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A statistical method for the evaluation of projectile dispersion

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defence Technology（防务技术） 2017年第3期13卷 164-176页

作者： C.A.rabbath d.Corriveau defence r&d Canada

As part of a research program, an extensive study on the dispersion characteristics of eight different7.62 ? 51 mm ammunition types was conducted. The paper presents the main steps in the experimental and analytical process carried out to evaluate, namely to measure and compare, the dispersion characteristics of the ammunitions; namely,(1) identify the number of rounds to fire in the trials,(2) establish a test plan and the setup for the precision trials,(3) fire the rounds, following an established protocol for the experiments,(4) collect the impact points, and measure the performance through statistical measures,(5) perform a statistical analysis of dispersion applied to the results obtained in the trials, and(6)conclude on the ammunition characteristics. In particular, the paper proposes a statistical method to evaluate the precision of ammunitions fired with precision(Mann) barrels. The practical method relies on comparison of confidence intervals and hypothesis testing on the standard deviation of samples,namely the impact points. An algorithm is proposed to compare the variances of two or more populations of ammunitions.

关键词：统计方法评估试验计划散布弹丸色散特性发射精度统计指标

Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

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Neural regeneration research 2025年第7期20卷 2001-2002页

作者： Tim Aberle Michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal *** the majority of OPCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and maintenance of the OPC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are linked to the network is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained for Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GPCr)with known relevance in differentiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation

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Journal of Pharmaceutical Analysis 2018年第5期8卷 302-306页

作者： Kevin P.Kent Chad E.Schroeder Chandana Sharma Upstream r&d MilliporeSigma

Freeze-thaw cycles impact the amount of aggregation observed in antibodies and Fc-fusion proteins. Various formulation strategies are used to mitigate the amount of aggregation that occurs upon putting a protein solution through a freeze-thaw cycle. Additionally, low pH solutions cause native antibodies to unfold, which are prone to aggregate upon pH neutralization, There is great interest in the mechanism that causes therapeutic proteins to aggregate since aggregate species can cause unwanted immunogenicity in patients, Herein, an increase in aggregation is reported when the pH is adjusted from pH 3 up to a pH ranging from pH 4 to pH 7 during the thaw process of a frozen antibody solution, raising the pH during the thaw process caused a significant increase in the percent aggregation observed. Two antibodies and one Fc-fusion protein were evaluated during the pH jump thaw process and similar effects were observed. The results provide a new tool to study the kinetics of therapeutic protein ag- gregation upon pH increase,

关键词： Monoclonal antibodies Freeze-thaw Protein aggregation Protein stability

Quaternion diffusion for Color Image Filtering

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Journal of Computer Science & Technology 2006年第1期21卷 126-136,F0003页

作者：刘忠轩廉士国任真 France Telecom r&d Beijing Beijing 100080 P.R. China

How to combine color and multiscale information is a fundamental question for computer vision, and quite a few color diffusion techniques have been presented. Most of these proposed techniques do not consider the direct interactions between color channel pairs. In this paper, a new method of color diffusion considering these effects is presented, which is based on quaternion diffusion （Qd） equation. In addition to showing the solution to linear Qd and its analysis, one form of nonlinear Qd is discussed. Compared with other color diffusion techniques, considering the interactions between channel pairs, Qd has the following advantages： 1） staircasing effect is avoided; 2） as diffusion tensor, the image derivative is regularized without requiring additional convolution; 3） less time is needed. Experimental results demonstrate the effectiveness of linear and nonlinear Qd applied to natural color images for denoising by both visual and quantitative evaluations.

关键词： color image processing nonlinear filtering quaternion diffusion quaternion partial differential equation

A new low-voltage and high-speed sense amplifier for flash memory

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Journal of Semiconductors 2011年第12期32卷 107-111页

作者：郭家荣冉峰 Microelectronic r&d Center Shanghai University

A new low-voltage and high-speed sense amplifier is presented, based on a very simple direct currentmode comparison. It adopts low-voltage reference current extraction and a dynamic output method to realize its performance indicators such as low voltage, low power and high precision. The proposed amplifier can sense a 0.5 #A current gap and work with a lowest voltage of 1 V. In addition, the current power of a single amplifier is optimized by 15%.

