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Assessing structural integrity of the pyramidal tracts with difusion spectrum imaging to predict postoperative motor function in pediatric epilepsy patients with hemispherectomy

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Acta Epileptologica 2023年第1期6卷 25-33页

作者： Huaqiang Zhang Penghu Wei Chao Lu Zhenming Wang Xiaotong Fan Yongzhi Shan guoguang Zhao department of Neurosurgery Xuanwu HospitalCapital Medical UniversityNo.45Changchun StreetXicheng DistrictBeijing 100053China department of radiology Xuanwu HospitalCapital Medical UniversityNo.45Changchun StreetXicheng DistrictBeijing 100053China Beijing Institute for Brain Disorders Capital Medical UniversityNo.10West Tou TiaoOuter You’an MenFengtai DistrictBeijing 100069China National Medical center for Neurological Diseases Beijing 100053China China International Neuroscience Institute Beijing 100053China Clinical Research center of Epilepsy Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Municipal geriatric Medical Research center Beijing 100053China

Background:Hemispherectomy is an efective treatment option for patients with drug-resistant epilepsy caused by hemispheric ***,patients often have deterioration of their motor functions *** spectrum imaging(DSI)was reliable in presenting the natural shape of the white matter *** the same time,the natural sprawl pyramid tract(PT)might be more intuitive for predicting postoperative motor ***,we assessed the motor functions by the natural shape revealed by DSI ***:Ten children with drug-resistant epilepsy who were candidates for hemispherectomy performed DSI PTs tractography and transcranial magnetic stimulation(TMS)for motor *** motor function was evaluated with muscle strength and hand grasping *** tract(PT)structural integrity and TMS mapping results were compared between patients who remained stable and those with deteriorated motor *** operating characteristic(ROC)curves with PTs asymmetric ratio were analyzed to evaluate DSI tractography diagnostic ***:All patients underwent DSI acquisition,while four patients successfully performed *** patient had no response to TMS until the maximal machine output was *** patients failed to perform TMS due to lacking *** patient was contraindicated to *** successfully reconstructed the sharp angle fan-shaped PTs within the *** accurate fber distribution with fber termination and thickness within the lesioned hemisphere was replicated with DSI *** signifcance was found in patients’age,sex,seizure frequency,or medication between patients with stable or deteriorated postoperative motor *** efectively predicted postoperative motor function as stable with damaged PTs,mild deterioration with atrophied PTs,and intact PTs with contralateral innervation confrmed by intracranial *** area under the curve(AUC)of DSI tractography was ***

关键词： Difusion spectrum image Epilepsy Hemispherectomy Motor function

人工智能深度学习对前列腺多序列MR图像分类的可行性研究

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中华放射学杂志 2019年第10期53卷 839-843页

作者：方俊华 Li Qiubai 余成新王兴刚方志华刘涛王良华中科技大学同济医学院附属同济医院放射科武汉430030 department of radiology University of Texas Southwestern Medical Center at Dallas Dallas TX USA 湖北省宜昌市中心人民医院放射科 443000 江西省景德镇市浮梁县人民(中医)医院放射影像科 333000 湖北省枝江市中医医院放射科工作 443200

目的开发一种能够自动分辨前列腺多序列MR图像的人工智能(AI)工具。方法回顾性分析2017年5月至2018年12月华中科技大学同济医学院附属同济医院前列腺多序列MR图像。前列腺多序列MR图像的分类由ResNet18卷积神经网络(CNN)模型来实现。运... 详细信息

目的开发一种能够自动分辨前列腺多序列MR图像的人工智能(AI)工具。方法回顾性分析2017年5月至2018年12月华中科技大学同济医学院附属同济医院前列腺多序列MR图像。前列腺多序列MR图像的分类由ResNet18卷积神经网络(CNN)模型来实现。运用深度残差网络提升训练精度和测试精度。所使用的数据集包括19 146张7个前列腺MR序列图像(横断面T1WI、横断面T2WI、冠状面T2WI、矢状面T2WI、横断面DWI、横断面ADC、横断面PWI),选取其中2 800张图像作为训练集,选取剩余图像中的388张图像作为测试集。采用准确度评价ResNet18 CNN模型的效能。结果7个前列腺MR序列(横断面DWI、冠状面T2WI、横断面灌注成像、矢状面T2WI、横断面ADC、横断面T1WI和横断面T2WI)图像测试准确率分别为100.0%(44/44)、77.5%(31/40)、96.7%(116/120)、100.0%(44/44)、100.0%(44/44)、100.0%(52/52)和100.0%(44/44)。横断面PWI的分类0.8%(1/120)被错误地分到了横断面T2WI序列,仅2.5%(3/120)错误地分到矢状面T2WI序列;对于冠状面T2WI的分类15.0%(6/40)被错误地分到了横断面T2WI序列,7.5%(3/40)错误地分到矢状面T2WI序列。结论开发的能够自动分辨前列腺多序列MR图像的AI工具准确率高。

