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Effect of purine diet on prognosis of deep brain stimulation for Parkinson's disease

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Food Science and Human Wellness 2024年

作者： Bowen Chang Yuge Jiang Chuanxing Feng Bowen Li Jiaming Mei Chaoshi Niu Key Laboratory of Xin'an Medicine， Ministry of Education， Anhui Province Key Laboratory of r&d of Chinese Medicine， Anhui University of Chinese Medicine 3. Center for Food Nutrition and Functional Food Engineering， School of Food Science and Technology， Jiangnan University department of Neurosurgery， The First Affiliated Hospital of USTC， division of Life Sciences and Medicine， University of Science and Technology of China

Uric acid (UA) is a naturally antioxidant that is strongly associated with the development and progression of Parkinson’s disease (Pd). The purine diet is an important exogenous pathway that modulates blood UA levels. deep brain stimulation (dBS) is an important tool for Pd treatment. This study aimed to explore the effects of preoperative purine diet on the prognosis of patients with Pd after dBS. 64 patients with Pd who underwent dBS were included in this study， and their clinical data， blood UA values， and daily purine intake. Patients were followed up for improvement 1 year after surgery. We found that patient higher purine intake was strongly associated with the rate of improvement after dBS and was a protective factor for patient prognosis. daily purine intake from meat and seafood was significantly higher in the responsive patients than in the less-responsive patients. Mediation analysis showed that UA mediated 78% of the effect of purine intake on motor symptom improvement after dBS. In summary， we observed that purine intake is strongly associated with the rate of improvement in motor symptoms after STN-dBS in patients with Pd. This study provides a reference for preoperative diet planning in patients with Parkinson’s disease undergoing dBS.

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Three-dimensional morphological and fluorescent imaging of zebrafish with a continuous-rotational light-sheet microscope

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 59-66页

作者： dongmin Zhang Guang Yang Yao Tan Chong Chen Jie Zhang Hui Li School of Biomedical Engineering(Suzhou)division of Life Sciences and Medicine University of Science and Technology of China Hefei 230041 P.R.China Suzhou Institute of Biomedical Engineering and Technology Chinese A cademy of Sciences Suzhou Jiangsu 215163P.R.China

Light-sheet fluorescence microscopy(LSFM)has been widely used to image the three-dimensional(3d)structures and functions of various millimeter-size bio-specimen such as ***,the sample adsorption and scattering cause shading of the light-sheet illumination,preventing the even 3d image of thick ***,we report a continuous-rotational light-sheet microscope(Cr-LSM)that enables simultaneous 3d bright-field and fluorescence *** a high-accuracy rotational stage,Cr-LSM records the outline projections and the fluorescent images of the sample at multiple rotation ***,3d morphology and fluorescent structure were reconstructed with a developed *** Cr-LSM,zebrafish’s whole-fish contour and blood vessel structures were obtained simultaneously.

关键词： Light-sheet microscope zebrafish blood vessels morphology

realizing High Thermoelectric Performance in n-Type Se-Free Bi2Te3 Materials by Spontaneous Incorporation of FeTe2 Nanoinclusions

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Energy & Environmental Materials 2024年第4期7卷 344-354页

作者： Jamil Ur rahman Woo Hyun Nam Yong-Jae Jung Jong Ho Won Jong-Min Oh Nguyen Van du Gul rahman Víctor M.García-Suárez ran He Kornelius Nielsch Jung Young Cho Won-Seon Seo Jong Wook roh Sang-il Kim Soonil Lee Kyu Hyoung Lee Hyun Sik Kim Weon Ho Shin Leibniz Institute for Solid State and Materials research Advanced Materials Convergence r&d division Korea Institute of Ceramic Engineering & Technology department of Electronic Materials Engineering Kwangwoon University department of Energy Engineering Dankook University Faculty of Fundamental Science Phenikaa University department of Physics Quaid-i-Azam University departamento de Física Universidad de Oviedo Nanomaterials and Nanotechnology research Center-CINN department of Materials Science and Engineering Yonsei University School of Nano & Materials Science and Engineering Kyungpook National University department of Materials Science and Engineering University of Seoul School of Materials Science and Engineering Changwon National University

Bi2Te3-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi2（Te,Se）3materials is still low due to the evaporation energy of Se (37.70 kJ mol-1) being much lower than that of Te (52.55 kJ mol-1).The evaporated Se from the material causes problems in interconnects of the module while degrading the efficiency.

