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discovery and structure-activity relationship studies of novel tetrahydro-β-carboline derivatives as apoptosis initiators for treating bacterial infections

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Journal of Integrative Agriculture 2024年第4期23卷 1259-1273页

作者： Shanshan Su Hongwu Liu Junrong Zhang Puying Qi Yue ding Ling Zhang Linli Yang Liwei Liu Xiang Zhou Song Yang National Key laboratory of Green Pesticide/Key laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education/Center for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China

developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food *** this paper,to discover the new bactericide candidates,we designed,prepared a new type of1,2,3,4-tetrahydro-β-carboline(THC)derivatives and evaluated the in vitro and in vivo bioactivities against the Xanthomonas oryzae ***(Xoo),Xanthomonas axonopodis ***(Xac),and Pseudomonas syringae ***(Psa).The in vitro bioassay results exhibited that most title molecules possessed good activity toward the three plant pathogenic bacteria,the compound A17 showed the most active against Xoo and Xac with EC50 values of 7.27 and 4.89 mg mL^(-1)respectively,and compound A8 exhibited the best inhibitory activity against Psa with EC50value of 4.87 mg mL^(-1).Pot experiments showed that compound A17 exhibited excellent in vivo antibacterial activities to manage rice bacterial leaf blight and citrus bacterial canker,with protective efficiencies of 52.67 and 79.79%at 200 mgmL^(-1),***,compound A8 showed good control efficiency(84.31%)against kiwifruit bacterial canker at 200 mg mL^(-1).Antibacterial mechanism suggested that these compounds could interfere with the balance of the redox system,damage the cell membrane,and induce the apoptosis of Xoo *** together,our study revealed that tetrahydro-β-carboline derivatives could be a promising candidate model for novel broadspectrum bactericides.

关键词： tetrahydro-β-carboline derivatives antibacterial activity rOS cell apoptosis

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Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants

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Science China(Life Sciences) 2024年第2期67卷 391-402页

作者： Awei Zhang Haizhen Zhang ronghua Wang Hongfu He Baoan Song runjiang Song National Key laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang 550025China

The prevention and control of rice bacterial leaf blight(BLB)disease has not yet been achieved due to the lack of effective agrochemicals and available ***,we develop a series of novel bissulfones and a novel target with a unique mechanism to address this *** developed bissulfones can control Xanthomonas oryzae ***(Xoo),and 2-(bis(methylsulfonyl)methylene)-N-(4-chlorophenyl)hydrazine-1-carboxamide(B_(7))is more effective than the commercial drugs thiodiazole copper(TC)and bismerthiazol(BT).Pyruvate kinase(PYK)in Xoo has been identified for the first time as the target protein of our bissulfone B_(7).PYK modulates bacterial virulence via a CrP-like protein(Clp)/two-component system regulatory protein(reg r)*** elucidation of this pathway facilitates the use of B_(7)to reduce PYK expression at the transcriptional level,block PYK activity at the protein level,and impair the interaction within the PYK-Clp-reg r complex via competitive inhibition,thereby attenuating bacterial biology and *** study offers insights into the molecular and mechanistic aspects underlying anti-Xoo strategies that target *** believe that these valuable discoveries will be used for bacterial disease control in the future.

关键词： 2-bissulfone-N-phenylhydrazine-1-carboxamide derivatives Xoo antibacterial activities pyruvate kinase regulatory mechanism

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Screening and identification of functional bacterial attachment genes in aerobic granular sludge

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Journal of Environmental Sciences 2024年第7期141卷 205-214页

作者： Kai Qiao Tingting Zhao LeiWang Wei Zhang WeiMeng Fan Liu Xu Gao Jianrong Zhu School of Environment Beijing Normal UniversityBeijing 100875China State Key laboratory of Water Simulation Beijing 100875China r&d Centre of Aerobic Granule Technology Beijing 100875China

The screening and identification of attachment genes is important to exploring the formation mechanism of biofilms at the gene *** is helpful to the development of key culture technologies for aerobic granular sludge(AGS).In this study,genome-wide sequencing and gene editing were employed for the first time to investigate the effects and functions of attachment genes in *** the help of whole-genome analysis,ten attachment genes were screened from thirteen genes,and the efficiency of gene screening was greatly ***,two attachment genes were selected as examples to further confirm the gene functions by constructing gene-knockout recombinant mutants of Stenotrophomonas maltophilia;when the two attachment genes were knocked out,the attachment potential was reduced by 50.67%and 43.93%,*** results provide a new theoretical principle and efficient method for the development of AGS from the perspective of attachment genes.

