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Analysis of an Adulterated Herbal Medicinal Product Using Ultra-Performance Liquid Chromatography Coupled with QTOF Mass Spectrometry

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World Journal of Traditional Chinese Medicine 2016年第3期2卷 1-9页

作者： Kate Yu Mark Powell Margaret Maziarz Dhavalkumar Narendrabhai Patel Waters Corporation quay pharmaceuticals Deeside Industrial Park Mark Powell Scientific Waters Pacific Pte Ltd The CapricornSingapore Science Park Ⅱ

The reports of severe adverse effects and fatalities associated with herbal medicinal products adulterated with synthetic compounds have raised global *** objective of this study is to analyze one commercial herbal medicinal product suspected to be adulterated with synthetic drugs in order to identify potential adulterants,to verify if the product contained the herbs listed as ingredients in label claim and to determine quality consistency among different batches of the *** of suspected product obtained from seven different batches were performed using ultra performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) with multiple data processing tools and multivariate *** addition,23 individual powdered herbs(12 as per label claim and 11 suspected herbs),11 marker compounds of the labeled herbs and five suspected synthetic drugs as adulterants were also concurrently analyzed to have clear understanding of product *** on our analysis,the major ingredients of studied product were found to be 5 synthetic compounds:caffeine,chlorphenamine,piroxicam,betamethasone and *** of them have been found to exceed their recommended *** the herbal composition analysis,Gan Cao(Glycyrrhizae radix et rhizoma) was found to be the main ingredient,which is not among the claimed 12 herbs that were supposed to be in the *** herbs detected as minor ingredients were Mu Gua(Chaenomelis fructus),Dang Gui(Angelicae sinensis radix),and Huang Qi(Astragali radix),which are among the 12 herbs that were supposed to be in the *** on our results we demonstrated that UPLC-QTOF MS is an effective and versatile tool for the analysis of herbal medicinal *** is highly desirable to have a streamlined process with automatic workflow and fit-forpurpose database to increase efficiency and productivity of sample *** of this work also highlight the need for the be

关键词： Synthetic adulterants Adulteration UPLC-QTOF-MS Herbal products Data independent acquisition Multi-Variate Statistical Analysis

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