu Department of Civil Environmentaland Construction EngineeringCatalysis Cluster for Renewable Energy and Chemical Transformations(REACT)NanoScience Technology Center(NSTC)University of Central FloridaOrlandoFL32816USA Key Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical EngineeringJiangsu Key Laboratory of Vehicle Emissions ControlSchool of EnvironmentCenter of Modern AnalysisNanjing UniversityNanjing 210023China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Institute of Engineering Technology Sinopec Catalyst Co.Ltd.Sinopec GroupBeijing 101111China

FeTiOx has been recognized as an environmental-friendly and cost-effective catalyst for selective catalytic reduction(SCR)of NOx with *** at further improving the low-temperature DeNOx efficiency of FeTiOx catalyst,a simple strategy of CeO_(2) doping was *** low-temperature(reaction mechanism study further suggested that the facile oxidative dehydrogenation of NH_(3) to highly reactive-NH_(2) played a key role in enhancing the low-temperature NH_(3)-SCR performance of FeCe_(0.2)TiOx catalyst.

关键词： NH3-SCR CeO_(2)doping Low-temperature NOx removal Improved redox property In situ XAFS analysis

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Beyond catalytic materials:Controlling local gas/liquid environment in the catalyst layer for CO_(2)electrolysis

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Journal of Energy Chemistry 2022年第3期31卷 45-51,I0003页

作者： Zhuo Xing Kaige Shi Xun Hu Xiaofeng Feng School of Material Science and Engineering University of JinanJinan 250022ShandongChina Department of Physics University of Central FloridaOrlandoFL 32816United States Renewable Energy and Chemical Transformations(react)Cluster University of Central FloridaOrlandoFL 32816United States

Electrochemical reduction of CO_(2)to value-added chemicals using renewable electricity provides a promising strategy to achieve sustainable fuel production and carbon *** with the development of electrocatalysts,fow cells with gas-diffusion electrodes(GDEs)have been used to reach commercially viable current densities for CO_(2)electrolysis,while the local environment and CO_(2)mass transport in the electrodes remain to be *** this review article,we highlight some insights into the microenvironment in the catalyst layer for CO_(2)electrolysis,including typical mass transport models for CO_(2)reduction in H-type cells and GDE fow cells,the effect of a hydrophobic microenvironment on CO_(2)mass transport and catalytic performance,and the formation of a gas/liquid balance and solid–liquid–gas interfaces for CO_(2)*** insights and discussions in this article can provide important guidelines on the design of catalysts,electrodes,and electrolyzers for CO_(2)electrolysis,as well as other gas-involving electrocatalytic reactions.

关键词： Electrocatalysis CO_(2)reduction Gas-diffusion electrode Microenvironment Activity

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Variational criterion for dissipative structures dominated by coupled mechanisms

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Chinese Science Bulletin 1999年第4期44卷 323-327页

作者： Jinghai Li Wei Ge Zhongdong Zhang Jie Yuan Chinese Acad Sci Inst Chem Met Multiphase React Lab Beijing 100080 Peoples R China Harbin Inst Technol Sch Energy Sci & Engn Harbin 150001 Peoples R China

Abstract By analyzing the similarity between the viscosity-inertia compromise for single fluid in turbulent pipe flow and the particle-fluid compromise in gas-solid fluidization, it is deduced that the variational criterion for dissipative structures dominated jointly by two sub-mechanisms (for instance, viscous elfect and inertial effect in turbulent flow; particle movement and fluid movement in fluidization) could be physically expressed as mutually constrained extremum between the individual extremum tendencies of the sub-mechanisms, and could thus be mathematically formulated as a two-objective optimization problem.

