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Development and in-vitro evaluation of an optimized carvedilol transdermal therapeutic system using experimental design approach

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Asian Journal of Pharmaceutical Sciences 2013年第1期8卷 28-38页

作者： Namrata Vora S.Lin P.L.Madan College of Pharmacy and Health Sciences St.John’s UniversityQueensNY 11439USA

The effect of formulation variables on in-vitro release and permeation properties of carvedilol from transdermal patch was studied by varying one factor at a time as preliminary *** on these results,design of experiments technique was applied followed by regression analysis and response surface methodology to optimize formulation *** Composite IV model design was used with four formulation variables:drug loading,matrix thickness,adhesive layer thickness,and propylene glycol *** formulations were prepared according to the design;and the effect of formulation variables was studied on in-vitro release and permeation profiles of these *** all cases,the permeation profiles paralleled in-vitro release *** drug released at 7 h and 24 h was used as release response parameters while permeation flux obtained was employed as permeation response *** four formulation variables were found to be significant for release properties and three of these exhibited significant effect on permeation profile of carvedilol across artificial *** optimization,using 47.9%of cumulative carvedilol released at 7 h and 99.8%at 24 h as well as 25.7 mg/cm2/h of permeation flux,was applied to obtain desired release and permeation ***,carvedilol was observed to release from the optimized formulation with 51.4%drug release at 7 h and 98.5%at 24 h with an observed flux value of 27.4 mg/cm2/h across artificial membrane,which showed an excellent agreement with the predicted *** results of this investigation show that the quadratic mathematical model developed could be used to further predict formulations with desirable release and permeation properties.

关键词： Transdermal Carvedilol Controlled release Experimental design approach

PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR

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Acta Pharmaceutica Sinica B 2014年第3期4卷 202-207页

作者： Nagaraju Anreddy Atish Patel Kamlesh Sodani Rishil J.Kathawala Eugenie P.Chen John N.D.Wurpel Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John's UniversityQueensNY 11439USA

Multidrug resistance protein 7(MRP7,ABCC10)is a recently identified member of the ATP-binding cassette(ABC)transporter family,which adequately confers resistance to a diverse group of antineoplastic agents,including taxanes,vinca alkaloids and nucleoside analogs among *** studies indicate an increased MRP7 expression in non-small cell lung carcinomas(NSCLC)compared to a normal healthy lung *** studies revealed increased paclitaxel sensitivity in the Mrp7^(-/-)mouse model compared to their wild-type *** demonstrates that MRP7 is a key contributor in developing drug *** our group reported that PD173074,a specific fibroblast growth factor receptor(FGFR)inhibitor,could significantly reverse P-glycoprotein-mediated ***,whether PD173074 can interact with and inhibit other MRP members is *** the present study,we investigated the ability of PD173074 to reverse MRP7-mediated *** found that PD173074,at non-toxic concentration,could significantly increase the cellular sensitivity to MRP7 *** studies indicated that PD173074(1μmol/L)significantly increased the intracellular accumulation and in-turn decreased the efflux of paclitaxel by inhibiting the transport activity without altering expression levels of the MRP7 protein,thereby representing a promising therapeutic agent in the clinical treatment of chemoresistant cancer patients.

关键词： PD173074 ABCC10 Fibroblast growth factor receptor Multidrug resistance Tyrosine kinase inhibitor

Signaling pathways and therapeutic interventions in gastric cancer

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4118-4155页

作者： Zi-Ning Lei Qiu-Xu Teng Qin Tian Wei Chen Yuhao Xie Kaiming Wu Qianlin Zeng Leli Zeng Yihang Pan Zhe-Sheng Chen Yulong He Guangdong Provincial Key Laboratory of Digestive Cancer Research Digestive Diseases CenterScientific Research CenterThe Seventh Affiliated Hospital of Sun Yat-Sen University518107ShenzhenGuangdongChina Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY11439USA Institute for Biotechnology St.John’s UniversityQueensNY11439USA

Gastric cancer(GC)ranks fifth in global cancer diagnosis and fourth in cancer-related *** tremendous progress in diagnosis and therapeutic strategies and significant improvements in patient survival,the low malignancy stage is relatively asymptomatic and many GC cases are diagnosed at advanced stages,which leads to unsatisfactory prognosis and high recurrence *** the recent advances in genome analysis,biomarkers have been identified that have clinical importance for GC diagnosis,treatment,and *** molecular classifications have uncovered the vital roles that signaling pathways,including EGFR/HER2,p53,PI3K,immune checkpoint pathways,and cell adhesion signaling molecules,play in GC tumorigenesis,progression,metastasis,and therapeutic *** biomarkers and molecular classifications open the way for more precise diagnoses and treatments for GC ***,the relative significance,temporal activation,interaction with GC risk factors,and crosstalk between these signaling pathways in GC are not well ***,we review the regulatory roles of signaling pathways in GC potential biomarkers,and therapeutic targets with an emphasis on recent *** therapies,including signaling-based and immunotherapies exploited in the past decade,and the development of treatment for GC,particularly the challenges in developing precision medications,are *** advances provide a direction for the integration of clinical,molecular,and genomic profiles to improve GC diagnosis and treatments.