关键词： flash memory sense amplifier current-mode low-voltage

A comparison of piecewise cubic Hermite interpolating polynomials,cubic splines and piecewise linear functions for the approximation of projectile aerodynamics

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defence Technology（防务技术） 2019年第5期15卷 741-757页

作者： C.A.rabbath d.Corriveau defence r&d Canada Valcartier Research Centre

Modelling and simulation of projectile flight is at the core of ballistic computer software and is essential to the study of performance of rifles and projectiles in various engagement *** effective and representative numerical model of projectile flight requires a relatively good approximation of the *** aerodynamic coefficients of the projectile model should be described as a series of piecewise polynomial functions of the Mach number that ideally meet the following conditions:they are continuous,differentiable at least once,and have a relatively low *** paper provides the steps needed to generate such piecewise polynomial functions using readily available tools,and then compares Piecewise Cubic Hermite Interpolating Polynomial(PCHIP),cubic splines,and piecewise linear functions,and their variant,as potential curve fitting methods to approximate the aerodynamics of a generic small arms projectile.A key contribution of the paper is the application of PCHIP to the approximation of projectile aerodynamics,and its evaluation against a set of ***,the paper provides a baseline assessment of the impact of the polynomial functions on flight trajectory predictions obtained with 6-degree-of-freedom simulations of a generic projectile.

关键词： Aerodynamic coefficients Piecewise polynomial functions Cubic splines Curve fitting Piecewise linear functions Piecewise cubic Hermite interpolating polynomial Projectile modelling and simulation Fire control inputs Precision Ballistic computer software

An rF front-end with an automatic gain control technique for a U/V band CMMB receiver

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Journal of Semiconductors 2011年第10期32卷 120-125页

作者：赵锦鑫胡雪青石寅王磊 Suzhou-CAS Semiconductor Integration r&d Center

This paper presents a fully integrated rF front-end with an automatic gain control（AGC） scheme and a digitally controlled radio frequency varied gain amplifier（rFVGA） for a U/V band China Mobile Multimedia Broadcasting（CMMB） direct conversion *** rFVGA provides a gain range of 50 dB with a 1.6 dB step. The adopted AGC strategy could improve immunity to adjacent channel signal,which is of importance for CMMB *** front-end,composed of a low noise amplifier（LNA）,an rFVGA,a mixer and AGC,achieves an input referred 3rd order intercept point（IIP3） of 4.9 dBm with the LNA in low gain mode and the rFVGA in medium gain mode,and a less than 4 dB double side band noise figure with both the LNA and the rFVGA in high gain *** proposed rF front-end is fabricated in a 0.35μm SiGe BiCMOS technology and consumes 25.6 mA from a 3.0 V power supply.

关键词： CMMB rF front-end rFVGA AGC LNA mixer

data-driven Healthcare:The role of Computational Methods in Medical Innovation

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 1-48页

作者： Hariharasakthisudhan Ponnarengan Sivakumar rajendran Vikas Khalkar Gunapriya devarajan Logesh Kamaraj department of Mechanical Engineering Dr.Mahalingam College of Engineering and TechnologyPollachiCoimbatoreTamil Nadu642003India department of Mechanical Engineering JKKN College of Engineering and TechnologyKumarapalayamNamakkalTamil Nadu637209India department of Mechanical Engineering Gharda Institute of TechnologyLavelMaharashtra415708India department of Electrical and Electronics Engineering Sri Eshwar College of EngineeringCoimbatoreTamilnadu641202India department of Mechanical Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai600062India

The purpose of this review is to explore the intersection of computational engineering and biomedical science,highlighting the transformative potential this convergence holds for innovation in healthcare and medical *** review covers key topics such as computational modelling,bioinformatics,machine learning in medical diagnostics,and the integration of wearable technology for real-time health *** findings indicate that computational models have significantly enhanced the understanding of complex biological systems,while machine learning algorithms have improved the accuracy of disease prediction and *** synergy between bioinformatics and computational techniques has led to breakthroughs in personalized medicine,enabling more precise treatment ***,the integration of wearable devices with advanced computational methods has opened new avenues for continuous health monitoring and early disease *** review emphasizes the need for interdisciplinary collaboration to further advance this *** research should focus on developing more robust and scalable computational models,enhancing data integration techniques,and addressing ethical considerations related to data privacy and *** fostering innovation at the intersection of these disciplines,the potential to revolutionize healthcare delivery and outcomes becomes increasingly attainable.

关键词： Computational models biomedical engineering bioinformatics machine learning wearable technology

Experimental research on characteristic of start-up pressure wave propagation in gelled crude oil by large-scale flow loop

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Journal of Central South University 2008年第S1期15卷 467-470页

作者：崔秀国艾慕阳姜保良霍连风张立新 PetroChina Pipeline r&d Center

In order to research start-up pressure wave propagation mechanism and determine pressure wave speed in gelled crude oil pipelines accurately,experiment of Large-scale flow loop was carried *** the experiment,start-up pressure wave speeds under various operation conditions were measured,and effects of correlative factors on pressure wave were *** experimental and theoretical analysis shows that thermal shrinkage and structural properties of gelled crude oils are key factors influencing on start-up pressure wave *** quantitative analysis for these effects can be done by using volume expansion coefficient and structural property parameter of gelled crude oil.A new calculation model of pressure wave speed was developed on the basis of Large-scale flow loop experiment and theoretical analysis.

关键词： gelled crude oil start-up pressure wave propagation characteristic lager-scale flow loop