关键词： Bi2Te3 energy harvesting FeTe2 nanoinclusion n-type materials thermoelectric

Preface: Security and safety in physical layer systems

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Security and Safety

Security and Safety 2024年第1期 4-6页

作者： Aiqun Hu Liang Jin Xiangyun Zhou Feng Shu Xiangwei Zhou State Key Laboratory of Mobile Communications Southeast University National digital Switching System Engineering & Technological r&d Center School of Engineering Australian National University School of Information and Communication Engineering Hainan University division of Electrical and Computer Engineering Louisiana State University

This special topic mainly focuses on the progress of physical-layer security (PLS) technologies and their potential applications for the future beyond fifth-generation (B5G) and sixth-generation (6G) *** tremendous growth in connectivity and the ubiquity of wireless communications have resulted in an unprecedented awareness of the importance of security and *** secure and trusted communications is vital for future intelligent connected applications,especially life-critical vehicle-toeverything (V2X) ***,the heterogeneous,dynamic and decentralized architecture of these networks leads to difficulties for cryptographic key management,and *** exploiting the physical characteristics of devices,wireless channels and noise,PLS offers reliable solutions against eavesdropper attacks as complementary approaches to cryptographic techniques.

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Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image

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Journal of Innovative Optical Health Sciences 2024年第3期17卷 105-113页

作者： Yiwei Chen Yi He Hong Ye Lina Xing Xin Zhang Guohua Shi Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163P.R.China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of China Hefei 230026P.R.China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031P.R.China

The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image *** comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from *** many deep learning models are available,a single model can only perform one or two of these prediction *** accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial *** three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test *** comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our *** high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error.

关键词： Fundus fluorescein angiography image fundus structure image image translation unified deep learning model generative adversarial networks

NIr-II fluorescence imaging in liver tumor surgery: A narrative review

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 29-44页

作者： Zihao Liu Lifeng Yan Qingsong Hu dalong Yin department of General Surgery Anhui Provincial Hospital Anhui Medical UniversityHefei 230001P.R.China department of Hepatobiliary Surgery and Centre for Leading Medicine and Advanced Technologies of IHM The First A±liated Hospital of USTC division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui 230001P.R.China Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Soft Matter Chemistry and department of Chemical Physics University of Science and Technology of China Hefei 230026P.R.China Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230001P.R.China

In liver tumor surgery,the recognition of tumor margin and radical resection of microcancer focis have always been the crucial points to reduce postoperative recurrence of ***,naked-eye inspection and palpation have limited effectiveness in identifying tumor boundaries,and traditional imaging techniques cannot consistently locate tumors in real *** an intraoperative real-time navigation imaging method,NIrfluorescence imaging has been extensively studied for its simplicity,reliable safety,and superior sensitivity,and is expected to improve the accuracy of liver tumor *** recent years,the research focus of NIrfluorescence has gradually shifted from the-rst near-infrared window(NIr-I,700–900 nm)to the second near-infrared window(NIr-II,1000–1700 nm).Fluorescence imaging in NIr-II reduces the scattering effect of deep tissue,providing a preferable detection depth and spatial resolution while signi-cantly eliminating liver autofluorescence background to clarify tumor *** combined with tumor antibodies will further improve the precision offluorescence-guided surgical *** the development of a bunch offluorophores with phototherapy ability,NIr-II can integrate tumor detection and treatment to explore a new therapeutic strategy for liver ***,we review the recent progress of NIr-IIfluorescence technology in liver tumor surgery and discuss its challenges and potential development direction.

关键词： Fluorescence guided-surgery liver cancer near infrared-II optical imaging

Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis

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Neural regeneration research 2024年第3期19卷 578-582页

作者： Markley Silva Oliveira Junior Laura reiche Emerson daniele Ines Kortebi Maryam Faiz Patrick Küry department of Neurology Neuroregeneration laboratoryMedical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Institute of Medical Science University of TorontoTorontoCanada division of Anatomy Department of SurgeryUniversity of TorontoTorontoCanada

Astrocytes are indispensable for central nervous system development and *** response to injury and disease,astrocytes are integral to the immunological-and the,albeit limited,repair *** this review,we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal *** will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate ***,we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response.

