检索结果-南通市图书馆

GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 698-711页

作者： Qiwei Jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan Chen Zhesheng Chen Zhi Shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineState Key Laboratory of Bioactive Molecules and Druggability AssessmentMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Gastrointestinal Surgery&General Surgery the Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Thoracic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Radiation Oncology The Fifth Hospital of Guangzhou Medical UniversityGuangzhou 510150China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 519000China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer.

关键词： Gastric cancer GLUL N-Cadherin β-Catenin Enzyme

维普期刊数据库

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 105-149页

作者： Yumin Wang Jing Hu Shuang Wu Joshua S.Fleishman Yulin Li Yinshi Xu Wailong Zou Jinhua Wang Yukuan Feng Jichao Chen Hongquan Wang Department of Respiratory and Critical Care Medicine Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300060PR China Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430000PR China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Outpatient Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050PR China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060PR China

Ferroptosis,a unique modality of cell death with mechanistic and morphological differences from other cell death modes,plays a pivotal role in regulating tumorigenesis and offers a new opportunity for modulating anticancer drug *** epigenetic modifications and posttranslational modifications(PTMs)promote anticancer drug resistance,cancer progression,and *** studies indicate that epigenetic modifications can transcriptionally and translationally determine cancer cell vulnerability to ferroptosis and that ferroptosis functions as a driver in nervous system diseases(NSDs),cardiovascular diseases(CVDs),liver diseases,lung diseases,and kidney *** this review,we first summarize the core molecular mechanisms of ***,the roles of epigenetic processes,including histone PTMs,DNA methylation,and noncoding RNA regulation and PTMs,such as phosphorylation,ubiquitination,SUMOylation,acetylation,methylation,and ADP-ribosylation,are concisely *** roles of epigenetic modifications and PTMs in ferroptosis regulation in the genesis of diseases,including cancers,NSD,CVDs,liver diseases,lung diseases,and kidney diseases,as well as the application of epigenetic and PTM modulators in the therapy of these diseases,are then discussed in *** the mechanisms of ferroptosis regulation mediated by epigenetic modifications and PTMs in cancer and other diseases will facilitate the development of promising combination therapeutic regimens containing epigenetic or PTM-targeting agents and ferroptosis inducers that can be used to overcome chemotherapeutic resistance in cancer and could be used to prevent other *** addition,these mechanisms highlight potential therapeutic approaches to overcome chemoresistance in cancer or halt the genesis of other diseases.

关键词： diseases epigenetic overcome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

采用改进的等同元件设计的高通滤波器

电子设计技术 2002年第1期 57-58页

作者： Richard Kurzrok queens village ny

集总参数电路低通滤波器采用改进的等同元件设计与采用一般等同元件设计相比,具有几个优点(参考文献1和2)。改进的等同元件设计具有优良的通带性能,而阻带选择性只有很小的下降。

关键词：高通滤波器低截止滤波器带通滤波器元件设计基准频率

Geometric Gibbs theory

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2020年第9期63卷 1777-1824页

作者： Yunping Jiang Department of Mathematics Queens College of the City University of New YorkNew YorkNY 11367-1597USA Department of Mathematics The CUNY Graduate CenterNew YorkNY 10016USA

We extend the classical Gibbs theory for smooth potentials to the geometric Gibbs theory for certain continuous *** study the existence and uniqueness and the compatibility of geometric Gibbs measures associated with these continuous *** introduce a complex Banach manifold structure on the space of these continuous potentials as well as on the space of all geometric Gibbs *** prove that with this complex Banach manifold structure,the space is complete and,moreover,is the completion of the space of all smooth potentials as well as the space of all classical Gibbs *** is a maximum metric on the space,which is *** prove that the topology induced by the newly introduced complex Banach manifold structure and the topology induced by the maximal metric are the *** prove that a geometric Gibbs measure is an equilibrium state,and the in mum of the metric entropy function on the space is zero.

关键词： geometric Gibbs measure continuous potential smooth potential Teichmuller's metric maximum metric Kobayashi's metric symmetric rigidity complex Banach manifold

维普期刊数据库

Pastoral Aspirations, Responsibilities and Strategies： A Novelist＇s Solution for the Moral Crisis in China

在线全文

学校读者我要写书评

暂无评论

Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2016年第2期10卷 169-183页

作者： Yunzhong SHU Department of Classical Middle Eastern and Asian Languages and Cultures Queens College The City University of New York Queens NY 11367-1597 USA

Since the late 1970s China has implemented sweeping economic reforms for almost 40 years. At the same time, it has not officially adjusted its previous moral code. As a result, the country is now faced with a widespread moral crisis characterized by greed and anomie. To offer a remedy for this crisis in his novel The Door of the Sheep （1999）, Li Peifu, a noted writer from Henan Province, creates a village leader intent on maintaining his authoritative moral position as a shepherd by restraining his corporeal desires and exercising his authority on his flock and for his flock. In a subsequent novel entitled pervasive moral disorientation in a village where nobody assumes a pastoral position. The present article analyzes these two novels in connection with the sociopolitical environment of contemporary China. Special attention will be paid to Li＇s interpretation of human selfishness as the root cause of the moral crisis and his attempt to offer a politically feasible and morally effective solution.

