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The inter-relationships of the neural basis of rumination and inhibitory control:neuroimaging-based meta-analyses

Psychoradiology 2022年第1期2卷 11-22页

作者： Xiaoqi Song Jixin Long Chanyu Wang Ruibin Zhang Tatia M.C.Lee Cognitive control and Brain Healthy Laboratory Department of PsychologySchool of Public healthSouthern Medical UniversityGuangzhou510515China Department of Psychiatry Zhujiang HospitalSouthern Medical UniversityGuangzhou510285China State Key Laboratory of Brain and Cognitive sciences The University of Hong KongHong Kong999077SAR China Laboratory of Neuropsychology and Human Neuroscience The University of Hong KongHong Kong999077SAR China center for Brain science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay Area510799

Rumination,as a clinical manifestation and pathogenic factor of depression,has long been the focus of psycho-logical research regarding its causes and ameliorating *** studies have shown that rumina-tion is related to inhibitory control deficits,which provides ideas for reducing ***,the neural relationship between them has not been clearly *** this study,we first used multi-level kernel density analysis to conduct two meta-analyses of published functional magnetic resonance imaging studies:one was rumination comprising 17 studies with 180 foci,and the other was inhibitory control comprising 205 studies with 3791 *** analysis was then performed to explore the common brain regions and further decode them through Neurosynth to confirm the cognitive *** showed that rumination was mainly related to the default mode network(DMN),while inhibitory control was associated with the frontoparietal network(FPN).In addition,the common activation areas were mainly concentrated in the bilateral precuneus,right supe-rior frontal gyrus,bilateral median cingulate,paracingulate gyri,and the left triangular part of inferior frontal gyrus(IFG).Decoding results also revealed they were involved in inhibition,memory retrieval,and self-related *** findings support that rumination is associated with inhibitory control and can be explained neu-rologically by an antagonistic relationship between the DMN and *** sum,inhibitory control may be related to rumination via inhibiting task-unrelated attention and controlling self-related *** research will help us understand and predict rumination from the perspective of inhibitory control and reduce rumination through behavioral training of inhibitory control or the application of neuromodulation techniques to common activation regions.

关键词： Rumination Inhibitory control Meta-analysis fMRI

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Whole-Brain Map of Long-Range Monosynaptic Inputs to Different Cell Types in the Amygdala of the Mouse

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Neuroscience Bulletin 2020年第11期36卷 1381-1394页

作者： Jia-Yu Fu Xiao-Dan Yu Yi Zhu Shi-Ze Xie Meng-Yu Tang Bin Yu Xiao-Ming Li center for Neuroscience and Department of Neurology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China NHC and CAMS Key Laboratory of Medical Neurobiology Center for Brain Science and Brain-Inspired IntelligenceGuangdong-Hong Kong-Macao Greater Bay AreaJoint Institute for Genetics and Genome Medicine between Zhejiang University and University of TorontoHangzhou 310058China

The amygdala,which is involved in various behaviors and emotions,is reported to connect with the whole ***,the long-range inputs of distinct cell types have not yet been ***,we used a retrograde trans-synaptic rabies virus to generate a whole-brain map of inputs to the main cell types in the mouse *** identified 37 individual regions that projected to neurons expressing vesicular glutamate transporter 2,78 regions to parvalbumin-expressing neurons,104 regions to neurons expressing protein kinase C-δ,and 89 regions to somatostatin-expressing *** amygdala received massive projections from the isocortex and *** nuclei,such as the caudate-putamen and the CA1 field of the hippocampus,exhibited input preferences to different cell types in the ***,we identified several novel input areas,including the substantia innominata and zona *** findings provide anatomical evidence to help understand the precise connections and diverse functions of the amygdala.