关键词：人工智能深度学习前列腺磁共振成像图像分类

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Human Hydatidosis: A Negliged Zoonosis and Underdeclared at the university hospital center of Tlemcen, Algeria: 16 Years of Registration from 2003 to 2018

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Journal of Health Science 2019年第6期7卷 385-390页

作者： Samira Benbekhti Abdrebbi Kaouel Meguenni Faculty of Medicine of Tlemcen Abou bekr Belkaid University of TlemcenTlemcen 13000Algeria department of Epidemiology and Preventive Medicine University Hospital Center of TlemcenTlemcen 13000Algeria

Hydatid disease is considered as an important emerging neglected disease *** echinococcosis is a neglected disease of public health significance in many low and middle-income *** objective of our study was to determine the epidemiological profile of human hydatidosis in Tlemcen.A prospective study was conducted at university hospital center(UHC)of Tlemcen,from 2003 to 2018 from the declaration of notifiable *** entry and analysis was done using Epi-info software *** hundred and fifty-eight(158)patients were declared during 16 years of registartion at the UHC of *** three point zero three percent(93.03%)of the reports of cases were received from the surgical services and 6 cases from the pneumology department.A slight female predominance was noted with sex-ratio(Females/Males):*** than half of the patients were subjects over 40 years *** cases were noted in *** average age was 42.38±17.14 *** liver was the most frequent organ involved in our study followed by pulmonary *** one point eight seven(51.87%)of cases were from rural areas and 46.2%from urban *** hydatidosis remains an under-reported and neglected disease in Tlemcen whose fight is essentially based on preventive measures and requires multisectoral collaboration.

关键词： Humans hydatidosis cystic echinococcosis epidemiology declaration prevention Tlemcen

^(18)F-FDg PET/MR Imaging for Evaluating of Obstructive Jaundice:Chinese Expert Consensus

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Clinical Cancer Bulletin 2022年第2期1卷 56-65页

作者： Lifang PANg Yushen gU Zhi YANg Zhifang WU Wei FAN Xiaohua ZHU Jun ZHAO Changjiu ZHAO Xuemei WANg Yongju gAO Li HUO Yi MO Meiyun WANg Jie LU Lingzhi HU Zheng ZHANg Feng WANg Xuemei DU Yue CHEN Jianjun LIU Zhaoping CHENg Yunlong LOU Shuzhan YAO Rong XU Sijin LI Hongcheng SHI department of Nuclear Medicine Zhongshan HospitalFudan UniversityShanghai Institute of Medical ImagingInstitute of Nuclear MedicineFudan UniversityCancer Prevention and Treatment CenterZhongshan HospitalFudan UniversityNo.180 Fenglin RoadShanghai 200032China department of Nuclear Medicine Peking University Cancer Hospital&InstituteNo.52 Fucheng RoadBeijing 100142China department of Nuclear Medicine First Hospital of Shanxi Medical UniversityTaiyuan 030001China department of Nuclear Medicine Sun Yat-sen University Cancer CenterNo.651 Dongfendong RoadGuangzhou 510060China department of Nuclear Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology1095 Jiefang AveWuhan 430030China department of Nuclear Medicine Shanghai East HospitalSchool of MedicineTongji UniversityNo.150 Jimo RoadShanghai 200120China department of Nuclear Medicine First Affiliated Hospital of Harbin Medical UniversityNo.23Youzheng StreetHarbin 150001China department of Nuclear Medicine Inner Mongolia Medical University Affilated HospitalNo.1 Tongdao North StreetHohhot 010050China department of Nuclear Medicine Henan Provincial People’s HospitalZhengzhou 450003China department of Nuclear Medicine Peking Union medical college HospitalNo.1 ShuaifuyuanBeijing 100730China department of PET-CT center Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityNo.283Tongzipo RoadChangsha 410013China department of Medical Imaging Henan Provincial People's HospitalNo.7 Weiwu RoadZhengzhouHenan 450003China department of radiology and Nuclear Medicine Xuanwu Hospital Capital Medical UniversityNo.45 Changchun StreetBeijing 100053China Shanghai United Imaging Healthcare Co. Ltd.Shanghai 201807China department of Nuclear Medicine Nanjing First HospitalNanjing Medical University68 Changle RoadNanjing 210006China department of Nuclear Medicine the First Affiliated Hospital of Dalian Medical UniversityNo.222 Zhongshan Road

The cause of obstructive jaundice is usually complex which renders its differential diagnosis and lesion localization challenging in clinical *** Positron Emission tomography/Magnetic Resonance(PET/MR)offers complementary information from PET and MR in the diagnosis of obstructive jaundice and is becoming widely adopted in clinical *** preserving its diagnostic accuracy,it is important to standardize and streamline the clinical scan protocol of PET/MR in evaluating obstructive *** on literature review and experience of large number of clinical cases from the author group,this article reports an expert consensus on imaging protocol optimization and case interpretation template standardization.