关键词： diagnosis therapeutic precise

Redox signaling-governed drug-tolerant persister cancer cell:a key spark of treatment failure

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Signal Transduction and Targeted Therapy 2022年第4期7卷 955-957页

作者： Liwu Fu Zhe-Sheng Chen State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteCancer CenterSun Yat-Sen UniversityGuangzhou 510060China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Institute for Biotechnology St.John’s UniversityQueensNY 11439USA

In a recent study published in EMBO Molecular medicine,Zhang et *** a novel insight regarding better knowledge of the drug resistant contribution of drug-tolerant persister(DTP)state in tumor evolution,especially in terms of mechanistic insights into redox regulation involved,unambiguously establishing a novel therapeutic strategy of treating multi-drug-resistant(MDR)cancer cells and preventing tumor recurrence by disequilibrating Niemann–Pick C1-like 1(NPC1L1)-mediated redox homeostasis.

关键词： cancer homeostasis insight

Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid

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Asian Journal of Pharmaceutical Sciences 2017年第1期12卷 73-82页

作者： Suhua Li Parshotam Madan Senshang Lin School of Pharmacy Fairleigh Dickinson UniversityFlorham ParkNJ 07932USA College of Pharmacy and Health Sciences St.John’s UniversityQueensNYUSA

The purpose of this study was to investigate the effect of ionization of drug on drug solubilization in SMEDDS(self-microemulsifying drug delivery system) prepared using Capmul MCM and caprylic acid. Solubilization capacity of blank SMEDDS dispersions for danazol,indomethacin and haloperidol as model drugs was determined. Based on the outcomes of solubilization capacity study, drug-loaded SMEDDS formulations were prepared and subjected to dispersion/precipitation study and droplet size analysis. Blank SMEDDS dispersions exhibited the highest solubilization capacity for haloperidol followed by indomethacin and danazol. Furthermore, the solubilization of the three drugs in blank SMEDDS dispersions was explained by a modified mathematical model. Dispersion/precipitation studies indicate that drug-loaded SMEDDS formulations exhibited superiority in solubilizing the drugs in comparison to their respective drug powder. In addition, indomethacin and haloperidol were found to reduce the droplet size of the microemulsions while danazol did not affect droplet size formation for drug-loaded SMEDDS formulations. These findings suggest that ionization of drug affects drug solubilization, droplet size formation, drug loading and drug dispersion/precipitation profiles for the SMEDDS formulations.

关键词： SMEDDS Capmul MCM Caprylic acid Ionization Indomethacin Haloperidol

A retrospective analysis of gender among patients admitted to a clinical decision unit at risk for acute coronary syndrome

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World Journal of Emergency Medicine 2023年第2期14卷 133-137页

作者： Joby Thoppil Lauren Kraut Collin Montgomery Wilfrido Castillo Robert Silverman Sanjey Gupta Frederick Davis Department of Emergency Medicine University of Texas Southwestern Medical CenterTexas 75002USA Department of Emergency Medicine Long Island Jewish Medical CenterQueens NY 11040USA Department of Emergency Medicine South Shore HospitalBay Shore NY 11706USA

INTRODUCTION Chest pain is a common chief complaint and encompasses nearly 5.2% of all patients seen in emergency departments(ED). In the United States, this accounts for approximately six million annual visits.[1-4]The evaluation of patients with chest pain in the ED is a time-consuming and challenging process because the physician must identify those with life-threatening cardiac chest pain, while avoiding unnecessary and costly evaluations of those with non-cardiac chest pain.

关键词： admitted consuming patients

Quiet Currents beneath the Torrents of Revolution： Everyday Life in Two Novels by Yan Geling

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2014年第4期8卷 617-630页

作者： Yunzhong SHU Classical Middle Eastern and Asian Languages and Cultures Queens College The City University of New York Queen NY 11367-1597 USA

As a revolutionary leader, Mao Zedong had a new vision of China as a reformed revolutionary society. Challenging this radical social vision in The Ninth Widow （Di jiu ge guafu, 2006） and One Woman＇s Epic （Yige nuren de shishi, 2007）, the contemporary Chinese writer Yan Geling describes how the characters retain their personal mentalities and habits in everyday life as they ignore, outmaneuver or even defy the political demands of revolutionary China. Focused on Yan＇s depiction of everyday life, the present paper offers a close reading and analysis of the two novels in relation to the theories of Pierre Bourdieu, Alf Ludtke and Michel de Certeau. It pays special attention to Yan＇s depiction of everyday life as a site where the characters in the novels bring their human agency into play as they satisfy their human needs and maintain their individual characteristics. Ultimately, it shows how Yan＇s depiction of everyday life questions the reach and efficacy of dominant ideology in revolutionary China.