关键词： Basolateral amygdala Central amygdala Rabies virus retrograde tracing Glutamatergic GABAergic Mouse

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Induction of Anxiety-Like Phenotypes by Knockdown of Cannabinoid Type-1 Receptors in the Amygdala of Marmosets

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Neuroscience Bulletin 2023年第11期39卷 1669-1682页

作者： Lin Zhu Di Zheng Rui Li Chen-Jie Shen Ruolan Cai Chenfei Lyu Binliang Tang Hao Sun Xiaohui Wang Yu Ding Bin Xu Guoqiang Jia Xinjian Li Lixia Gao Xiao-Ming Li Department of Neurobiology and Department of Neurology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhou310058China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brian MedicineZhejiang UniversityHangzhou310058China Interdisciplinary Institute of Neuroscience and Technology Zhejiang University School of MedicineHangzhou310029China center for Brain science and Brain-Inspired Intelligence Research Units for Emotion and Emotion DisordersChinese Academy of Medical SciencesChina/Guangdong-Hong Kong-Macao Greater Bay AreaJoint Institute for Genetics and Genome Medicine Between Zhejiang University and University of TorontoHangzhou310058China Rehabilitation Medicine center Rehabilitation&Sports Medicine Research Institute of Zhejiang ProvinceDepartment of Rehabilitation MedicineZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou311399China

The amygdala is an important hub for regulating emotions and is involved in the pathophysiology of many mental diseases,such as depression and ***,the endocannabinoid system plays a crucial role in regulating emotions and mainly functions through the cannabinoid type-1 receptor(CB1R),which is strongly expressed in the amygdala of non-human primates(NHPs).However,it remains largely unknown how the CB1Rs in the amygdala of NHPs regulate mental ***,we investigated the role of CB1R by knocking down the cannabinoid receptor 1(CNR1)gene encoding CB1R in the amygdala of adult marmosets through regional delivery of *** found that CB1R knockdown in the amygdala induced anxiety-like behaviors,including disrupted night sleep,agitated psychomotor activity in new environments,and reduced social ***,marmosets with CB1R-knockdown had up-regulated plasma cortisol *** results indicate that the knockdown of CB1Rs in the amygdala induces anxiety-like behaviors in marmosets,and this may be the mechanism underlying the regulation of anxiety by CB1Rs in the amygdala of NHPs.

关键词： Cannabinoid type-1 receptor Amygdala Marmoset Anxiety CRISPR/Cas9

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Determining the contribution of Mo single atoms components in MoO_(2)nanocatalyst in transfer hydrogenation

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Nano Research 2023年第2期16卷 2302-2310页

作者： Ze-Nan Hu Yongjian Ai Yan Zhao Yiming Wang Kelong Ding Wenhui Zhang Rongxiu Guo Xinyue Zhang Xiangbin Cai Ning Wang Jianshe Hu Qionglin Liang hongyang Liu Fei Huang Limin Wu Jiangwei Zhang hong-bin Sun School of Environmental Engineering and Chemistry Luoyang Institute of Science and TechnologyLuoyang 471023China Department of Chemistry Northeastern UniversityShenyang 110819China MOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Beijing Key Lab of Microanalytical Methods&InstrumentationDepartment of ChemistryCenter for Synthetic and Systems BiologyTsinghua UniversityBeijing 100084China College of Energy Material and Chemistry Inner Mongolia UniversityHohhot 010021China Department of Physics and center for quantum Materials Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Shenyang National Laboratory for Materials science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Nanocatalysts are likely to contain undetected single-atom components,which may have been ignored but have significant effect in catalytic ***,we report a catalyst composed of Mo single atoms(SAs)and MoO_(2)nanoparticles(NPs)(MoSAs-MoO_(2)@NC),which is an exact model to understand how the SAs contribute to the *** experimental results and the density functional theory calculations reveal that Mo SAs on nitrogen-doped carbon provides the reaction zone for nitro reduction,while MoO_(2)is the active site for decomposing hydrazine hydrate to produce H*.Thanks to the synergy between Mo SAs and MoO_(2)NPs,this catalyst exhibits noble metal-like catalytic activity(100%conversion at 4 min)for the dechlorination-proof transfer ***,the hydrogen migration on the catalyst is verified by the electrochemical tests in the absence of a hydrogen *** work provides a model for further study on the coexistence of single atoms in nanoparticle catalysts.