关键词： hepatobiliary system obstructive jaundice positron emission tomography/magnetic resonance imaging(PET/MR) consensus

1.5T与3.0T MRI评估膝关节软骨对比

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国际医学放射学杂志 2009年第3期 282-282页

作者： R.Kijowski D.g.Blankenbaker K.W.Davis K.Shinki L.D.Kaplan A.A.De Smet 胡睿 department of radiology University of Wisconsin Hospital600 Highland AveClinical Science Center-E3/311MadisonWI 53792-3252USA

目的回顾性比较1.5T及3.0T MRI在评估有相关症状病人膝关节软骨的诊断价值。方法此研究符合HIPAA,经伦理委员会同意,在病人不知情情况下进行。研究组(包括200例有相关症状的病人)接受MRI膝关节扫描,采用1.5T(61例男性,39例女性;平均年龄... 详细信息

目的回顾性比较1.5T及3.0T MRI在评估有相关症状病人膝关节软骨的诊断价值。方法此研究符合HIPAA,经伦理委员会同意,在病人不知情情况下进行。研究组(包括200例有相关症状的病人)接受MRI膝关节扫描,采用1.5T(61例男性,39例女性;平均年龄38.9岁)或3.0T(52例男性,48例女性;平均年龄39.1岁)设备,病人随后行膝关节镜手术治疗。所有1.5T及3.0T MR扫描均采用多层面快速自旋回波序列,并应用相似的组织对比度。

关键词：膝关节软骨相关症状病人 MRI 特异度

肝纤维化、炎症和脂肪变性:对慢性肝病病人MR弹性成像和扩散参数的影响

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国际医学放射学杂志 2017年第3期 345-345页

作者： H.S.Leito S.Doblas P.garteiser g.d'Assignies V.Paradis F.Mouri 李晓栋 Laboratory of Imaging Biomarkers Center of Research on InflammationDepartment of RadiologyUMR1149INSERM-University Paris DiderotSorbonne Paris CitéBeaujon Hospital

摘要目的明确慢性肝病病人肝纤维化、炎症和脂肪变性与MR弹性成像和扩散参数改变的关系,评价成像参数对肝纤维化不同分期诊断的准确性。材料与方法本研究经伦理委员会批准并获得知情同意。从2010年11月—2012年10月,前瞻性连续招募计划... 详细信息

摘要目的明确慢性肝病病人肝纤维化、炎症和脂肪变性与MR弹性成像和扩散参数改变的关系,评价成像参数对肝纤维化不同分期诊断的准确性。材料与方法本研究经伦理委员会批准并获得知情同意。从2010年11月—2012年10月,前瞻性连续招募计划进行肝脏穿刺活检的慢性肝病病人。68例病人均行1.5 T三维MR弹性成像和体素不相干运动扩散加权成像。用METAVIR和脂肪变性、炎症反应活动程度及纤维化(或SAF)评分系统对纤维化、炎症和脂肪变

关键词：弹性成像扩散参数结构参数脂肪变性 MR 肝纤维化肝疾病慢性肝病病人炎症病理

Budd-Chiari综合征的经皮再通术:单一中心117例中国病人通畅性和生存模式的11年回顾性研究

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国际医学放射学杂志 2013年第2期 178-178页

作者： g.H. Han X.S. Qi W. Zhang C.Y. He Z.X. Yin J.H. Wang 郭凌飞 department of Digestive Interventional radiology Xijing Hospital of Digestive Diseases Fourth Military Medical University

目的评估经皮再通术的长期效果,确定在大样本的Budd-Chiari（BCS）综合征中国病人中对通畅性和生存的预测因素。材料与方法机构伦理委员会批准了该项回顾性研究。所有病人在参加本研究前均签订知情同意书。在1999年7月—2010年8月,177... 详细信息