关键词： astrocytes demyelination drug-based therapies myelin repair oligodendrocyte precursor cells reactive astrogliosis

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Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates

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Asian Journal of Urology 2024年第1期11卷 48-54页

作者： Michele Marchioni Giulia Primiceri Alessandro Veccia Marta di Nicola Umberto Carbonara Fabio Crocerossa Ugo Falagario Ambra rizzoli riccardo Autorino Luigi Schips Laboratory of Biostatistics Department of MedicalOral and Biotechnological Sciences“G.d'Annunzio”University of ChietiChietiItaly Urology Unit Department of MedicalOral and Biotechnological Sciences“G.d'Annunzio”University of ChietiChietiItaly division of Urology VCU HealthRichmondVAUSA

Objective:Prostate cancer(PCa)patients might experience lower urinary tract symptoms as those diagnosed with benign prostatic hyperplasia(BPH).Some of them might be treated for their lower urinary tract symptoms instead of *** aimed to test the effect of PCa versus BPH on surgical outcomes after transurethral prostate surgery,namely complication and mortality ***:Within the American College of Surgeons National Surgical Quality Improvement Program database(2011-2016),we identified patients who underwent transurethral resection of the prostate,photoselective vaporization,or laser *** were stratified according to postoperative diagnosis(PCa ***).Univariable and multivariable logistic regression models evaluated the predictors of perioperative morbidity and mortality.A formal test of interaction between diagnosis and surgical technique used was ***:Overall,34542 patients were *** all,2008(5.8%)had a diagnosis of *** multivariable logistic regression model failed to show statistically significant higher rates of postoperative complications in PCa patients(odds ratio:0.9,95%confidence interval:0.7-1.1;p=0.252).Moreover,similar rates of perioperative mortality(p=0.255),major acute cardiovascular events(p=0.581),transfusions(p=0.933),and length of stay of more than or equal to 30 days(p=0.174)were ***,all tests failed to show an interaction between post-operative diagnosis and surgical technique ***:Patients diagnosed with PCa do not experience higher perioperative morbidity or mortality after transurethral prostate surgery when compared to their BPH ***,the diagnosis seems to not influence surgical technique outcomes.

关键词： Prostatecancer Transurethral surgery of the prostate Prostate surgery Population-based analysis Benign prostatic hyperplasia Lasersurgery

Bio-based rejuvenators in asphalt pavements:A comprehensive review and analytical study

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Journal of road Engineering 2024年第3期4卷 282-291页

作者： Maria Chiara Cavalli Wangjie Wu Lily Poulikakos division of Highway and railway Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden School of Highway Chang'an UniversityXi'an 710064China Empa Dübendorf 8600Switzerland

The pressing demand for sustainable advancements in road infrastructure has catalyzed extensive research into environmentally conscious alternatives for the maintenance and restoration of asphalt concrete *** paper offers a comprehensive review and analysis of bio-based rejuvenators as a promising avenue for enhancing the longevity and sustainability of *** a multifaceted exploration,it delves into various aspects of this innovative *** a thorough overview of bio-based rejuvenators,the study highlights their renewable and environmentally friendly *** conducts an in-depth examination of a wide spectrum of bio-derived materials,including vegetable oils,waste-derived bio-products,and biopolymers,through a comprehensive *** paper evaluates how bio-based rejuvenators enhance aged asphalt binders and mixes,effectively mitigating the adverse impacts of ***,it investigates how these rejuvenators address environmental concerns by identifying compatibility issues,assessing long-term performance,and evaluating economic ***,the paper outlines potential advancements and research pathways aimed at optimizing the utilization of bio-based rejuvenators in asphalt concrete,thereby contributing to the sustainable evolution of road infrastructure.

关键词： Bio-based rejuvenator Bio-based asphalt concrete Bio-based asphalt mechanical performance Environmental benefit Optimized utilization of bio-based rejuvenator