关键词： synergistic effect Mo single atoms MoO_(2)nanocatalyst transfer hydrogenation nitroarenes

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Treadmill Exercise Relieves Chronic Restraint Stress-induced Cognitive Impairments in Mice Via Activating Protein Phosphatase 2A

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Neuroscience Bulletin 2021年第10期37卷 1487-1492页

作者： Wenjing Zhang Haining Ou Borui Zhang Meifeng Zheng Lan Yan Yang Chen Kwok-Fai So Li Zhang Department of Rehabilitation The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700China Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou 510600China School of Pharmaceutical sciences Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Brain and Cognitive science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina center for Brain science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510080China Bioland Laboratory(Guangzhou Regenerative Medicine and Health guangdong Laboratory) Guangzhou 510700China

Dear Editor,Aerobic exercise is well known to improve cognitive functions including hippocampus-dependent spatial memory[1]and object recognition[2].Regarding the molecular mechanisms,the indispensable role of brain-derived neurotrophic factor(BDNF)in governing exercise-induced neural plasticity has been demonstrated for the improvement of learning and memory[3].Our recent study further demonstrated the activation of mechanistic target of rapamycin pathways downstream of BDNF to drive synaptic protein synthesis upon persistent exercise[4],but leaving the effect of exercise on the post-translational modification of proteins largely unknown.

关键词： exercise translational indispensable

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MnBi_(2)Te_(4)轴子绝缘态中巨大的非局域边缘导电信号

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science Bulletin 2023年第12期68卷 1252-1258,M0003页

作者：李耀鑫刘畅王永超连梓臣李帅李昊吴扬卢海舟张金松王亚愚 State Key Laboratory of Low Dimensional quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Beijing Academy of quantum Information sciences Beijing 100193China Beijing Key Laboratory of Opto-electronic Functional Materials&Micro-Nano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China Key Laboratory of quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Shenzhen Institute for quantum science and Engineering and Department of Physics Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of quantum science and Engineering Shenzhen 518055China quantum science center of guangdong-hong kong-macao greater bay area(guangdong) Shenzhen 518045China International quantum Academy Shenzhen 518048China School of Materials science and Engineering Tsinghua UniversityBeijing 100084China Tsinghua-Foxconn Nanotechnology Research center Department of PhysicsTsinghua UniversityBeijing 100084China College of science Beijing University of Chemical TechnologyBeijing 100029China New Cornerstone science Laboratory Frontier Science Center for Quantum InformationBeijing 100084China Hefei National Laboratory Hefei 230088China

近年发现的反铁磁拓扑绝缘体MnBi_(2)Te_(4)是一种具有多重新奇性质的材料.由于范德瓦尔斯层状结构和层间反铁磁序,这一材料可用于探索在微纳尺度下的器件中独特的拓扑量子现象,比如奇数层MnBi_(2)Te_(4)的量子反常霍尔效应和偶数层的... 详细信息

近年发现的反铁磁拓扑绝缘体MnBi_(2)Te_(4)是一种具有多重新奇性质的材料.由于范德瓦尔斯层状结构和层间反铁磁序,这一材料可用于探索在微纳尺度下的器件中独特的拓扑量子现象,比如奇数层MnBi_(2)Te_(4)的量子反常霍尔效应和偶数层的轴子绝缘态.理论预言,MnBi_(2)Te_(4)轴子绝缘态具有独特的螺旋棱态电流,从而产生非局域输运,但目前还没有在实验上观测到.本文报道了少层MnBi_(2)Te_(4)器件中的输运研究,厚度范围从6层到9层.当系统处于轴子绝缘态时,作者观察到偶数层器件的巨大非局域输运信号.而在同样的磁场范围内,奇数层器件的非局域信号几乎为零,结合理论计算,作者发现这种非局域输运是通过分布在侧面与上下表面之间的棱处的螺旋电流实现的,轴子绝缘态中的螺旋棱态电流的观测有助于对宇称反常的半量子化物理的进一步探索,可能在未来的拓扑和量子器件中发挥其独特的重要作用。