目的评估经皮再通术的长期效果,确定在大样本的Budd-Chiari（BCS）综合征中国病人中对通畅性和生存的预测因素。材料与方法机构伦理委员会批准了该项回顾性研究。所有病人在参加本研究前均签订知情同意书。在1999年7月—2010年8月,177例连续原发BCS中国病人接收了经皮再通术,随访至死亡或至最后一次临床评估。记录再通治疗策略和并发症。累积的通畅性和生存率通过Kaplan-Meier曲线进行分析。使用Cox回归分析模型来计算通畅和生存的独立预测因素。结果 177例病人中有168例（95%）接受经皮再通术获得成功。168例病人中有51例（30%）单独接收了经皮腔内血管成形术（PTA）,117例病人接收了PTA和支架植入术。168例病人中有7例出现了与该治疗有关的并发症。1、5、10年累积的初始通畅率分别为95%、77%、58%。闭塞的独立预测因素为白细胞计数的增加和单独使用PTA。1、5、10年累积的二次通畅率分别为97%、90%、86%。在中位值30个月的随访中有22例病人死亡（范围0.25;37个月）。1、5、10年累积的生存率分别为96%、83%、73%。与生存有关的独立预测因素为静脉曲张性出血、碱性磷酸酶及血尿素氮水平升高、再闭塞。结论在有BCS的大部分中国病人中经皮再通术可以达到很好的长期通畅性和生存效果。PTA联合支架植入可以减少再次闭塞的发生率和与其相关的死亡率。

关键词：再通术通畅性 Budd-Chiari 经皮回顾性研究病人综合征综合病症中华人民共和国

应用低分子肝素对扩张性心肌病继发慢性心力衰竭患者进行辅助治疗:一项随机试验的1年随访结果

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世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 23-24页

作者： Wojnicz R. Nowak J. Szygula-Jurkiewicz B. 朱冰坡 Dr.3rd department of Cardiology Silesian Center of Heart Disease Silesian Medical University Zabrze Poland

背景:扩张性心肌病患者的内皮功能存在缺陷。故采用低分子肝素(LMWH)治疗改善内皮功能可能具有临床价值。因此,作者研究了在扩张性心肌病的标准治疗中增加依诺肝素(一种LMWH)的效果。

关键词：心肌病低分子肝素慢性心力衰竭依诺肝素随机试验射血分数脑利钠肽运动耐量冠状动脉造影心

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过度通气能够改善幕上开颅术的手术条件吗？一项多中心随机交叉试验研究

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麻醉与镇痛 2009年第3期5卷 17-27页

作者： Adrian W. gelb Rosemary A. Craen g. S. Umamaheswara Rao K. R. Madhusudan Reddy Joseph Megyesi Bibek Mohanty Hari H. Dash Kai C. Choi Mathew T.V. Chan 谢珺田(译) department of Anesthesia and Perioperative Care University of California at San Francisco San Francisco California department of Anesthesia and Perioperative Medicine University of Western Ontario Canada departments of Anesthesia and Neuroanaesthesia National Institute of Mental Health and Neurosdences Bangalore India department of Neurosurgery University of Western Ontario Canada department of Neuroanesthesiology All India Institute of Medical Sdences Delhi India Centre for Epidemiology and Biostatistics The Chinese University of Hong Kong Hong Kong Spedal Administrative Region department of Anaesthesia and Intensive Care CUHK Brain Tumor Center The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong Special Administrative Region 不详

背景过度通气作为神经外科手术麻醉中的重要方法，其有效性还缺乏验证。我们在由手术医师评估脑肿胀分级和测定颅内压（ICP）的条件下，选择中度低碳酸血症和正常血液碳酸数值两种情况对接受开颅手术的幕上脑肿瘤患者进行一项双周期随... 详细信息

背景过度通气作为神经外科手术麻醉中的重要方法，其有效性还缺乏验证。我们在由手术医师评估脑肿胀分级和测定颅内压（ICP）的条件下，选择中度低碳酸血症和正常血液碳酸数值两种情况对接受开颅手术的幕上脑肿瘤患者进行一项双周期随机交叉试验研究。方法275例幕上脑肿瘤患者随机接受以下治疗程序：一是过度通气（动脉二氧化碳分压，PaCO2=25±2mmHg）继以正常通气（动脉二氧化碳分压，PaCO2=37±2mmHg）；二是正常通气继以过度通气。通气和呼气末CO2分压保持稳定20分钟。患者随机接受丙泊酚输注或异氟烷吸入麻醉。在每一试验阶段末由不了解治疗程序的手术医师测定ICP，并以4级评定方法评估脑肿胀分级。结果以通用估计方程模型分析，我们发现过度通气降低了45％脑肿胀加重的风险，P=0．004，95％可信区间为22％-61％，需要治疗患者数为8。过度通气期间ICP均数±标准差为12．3±8．1mmHg，低于正常通气时的16．2±9．6mmHg，P〈0．001。麻醉方式对脑肿胀评估和ICP无影响。结论对幕上脑肿瘤患者而言，手术中过度通气可改善与ICP降低相关的由手术医师评估的脑肿胀程度。

关键词：试验研究随机手术条件动脉二氧化碳分压开颅术多中心呼气末CO2分压过度通气