关键词：文竹

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Regulating local coordination environment of rhodium single atoms in Rh/CeO_(2) catalysts for N_(2)O decomposition

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Journal of Rare Earths 2023年第6期41卷 941-951,I0005页

作者： Shaohua Xie Daekun Kim Kailong Ye Laurene Tetard Fudong Liu Department of Civil Environmentaland Construction EngineeringCatalysis Cluster for Renewable Energy and Chemical Transformations(REACT)NanoScience Technology Center(NSTC)University of Central FloridaOrlandoFL32816United States Department of Physics NanoScience Technology Center(NSTC)University of Central FloridaOrlandoFL32816United States

Rh single atom catalysts(SACs)have been insensitively investigated recently due to the maximum utilization efficiency of Rh,one of the most expensive precious *** great efforts have been made in the development and application of Rh SACs,there are few reports on the precise control of the local coordination environment of Rh single sites on CeO_(2) and their catalytic performance for N_(2)O ***,Rh/CeO_(2) catalysts with different Rh-O coordination numbers(CNs)were successfully prepared using different CeO_(2) supports and a simple incipient wetness impregnation(IWI)*** is observed that the Rh/CeO_(2) catalyst with slightly higher CN of Rh-O(Rh/CeO_(2)-H)prepared from CeO_(2) shows much higher N_(2)O decomposition activity than the catalyst with lower CN of Rh-O(Rh/CeO_(2)-L)obtained from Ce(OH)_(x).The Rh species within Rh/CeO_(2)-H are found to be more reactive than those within Rh/CeO_(2)-L,which can better facilitate the O_(2)desorption once formed during N_(2)O deco *** additio n,more surface oxygen vacancies are present on Rh/CeO_(2)-H than on Rh/CeO_(2)-L,well explaining the superior N_(2)O adsorption and activation capability on the former *** is concluded that more abundant oxygen vacancies and reactive Rh single atom sites with slightly higher CN of Rh-O and significantly higher reducibility altogether contribute to the superior N_(2)O decomposition activity on the Rh/CeO_(2)-H catalyst.

关键词： Rh single-atom catalyst Coordination environment N_(2)O decomposition Oxygen vacancy O_(2)desorption Rare earths

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Catalytic performance of Nb2O5 modified Ru/CeO2 for dichloromethane oxidation

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Progress in Natural Science:Materials International 2023年第4期33卷 486-494页

作者： Wencheng Hao Zhiwei Wang Shaohua Xie Lu Wei Zhiquan Hou Yuxi Liu Hongxing Dai Jiguang Deng Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution Control Faculty of Environment and Life Beijing University of Technology Department of Civil Environmental and Construction Engineering Catalysis Cluster for Renewable Energy and Chemical Transformations(REACT) Nano Science Technology Center(NSTC) University of Central Florida

1 wt% Ru/5 wt% Nb2O5/CeO2(RuNbCe) catalyst was synthesized via the incipient wetness impregnation method, and measured for the catalytic oxidation of dichloromethane(DCM). The physicochemical properties of catalysts were determined used various characterization techniques. Compared with 1 wt% Ru/CeO2, 5 wt%Nb2O5/CeO2, CeO2, 1 wt% Ru/xNb2O5/CeO2(x = 1 wt%, 2 wt%, and 3 wt%) and 1 wt% Ru/yMOn/CeO2(M =Co, Cr, Fe, Mg, Cu; y = 5 wt%), the addition of 5 wt% Nb2O5obviously improved the catalytic performance of 1 wt% Ru/CeO2, with the T90%and apparent activation energy(Ea) being 287℃ and 43.5 kJ/mol, respectively, and less formation of polychlorinated byproducts at space velocity(SV) = 15,000 mL g-1h-1. The RuNbCe catalyst showed good thermal and hydrothermal stability, as well as HCl-resistance performance. We deduced that the higher oxidation performance of the RuNbCe catalyst may be attributed to the suitable acidic sites, good redox capacity, high surface adsorbed oxygen species concentration, and the strong interaction among Ru, Nb2O5and CeO2. The RuNbCe catalyst has the potential to be applied for the elimination of chlorinated volatile organic compounds(CVOCs).

关键词： Ru/Nb_2O_5/CeO_2 dichloromethane oxidation Catalytic stability Acidic sites CVOCs removal

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