关键词：范德瓦尔斯拓扑绝缘体量子反常霍尔效应量子现象量子化反铁磁序宇称量子器件

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A Number Estimate of Detectable Detached Black Hole-star Binaries using a Photometric Telescope

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Research in Astronomy and Astrophysics 2023年第8期23卷 141-152页

作者： Zhe-Cheng Hu Yan-Lv Yang Yuan-Hao Wen Rong-Feng Shen Pak-Hin Thomas Tam School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST science center for the guangdong-hong kong-macao greater bay area Zhuhai 519082China Now at Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei230026China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

Detached and wide-orbit black hole-star binaries(BHSBs)can generate three types of periodic photometric signals:Ellipsoidal Variation,Doppler beaming and Self-Lensing(SL),providing a proxy to discover these black *** estimate the relative amplitude of the three signals for such systems and the detectability for black holes of a photometric telescope like Kepler in several *** estimate the searchable star number by assuming every star has a black hole companion,and apply the occurrence of BHSBs in field stars to estimate the detectable black hole *** consider three types of Initial Mass Function(IMF)model with different high end exponential slopes.“When spot and white noise are both considered,there is about one detectable signal for SL and less than one event is expected for beaming and Ellipsoidal Variation signal in Kepler Input Catalog stars with the standard IMF model.”to“Due to contamination by stellar spots and white noise,one may expect one detectable signal for SL and less than one detectable signal for both beaming and Ellipsoidal Variation in Kepler Input Catalog stars with the standard IMF model.”On the other hand,if we assume that only white noise affects the detection efficiency of the BHSBs,we expect about 10 Ellipsoidal Variation signals and 17 beaming signals to be detectable while the number of SL signals remains unchanged.

关键词： black hole physics-techniques photometric-surveys-stars black holes-stars variables general

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TNF-α,IL-6 and hs CRP in patients with melancholic,atypical and anxious depression:an antibodyyarrayanalysis related to somatic symptoms

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General Psychiatry 2022年第5期35卷 354-365页

作者： hongmei Liu Xiaohui Wu Yun Wang Xiaohua Liu Daihui Peng Yan Wu Jun Chen Yun-Ai Su Jia Xu Xiancang Ma Yi Li Jianfei Shi Xiaodong Yang Han Rong Marta Di Forti Yiru Fang Clinical Research center Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina Peking University Sixth Hospital BeijingChina Harbin First Specific Hospital HarbinChina Department of Psychiatry The First Affiliated Hospital of Xi'an Jiaotong UniversityXianChina Wuhan Mental Health center WuhanChina Hangzhou Seventh People's Hospital HangzhouChina Shandong Mental Health center JinanChina Shenzhen Mental Health center ShenzhenChina Department of Social Genetics and Developmental Psychiatry Institute of Psychiatry Psychology and Neuroscience King's College LondonLondonUK guangdong-hong kong-macao greater bay area center for Brain science and Brain-Inspired Intelligence GuangzhouChina State Key Laboratory of Neuroscience Shangha nstitute for Biological SciencesCASShanghaiChina