关键词： Attachment gene Genome-wide sequence Gene-knockout Attachment potential Aerobic granular sludge biofilm

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review on Security defense Technology research in Edge Computing Environment

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Chinese Journal of Electronics 2024年第1期33卷 1-18页

作者： Ke SHANG Weizhen HE Shuai ZHANG National digital Switching System Engineering and Technological r&d Center

Edge computing, which achieves quick data processing by sinking data computing and storage to the network edge, has grown rapidly along with the Internet of things. The new network architecture of edge computing brings new security challenges. Based on this, this paper investigates the edge computing security literature published in recent years and summarizes and analyzes research work on edge computing security from different attack surfaces. We start with the definition and architecture of edge computing. From the attack surface between device and edge server, as well as on edge servers, the research describes the security threats and defense methods of edge computing. In addition, the cause of the attack and the pros and cons of defense methods is introduced. The challenges and future research directions of edge computing are given.

关键词： Cloud computing Systems architecture Computer architecture Network architecture data processing Security Servers

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Microstructure evolution and phase transformation of the mushy zone in a quenchedβ-solidifying TiAl alloy

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Journal of Materials Science & Technology 2024年第2期169卷 28-41页

作者： Fuqiang Zhang Xianfei ding Leming Xu Xin Feng Hai Nan Jianping He Yongfeng Liang Junpin Lin State Key laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Cast Titanium Alloy r&d Center Beijing Institute of Aeronautical MaterialsBeijing 100095China

This study investigates the phase constitutions and transformations that occur in the mushy zone and in the adjacent phase fields of a directionally solidified Ti-44Al-8Nb-1Cr alloy via quenching *** results indicate that the mushy zone consists of unmeltedβdendrites and interdendritic liquid,whose formation can be attributed to the difference in melting point aroused by local heterogeneity in ***βdendrite is composed of numerous subgrains with various *** quenching,theβdendrite transforms into Widmanstättenαvia a precipitation reaction,owing to the decreasing cooling rate caused by heat transfer from the surrounding ***,after quenching,the interdendritic liquid is transformed intoγ*** the singleβphase field and the lower part of the mushy zone,a massive transformation ofβtoγ***,in theβ+αphase field,bothβandαphases are retained to ambient *** the heating process,the transformation ofα→βgives rise to the formation ofβvariants,which affects the orientation ofβdendrites in the mushy *** growth kinematics of theα→βtransformation was elucidated,revealing the preferential growth directions of111and112forβ***,this study presents an illustration of the formation process of the mushy zone and the microstructural evolution during the heating and quenching process.

关键词： Titanium aluminides Mushy zone Quenching Electron backscattering diffraction Phase transformation

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Heterovalent ion exclusion principle in atomically single site metal(hydr)oxide catalysts design

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Science Bulletin 2024年第13期69卷 2009-2012页

作者： daojin Zhou Fengmei Wang Yun Kuang Xiaoming Sun State Key laboratory of Chemical resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Ocean Hydrogen Energy r&d Center Research Institute of Tsinghua University in ShenzhenShenzhen 518057China

Single-atom catalysts(SACs)are a series of catalysts in which all metal species are atomically dispersed on oxides,zeolites,sulfides,carbons,and so *** concept describing how atoms arrange with their nearest neighbors was proposed in 1969 by Van Hardeveld and co-workers[1],and researchers witness the growing popularity of SACs[2].However,the first long-standing issue in SACs is that the low concentration of active sites on the ***,weak chemical bonds between active sites with supports cannot sustain the functionalities of the SACs during long-term reactions,especially ones run at harsh conditions(high temperature or humidity,strong oxidative conditions).The loss or aggregation of active sites in SACs require substantial efforts to address the existing drawbacks in traditional SACs.

关键词： atomic bonds valent

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Cytoplasmic FKBPs are involved in molting and metamorphosis through regulating the nuclear localization of Ecr

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Insect Science 2024年第3期31卷 759-772页

作者： Xian Zhang Qiao-ran Wang Qian Wu Jun Gu Li-Hua Huang Guangdong Provincial Key laboratory of Insect developmental Biology and Applied Technology School of Life SciencesSouth China Normal UniversityGuangzhouChina Guangmeiyuan r&d Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouChina

Molting and metamorphosis are important physiological processes in insects that are tightly controlled by ecdysone receptor(Ecr)through the 20-hydroxyecdysone(20E)signaling *** is a steroid nuclear receptor(Sr).Several FK506-binding proteins(FKBPs)have been identified from the mammal Sr complex,and are thought to be involved in the subcellular trafficking of ***,their roles in insects are poorly *** explore whether FKBPs are involved in insect molting or metamorphosis,we injected an FKBP inhibitor(FK506)into a lepidopteran insect,Spodoptera litura,and found that molting was inhibited in 61.11%of the larvae,and that the time for larvae to pupate was significantly extended.A total of 10 FKBP genes were identified from the genome of *** and were clustered into 2 distinct groups,according to their subcellular localization,with FKBP13 and FKBP14 belonging to the endoplasmic reticulum(Er)group and with the other members belonging to the cytoplasmic(Cy)*** the CyFKBPs were significantly upregulated in the prepupal or pupal stages,with the opposite being observed for the Er group ***506 completely blocked the transfer of Ecr to the nucleus under 20E induction,and significantly downregulated the transcriptional expression of many 20E signaling genes.A similar phenomenon was observed after rNA interference of2 CyFKBPs(FKBP45 and FKBP12b),but not for *** together,our data indicate that the cytoplasmic FKBPs,especially FKBP45 and FKBP12b,mediate the nuclear localization of Ecr,thereby regulating the 20E signaling and ultimately affecting molting and metamorphosis in insects.