关键词： Yan Geling habitus everyday life revolutionary China politicalsocialization human agency

Impact of erythropoietin therapy on cardiorenal syndrome:A systematic review with meta-analysis

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World Journal of Cardiology 2023年第5期15卷 273-283页

作者： Rubal Bhangal Ivan Cancarevic Mahmoud Nassar Zaryab Umar Department of Internal Medicine Icahn School of Medicine at Mount Sinai/NYC Health+Hospitals QueensNew YorkNY 11432United States Department of Internal Medicine Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Internal Medicine NYC Health+Hospital QueensNew YorkNY 11432United States

BACKGROUND Heart and kidney dysfunction frequently coexist in patients with acute heart failure due to the overlap between these two organ *** syndrome(CRS)results from pathology occurring in the heart and kidneys along with the consequences of dysfunction in one organ contributing to dysfunction in the other and vice *** To evaluate the use of erythropoietin(EPO)in patients with CRS and its effects on hemoglobin(Hb),major cardiovascular(CV)events,and hospitalization *** On February 24,2022,searches were conducted using PubMed,MEDLINE,and EMBASE,and 148 articles were identified.A total of nine studies were considered in this systematic *** assessed the included articles based on the National Heart,Lung,and Blood Institute quality assessment tools for controlled intervention and observational cohort or cross-sectional *** assessment of bias risk was conducted on the chosen studies,and data relevant to our review was *** The systematic review of these studies concluded that most existing literature indicates that EPO improves baseline Hb levels and decreases myocardial remodeling and left ventricular dysfunction without reducing CV *** addition,the effect of EPO on the hospitalization rate of patients with CRS needs to be further studied since this relationship is *** studies,such as randomized controlled clinical trials and prospective cohort studies,should be conducted to enhance the literature on the potential of EPO therapy in patients with *** Our systematic review suggests that EPO therapy may have a significant role in managing *** review highlights the potential benefits of EPO in improving baseline Hb levels,reducing the risk of major CV events,improving cardiac remodeling,myocardial function,New York Heart Association class,and B-type natriuretic peptide ***,the effect of EPO treatment on hospitalization remains unclear and needs further exploration.

关键词： Cardiorenal syndrome Anemia Cardiovascular disease End-stage renal disease Erythropoietin Congestive heart failure

A Consistent Model of Terrestrial Planet Magnetospheres and Rotations in Our Solar System

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World Journal of Condensed Matter Physics 2021年第2期11卷 13-27页

作者： Fred J. Cadieu Physics Department Queens College of CUNY Flushing NY USA

The Sun comprises 99.9% of the solar system mass so it is expected that Sun terrestrial planet interactions can influence the motion as well as the rotation of the terrestrial planets. Gravity affects the planet orbital motions while the changing magnetic fields of the Sun can influence the planet rotations. Planets that manifest a magnetic field dominate any weaker magnetic fields from the Sun, but the rotation of terrestrial planets without a magnetic field interacts with the changing Sun’s field dependent on the electrical conductivity of the core region. It is determined that the average planet density becomes a useful quantity to describe the magnetic state of a terrestrial planet. An average density of 5350 ± 50 kg/m3 is hypothesized to separate planets that develop magnetospheres from those that do not. Planets with higher average densities, Mercury and Earth, developed magnetospheres. While those with lower average densities, Venus and Mars never developed magnetospheres. Terrestrial planets with magnetospheres are the ones to also exhibit plate tectonics. The small size of Mercury led to Mercury only exhibiting a frozen in magnetization of potentially magnetic regions. The lack of magnetospheres as well as lack of plate tectonics prevented the continual transfer of core heat to the surface that limited the surface vulcanism to an initial phase. For Venus, it meant that the surface regions would only sporadically convulse. In this picture, the apparent anomalous axial rotation of Venus is a natural consequence of the rotation of the Sun. For Mars with relatively low surface temperatures, it meant that there was little heat exchange through the crust that would allow the lower crust to retain large amounts of water. For Mars to have initially had flowing liquid water required that the atmosphere at that time contained high concentrations of infrared absorbing gases at least as compared to the present level of infrared absorbing gases on the Earth.

关键词： Earth Mercury Venus Mars Magnetic Fields Sun Early Solar System Plate Tectonics