Background The association between inflammation and major depressive disorder(MDD)remains poorly understood,given the heterogeneity of patients with *** We investigated inflammatory markers,such as interleukin(IL)-6,high-sensitivity C reactive protein(hsCRP)and tumour necrosis factor-α.(TNF-α)in melancholic,atypical and anxious depression and explored whether baseline inflammatory protein levels could indicate *** The sample consisted of participants(aged 18-55 years)from a previously reported multicentre randomised controlled trial with a parallel-group design registered with ***,including melancholic(n=44),atypical(n=37)and anxious(n=44)patients with depression and healthy controls(HCs)(n=33).Subtypes of MDD were classified according to the 30-item Inventory of Depressive Symptomatology,Self-Rated Version and the.17-item Hamilton Depression Rating *** *** TNF-α,IL-6 and hsCRP were assessed using antibody array *** Patients with MDD,classified according to melancholic,atypical and anxious depression subtypes,and HCs did not differ significantly in baseline TNF-α,IL-6 and hsCRP levels after *** patients with anxious depression,hsCRP levels increased significantly if they experienced no pain(adjusted(adj.)p=0.010)or mild to moderate pain(adj.p=0.038)compared with those with severe ***,the patients with anxious depression and severe pain showed a lower trend in hsCRP levels than patients with atypical depression who experienced severe pain(p=0.022;adj.p=0.155).Baseline TNF-α(adj.p=0.038)and IL-6(adj.p=0.006)levels in patients in remission were significantly lower than those in patients with no remission among the participants with the atypical depression subtype at the eighth-week *** This study provides evidence of differences in inflammatory proteins in patients with varied symptoms among melancholic,atypical and anxious depression *** studies on the immuno

关键词： patients atypical Blood

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Literature review on the mechanical properties of materials after surface mechanical attrition treatment(SMAT)

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Nano Materials science 2020年第1期2卷 3-31页

作者： Temitope Olumide Olugbade Jian Lu Department of Mechanical Engineering City University of Hong KongHong Kong SARChina hong kong Branch of National Precious Metals Material Engineering Research center(NPMM) City University of Hong KongHong KongChina Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstituteGreater Bay Joint DivisionShenyang National Laboratory for Materials ScienceShenzhenChina

Most of the challenges experienced by many engineering materials originate from the surface which later leads to total failure,hence affecting the resultant mechanical properties and service ***,these challenges have been addressed thanks to the invention of a novel surface mechanical attrition treatment(SMAT)method which protects the material surface by generating a gradient-structured layer with improved strength and hardness without jeopardizing the *** present work provides a comprehensive literature review on the mechanical properties of materials after SMAT including the hardness,tensile strength and elongation,and residual ***,a brief introduction on the different forms of surface nanocrystallization is given to get a better understanding of the SMAT process and its advantages over other forms of surface treatments,and then the grain refinement mechanisms of materials by SMAT from the matrix region(base material)to the nanocrystallized layer are *** effects of fatigue,fracture,and wear of materials by the enhanced mechanical properties after SMAT are also discussed in *** addition,the various applications of SMAT ranging from automotive,photoelectric conversion,biomedical,diffusion,and 3 D-printing of materials are extensively *** prospects and recent research trends in terms of mechanical properties of materials affected by SMAT are then summarized.

关键词： SMAT Nanostructured materials Ultra-high strength Ductility Fatigue

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Development of Bioimplants with 2D, 3D, and 4D Additive Manufacturing Materials

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Engineering 2020年第11期6卷 1232-1243页

作者： Guo Liu Yunhu He Pengchao Liu Zhou Chen Xuliang Chen Lei Wan Ying Li Jian Lu Department of Mechanical Engineering City University of Hong KongHong Kong 999077China Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstituteGreater Bay Joint DivisionShenyang National Laboratory for Materials ScienceShenzhen 518057China hong kong Branch of National Precious Metals Material Engineering Research center(NPMM) City University of Hong KongHong Kong 999077China CityU-Shenzhen Futian Research Institute Shenzhen 518045China

Over the past 30 years,additive manufacturing(AM)has developed rapidly and has demonstrated great potential in biomedical *** is a materials-oriented manufacturing technology,since the solidification mechanism,architecture resolution,post-treatment process,and functional application are based on the materials to be ***,3D printable materials are still quite limited for the fabrication of *** this work.2D/3D AM materials for bioimplants are ***,inspired by Tai Chi,a simple yet novel soft/rigid hybrid 4D AM concept is advanced to develop complex and dynamic biological structures in the human body based on 4D printing hybrid ceramic precursor/ceramic materials that were previously developed by our *** the development of multi-material printing technology,the development of bioimplants and soft/rigid hybrid biological structures with 2D/3D/4D AM materials can be anticipated.

关键词： Bioprinting 2D additive manufacturing 3D printing 4D printing Bioimplants

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