关键词： Ecr FKBP metamorphosis molting rNAi subcellular localization

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recent Advances in Biomass-derived Porous Carbon Materials:Synthesis,Composition and Applications

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Chemical research in Chinese Universities 2024年第1期40卷 3-19页

作者： ZHAI Ziqi LU Yumiao LIU Guangyong dING Wei-Lu CAO Bobo HE Hongyan CAS Key laboratory of Green Process and Engineering State Key Laboratory of Mesoscience and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Longzihu New Energy laboratory Zhengzhou Institute of Emerging Industrial TechnologyZhengzhou 450000P.R.China

Porous carbon materials(PCMs)play a pivotal role in diverse applications,such as energy storage,adsorption,catalysis,environmental remediation,and microwave *** selection of carbon precursors,in particular,is crucial for tailoring porous structures with specific ***,with its rich carbon feedstock,abundant availability,renewability,and versatile structures,has emerged as a promising precursor for porous carbon material *** review comprehensively summarizes the recent advances in biomass-derived porous carbon materials(BPCMs)encompassing synthetic strategy,morphology,structural composition,and multiple *** first review synthetic approaches aiming at regulating porosity,followed by morphological and composition features of BPCMs,with a special emphasis on elucidating the dimensional clarification and heteroatom doping *** discussion then extends to the wide-ranging applications of BPCMs,covering energy-related applications and CO_(2) adsorption to environmental ***,the review outlines the existing challenges and prospects in the *** summary,this review systematically describes BPCMs and provides valuable guidance for researchers to select and synthesize BPCMs that meet specific functional requirements.

关键词： Biomass Porous carbon Pyrolysis Heteroatom-doping Supercapacitor CO_(2)adsorption

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dynamic Location Method for Shallow Ocean Bottom Nodes Using the Levenberg-Marquart Algorithm

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Journal of Ocean University of China 2024年第4期23卷 953-960页

作者： TONG Siyou LI Junjie XU Xiugang FANG Yunfen WANG Zhongcheng Key laboratory of Submarine Geosciences and Prospecting Techniques MOEOcean University of ChinaQingdao 266100China laboratory for Marine Mineral resources Qingdao Marine Science and Technology CenterQingdao 266237China r&d Center of BGP CNPCZhuozhou 072751China Insitute of Shengli Oilfield SINOPECDongying 257022China

Ocean bottom node(OBN)data acquisition is the main development direction of marine seismic exploration;it is widely promoted,especially in shallow sea ***,the OBN receivers may move several times because they are easily affected by tides,currents,and other factors in the shallow sea environment during long-term *** uncorrected,then the imaging quality of subsequent processing will be *** conventional secondary positioning does not consider the case of multiple movements of the receivers,and the accuracy of secondary positioning is *** first arrival wave of OBN seismic data in shallow ocean mainly comprises refracted *** this study,a nonlinear model is established in accordance with the propagation mechanism of a refracted wave and its relationship with the time interval curve to realize the accurate location of multiple receiver *** addition,the Levenberg-Marquart algorithm is used to reduce the influence of the first arrival pickup error and to automatically detect the receiver movements,identifying the accurate dynamic relocation of the *** simulation and field data show that the proposed method can realize the dynamic location of multiple receiver movements,thereby improving the accuracy of seismic imaging and achieving high practical value.

关键词： OBN dynamic location method Levenberg-Marquart algorithm seismic exploration of shallow sea

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Three-channel CMOS transimpedance amplifier for LidAr sensor receiver

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Journal of Systems Engineering and Electronics 2024年第1期35卷 74-80页

作者： LIU ruqing ZHU Jingguo JIANG Yan LI Feng JIANG Chenghao MENG Zhe Photoelectric r&d Center Academy of Opto-ElectronicsChinese Academy of SciencesBeijing 100094China

For time-of-flight(TOF)light detection and ranging(LidAr),a three-channel high-performance transimpedance amplifier(TIA)with high immunity to input load capacitance is presented.A regulated cascade(rGC)as the input stage is at the core of the complementary metal oxide semiconductor(CMOS)circuit chip,giving it more immunity to input photodiode detectors.A simple smart output interface acting as a feedback structure,which is rarely found in other designs,reduces the chip size and power consumption *** circuit is designed using a 0.5μm CMOS process technology to achieve low *** device delivers a 33.87 dB?transimpedance gain at 350 *** a higher input load capacitance,it shows a-3 dB bandwidth of 461 MHz,indicating a better detector tolerance at the front end of the *** a 3.3 V supply voltage,the device consumes 5.2 mW,and the total chip area with three channels is 402.8×597.0μm2(including the test pads).

关键词： transimpedance amplifier(TIA) three-channel regulated cascade(rGC) light detection and ranging(LidAr)

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