关键词： Li Peifu moral crisis human selfishness pastoral position,self-restraint

Kobayashi＇s and Teichmiiller＇s Metrics on the Teichmiiller Space of Symmetric Circle Homeomorphisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2011年第3期27卷 617-624页

作者： Jun HU Yun Ping JIANG Department of Mathematics Brooklyn College of CUNY Brooklyn NY 11210 USA Department of Mathematics CUNY Graduate Center 365 Fifth Avenue New York NY 10016 USA Department of Mathematics Queens College of CUNY Flushing NY 11367 USA

We give a direct proof of a result of Earle, Gardiner and Lakic, that is, Kobayashi＇s metric and Teichmuller＇s metric coincide with each other on the Teichmfiller space of symmetric circle homeomorphisms.

关键词： Universal asymptotically conformal Teichmiiller space Teichmiiller's metric Kobayashi's metric

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

抑制噪声和交流声的低成本音频滤波器

电子设计技术 EDN CHINA 2006年第6期13卷 108-108,110页

作者： Richard M Kurzrok RMK Consultants queens village ny RMK Consultants Queens VillageNY

本设计实例中的低成本组合无源滤波器无需直流电源，就可以抑制电源的交流声以及从AM、FM和低频段VHF传输中拾取的寄生干扰．从而提高音频设备和仪器的性能（图1）。该组合滤波器包括级联的三个简单滤波器：一个T型高通滤波器，用于抑... 详细信息

本设计实例中的低成本组合无源滤波器无需直流电源，就可以抑制电源的交流声以及从AM、FM和低频段VHF传输中拾取的寄生干扰．从而提高音频设备和仪器的性能（图1）。该组合滤波器包括级联的三个简单滤波器：一个T型高通滤波器，用于抑制电源的交流声；两个π型低通滤波器，用于抑制寄生射频信号。开始时，三个滤波器段在50Ω的阻抗水平上呈现无损的0．01 dB Chebyshev响应，但可以调整各元件的值来满足其它的阻抗要求。

关键词：无源滤波器音频设备交流声抑制噪声直流电源高通滤波器低通滤波器设计实例

维普期刊数据库

Intra-procedural arrhythmia during cardiac catheterization: A systematic review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Cardiology 2020年第6期12卷 269-284页

作者： Fatima A Shaik David J Slotwiner Gregory M Gustafson Xuming Dai Division of Cardiology New York Presbyterian Queens HospitalFlushingNY 11355United States

BACKGROUND Cardiac catheterization is among the most performed medical procedures in the modern *** were sporadic reports indicating that cardiac arrhythmias are common during cardiac catheterization,and there are risks of developing serious and potentially life-threatening arrhythmias,such as sustained ventricular tachycardia(VT),ventricular fibrillation(VF)and high-grade conduction disturbances such as complete heart block(CHB),requiring immediate ***,there is lack of systematic overview of these *** To systematically review existing literature and gain better understanding of the incidence of cardiac arrhythmias during cardiac catheterization,and their impact on outcomes,as well as potential approaches to minimize this *** We applied a combination of terms potentially used in reports describing various cardiac arrhythmias during common cardiac catheterization procedures to systematically search PubMed,EMBASE and Cochrane databases,as well as references of full-length *** During right heart catheterization(RHC),the incidence of atrial arrhythmias(premature atrial complexes,atrial fibrillation and flutter)was low(<1%);these arrhythmias were usually transient and *** associated with the development of a new RBBB at a rate of 0.1%-0.3%in individuals with normal conduction system but up to 6.3%in individuals with pre-existing left bundle branch *** patients may require temporary pacing due to transient *** premature ventricular complexes or non-sustained VT are common during RHC(up to 20%of cases).Sustained ventricular arrhythmias(VT and/or VF)requiring either withdrawal of catheter or cardioversion occurred infrequently(1%-1.3%).During left heart catheterizations(LHC),the incidence of ventricular arrhythmias has declined significantly over the last few decades,from 1.1%historically to 0.1%*** overall reported rate of VT/VF in diagnostic LHC and coronary angiography is 0.8

关键词： Catheterization Coronary angiography Percutaneous coronary intervention Ventricular fibrillation Ventricular tachycardia

Inverse design of two-dimensional materials with invertible neural networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2021年第1期7卷 1822-1830页

作者： Victor Fung Jiaxin Zhang Guoxiang Hu P.Ganesh Bobby G.Sumpter Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Computer Science and Mathematics Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Chemistry and Biochemistry Queens College of the City University of New YorkQueensNY 11367USA

The ability to readily design novel materials with chosen functional properties on-demand represents a next frontier in materials ***,thoroughly and efficiently sampling the entire design space in a computationally tractable manner remains a highly challenging *** tackle this problem,we propose an inverse design framework(MatDesINNe)utilizing invertible neural networks which can map both forward and reverse processes between the design space and target *** approach can be used to generate materials candidates for a designated property,thereby satisfying the highly sought-after goal of inverse *** then apply this framework to the task of band gap engineering in two-dimensional materials,starting with MoS_(2).Within the design space encompassing six degrees of freedom in applied tensile,compressive and shear strain plus an external electric field,we show the framework can generate novel,high fidelity,and diverse candidates with near-chemical *** extend this generative capability further to provide insights regarding metal-insulator transition in MoS_(2)which are important for memristive neuromorphic applications,among *** approach is general and can be directly extended to other materials and their corresponding design spaces and target properties.

关键词： properties inverse satisfying